• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3805-3809
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• 2014

Background: In Mexico, breast cancer (BCa) is the leading type of cancer in women. Cytochrome P450 (CYP450) is a superfamily of major oxidative enzymes that metabolize carcinogens and many antineoplastic drugs. In addition, these enzymes have influence on tumor development and tumor response to therapy. In this report, we analyzed the protein expression in patients with BCa and in healthy women. Links with some clinic-pathological characteristic were also assessed. Materials and Methods: Immunohistochemical analyses were conducted on 48 sets of human breast tumors and normal breast tissues enrolled in Hospital Militar de Especialidades de la Mujer y Neonatologia and Hospital Central Militar, respectively, during the time period from 2010 to 2011. Informed consent was obtained from all participants. Statistical analysis was performed using ${\chi}^2$ or Fisher exact tests to estimate associations and the Mann Whitney U test for comparison of group means. Results: We found a significant CYP3A4 overexpression in BCa stroma and gland regions in comparison with healthy tissue. A significant association between protein expression with smoking, alcoholism and hormonal contraceptives use was also observed. Additionally, we observed estrogen receptor (ER) and progesterone receptor (PR) positive association in BCa. Conclusions: We suggest that CYP3A4 expression promotes BCa development and can be used in the prediction of tumor response to different treatments. One therapeutic approach may thus be to block CYP3A4 function.

• 미술이론과 현장
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• 제14호
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• pp.217-245
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• 2012

The aim of this paper is to show how the paradigm of disaster resilience may help reorienting urban planning policies in order to mitigate various types of risks, thanks to carefully thought action on heritage and conservation practices. Resilience is defined as the "capacity of a social system to proactively adapt to and recover from disturbances that are perceived within the system to fall outside the range of normal and expected disturbances." It relies greatly on risk perception and the memory of catastrophes. States, regions, municipalities, have been giving territorial materiality to collective memory for centuries, but this trend has considerably increased in the second half of the 20th century. This is particularly true regarding the memory of disasters: for example, important traces of catastrophes such as urban ruins have been preserved, because they were supposed to maintain some awareness and hence foster urban resilience - Berlin's Gedachtniskirche is a well-known example of this policy. Yet, in spite of preserved traces of catastrophes and various warnings and heritage policies, there are countless examples of risk mismanagement and urban tragedies. Using resilience as a guiding concept might change the results of these failed risk mitigation policies and irrelevant disaster memory processes. Indeed, the concept of resilience deals with the complexity of temporal and spatial scales, and with partly emotional and qualitative processes, so that this approach fits the issues of urban memory management. Resilience might help underlining the complexity and the subtlety of remembrance messages, and lead to alternative paths better adapted to the diversity of risks, places and actors. However, when it is given territorial materiality, memory is almost always symbolically and politically framed and interpreted; Vale and Campanella had already outlined this political aspect of remembrance and resilience as a discourse. Resilience and the territorialization of memory are not ideologically neutral, but urban risk mitigation may come at that price.

• 한국멀티미디어학회논문지
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• 제16권5호
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• pp.558-565
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• 2013

X-ray를 이용한 여성의 유방암 검사인 유방조영술은 유방암의 초기 단계에서의 진단을 위한 효과적인 방법이다. 컴퓨터 지원 검출(CAD) 시스템은 유방조영술을 통한 진단 시 의사가 놓치기 쉬운 유방암의 징후인 종괴의 검출을 도와 유방암 진단율을 높이는 수단이다. 종괴는 다양한 모양을 지니며 경계가 뚜렷하지 않기 때문에 검출이 어렵고 결과적으로 비-종괴 영역을 포함한 많은 수의 종괴 후보영역이 CAD 시스템에서 검출된다. 따라서 CAD 시스템 설계 시 검출된 많은 수의 종괴 후보영역으로부터 실제 악성 종괴 영역을 분류할 수 있도록 우수한 성능의 분류기가 요구된다. 본 논문에서는 피셔 분별 사전학습을 통해 개선된 Sparse 표현(SR) 기반 분류방법을 제안한다. 개선된 SR 기반 분류기가 기존의 CAD 시스템에서 주로 사용되어온 Support Vector Machine (SVM) 분류기 보다 우수함을 비교실험을 통해 확인했다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권6호
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• pp.598-602
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• 2006

저자 등은 우측 측방 경부 및 이하부에 발생한 침습성 지방종을 가진 57세 여자 환자에서 이하선 천엽 절제술과 함께 외과적 절제술로 종물을 제거하였다. 술 후 약 2.5년 동안 추적 관찰한 결과 현재까지 재발 등 이상 소견 없이 기능적, 심미적으로 양호한 결과를 얻었기에 문헌고찰과 함께 보고함으로써 지방종의 진단과 치료에 도움이 되고자 한다.

