• 한국노년학
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• 제36권4호
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• pp.981-1001
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• 2016

노년기에는 의사소통의 전체적인 맥락을 해석할 때 표면적으로 드러나는 단서에 주로 의존하게 되면서, 함축적이고 우회적인 표현인 비유언어를 처리하는 능력이 저하된다. 따라서 의사소통 시, 타인의 의도를 효과적으로 이해하고 자신의 의사를 전달하는 데 어려움을 보일 수 있다. 본 연구는 정상 청년층 50명과 정상 노년층 50명을 대상으로 비유언어의 하위영역인 직유 은유 관용어 속담 이해 과제를 실시하여 노화에 따른 비유언어 처리능력의 특성을 확인하고자 하였다. 과제는 제시되는 전체적인 내용과 적합한 비유언어를 보기문항 중에서 선택하도록 하였다. 분석 결과, 첫째, 노년층은 청년층에 비해 모든 비유언어 하위 과제에서 더 저하된 수행력을 보였다. 둘째, 노년층은 비친숙한 관용어와 속담 이해과제에서 더 저하된 수행력을 보였다. 셋째, 노년층은 문자 그대로의 의미에 국한하여 문항을 이해하는 양상을 빈빈히 보였다. 노년층은 특정 상황 맥락에 맞게 효과적인 의사소통을 할 수 있는 능력인 화용언어 능력과 더불어 내포된 의미를 추론하는 능력 및 문자 그대로의 의미와 같은 표면적인 단서를 억제할 수 있는 능력이 저하될 수 있다. 이러한 결과는 노화로 인하여 일상의 의사소통 상황에서 화자의 내포된 의미를 이해하는 것에 어려움을 보일 수 있음을 시사한다.

• 한국음향학회지
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• 제25권6호
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• pp.277-281
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• 2006

본 논문에서는 시간지연 회귀신경회로망을 이용한 음절 레벨에서의 피치 악센트 자동 인식 방법을 제안한다. 시간지연 회귀 신경회로망은 두 종류의 동적 문맥정보를 표현한다. 시간지연 회귀신경회로망의 시간지연 입력 노드는 시간 축 상의 피치 및 에너지 궤도를 표현하고, 회귀 노드는 피치 악센트의 특성을 반영하는 문맥 정보를 표현한다. 본 논문에서는 이러한 시간지연 회귀신경회로망을 두 가지 형태로 구성하여 피치 악센트 자동 인식에 적용한다. 하나의 형태는 단일 시간지연 회귀 신경회로망에서 복수 개의 운율 특정파라미터 (피치, 에너지, 지속시간)를 입력 노드에 함께 공급하여 피치 악센트 인식을 수행하고, 다른 하나는 분산 시간지연 회귀 신경회로망을 이용하여 피치 악센트 인식을 수행한다. 분산 시간지연 회귀 신경회로망은 여러 개의 시간지연 회귀 신경회로망으로 구성되고, 각 시간지연 회귀 신경회로망은 단일 운율 특징 파라미터만으로 학습된다. 분산 시간지연 회귀 신경회로망의 인식결과는 개별 시간지연 회귀 신경회로망의 출력 값의 가중치 합으로 결정된다. 화자 독립 피치 악센트 인식 실험을 위해 보스톤 라디오 뉴스 코퍼스 (BRNC)를 사용하였다. 실험결과, 분산 시간지연 회귀 신경회로망은 83.64%의 피치 악센트 인식률을 보였다.

