• Journal of Genetic Medicine
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• v.8 no.1
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• pp.53-57
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• 2011

Purpose: Wilson disease is an autosomal recessive disorder which causes excessive copper accumulation in the hepatic region. So far, ATP7B gene is the only disease-causing gene of Wilson disease known to date. However, ATP7B mutations have not been found in ~15% of the patients. This study was performed to identify any causative gene in Wilson disease patients without an ATP7B mutation in either allele. Materials and Methods: The sequence of the coding regions and exon-intron boundaries of the five ATP7B-interacting genes, ATOX1, COMMD1, GLRX, DCTN4, and ZBTB16, were analyzed in the 12 patients with Wilson disease. Results: Three nonsynonymous variants including c.1084A>G (p.Thr362Ala) in the exon 12 of the DCTN4 gene were identified in the patients examined. Among these, only p.Thr362Ala was predicted as possibly damaging protein function by in silico analysis. Examination of allele frequency of c.1084A>G (p.Thr362Ala) variant in the 176 patients with Wilson disease and in the 414 normal subjects revealed that the variant was more prevalent in the Wilson disease patients (odds ratio [OR]=3.14, 95% confidence interval=1.36-7.22, P=0.0094). Conclusion: Our result suggests that c.1084A>G (p.Thr362Ala) in the ATP7B-interacting DCTN4 gene may be associated with the pathogenesis of Wilson disease.

• Journal of Acupuncture Research
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• v.18 no.6
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• pp.93-104
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• 2001

Objective : To localize and compare the cerebral regions- activated by the the stimulation of traditional and burning acupunctures in right Hap-Kok (LI4) acupoints. Methods : Thirty-four healthy normal volunteers (19 males, 15 females, age 31${\pm}$11 years) were studies by rest/acupuncture Tc-99m HMPAO SPECT using same-dose sequential injection method using right Hap-Kok(LI4), traditional and burning acupunctures. All images were spatially normalized and the differences between rest and acupuncture activation state were statistically analyzed using SPM 96. Results : Statistical analysis of the effect by the stimulation using traditional acupuncture in right L14 showed regional cerebral perfusion increase in right inferior frontal lobe, right straight gyrus, left anterolateral frontal lobe, left anteroinferior temporal lobe, left posterior temporal lobe, and left cerebellum. In the stimulation using burning acupuncture in right LI4, regional cerebral perfusion increased in right posterior prefrontal lobe, right precental gyrus, right postcentral gyrus, right poteroinferior temporal lobe, left precentral gyrus, left Broca's area, left anterior parietal lobe, left posterior prefrontal lobe, and left cerebellum. In right LA, diffuse perfusion increase were noted in the both inferior frontal lobe by traditional acupuncture compared to burning acupuncture. Conclusion : The results localized the cerebral areas showed the effect of the acupuncture on cerebral blood flow. The effects of traditional and burning acupunctures on cerebral blood flow were similar in right Hap-Kok (LI4) acupoints. But the effects of traditional acupunctures on cerebral blood flow are stronger than those of burning acupunctures on cerebral blood flow.

• Journal of the Korean Data and Information Science Society
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• v.26 no.6
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• pp.1353-1366
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• 2015

These days Shewhart control chart for evaluating stability of the process is widely used in various field. But it must follow strict assumption of distribution. In real-life problems, this assumption is often violated when many quality characteristics follow non-normal distribution. Moreover, it is more serious in multivariate quality characteristics. To overcome this problem, many researchers have studied the non-parametric control charts. Recently, SVDD (Support Vector Data Description) control chart based on RBF (Radial Basis Function) Kernel, which is called K-chart, determines description of data region on in-control process and is used in various field. But it is important to select kernel parameter or etc. in order to apply the K-chart and they must be predetermined. For this, many researchers use grid search for optimizing parameters. But it has some problems such as selecting search range, calculating cost and time, etc. In this paper, we research the efficiency of selecting parameter regions as data structure vary via simulation study and propose a new method for determining parameters so that it can be easily used and discuss a robust choice of parameters for various data structures. In addition, we apply it on the real example and evaluate its performance.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.2
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• pp.159-173
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• 1991

