• Journal of the Korean Society for Library and Information Science
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• v.45 no.2
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• pp.209-228
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• 2011

Web search behavior has evolved. People now search using many diverse information devices in various situations. To monitor these scattered and shifting search patterns, an improved way of learning and analysis are needed. Traditional web search studies relied on the server transaction logs and single query instance analysis. Since people use multiple smart devices and their searching occurs intermittently through a day, a bundled query research could look at the whole context as well as penetrating search needs. To observe and analyze bundled queries, we developed a proprietary research software set including a log catcher, query bundling tool, and bundle monitoring tool. In this system, users' daily search logs are sent to our analytic server, every night the users need to log on our bundling tool to package his/her queries, a built in web survey collects additional data, and our researcher performs deep interviews on a weekly basis. Out of 90 participants in the study, it was found that a normal user generates on average 4.75 query bundles a day, and each bundle contains 2.75 queries. Query bundles were categorized by; Query refinement vs. Topic refinement and 9 different sub-categories.

• Journal of Life Science
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• v.21 no.11
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• pp.1641-1651
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• 2011

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) is a recently identified member of the TNF ligand family that can initiate apoptosis through the activation of their death receptors. TRAIL has been paid attention as a potential anti-cancer drug, because it selectively induces apoptosis in tumor cells in vitro and in vivo but not in most normal cells. However, recent studies have shown that some cancer cells including malignant renal cell carcinoma and hepatocellular carcinoma, are resistant to the apoptotic effects of TRAIL. Therefore, single treatment with TRAIL may not be sufficient for the treatment of various malignant tumor cells. Understanding the molecular mechanisms of TRAIL resistance and identification of sensitizers capable of overcoming TRAIL resistance in cancer cells is needed for the establishment of more effective TRAIL-based cancer therapies. Chemotherapeutic drugs induce apoptosis and the upregulation of death receptors or activation of intracellular signaling pathways of TRAIL. Numerous chemotherapeutic drugs have been shown to sensitize tumor cells to TRAIL-mediated apoptosis. In this study, we summarize biological agents and drugs that sensitize tumors to TRAIL-mediated apoptosis and discuss the potential molecular basis for their sensitization.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.2
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• pp.232-237
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• 2018

According to the MAIIF report, from 1998 to 2009, 101 incidents involving entering enclosed spaces aboard ships resulted in 93 deaths and 96 casualties. IMO has therefore amended the Recommendations for entering Enclosed Spaces Entry and SOLAS 1974 Convention Chapter 3 Regulation 19, which mandates enclosed spaces entry and rescue drill on a regular basis. The training of entering such enclosed spaces should be practical, recognizing all possible risks of entering enclosed spaces aboard ships, while also considering the safety of trainees during the training. Recently, educational contents utilizing virtual reality (VR) have been applied in various fields to improve education and training effects, and these methods have proven to have advantages in actual and repetitive learning without being limited to physical space. In this study, the effectiveness, characteristics and differentiation of training of entering enclosed spaces aboard ships using VR were compared with traditional class room lectures through quantitative evaluation and questionnaires of training participants. Through the evaluation and questionnaire, it was found that participants using VR understood and learned the required training elements better than the control group, all of whom were trained through the normal class room lecture. Moreover, participants reported to display preference for training with the help of VR. As a result of the study, it was confirmed that the learning effects of VR onboard training can be used as an effective training method, especially by using video and other types of simulators.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.273-275
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• 2009

A 6-year-old castrated male Shih-tzu was presented because of a 1-month history of progressive tetraplegia. On the basis of the findings of neurological examination, radiographs and magnetic resonance imaging, herniated intervertebral disc of C4-C5, C5-C6 and C6-C7 compressed spinal cord. The oxygen-ozone was intra-operatively injected into the C4-C5 and C6-C7 intervertebral disc and a ventral decompression performed at C5-C6 intervertebral space. Immediately after the surgery, neck pain was disappeared and three weeks after surgery, there was complete resolution of the neurological deficits with normal gaits. On magnetic resonance images at 2-month after surgery, herniated disc materials of C5-C6 and C6-C7 were completely removed and that of C4-C5 remarkably reduced. Consequently decompression which was performed at all of the three lesions resulted in good clinical outcome without additional internal fixation for minimizing postoperative instability.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.125-131
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• 2015