• BMB Reports
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• 제41권9호
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• pp.651-656
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• 2008

A mouse with cataract, Kec, was generated from N-ethyl-N-nitrosourea (ENU) mutagenesis. Cataract in the Kec mouse was observable at about 5 weeks after birth and this gradually progressed to become completely opaque by 12 weeks. Dissection microscopy revealed that vacuoles with a radial or irregular shape were located primarily in the cortex of the posterior and equatorial regions of the lens. At the late stage, the lens structure was distorted, but not ruptured. This cataract phenotype was inherited in an autosomal recessive manner. We performed a genetic linkage analysis using 133 mutant and 67 normal mice produced by mating Kec mutant (BALB/c) and F1 (C57BL/6 $\times$ Kec) mice. The Kec locus was mapped to the 3 cM region encompassed by D14Mit34 and D14Mit69. In addition we excluded coding sequences of 9 genes including Rcbtb2, P2ry5, Itm2b, Med4, Nudt15, Esd, Lcp1, Slc25a30, and 2810032E02Rik as the candidate gene that causes cataract in the Kec mouse.

• Asian-Australasian Journal of Animal Sciences
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• 제3권1호
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• pp.15-20
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• 1990

The nutritional status of trace minerals in cattle of Java in Indonesia was investigated by evaluating Cu, Fe, Mo, Zn and Mn concentrations in diets and livers, and Cu and Zn concentrations in blood plasma. Investigations were conducted on Jonggol (West Java), Malang (East Java) and Mojokerto (East Java) in both the rainy and the dry seasons in 1988. In Jonggol, low Cu concentrations in diets showing 7.1 mg/kg in the rainy season and 10.9 mg/kg in the dry season were observed and all plasma samples showed Cu concentrations below the critical level ($0.65{\mu}g/ml$). Thirty percent of the liver samples in Malang and 54% of those in Mojokerto showed lower Cu concentrations than the critical level (75 mg/kg on a dry matter basis). Fe concentrations in diets from the three regions showed a wide variation of values ranging from 249 to 30,000 mg/kg. A large amount of Fe was accumulated in livers from Malang and Mojokerto, giving average concentrations of 498 mg/kg. Zn concentration in diet and plasma samples were close to the borderline and some Zn concentration in these samples showed deficient levels. Mo and Mn concentrations in diets and livers showed normal levels.

• The Korean Journal of Physiology and Pharmacology
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• 제5권5호
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• pp.367-371
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• 2001

The chromosome 7-linked long QT syndrome (LQT2) is caused by mutations in the human ether-a- go-go-related gene (HERG) that encodes the rapidly activating delayed rectifier $K^+$ current, $I_{Kr},$ in cardiac myocytes. Different types of mutations have been identified in various locations of HERG channel. One of the mechanisms for the loss of normal channel function is due to membrane trafficking of channel protein. The decreased channel function in some deletion mutants appears to be due to loss of coupling with wild type HERG to form the functional channel as the tetramer. Most of missense mutants with few exceptions could interact with wild type HERG to form functional tetramer and caused dominant negative suppression with co-injection with wild type HERG showing variable effects on current amplitude, voltage dependence, and kinetics of activation and inactivation. Two missense mutants at pore regions of HERG found in Japanese LQT2 (A614V and V630L) showed accentuated inward rectification due to a negative shift in steady-state inactivation and fast inactivation. One mutation in S4 region (R534C) produced a negative shift in current activation, indicating the S4 serving as the voltage sensor and accelerated deactivation. The C-terminus mutation, S818L, could not express the current by mutant alone and did not show dominant negative suppression with co-injection of equal amount of wild type cRNA. Co-injection of excess amount of mutant with wild type produced dominant negative suppression with a shift in voltage dependent activation. Therefore, multiple mechanisms are involved in different mutations and functional abnormality in LQT2. Further characterization with the interactions between various mutants in HERG and the regulatory subunits of the channels (MiRP1 and minK) is to be clarified.