• 동서간호학연구지
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• 제3권1호
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• pp.7-16
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• 1998

This paper reviewed the concept of the energy flow in east and west. The differences in the views of the energy flow between oriental and western thought were compaired according to the ontological point of view. Human body take up energy and material on open system which maintains homeostasis. Human and environment are continuously interacting in a state of co-existence. Human has energy field called "aura" and seven chakra in energy outflow moving came as meridian. Qi is an invisible cosmic energy helping the fundamental human activity and changes. The basic action of Qi is helping the human growth and development, maintain the body temperature and preventing the intrusion of microorganism. In the normal healthy organism, all are maintained in balance and in a continuous circulation of Qi, while illness is the result of the disturbed Qi flow in the aspect of Qi-theory. Although there are differences between oriental and western medicine in approaches to clients, the basic point of view and philosophy have many similarities on fundamental level. An understanding of the basic thought of energy flow and oriental concept of energy flow implies a more comprehensive meaning than the perspective of unitary transformation discussed in modern western thought of energy flow. Now we should avoid narrow view of energy concept and regard energy flow as an integrated concept with Korean culture. Regarding Qi-theory which provides a comprehensive and humanistic and ethical foundation for nursing philisophy through this overview, it is hoped that a contribution will be made to the development of nursing intervention which is suitable to Korean context.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5327-5332
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• 2012

In this review, we describe the patterns of known immunological components in breast milk and examine the relationship between breastfeeding and reduced risk of breast cancer. The top risk factors for breast cancer are a woman's age and family history, specifically having a first-degree relative with breast cancer. Women that have a history of breastfeeding have been shown to have reduced rates of breast cancer. Although the specific cause has not been elucidated, previous studies have suggested that breastfeeding reduces the risk of breast cancer primarily through two mechanisms: the differentiation of breast tissue and reduction in the lifetime number of ovulatory cycles. In this context, one of the primary components of human milk that is postulated to affect cancer risk is alpha-lactalbumin. Tumour cell death can be induced by HAMLET (a human milk complex of alpha-lactalbumin and oleic acid). HAMLET induces apoptosis only in tumour cells, while normal differentiated cells are resistant to its effects. Therefore, HAMLET may provide safe and effective protection against the development of breast cancer. Mothers should be encouraged to breastfeed their babies because the complex components of human milk secretion make it an ideal food source for babies and clinical evidence has shown that there is a lower risk of breast cancer in women who breastfed their babies.

• Journal of Periodontal and Implant Science
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• 제37권3호
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• pp.535-542
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• 2007

Background : Repeated dis/re-connection of implant abutment caused bone loss around implant fixtures due to the new formation of biologic width of the mucosal-implant barrier. The aim of this clinical study was to evaluate whether the repeated dis/re-connection of implant abutment cause bone loss clinically and the effect of cleansing methods on a bone loss during the early healing period. Methods : A total 50 implants were installed in 20 patients and repeated dis/re-connection of abutment was performed at the time of surgery and once per week for 12 weeks. 0.9% normal saline solution as group1 and 0.1% chlorhexidine solution as group 2 was used to clean abutments. All patients had radiographs taken at the placement of implant and 4, 8, and 12 weeks postoperatively. The data for bone loss around implant were analyzed. Results: The marginal bone loss at 12 weeks were $1.28{\pm}0.51mm$, $1,32{\pm}0,57mm$ in the mesial and distal sides in group1, $1.94{\pm}0.75mm$, $1.81{\pm}0.84mm$ in group 2, respectively. In view of marginal bone loss, there was not a significant statistical difference between groups. Conclusions : Repeated dis/re-connection of implant abutment may not cause marginal bone loss around implant fixture although limited samples and short-term observation period. In spite of more bone loss in group 2, there was no statistical significant difference between groups. In context of those results, the clinical significance of the repeated dis/re-connection of implant abutment and the cleansing method of abutments is debatable when it comes to marginal bone loss during early healing period.

