• Biomolecules & Therapeutics
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• v.15 no.1
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• pp.16-26
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• 2007

Tissue plasminogen activator (tPA) is a serine protease catalyzing the proteolytic conversion of plasminogen into plasmin, which is involved in thrombolysis. During last two decades, the role of tPA in brain physiology and pathology has been extensively investigated. tPA is expressed in brain regions such as cortex, hippocampus, amygdala and cerebellum, and major neural cell types such as neuron, astrocyte, microglia and endothelial cells express tPA in basal status. After strong neural stimulation such as seizure, tPA behaves as an immediate early gene increasing the expression level within an hour. Neural activity and/or postsynaptic stimulation increased the release of tPA from axonal terminal and presumably from dendritic compartment. Neuronal tPA regulates plastic changes in neuronal function and structure mediating key neurologic processes such as visual cortex plasticity, seizure spreading, cerebellar motor learning, long term potentiation and addictive or withdrawal behavior after morphine discontinuance. In addition to these physiological roles, tPA mediates excitotoxicity leading to the neurodegeneration in several pathological conditions including ischemic stroke. Increasing amount of evidence also suggest the role of tPA in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis even though beneficial effects was also reported in case of Alzheimer's disease based on the observation of tPA-induced degradation of $A{\beta}$ aggregates. Target proteins of tPA action include extracellular matrix protein laminin, proteoglycans and NMDA receptor. In addition, several receptors (or binding partners) for tPA has been reported such as low-density lipoprotein receptor-related protein (LRP) and annexin II, even though intracellular signaling mechanism underlying tPA action is not clear yet. Interestingly, the action of tPA comprises both proteolytic and non-proteolytic mechanism. In case of microglial activation, tPA showed non-proteolytic cytokine-like function. The search for exact target proteins and receptor molecules for tPA along with the identification of the mechanism regulating tPA expression and release in the nervous system will enable us to better understand several key neurological processes like teaming and memory as well as to obtain therapeutic tools against neurodegenerative diseases.

• Journal of the Korean earth science society
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• v.18 no.6
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• pp.559-564
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• 1997

The New Hebrides Basin is an inactive non back-arc basin located at the convergent boundary of the Pacific and Info-Australian plates. This basin was formed from 46 Ma to 60 Ma. The basin has two spreading episodes with rates of 34 mm/a for 42 to 47 Ma and 17 mm/a for 47 to 60 Ma. The sediments covered in the basin has uniform thickness of 0.65 sec. The age-depth correlation curve of the New Hebrides Basin can be represented by the following equation: $Depth(m)=2689+312\sqrt{Age}(Ma)$ The coefficient of 312 in this equation is close to that for major oceans, 350. This suggests that the cooling processes of the lithospheres in the New Hebrides Basin and major oceans are similar to each other. Free-air gravity anomalies of the basin varying from -22.3 mgal to +59.0 mgal. The mean value is +30.2 mgal higher than those of the normal oceans. Moderately large free-air gravity anomalies in the New Hebrides Basin are presumably owing to its location on a marginal swell along the New Hebrides Trench. It is generally observed that the ocean floor is very gently uplifted in a zone about 200 km oceanward of the trench axis. Positive free-air gravity anomalies amounting to $50{\sim}60$ mgal are usually observed on the crest of the swell. This topography is presumably by bending of the oceanic lithosphere so as to dynamically maintain nonisostatic states for some duration.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.2
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• pp.94-101
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• 2016

Acinetobacter species isolates are important opportunistic pathogens and commonly implicated in nosocomial infections. The therapeutic options for treatment of the bacterial infections are limited because the bacteria isolates are usually multidrug resistant (MDR). In the current study, we investigated various carbapenemase genes in 68 Acinetobacter species isolates. Antimicrobial susceptibilities were tested using the disk diffusion method. Screening of carbapenemase genes was performed via multiplex PCR. In addition, PCR and DNA sequencing were used to identify the carbapenemase genes. Repetitive extragenic palindromic-PCR (REP-PCR) was also performed to assess the clonality of isolates. In our study, A. baumannii isolates were highly resistant to all agents tested while all non-A. baumannii isolates were susceptible to all agents tested, with the exception of aztreonam and cefotaxime. All 51 A. baumannii isolates contained the $bla_{OXA-51}$ gene and 37 (72.5%) isolates also harbored the $bla_{OXA-23}$ gene. In addition, 39 MDR A. baumannii isolates were identified in our study and 37 isolates contained the $bla_{OXA-23}$ gene. The 37 MDR strains harboring $bla_{OXA-23}$ showed type I (n=22) or type II (n=15) banding patterns on their REP-PCR profiles. Our results suggest clonal relation and horizontal spreading of MDR A. baumannii isolates containing the $bla_{OXA-23}$ gene at the hospital located in Daejeon. Continuous investigation of antimicrobial resistant determinants and monitoring emergence and dissemination of MDR isolates is required to prevent and control infection and colonization of MDR A. baumannii isolates.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.10
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• pp.987-993
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• 2013

