• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1571-1576
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• 2005

DCS has many processing components and various communication elements. And its communication delay characteristic is affected diverse operating situation and context. Especially, binding signal which traversed from one control-node to another control-node undergo all sort of delay conditions. So its delay value has large deviation with the lapse of time, and the measurement of delay statistics during long time is very difficult by using general oscilloscope or other normal instruments. This thesis introduces the design and implementation of PC-based BDAS(Binding Delay Analysis System) System developed to overcomes these hardships. The system has signal-generator, IO-card, data-acquisition module, delay-calculation and analyzer module, those are implemented on industrial standard PC/Ethernet hardware and Windows/Linux platforms. This system can detect accurate whole-system-wide delay time including io, control processing and network delay, in the resolution of msec unit, and can analyze each channel's delay-historic data which is maintained by realtime database. So, this system has strong points of open system architecture, for example, user-friendly environment, low cost, high compatibility, simplicity of maintenance and high extension ability. Of all things, the measuring capability of long-time delay-statistics obtained through historic-DB make the system more valuable and useful, which function is essential to analyze accurate delay performance of DCS system. Using this system, the verification of delay performance of DCS for nuclear power plants is succeeded in KNICS(Korea Nuclear Instrumentation & Control System) projects

• Journal of Oral Medicine and Pain
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• 제40권3호
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• pp.96-101
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• 2015

Purpose: Thermal sensory test as an essential part of quantitative sensory testing (QST) has been recognized as a useful tool in the evaluation of the trigeminal nerve function. Normative data in the orofacial region have been reported but the data on differences in the test site, sex and ethnicity are still insufficient. Thus, this study aimed to investigate the normal range of orofacial thermal QST data in the healthy Korean women, and assess sex difference of thermal perception in the orofacial regions. Methods: Thermal QST was conducted on 20 healthy women participants (mean age, 26.4 years; range, 21 to 34 years). The thermal thresholds (cold detection threshold, CDT; warm detection threshold, WDT; cold pain threshold, CPT; and heat pain threshold, HPT) were measured bilaterally at the 5 trigeminal sites (the forehead, cheek, mentum, lower lip and tongue tip). The normative thermal thresholds of women in the orofacial region were evaluated using one-way ANOVA and compared with the previously reported data from age- and site-matched 30 healthy men (mean age, 26.1 years; range, 23 to 32 years) using two-way ANOVA. One experienced operator performed the tests of both sexes and all tests were done in the same condition except the time variability. Results: Women showed significant site differences for the CDT (p<0.001), WDT (p<0.001), and HPT (p=0.047) in the orofacial region. The CDT (p<0.001) and the CPT (p=0.007) presented significant sex difference unlike the WDT and the HPT. Conclusions: The thermal sensory evaluation in the orofacial region should be considered in the context of site and sex and the normative data in this study could be useful for assessment of the sensory abnormalities in the clinical setting.

• 지역사회간호학회지
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• 제9권1호
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• pp.64-71
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• 1998

This study uses [the instrument of ageing anxiety] in order to find if a negative prejudice against the old affects the attitude toward sex of the aged. The result shows no significant relation between ageing anxiety and the knowledge of and attitude toward sex of the aged. However, it does show that the higher the ageing anxiety is, the lower the knowledge of sex and the more restrictive the attitude toward it. The knowledge of and attitude toward sex of the aged shows meaninggul changes after education. Nursing students who were educated come to have more knowledge about and are more open to it. This result supports the preposition of this study. As society grows older the endeavour to guarantee a high-quality life for the old is necessary and the old should be regarded as an entity which has its own characteristic desires. Especially for the old to enjoy a good life as a sexual being, the mystical barriers about sex and old age ought to be removed. In the future the old themselves may maintain sexual desires regardless of age and society will be required to correct its prejudice against the old having sex. Particularly nursing students, as an effort to provide the old with overall care, should examine the elderly's sexual desires in a physical, psychological, and social context and consider the normal sexual changes occuring during the aging process and finally integrate this information into their nursing plans. In order to fulfill this role successfully they should overcome their own prejudice and educate themselves about this particular problem. As the proportion of the old becomes bigger and the concern about the quality of their life grows, sex among the old will become more important in the nursing field. By putting an educational mediation programme into operation with nursing students and estimating the effect, this study supplies the foundation to activate new educational programmes. In short it tells us that education can be a practical method to confront the myth and conventions concerning sex among the aged.