• 디자인학연구
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• 제18권4호
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• pp.45-52
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• 2005

인간과 컴퓨터 사이의 상호자웅(Human-Computer Interaction)에 있어 핵심적인 인터페이스 역할을 하고 있는 디스플레이는 미디어의 발전과 함께 보다 선명하고 생생한 화질을 전달하기 위해 계속해서 발전해 왔으며, 최근에는 중형크기 이상의 디스플레이로 LCD(Liquid Crystal Display)와 PDP(Plasma Display Panel)가 가장 보편적으로 사용되고 있다. 기술의 발달로 인해 디스플레이는 점차 대형화 슬림화 되어 마트, 역, 영화관 등과 같이 유동인구가 많은 공간에 설치되어 인쇄매체나 전광판보다 다양한 정보를 전달하고 있는데 디지털 디스플레이는 주로 멀티미디어 컨텐츠를 전달하며 문자정보는 대부분 제한된 공간에서 동적으로 제공되고 있다. Leading은 멀티미디어 컨텐츠를 배경으로 동적 문자정보를 전달하기 위해 가장 많이 사용되는 방법이며 실시간 정보를 나타내기 위해 주로 사용되고 있다. 본 연구에서는 최적의 trading 방법을 알아보기 저해 디스플레이 종류, 화면 관찰 상황, 문자색과 배경색, 문자 제시 속도의 변화에 따라 사용자가 평가하는 읽힘성, 이해도, 만족도를 살펴보았다. 디스플레이 종류에 있어서 모든 평가항목에서 LCD가 PDP 보다 효율적인 것으로 나타났으면 색상에 있어서는 횐색-검정색의 색상 조합이 다른 색상 조합보다 우수하게 평가되었다. 문자 제시 속도에 있어서는 문자정보만을 제공했을 때는 보통속도와 비교적 빠른 속도에서 좋은 결과를 보였으나 동영상과 문자가 동시에 제시되었을 때는 느린 속도가 효과적인 것으로 나타났다.

• Bioinformatics and Biosystems
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• 제1권1호
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• pp.67-72
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• 2006

The aim of this paper is to discuss the effect of missing values in detecting differentially expressed genes in a cDNA microarray experiment in the context of a one sample problem. We conducted a cDNA micro array experiment to detect differentially expressed genes for the metastasis of colorectal cancer based on twenty patients who underwent liver resection due to liver metastasis from colorectal cancer. Total RNAs from metastatic liver tumor and adjacent normal liver tissue from a single patient were labeled with cy5 and cy3, respectively, and competitively hybridized to a cDNA microarray with 7775 human genes. We used $M=log_2(R/G)$ for the signal evaluation, where Rand G denoted the fluorescent intensities of Cy5 and Cy3 dyes, respectively. The statistical problem comprises a one sample test of testing E(M)=0 for each gene and involves multiple tests. The twenty cDNA microarray data would comprise a matrix of dimension 7775 by 20, if there were no missing values. However, missing values occur for various reasons. For each gene, the no missing proportion (NMP) was defined to be the proportion of non-missing values out of twenty. In detecting differentially expressed (DE) genes, we used the genes whose NMP is greater than or equal to 0.4 and then sequentially increased NMP by 0.1 for investigating its effect on the detection of DE genes. For each fixed NMP, we imputed the missing values with K-nearest neighbor method (K=10) and applied the nonparametric t-test of Dudoit et al. (2002), SAM by Tusher et al. (2001) and empirical Bayes procedure by $L\ddot{o}nnstedt$ and Speed (2002) to find out the effect of missing values in the final outcome. These three procedures yielded substantially agreeable result in detecting DE genes. Of these three procedures we used SAM for exploring the acceptable NMP level. The result showed that the optimum no missing proportion (NMP) found in this data set turned out to be 80%. It is more desirable to find the optimum level of NMP for each data set by applying the method described in this note, when the plot of (NMP, Number of overlapping genes) shows a turning point.