Chaos communication system has characteristics of non-periodic, non-predictability, broadband signal and easy implementation. Also, chaos communication system is sensitive to the initial value, because completely another signal is generated when initial value of chaos equation is changed subtly. By these characteristics, security of chaos communication system is generally evaluated better than other digital communication systems. However, BER(Bit Error Rate) performance is worse than other digital communication systems, because transmitter and receiver of existing chaos communication system are strongly influenced by reference signal and noise. So, studies in order to improve the BER performance of chaos communication system is continuously performed. In this paper, We will propose a new CDSK (Correlation Delay Shift Keying) receiver in order to improve the BER performance. After we compare to the performance of existing receiver and proposed receiver, BER performance of proposed receiver evaluate. A novel receiver has characteristic that BER performance is better than existing receiver. However, if existing transmitter is used, existing receiver is possible to recover information bits even though BER performance is bad. Therefore, we propose a novel CDSK transmitter in order to improve the security of proposed receiver. When information bits are transmitted by using proposed transmitter, existing receiver is impossible to recover information bits, and proposed receiver is possible to recover information bits.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.89-99
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• 2022

Due to COVID-19, non-face-to-face cultures such as remote classes, remote work, and tele-medicine are spreading. The major contributors to the settlement of such a non-face-to-face society are small and medium SW companies and SW manpower. However, recently as large platform companies and foreign big tech companies hire thousands of SW manpower, SW small and medium-sized companies are experiencing a serious manpower shortage. Therefore, the purpose of this study is to suggest policy alternatives for SMEs to stably secure SW manpower and support continuous business operation. To achieve this purpose, this study examines the current status of the SW industry and manpower, then summarizes related issues and suggests policy alternatives to solve these issues. Those policies include the reinforcement of incentives to support manpower retention such as the Naeil Chaeum deduction system, youth housing union composition, special military service system, recruitment of manpower through the contract semester system of employment conditions, reinforcement of customized education through supplementation of the SW manpower training voucher system, SW field skill standardization, establishment of a governance system for nurturing SW manpower, preparation of countermeasures against the outflow of manpower to large companies, and a win-win cooperation program for large and SME SW manpower.

• Journal of Service Research and Studies
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• v.13 no.2
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• pp.41-61
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• 2023

The universal form of life in the era of the 4th industrial revolution can probably be summarized as the keyword "non-face-to-face". In particular, in terms of consumption activities, face-to-face contact is gradually changing to a system that minimizes, and offline stores are rapidly changing to non-contact services through kiosks and robots. The social structure is also changing with the passage of time, and most fundamentally, our dietary consumption patterns are changing. In particular, the increase in single-person households and the aging population are having a great impact on changes in the food service industry, which is closely related to dietary life. The HMR (Home Meal Replacement) market has grown significantly as the labor of cooking at home has decreased and the use of substitute foods has increased. As the size of the market has grown, the types of businesses that provide products have also diversified. The development of technology, non-face-to-face culture, and corporate management efficiency are intertwined, and unmanned stores are spreading recently. In this study, service quality attributes of HMR unmanned stores, where competition is gradually intensifying, are classified, and service quality classification using the Kano model and Timko's customer satisfaction coefficient are calculated to provide implications for service management based on customer satisfaction. As a result of the analysis, 'products with short cooking time' and 'variety of products (menu)' were classified as attractive qualities, and 'cleanliness inside/outside of the store' and 'products at reasonable prices' were classified as unified quality. In addition, 'convenience of self-checkout process' was classified as a natural quality, and 'convenience of in-store passage' was classified as an indifferent quality. Furthermore, when the service factor was satisfied within the HMR unmanned store, the factor with the highest satisfaction coefficient was 'product (menu) variety', and the factor with the highest dissatisfaction factor was 'convenience of self-checkout process'. Through the results of this study, it is intended to derive priorities in service quality management of HMR unmanned stores and provide strategic implications for related businesses.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.2
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• pp.136-142
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• 2020