• 한국운동역학회지
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• 제22권1호
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• pp.113-121
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• 2012

The purpose of this study was to evaluate the effects of forefoot rocker shoes equipped with a metatarsal bar on lower extremity muscle activity and plantar pressure distribution. Ten healthy women in the age of twenties were participated in this study as the subjects. All subjects walked on a treadmill(Gait Trainer, BIODEX, USA) wearing normal shoes and metatarsal bar shoes, during which the plantar pressure distribution and muscle activity were measured. Using Pedar-X system(Novel Gmbh, Germany), the plantar pressure was measured for six regions of the foot: forefoot, midfoot, rearfoot, 1st metatarsal, 2-3th metatarsal, and 4-5th metatarsal, and for each sub-region, 4 features such as maximum force, contact area, peak pressure, and mean pressure were analyzed based on the plantar pressure. EMG(Electromyography) activity was measured by attaching surface electrodes to the rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius medial head, and magnitude of muscle contraction was analyzed in IEMG(Integrated EMG) value. The results show that the maximum force, contact area, peak pressure, and mean pressure in the midfoot all increased while maximum force, peak pressure, contact area, mean pressure in the 1st metatarsal and 2-3th metatarsal all decreased when wearing functional shoes. Also, muscle activities in the four muscles were all decreased when wearing the functional shoes. This paper suggests that forfoot rocker shoes equipped with a metatarsal bar can help disperse the high pressure and absorb the shock to the foot as well as give positive influence on gait pattern and postural stability by reducing muscle fatigue during walking.

• 한국임상수의학회지
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• 제7권1호
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• pp.391-402
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• 1990

To examine the effects of vaccination against Babesia gibsoni infection in dogs, 15 normal mixed-breed dogs(5 month to 1 year old) divided into 3 groups with 5 dogs in a group. One of them was selected as control group(group A) and others were selected as experimental groups(group B and C). The group B was vaccinated with sonicated antigens and the group C was vaccinated with 0.2% of formalin treated antigens. The results obtained in the examination were summarized as follows : 1. In the western blot, the lane A revealed specific two bands on the regions of 54kd and 100kd, respectively. 2. After the first vaccination, the antibody titers of group B and C were higher 5 times(1 ： 200) than those of control group(1：40). After the second vaccination, the antibody titers of group B and C have not changed. When challenged with the protozoa(Babesia gibsoni), the antibody titers(1 : 5,000) were elevated in all groups. But these were not exceeded over 1 ： 5,000 for 4 weeks. 3. After challenge, the peak time of increased numbers of the protozoa was the 15th day (12-18 days) in all groups. During these days, the rate of parasitized erythrocytes in control group was 55.0${\pm}$5.4%. But those of group B and group C were 26.0${\pm}$6.4%, and 15.6${\pm}$7.8％, respectively. 4. After challenge, all of the values of PCV, Hb, RBC were shown to decrease in all of the control and experimental groups. 5. The total leukocytes counts are shown a tendency of reduction in all groups after challenge. 6. In all groups, there were increase in lymphocytes and monocytes after challenge.

• Childhood Kidney Diseases
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• 제22권2호
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• pp.37-41
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• 2018

Purpose: Familial renal glucosuria (FRG, OMIM #233100) is a rare but relatively benign genetic condition characterized by persistent isolated glucosuria with a normal blood glucose level. We report three additional SLC5A2 mutations and examine their phenotypic and genetic characteristics in a Korean FRG cohort. We also reviewed the literature and summarized the genotypes of all Korean patients with FRG. Methods: A genetic analysis was conducted by directly sequencing all 14 exons of the SLC5A2 gene and their flanking regions in six unrelated Korean children with FRG and their family members. Novel non-synonymous single-nucleotide polymorphisms were identified and compared with known mutations that are repeatedly detected in the Korean population. Results: We found two novel mutations [c.274G>A (G92S) and c.1168C>T (L390F)] and one known [c.1382G>A (S461N)] mutation in each family and one recurrent mutation [c.1346G>A (G449D) (rs768392222)] in two pedigrees. The recurrent G449D was predicted to be "possibly damaging," with a score of 0.883 in Polyphen-2, while G92S, L390F, and S461N were predicted to be "probably damaging," with scores of 1.000, 0.999, and 0.996, respectively. Conclusions: Two novel, one previously reported, and one recurrent mutation were identified in six Korean FRG pedigrees as causative mutations of renal glucosuria. Sequence variations in the SLC5A2 gene were frequently detected in children with persistent isolated glucosuria. A long-term follow-up of this FRG cohort is needed to understand how these specific SGLT2 mutations impair kidney function and energy homeostasis.