• 전기학회논문지
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• 제58권1호
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• pp.203-209
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• 2009

The purpose of this study is to develop a minimally constraint joint angle measurement system for the feedback control of FES (functional electrical stimulation) locomotion. Feedback control is desirable for the efficient FES locomotion, however, the simple on-off control schemes are mainly used in clinic because the currently available angle measurement systems are heavily constraint or cosmetically poor. We designed a new angle measurement system consisting of a magnet and magnetic sensors located below and above the ankle joint, respectively, in the rear side of ipsilateral leg. Two magnetic sensors are arranged so that the sensing axes are perpendicular each other. Multiple positions of sensors attachment on the shank part of the ankle joint model and also human ankle joint were selected and the accuracy of the measured angle at each position was investigated. The reference ankle joint angle was measured by potentiometer and motion capture system. The ankle joint angle was determined from the fitting curve of the reference angle and magnetic flux density relationship. The errors of the measured angle were calculated at each sensor position for the ankle range of motion (ROM) $-20{\sim}15$ degrees (dorsiflexion as positive) which covers the ankle ROM of both stroke patients and normal subjects during locomotion. The error was the smallest with the sensor at the position 1 which was the nearest position to the ankle joint. In case of human experiment, the RMS (root mean square) errors were $0.51{\pm}1.78(0.31{\sim}0.64)$ degrees and the maximum errors were $1.19{\pm}0.46(0.68{\sim}1.58)$ degrees. The proposed system is less constraint and cosmetically better than the existing angle measurement system because the wires are not needed.

• 한국산학기술학회논문지
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• 제20권12호
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• pp.418-424
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• 2019

백팩은 한쪽 어깨에 매는 가방에 비해 척추에 대칭적으로 무게분산이 가능하지만, 무게중심이 뒤쪽으로 이동하게 하여, 체간이 전방굴곡되는 자세 변형을 야기한다. 본 연구는 모멘트팔의 길이차이에 따른 가방 착용 시 균형과 보행에 미치는 영향에 대해 확인하였다. 정형외과적 손상 및 신경학적 손상이 없는 정상 성인 30명을 대상으로 하였다. 대상자는 1) 백팩 미 착용, 2) 일반적인 백팩, 3) 모멘트 길이를 감소시킨 백팩의 3가지 조건에서 각각 균형 및 보행을 측정하였다. 자세동요면적과 속도에서 백팩 미착용과, 일반적인 백팩, 특수 백팩의 3가지 조건에 따른 유의한 차이가 있었으나, 백팩의 모멘트팔의 길이에 따른 유의한 차이는 없었다. 양하지 지지기와 보행속도는 백팩 미착용과, 일반적인 백팩, 특수 백팩의 3가지 조건에서 유의한 차이가 있었으며, 양하지 지지기에서만 백팩의 모멘트팔의 길이에 따른 유의한 차이가 있었다. 본 연구의 결과를 통해 백팩 착용시 모멘트팔의 길이 변화가 보행에 도움이 될 수 있었다.

• Annals of Clinical Neurophysiology
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• 제1권2호
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• pp.126-146
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• 1999

In clinical neurology various different electrophysiological tests are widely used to demonstrate the unsuspected malfunctioning in the nervous system and to monitor over time the clinical status of patients. In addition clinical neurologists and neurosurgeons take advantage of the intraoperative monitorings to increase the quality of neurosurgical operations in the posterior fossa, in the spinal cord, or in visual pathways. In the field of movement disorders, elecrophysiolgical tests provide neurologists with making accurate differential diagnoses with useful therapeutic stratergies as well as with investigating the pathophysiological machanisms. By using the electromyographic tests it could be possible for us to evaluate the types of blephalospasm, the extent of hemifacial spasm, the level of myoclonus, and the prime muscles of torticollis etc. Sometimes the myographic guidance may be critical for choosing the exact injecting site of botulinum toxin. These several decades various electroencephalographic and evoked potential tests has been utilized in the electrophysiological laboratories to understand the basic pathophysiology of myoclonus, spasticity and other central motor dysfunctions. It could be one of the breakthroughs in the area of behavorial neurology that the brain function can be mapped by the spontaneous or evoked electrical activities of nervous system since the movement related potentials (MRPs) had been studies for several decades. Various reflex tests such as masseter reflex, blink reflex, click evoked vestibulocollic reflex, facial reflex, stretch reflex, flexor reflex, H-reflex, H-reflex recovery curve, vestibular inhibition of H-reflex, reciprocal inhibition, recurrent or Renshaw reflex, Ib inhibition, cutaneous reflex have been also used to understand normal or abnormal physiology in movement disorders. Polysomnography, posturography and gait studies are also applied in clinical neurology in association with with movement disorders which are useful in deciding the treatment regimen.