• 한국한의학연구원논문집
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• 제8권2호통권9호
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• pp.95-107
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• 2002

Yukmijihwang-tang(YM) is a noted herbal prescription in Chinese and Korean traditional medicines, and it has been known to reinforce the vital essence and has been widely used for a variety of disease such as stroke, osteoporosis, anti-tumor, and hypothyrodism. Regarding its traditional use, YM has been known to reinforce the Yin (vital essence) of liver and kidney. Also it has been known to reinforce nutrition and biological function in brain. Recently, studies suggested that YM increase antioxidant activities and exert the protective effect against oxidant-induced liver cell injury. We investigated the high-throughput gene expression analysis on the Yukmijihwang-tang administrated in SD rats. Microarray data were validated on a limited number of genes by semiquantitative RT-PCR and Western blot analyses. The recent availability of microarrays provides an attractive strategy for elaborating an unbiased molecular profile of large number of genes in drug discovery This experimental approach offers the potential to identify molecules or cellular pathways not previously associated with herbal medicine. Total RNA from normal control brain and Yukmijihwang-tang administrated brain were hybridized to microarrays containing 10,000 rat genes. The 52 genes were found to be up-regulated(twice or more) excluding EST gene. The nine genes were found to be down-regulated(twice or more) excluding EST gene. Gene array technology was used to identify for the first time many genes expression pathway analysis that arecell cycle pathway, apoptosis pathway, electron transport chain pathway, cytoplasmic ribosomal protein pathway, fatty acid degradation pathway, and TGF-beta signaling pathway. These differentially expressed genes pathway analysis have not previously been iavestigated in the context of herbal medicine efficacy and represent novel factors for further study of the mechanism of herbal medicine efficacy.

• Preventive Nutrition and Food Science
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• 제16권4호
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• pp.283-290
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• 2011

The recent increase of colon, breast, and prostate cancer incidence in Korea has been attributed to a diet pattern change to a more Western style, in which the foods eaten are higher in protein and fat. Whether high protein intake itself stimulates tumor cell growth and exacerbates disease status has been investigated, however, many epidemiological studies have inconsistent results between meat intake and the risk of certain cancers. These inconsistent results are partly because of the difficulty of studying the effects of just the meat intake. Other factors, such as overall meal context, could not be completely excluded in the study. To address the question of whether high protein itself is independently associated with carcinogenesis, we initiated ICR mice with 200 nmol ($50{\mu}g$) 7,12-dimethylbenz[a]anthracene (DMBA) and fed animals either a normal diet (ND, 14% casein) or a high protein diet (HPD, 50% casein) for 15 weeks with 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion in two-stage skin carcinogenesis protocol. There was no significant difference between ND and HPD group in food intake and body weight throughout the experiment. However, tumor multiplicity of the HPD group was decreased by 75.5% compared to that of the ND group. In addition, HPD inhibited skin hyperplasia and epidermal cell proliferation. Western analyses with whole skin lysates showed that HPD inhibited TPA-induced Akt (S473), S6K (T389), 4E-BP1 (Thr 37/46) and Erk1/2 (Thr202/Tyr204) phosphorylation as well as COX-2 expression. Taken together, these data suggest that a high protein diet has an anticarcinogenic effect by inhibiting the TPA-induced Akt signaling pathway.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6349-6355
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• 2012

Previous studies showed that Math1 homologous to human Hath1 can cause mouse goblet cells to differentiate. In this context it is important that the majority of colon cancers have few goblet cells. In the present study, the potential role of Hath1 in colon carcinogenesis was investigated. Sections of paraffin-embedded tissues were used to investigate the goblet cell population of normal colon mucosa, mucosa adjacent colon cancer and colon cancer samples from 48 patients. Hath1 and Muc2 expression in these samples were tested by immunohistochemistry, quantitative real-time reverse transcription -PCR and Western blotting. After the recombinant plasmid, pcDNA3.1(+)-Hath1 had been transfected into HT29 colon cancer cells, three clones were selected randomly to test the levels of Hath1 mRNA, Muc2 mRNA, Hath1, Muc2, cyclin D1 and p27 by quantitative real-time reverse transcription-PCR and Western blotting. Moreover, the proliferative ability of HT29 cells introduced with Hath1 was assessed by means of colony formation assay and xenografting. Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected by Western blotting. No goblet cells were to be found in colon cancer and levels of Hath1 mRNA and Hath1, Muc2 mRNA and Muc2 were significantly down-regulated. Hath1 could decrease cyclin D1, increase p27 and Muc2 in HT29 cells and inhibit their proliferation. Hath1 may be an anti-oncogene in colon carcinogenesis.