• 인터넷정보학회논문지
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• 제6권1호
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• pp.27-38
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• 2005

최근 급격한 컴퓨팅 환경의 발전과 인터넷의 확산에 따라 손쉽게 필요한 정보를 획득, 이용하는 것이 가능해지게 되었으나, 이에 대한 역기능으로 전산망에 대한 해커(Hacker)들의 불법적인 침입과 위험이 날로 증대되고 있다 특히 Unix와 TCP/IP로 구성된 인터넷은 정보 보호 측면에서 많은 취약점을 가지고 있어서, 인증과 접근제어 등의 보안기술만으로는 보안문제를 해결하기에 충분치 못하였고 정보 보호를 위한 2차 방어선으로 침입 탐지 시스템이 개발되었다. 본 논문에서는 베이지안 네트워크를 이용하여 네트워크 행위를 서비스별로 구분하여 프로파일하는 방법을 제안한다. 네트워크 행위를 서비스별로 구분하고, 서비스별 각 세션에서 TCP/IP 플래그를 통한 행위의 전후 관계를 베이지안 네트워크와 확률값으로 정상 행위를 프로파일링을 수행한다 베이지안 네트워크를 이용한 정상 행위 프로파일에 의해서 변형되거나 프로파일에 존재하지 않는 새로운 행위에 대해서도 탐지가 가능하였다. 본 논문에서는 DARPA 2000년 침입 탐지 데이터 집합을 이용하여 시뮬레이션을 수행하였다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1571-1576
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• 2005

DCS has many processing components and various communication elements. And its communication delay characteristic is affected diverse operating situation and context. Especially, binding signal which traversed from one control-node to another control-node undergo all sort of delay conditions. So its delay value has large deviation with the lapse of time, and the measurement of delay statistics during long time is very difficult by using general oscilloscope or other normal instruments. This thesis introduces the design and implementation of PC-based BDAS(Binding Delay Analysis System) System developed to overcomes these hardships. The system has signal-generator, IO-card, data-acquisition module, delay-calculation and analyzer module, those are implemented on industrial standard PC/Ethernet hardware and Windows/Linux platforms. This system can detect accurate whole-system-wide delay time including io, control processing and network delay, in the resolution of msec unit, and can analyze each channel's delay-historic data which is maintained by realtime database. So, this system has strong points of open system architecture, for example, user-friendly environment, low cost, high compatibility, simplicity of maintenance and high extension ability. Of all things, the measuring capability of long-time delay-statistics obtained through historic-DB make the system more valuable and useful, which function is essential to analyze accurate delay performance of DCS system. Using this system, the verification of delay performance of DCS for nuclear power plants is succeeded in KNICS(Korea Nuclear Instrumentation & Control System) projects

• Journal of Oral Medicine and Pain
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• 제40권3호
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• pp.96-101
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• 2015

Purpose: Thermal sensory test as an essential part of quantitative sensory testing (QST) has been recognized as a useful tool in the evaluation of the trigeminal nerve function. Normative data in the orofacial region have been reported but the data on differences in the test site, sex and ethnicity are still insufficient. Thus, this study aimed to investigate the normal range of orofacial thermal QST data in the healthy Korean women, and assess sex difference of thermal perception in the orofacial regions. Methods: Thermal QST was conducted on 20 healthy women participants (mean age, 26.4 years; range, 21 to 34 years). The thermal thresholds (cold detection threshold, CDT; warm detection threshold, WDT; cold pain threshold, CPT; and heat pain threshold, HPT) were measured bilaterally at the 5 trigeminal sites (the forehead, cheek, mentum, lower lip and tongue tip). The normative thermal thresholds of women in the orofacial region were evaluated using one-way ANOVA and compared with the previously reported data from age- and site-matched 30 healthy men (mean age, 26.1 years; range, 23 to 32 years) using two-way ANOVA. One experienced operator performed the tests of both sexes and all tests were done in the same condition except the time variability. Results: Women showed significant site differences for the CDT (p<0.001), WDT (p<0.001), and HPT (p=0.047) in the orofacial region. The CDT (p<0.001) and the CPT (p=0.007) presented significant sex difference unlike the WDT and the HPT. Conclusions: The thermal sensory evaluation in the orofacial region should be considered in the context of site and sex and the normative data in this study could be useful for assessment of the sensory abnormalities in the clinical setting.