This paper describes a potential-based panel method formulated for the analysis of a super-cavitating two-dimensional hydrofoil. The method employs normal dipoles and sources distributed on the foil and cavity surfaces to represent the potential flow around the cavitating hydrofoil. The kinematic boundary condition on the wetted portion of the foil surface is satisfied by requiring that the total potential vanish in the fictitious inner flow region of the foil, and the dynamic boundary condition on the cavity surface is satisfied by requiring thats the potential vary linearly, i.e., the tangential velocity be constant. Green's theorem then results in a potential-based integral equation rather than the usual velocity-based formulation of Hess & Smith type. With the singularities distributed on the exact hydrofoil surface, the pressure distributions are predicted with improved accuracy compared to those of the linearized lilting surface theory, especially near the leading edge. The theory then predicts the cavity shape and cavitation number for an assumed cavity length. To improve the accuracy, the sources and dipoles on the cavity surface are moved to the newly computed cavity surface, where the boundary conditions are satisfied again. This iteration process is repeated until the results are converged. Characteristics of iteration and discretization of the present numerical method are much faster and more stable than the existing nonlinear theories. The theory shows good correlations with the existing theories and experimental results for the super-cavitating flow. In the region of small angles of attack, the present prediction shows and excellent comparison with the Geurst's linear theory. For the long cavity, the method recovers the trends of the Wu's nonlinear theory. In the intermediate regions of the short super-cavitation, the method compares very well with the experimental results of Parkin and also those of Silberman.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.83-83
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• 1993

The nuclear phosphoprotein p53 is expressed in all normal cells and appears to function in cell cycle regulation. Abnormally high levels of the protein are found in many different types of cancer. In human cancer overexpression of p53 is associated with point mutations within highly conserved regions of p53 gene. These altered genes encode stable p53 proteins that can detected by standard immunocytochemical techniques unable to detect rapidly degraded wild-type protein. Using of a monoclonal antibody to p53 antigen, immunocytochemical analysis of 29 squamous cell carcinomas of tongue(n= 19) and tonsil(n= 10) was performed. Non-tumor nuclei showed all negative reactivity. Positive reactivity was found in 4/29(13.8%)of SCCs of tongue and tonsil. In sizes of primary tumor, the cases over 4cm showed more positive reactivity than the cases under 4cm(p < 0.05). There was no stastical correlation between the reactivity and histopathologic grades, the primary sites of tumor or the presence of cervical metastasis.

• Journal of Korea Water Resources Association
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• v.51 no.9
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• pp.747-759
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• 2018

Multivariate regional frequency analysis has advantages of regional and multivariate framework as adopting a large number of regional dataset and modeling phenomena that cannot be considered in the univariate frequency analysis. To the best of our knowledge, the multivariate regional frequency analysis has not been employed for hydrological variables in South Korea. Applicability of the multivariate regional frequency analysis should be investigated for the hydrological variable in South Korea in order to improve our capacity to model the hydrological variables. The current study focused on estimating parameters of regional copula and regional marginal models, selecting the most appropriate distribution models, and estimating regional multivariate growth curve in the multivariate regional frequency analysis. Annual maximum rainfall and duration data observed at 71 stations were used for the analysis. The results of the current study indicate that Frank and Gumbel copula models were selected as the most appropriate regional copula models for the employed regions. Several distributions, e.g. Gumbel and log-normal, were the representative regional marginal models. Based on relative root mean square error of the quantile growth curves, the multivariate regional frequency analysis provided more stable and accurate quantiles than the multivariate at-site frequency analysis, especially for long return periods. Application of regional frequency analysis in bivariate rainfall-duration analysis can provide more stable quantile estimation for hydraulic infrastructure design criteria and accurate modelling of rainfall-duration relationship.

• Journal of the Korea Concrete Institute
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• v.20 no.2
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• pp.193-202
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• 2008

Seismic design for bridge columns of the current Korea Highway Bridge Design Specifications which adopt full ductility design concept results in reinforcement congestion problems in construction site. It is due to large amount of confining steel is required even for small ductility demand which is a normal case in low and moderate seismicity regions like Korean peninsular. Therefore a new seismic design method based on limited ductility concept was proposed, which is called ductility demand based design method. It uses the new confining steel design equation considering ductility demand and aspect ratio of the column as well as material strength. The purpose of this study is to verify safety of the ductility demand based design method by the confining steel design equation. Eighty nine circular column test results are selected and investigated in terms of ductility factor and its safety. The safety factor for the circular column test results ranges between 1.11 and 3.98, and the average is 1.90. In this paper, the basic concept and detailed design procedure of the ductility demand based design method are also introduced as well as the investigation of the safety with respect to the major variables in confining steel design.