• 대한교통학회지
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• 제22권3호
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• pp.159-166
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• 2004

도로용량편람에서 정의하고 있는 용량은 하류부에 용량을 제한하는 요소가 없다는 것을 가정한 정상교통류에 대한 용량 개념으로서, 이는 전통적으로 계획, 설계, 현재 및 장래 도로시설의 운영상태 분석 등에 사용되어 왔다. 실시간 제어는, 용량을 초과하지 않는 교통류를 유지시켜 혼잡교통류로의 전이를 막고, 물리적 여건이나 제반 확률적 요인으로 혼잡이 발생하였을 경우 조속히 용량이하로 교통량을 떨어뜨려 정상교통류로 회복시키는 데 목표를 둔다. 이러한 맥락에서 용량은 실시간 제어의 효과를 좌우하는 중요한 입력변수이며, 정상교통류 상태라면 혼잡으로 전이되지 않을 임계치로서의 용량 산정이 중요한 관건이다. 그러나 혼잡교통류 상태에서 정상교통류로 되도록 빨리 회복시켜 주기 위한 제어 기준으로서의 용량은, 하류부 혼잡의 시공간적 전개에 따라 변하는 값이어야 하며 이러한 동적 용량변화를 정확히 예측할 수 있는 방법론이 요구된다. 이에 본 연구에서는 기존의 용량 개념을 출력 개념의 용량으로 정의하고, 입력 개념의 용량을 최대가능처리량(Maximum Sustainable Throughput)으로 새롭게 정의하였다. 이 최대가능처리량은 혼잡의 시공간적 전개에 따라 결정되는 동적 용량이며, 이러한 혼잡의 시공간적 전개는 Newell의 단순화된 교통량-밀도 모형으로 예측할 것을 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.317-321
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• 2016

Detection of micrometastasis in sentinel lymph nodes (SLNs) is a very useful tool for appropriate assessment of the clinical stage of disease in breast cancer patients. Early identification of clinically relevant disease could lead to early treatment or staging approaches for breast cancer patient. Micrometastases in SLNs of women with invasive breast cancer are of great significance in this context. In this study we examined SLN biopsies considered to have small numbers of cancerous cells by real time RT-PCR. All of the samples underwent immunohistochemical staining for cytokeratin for confirmation of the presence or absence of micrometastases. BUB1b expression assay of selected patients with and without metastasis showed overexpression in the former, but not in normal breast and lymph node tissue. Our results may be taken into account in the discussion about the merits of routine use of molecular assessment in pathogenetic studies of SLNs.

• 한국콘텐츠학회논문지
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• 제11권10호
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• pp.115-127
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• 2011

방송시장에서 지상파 재전송 제도의 개선과 PAR 등의 도입이 거론되는 이유는 방송 콘텐츠가 주요 경쟁수단으로 인식되고 있기 때문이다. 특히 유료방송시장에서 SO와 PP의 전략적 제휴는 경쟁 사업자에 대한 콘텐츠의 배타적 거래로 이어져 상대 사업자의 정상적인 경쟁을 저해하고 시청자의 접근권을 제한하는 결과를 초래하고 있다. 이로 인해 방송시장에도 필수설비 이론이 도입되어야 한다는 주장이 제기되고 있으며, IPTV법의 콘텐츠동등접근조항과 방송법상 금지행위 도입도 이와 같은 맥락에서 이해될 수 있다. 그러나 방송 시장에 대한 필수설비 이론의 적용은 일반 설비와 콘텐츠가 기반하는 철학적 경제적 법체계적 차이로 인해 부작용을 초래할 것으로 예상된다. 따라서 필수설비의 개념과 필수설비의 거래거절에 대한 기본적인 개념과 이것이 경쟁 시장에서 구현되는 구체적인 심결례 및 판례를 검토하는 기초작업이 필요한 시점이다. 본 연구는 이러한 검토를 통해 방송 콘텐츠에 필수설비 이론의 적용이 타당한 것인지 사전적인 제언을 하는데 그 목적이 있다.

• 대한불안의학회지
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• 제10권1호
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• pp.3-10
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• 2014

Reactive disorder is a group of diagnosis with a definitely known etiology and whose etiological factor is essential to the diagnosis. In DSM system, such reactive disorders are listed as adjustment disorder, acute stress disorder, brief psychotic disorder with marked stressor and posttraumatic stress disorder (PTSD). However, a growing number of individuals is suffering from a prolonged feeling of embitterment after exceptional negative life events and this condition could be diagnosed neither PTSD nor adjustment disorder nor depressive disorder in the context of DSM-IV diagnostic system. This clinical condition can be described as 'posttraumatic embitterment disorder' (PTED). PTED is a reactive disorder triggered by exceptional, though normal negative life events such as conflict in the workplace, unemployment, death of a relative, divorce, severe illness, or experience of loss or separation. The common feature of such events is that they are experienced as unjust, as a personal insult, accompanied by psychological violation of basic beliefs and values. The central psychopathological response pattern in PTED is a prolonged feeling of embitterment. In particular, the core emotion of embitterment can lead to the rejection of treatment. Therefore, "wisdom therapy" as a new treatment approach specifically designed for PTED has been developed. It is assumed that many patients suffering from PTED are often misunderstood and misdiagnosed. This review would help to introduce PTED into the clinical field in psychiatry.