Purpose: The effect of pigmentation in circle contact lens on lens wearers' tear film stability was investigated in this study. Methods: Non-invasive tear film break-up times of 54 normal eyes before and after lens wearing in twenties and the portion of first tear breakup were measured. The frontal and back surface roughness of circle contact lens was further observed with a scanning electron microscope. The clear lens which was made of hilafilcon B and circle contact lenses which were made of hilafilcon B, polymacon and copolymer of HEMA NVP were tested. Results: Non-invasive tear film breakup time was significantly reduced compared with it before lens wearing. In some case, statistically significant difference in tear film breakup time was also observed between circle contact lenses. The tear file break-up was usually early started in lower than upper portion, and in temporal than nasal portion although there was variation in the lens material. The tear film break-up of circle contact lenses made of hilafilcon B was more commonly observed in peripheral portion(pigmented area) compared with clear contact lens made of same material. Conclusions: The present study revealed that the stability of tear film was affected by wearing circle contact lens and the result seems to be used as the basis for the problem solving that can occur due to the pigmentation when wearing circle contact lens.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.2
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• pp.174-180
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• 2012

In case of an immature tooth with necrotic pulp, regeneration of pulp tissue into a canal would be the ideal outcome. It may be capable of promoting the continuation of normal root development. Platelet-rich fibrin has been suggested as a potentially ideal scaffold for regenerative endodontic treatment. Immature permanent teeth of young children were diagnosed with pulp necrosis and apical abscess as the result of clinical and radiographic examination. After removal of necrotic pulp, canal was irrigated with 5.25% NaOCl and dried with paper point. A triple antibiotic mixture was placed in canal space in 3 weeks. After removal of the antibiotic mixture, the platelet-rich fibrin was injected into the canal space with MTA placed directly over the platelet-rich fibrin clot. The coronal region was restored by composite resin. On the basis of short-term results of the present 3 cases, regeneration of vital tissues appears to be possible in a tooth with necrotic pulp and a periapical lesion. Also, platelet-rich fibrin proves to be potentially an ideal scaffold for this procedure. Therefore, long-term clinical observation and examination about this treatment using platelet-rich fibrin in immature permanent teeth of young children are considered to be necessary.

• Journal of Families and Better Life
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• v.32 no.4
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• pp.75-89
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• 2014

The purpose of this study is to explore whether the phenomenon of both married and unmarried adults' cohabiting with their parents in Korean society is "unilaterally parasitic" on the child's side, or is "interdependent", characterized by expectation and dependence from the parent's side. As a result of this study possessing the characteristics of theoretic research, the following propensities of parent-dependent adults have been discussed. First of all, it was discovered that the ratio of adult children dependent on and cohabiting with their parents is considerable. Second, parents cohabiting with their adult children have unfavorable sociological features, such as high age, low level of education and income, and lower standards of education and income, compared to parents in normal households. Third, it was found that parent-dependent adults in Korean society maintain a relatively high rate of financial activity and stable employment-based occupation status. Fourth, it was shown that the level of satisfaction on the relationship between parent-dependent adults and their parents was discovered to be high, which is contrastive to the prediction of negative results based on some previous researches. Single adult children's age, their level of education and financial activity status, and their parents' age and level of education were deducted as variables related to the level of satisfaction of the relationship between parents and their children. It seems that the issue of married and unmarried adults' cohabiting with their parents in Korean society should be approached from various perspectives such as political, economic, socio-cultural and developmental aspects. On the basis of this fundamental awareness and several of the materials, it is pertinent that approaches to both married and unmarried adults' cohabiting with parents in Korean society should be distinguished from approaches to those in Japanese or Western society because it reflects the uniqueness of Korean society. In the phenomenon of married and unmarried adults' cohabiting with their parents in Korean society, there are several factors besides the economic factor, especially the socio-cultural factor that have the characteristics of mutual dependence between parents and their children rather than those of unilateral parasitism, in contrast with the phenomenon in Japanese or Western society. This research was aimed to contribute by establishing basic data for policy making by providing necessary information to treat the issues of instability and anxiety related to families and reflection on the matters of generations and parent-child relationships in current Korean society.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2993-2998
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• 2009