The antimicrobial resistance rate in bacteria has increased over the last several decades. The transfer of antimicrobial resistant determinants on mobile genetic elements could cause the accelerated emergence and spread of multidrug resistant bacteria. This study investigated the aminoglycoside resistance determinants transferred by mobile genetic elements in a total of 33 aminoglycoside non-susceptible E. coli isolated from clinical specimens in Chungcheong province. 16S ribosomal RNA methyl-transferases (RMTases) and aminoglycoside-modifying enzyme (AME) genes were detected via PCR and DNA sequencing. The most common AME genes were aac(3')-II gene (54.5%), followed by aph(3')-Ia (18.2%) and aac(6')-Ib (15.2%). None of the evaluated RMTase genes were detected in the 33 isolates. Seventeen of the 18 isolates harboring aac(3')-II gene were resistant to gentamicin, and 16 of them were resistant to tobramycin. The 5 isolates harboring aac(6')-Ib gene were all resistant to tobramycin. In this study, we confirmed that one of the important mechanisms of aminoglycoside resistance in E. coli isolated from human is the acquisition of AME genes. Continuing investigations of antimicrobial resistant determinants in bacteria isolated from human may be required to prevent dissemination of antimicrobial resistant bacteria.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.4
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• pp.897-905
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• 2015

This research suggested the traffic signal calculation model of active transit signal priority using a shockwave model. Using this signal priority timing optimization model, the shockwave area is computed under the condition of Early Green and Green Extension among active transit signal priority techniques. This study suggested the speed estimation method of backward shockwave using average travel time and intersection passing time. A shockwave area change is calculated according to signal timing change of transit signal priority. Moreover, this signal timing calculation model could determine the optimal signal priority timings to minimize intersection delay of general vehicles. A micro simulation analysis using VISSIM and its user application model ComInterface was applied. This study checked that this model could calculate the signal timings to minimize intersection delay considering saturation condition of traffic flow. In case studies using an isolated intersection, this study checked that this model could improve general vehicle delay of more over ten percentage as compared with equality reduction strategy of non-priority phases. Recently, transit priority facilities are spreading such as tram, BRT and median bus lane in Korea. This research has an important significance in that the proposed priority model is a new methodology that improve operation efficiency of signal intersection.

• The Journal of the Korea Contents Association
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• v.11 no.12
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• pp.28-39
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• 2011

While the broadband multimedia technologies have been developing, the commercial market of digital contents has also been widely spreading. Most of all, digital cartoon market like internet cartoon has been rapidly large so video cartooning continuously has been researched because of lack and variety of cartoon. Until now, video cartooning system has been focused in non-photorealistic rendering and word balloon. But the meaningful frame extraction must take priority for cartooning system when applying in service. In this paper, we propose new automatic frame extraction method for video cartooning system. At frist, we separate video and audio from movie and extract features parameter like MFCC and ZCR from audio data. Audio signal is classified to speech, music and speech+music comparing with already trained audio data using GMM distributor. So we can set speech area. In the video case, we extract frame using general scene change detection method like histogram method and extract meaningful frames in the cartoon using face detection among the already extracted frames. After that, first of all existent face within speech area image transition frame extract automatically. Suitable frame about movie cartooning automatically extract that extraction image transition frame at continuable period of time domain.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.3
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• pp.22-30
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• 2010

This paper proposes a combination system of Adaptive Modulation and Coding (AMC) and Multiple Input Multiple Output (MIMO), which improves the throughput and has a better reliability. In addition, the system includes Precoding, Antenna Subset Selection and MIMO Mode Selection scheme. Finally, we make a performance analysis of the proposed system. The principal environmental parameters for the simulation experiment consist of a frequency non-selective rayleigh fading channel and a Spreading Factor (SF) of 16. Other parameters may be included in order to fulfill the requirements of the HSDP A Standard. The proposed system has a higher throughput and more reliability than the conventional system, which does not include MIMO Mode Selection scheme, Precoding or Antenna Subset Selection. According to the simulation results, the proposed system reaches the maximum throughput at 8dB, presentlng an improvement of 6dB and twice higher throughput, respect to the conventional system. Specifically, at the point of -6dB, the conventional system reaches 2.5Mbps, while the proposed system reaches 6.4Mbps at the same SNR. Also, at the point of 2dB, each system reaches 7.5Mbps (conventional system) and 15.3Mbps (proposed system), with near twice the difference. According to the results exposed above, we can conclude that the system proposed in this paper has, as the greatest contribution, the improvement of the throughput, especially, the average throughput.