• 대한공업교육학회지
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• v.40 no.2
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• pp.92-110
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• 2015

The purpose of this study is to provide necessary information to understand characteristics of vocational high school students and to enhance academic engagement through social support of teachers, leading to help research of teaching and learning strategy. A survey was conducted on 990 engineering major students attending 11 vocational high schools in Seoul metropolitan, Chungcheong, Jeolla, Kyeongsang and Kangwon regions. A questionnaire consists of measurement tools for the academic engagement (21 questions) and the social support of teachers (25 questions). The findings of this study are as follows: First, it is found that the level of students' academic engagement was high. But it appears that the students showed low engagement of emotion compared with that of behavior and cognition. There was no level difference according to gender, but there was a considerable difference according to a school year. The first year students' level of engagement was higher than the second and the third year students' in terms of cognition and emotion. Second, it shows that the level of the teachers' social support was normal, which was in the order of appraisal support, instrumental support, informational support, and emotional support. Especially, the level of appraisal support and instrumental support was most. Third, there were correlation and explanation between students' academic engagement and teachers' social support. Moreover, the result that teachers' emotional support has high correlation and explanation in qualitative terms of academic engagement support the importance. Therefore, it is concluded that the social support of teachers can make an positive influence on improving the academic engagement of students and provide students with adaptability and satisfaction with their school life, which may give students a positive effect in emotional development, self-formation, and complement.

• Journal of Intelligence and Information Systems
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• v.15 no.2
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• pp.33-48
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• 2009

Capsule endoscopy is one of the most remarkable inventions in last ten years. Causing less pain for patients, diagnosis for entire digestive system has been considered as a most convenience method over a normal endoscope. However, it is known that the diagnosis process typically requires very long inspection time for clinical experts because of considerably many duplicate images of same areas in human digestive system due to uncontrollable movement of a capsule endoscope. In this paper, we propose a method for clinical diagnosticians to get highly valuable information from capsule-endoscopy video. Our software system consists of three global maps, such as movement map, characteristic map, and brightness map, in temporal domain for entire sequence of the input video. The movement map can be used for effectively removing duplicated adjacent images. The characteristic and brightness maps provide frame content analyses that can be quickly used for segmenting regions or locating some features(such as blood) in the stream. Our experiments show the results of four patients having different health conditions. The result maps clearly capture the movements and characteristics from the image frames. Our method may help the diagnosticians quickly search the locations of lesion, bleeding, or some other interesting areas.

• Applied Microscopy
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• v.34 no.2
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• pp.121-130
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• 2004

In this study, ultrastructural change of the bile duct fibroblast at infected rat with Clonorchis sinensis, and the distribution of lectin receptors and actin protein in cultured bile duct infected with Clonorchis sinensis. It explored using colloidal gold label complex with lectin WGA purified from wheat germ (Triticum vulgaris) and anti actin antibody purified actin (43 kDa) isolated from chicken back muscle. The lectin WGA with protein A gold complex labeled sections of the cultured fibroblast revealed gold particles specifically distributed on the multi vesicular form Golgi complex and cell surface of the fibroblast. The actin antibody with protein A gold complex labeled sections of the cultured fibroblast revealed gold particles specifically distributed on the cytoplasm of the fibroblast. Labeling of cultured fibroblast in rat bile duct infected with Clonorchis sinensis was then quantified and compared to that of cultured Fibroblast in Rat Bile duct. These results indicate that lectin WGA receptors are located in the multi vesicular form Golgi complex in the cytoplasm to the cytoplasmic process of the Rat bile duct fibroblast infected with Clonorchis sinensis. Therefore, the GlcNAc and NeuNac regions on the cell surface and cytoplasmic process appear to be functionally associated with cell-recognition and protection from other cell of the tissue, and linked with secretion and exocytosis of the fibroblst cytoplasm. GlcNAc and NeuNAc product in the multi vesicular form Golgi complex then it is transported to cell surface. Actin protein is many appears that infected fibroblast rather than normal fibroblast. The fibroblast of infected with Clonorchis sinensis are against of the physical and chemical stimulation. Then development of cytoplasmic process is relative some stimulation.