• 한국임상수의학회지
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• 제26권6호
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• pp.655-658
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• 2009

복부 팽만과 간헐적인 가벼운 좌측후지의 파행을 나타낸 11년령의 암컷 말티즈견이 내원하였다. 신체검사에서 복부 촉신 시 동통을 호소하였고 농성의 질 삼출물을 나타내었다. 혈액화학적 검사결과 독성변화를 동반한 심한 백혈구감소증, 질소혈증, 고인산혈증, 그리고 저나트륨혈증이 관찰되었다. 복부 방사선검사에서 소장을 앞쪽과 등쪽으로 변위시키는 연부조직음영의 관상구조를 가진 매스가 관찰되었고 복부 초음파검사에서 에코성의 물질이 함유된 종괴는 자궁음영으로 판단되어 자궁축농증으로 진단하였다. 후지의 방사선검사결과 양쪽 무릎에서 내측 슬개골탈구와 외측 종자뼈가 4-5 조각으로 분화된 다분화를 관찰하였다. 환자는 곧바로 난소자궁적출술을 받아 잘 회복되었으며 정상적인 혈액화학 수치를 보였다. 좌측 후지의 파행은 간헐적이고 매우 경미하였으므로 특별한 처치를 하지 않았다. 이후 지금까지 3개월동안 뚜렷한 후지파행은 관찰되지 않았다. 여러조각으로 갈라진 후지의 양측성 외측종자뼈는 선천적인 종자골 다분화로 여겨지며 파행과 직접적인 관련성은 없는 것으로 판단된다.

• 한국임상수의학회지
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• 제27권1호
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• pp.117-120
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• 2010

A 5-years-old 3.7 kg intact female Pomeranian dog was presented with the history of swelling and pain in the distal part of the right forelimb. The swollen lesion was firm as bony material on palpation. On radiographic examination, there was a well-marginated, radiolucent, and expansile bone lesion in the distal metaphysis of the right ulna. Because of very narrow zone of transition, well-defined margins and absence of any periosteal reactivity, benign bone cyst was strongly suspected. The lesion was removed by en bloc resection and packed the space with $Gelfoam^{(R)}$ and aneurysmal bone cyst was finally diagnosed according to histopathological examination. Normal gait was showed on postoperative day 9 and there have been no pain and complication for 1 year since then.

• 한국임상수의학회지
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• 제31권5호
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• pp.445-448
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• 2014

7년령 수컷 말라뮤트 견이 정기적인 치과진료를 목적으로 내원하였다. 신체검사 상에서 뒷다리의 운동 실조가 확인되었으며, 우측 뒷다리의 고유 자세반응이 미약하게 지연되었다. 감별진단을 위한 MRI 검사에서, 허리뼈 1번과 2번 사이 척수강에 경막외 낭종이 확인되었다. 낭종은 디스크 바로 등쪽에서 척수실질 배쪽을 등쪽으로 심하게 압박하고 있었으며, T1 저신호, T2 고신호 및 낭종 벽을 따라 조영증강이 확인되었다. 편측성 추궁절제술을 통해 낭종을 제거하였고, 조직검사 결과 낭종의 벽은 섬유소 및 섬유아세포가 혼재되어 있었으며 일부분에서 호염성 디스크 물질이 확인되어 디스크 낭종으로 진단하였다. 환자는 수술 후 신경증상은 정상적으로 회복하였으며, 6개월 후 신체검사에서 정상적인 보행 이 관찰되었다.

• 대한임상독성학회지
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• 제11권1호
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• pp.28-30
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• 2013

A 66-year-old male with chronic alcoholism presented with tremor, gait disturbance, memory impairment, insomnia, decreased appetite, and confusion. The patient had been taking lithium daily for treatment of bipolar disorder. Brain CT showed no specific abnormality, and serum lithium and ammonia levels were 3.63 mEq/L (therapeutic range, 0.6~1.2 mEq/L) and $85{\mu}g/dL$ (reference range: $19{\sim}54{\mu}g/dL$), respectively. Therefore, the initial differential diagnosis included chronic lithium intoxication, hepatic encephalopathy, Wernicke encephalopathy, or alcohol withdrawal syndrome. Even with the provision of adequate hydration, the patient's neurologic status did not show improvement, so that lactulose enema, thiamine replacement, and continuous venovenous hemodiafiltration (CVVHDF) were started on the third admission day. By the fifth admission day he had made a rapid neurologic recovery, and was discharged on the 20th admission day. Therefore, CVVHDF might be a treatment for patients with chronic lithium intoxication, because, even if serum lithium concentration is normal, lithium concentration in the brain may be different from that of the serum.