An enzyme-linked immunosorbent assay (ELISA)-on-a-chip (EOC) biosensor combined with cell concentration technology based on immuno-magnetic separation (IMS) was investigated for use as a potential tool for early screening of Listeria monocytogenes (L. monocytogenes) in food products. The target analyte is a well-known pathogenic foodborne microorganism and outbreaks of the food poisoning typically occur due to contamination of normal food products. Thus, the aim of this study was to develop a rapid and reliable sensor that could be utilized on a daily basis to test food products for the presence of this pathogenic microorganism. The sensor was optimized to provide a high detection capability (e.g., 5.9 ${\times}\;10^3$ cells/mL) and, to eventually minimize cultivation time. The cell density was condensed using IMS prior to analysis. Since the concentration rate of IMS was greater than 100-fold, this combination resulted in a detection limit of 54 cells/mL. The EOC-IMS coupled analytical system was then applied to a real sample test of fish intestines. The system was able to detect L. monocytogenes at a concentration of 2.4 CFU/g after pre-enrichment for 6 h from the onset of cell cultivation. This may allow us to monitor the target analyte at a concentration less than 1 CFU/g within a 9 h-cultivation provided a doubling time of 40 min is typically maintained. Based on this estimation, the EOC-IMS system can screen and detect the presence of this microorganism in food products almost within working hours.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.577-585
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• 2014

The cosmetic and stimulating effects of lemon oil have been widely proven in the fields of beauty therapy and psychology therapy. But the lemon oil's proper effects on the anti asthma and the anti inflammation have not rarely been verified. This study was conducted to find out the lemon oil's effects on the anti asthma and anti inflammation in the OVA-induced allergic asthma mice model. OVA-induced allergic asthma mice were divided into 4 groups consisting of normal group, control group, positive control group and experimental group. 0.3% of lemon oil was nebulized to experimental group for 3 weeks on a basis of 3 times per week and 30 min each time. After 6 weeks from the initial experiment, the degree of hyper activeness of respiratory system, the hematological change, the amount of the cytokein in serum, the change of airway organization were evaluated. The results showed that lemon oil controled effectively the hyper activeness of respiratory system and restricted the multiplication of cells in acidophil in terms of statistical significance. It also turned out that lemon oil restricted effectively the infection of airway reaction and the hyper sensitiveness of respiratory system by controlling the creation of histamine(cytokein) and IgE.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.789-795
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• 2020

Many deaths have been reported due to the worldwide pandemic of COVID-19. In order to prevent the further spread of COVID-19, it is necessary to quickly and accurately read images of suspected patients and take appropriate measures. To this end, this paper introduces a deep learning-based COVID-19 chest X-ray reading technique that can assist in image reading by providing medical staff whether a patient is infected. First of all, in order to learn the reading model, a sufficient dataset must be secured, but the currently provided COVID-19 open dataset does not have enough image data to ensure the accuracy of learning. Therefore, we solved the image data number imbalance problem that degrades AI learning performance by using a Stacked Generative Adversarial Network(StackGAN++). Next, the DenseNet-based classification model was trained using the augmented data set to develop the reading model. This classification model is a model for binary classification of normal chest X-ray and COVID-19 chest X-ray, and the performance of the model was evaluated using part of the actual image data as test data. Finally, the reliability of the model was secured by presenting the basis for judging the presence or absence of disease in the input image using Grad-CAM, one of the explainable artificial intelligence called XAI.