• 대한한의학방제학회지
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• 제24권3호
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• pp.153-161
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• 2016

Chronic alcoholic myopathy is one of the most common skeletal muscle disorders. It is characterized by a reduction in the entire skeletal musculature, skeletal muscle weakness, and difficulties in gait. Patients with alcoholic hepatitis and cirrhosis have severe muscle loss that contributes to worsening outcome. Although the myopathy selectively affects Type II (fast twitch, glycolytic, anaerobic) skeletal muscle fibers, total skeletal musculature is reduced. The severity of the muscle atrophy is proportional to the duration and amount of alcohol consumed and leads to decreased muscle strength. The mechanisms for the myopathy are generally unknown but it is not due to overt nutritional deficiency, nor due to either neuropathy or severe liver disease. Skeletal muscle mass and protein content are maintained by a balance between protein synthesis and breakdown and in vivo animal models studies have shown that ethanol inhibits skeletal muscle protein synthesis. Daekumeumja is a traditional Korean medicine that is widely employed to treat various alcohol-induced diseases. Muscle diseases are often related to liver diseases and conditions. The main objective of this study was to assess that Daekumeumja extract could have protective effect against alcoholic myopathy in a Sprague-Dawley rat model. Rats were orally given 25% ethanol (5ml/kg, body weight) for 8 weeks. After 30 minutes, rats were administrated with Daekumeumja extract. Controls were similarly administrated with the vehicle alone. The weights of gastrocnemius, soleus and plantaris muscles were assessed and the morphologic changes of gastrocnemius and plantaris muscles were also assessed by hematoxylin and eosin staining. In results, The muscles from ethanol treated rats displayed a significant reduction in muscle weight and average cross section area compared to Normal group. Daekumeumja extract treated group showed increased muscle weight and muscle fiber compared to the ethanol treated group. It was concluded that Daekumeumja extract showed ameliorating effects on chronic alcohol myopathy in skeletal muscle.

• 한국ITS학회 논문지
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• 제16권6호
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• pp.156-168
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• 2017

개인교통수단(PM)은 개인의 이동편의를 향상시켜준다는 측면에서 보행능력이 떨어지는 고령자가 주요 활용 대상이 될 수 있다. 본 연구에서는 고령자가 보도 등 보행환경에서 안전하게 이용할 수 있는 개인교통수단을 설계하고자 한다. 보행환경에는 다양한 통행 장애요인이 존재하며, 개발하고자 하는 수단은 장애요인을 극복하기 위한 기기 성능이 확보되어야 한다. 본 연구에서는 고령자용 개인교통수단의 성능수준 결정을 위하여 보행환경 상 통행 장애요인 현황 및 수준을 조사한다. 관련 지침을 검토하여 조사 대상 항목 및 조사 방법론을 정의하고, 고령자 일상생활 기반 통행 시나리오를 통해 선정된 특정 도로구간에 대하여 조사를 수행한다. 조사 결과를 바탕으로 수단의 기기 성능을 지침 상 제시된 기준에 근거하여 확보하였을 때 발생 가능한 문제점을 확인하며, 장애인용 전동휠체어의 운전 성능 기준을 근거하여 개발 수단의 기기 성능에 대한 요구사항을 정의한다.

• 대한약침학회지
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• 제19권3호
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• pp.253-258
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• 2016

Objectives: The goals of this research were to evaluate acute (single-dose) and sub-acute (repeated-dose) toxicity profiles of methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar rats and to assess the safety profile of PI by observing physiological changes, mortality, changes in body weight, the histopathology of body organs, the hematology and the biochemistry of the animals. Methods: The toxicity profile of PI was evaluated using Wistar rats of both sexes. Animals were divided into four groups: Group 1; control group (normal saline), Group 2; PI-1 (250 mg/kg), Group 3; PI-2 (500 mg/kg), Group 4; PL-3 (1,000 mg/kg). An acute-toxicity study in which animals received a single dose of PI extract (2,000 mg/kg) and were then observed for 14 days for changes in skin, fur, eye color, mucous membrane secretions and excretions, gait, posture, and tonic or clonic movements was performed according to guideline 425 of the Organization of Economic and Corporation Development (OECD). In the repeated-dose toxicity study (OECD - 407) animals received a daily dose of PI extract for 28 days (4 weeks). The parameters observed in this study include body weight, hematology and biochemistry of the animals. Results: In the acute toxicity study, no mortalities or changes in behavior were noted in the animals. The repeated-dose toxicity study was also devoid of any toxicity in the animals during the 28 days of testing with PI extract. The extract did not alter- the body weight, hematology or biochemistry of the animals. The methanolic extract of PI was to be found safe to the no-observed-adverse-effect-level (NOAEL) for the single-dose and repeated-dose toxicity tests in rats. Conclusion: The methanolic extract of PI was devoid of toxicity; hence, it can be used for various ayurvedic preparations and treatments of diseases.