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Iontiophoretic Transdermal Delivery of Triamcinolone Acetonide on Delayed Onset Muscle Soreness (지연성 근육통에 대한 Triamcinolone Acetonide의 이온도입 경피투과)

  • Jung, Dae-In;Kim, Myong-Hoon;Hwang, Tae-Yeun;Yoon, Se-Won;Choi, Eun-Young
    • Journal of the Korean Academy of Clinical Electrophysiology
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    • v.1 no.1
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    • pp.45-56
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    • 2003
  • This study investigated the effects of triamcinolone acetonide by iontophoretic transdermal drug delivery on anti-inflammatory action into the human which had excentric exercise-induced delayed onset muscle soreness in the non-dominant arm. The degree of anti-inflammation was evaluated creatine posphokinase(CPK) by serum enzyme activity and subjective pain threshold by soreness muscle scale in clinical study. The results Were as follows; 1. In a subjective pain scale, all groups showed non-significant difference but, showed a tendency to decrease numerical value in human. 2. In the serum CPK level, iontophoresis group showed more significant reduction than other groups at 24, 48 and 72 hours. From the results, the iontophoresis with triamcinolone acetonide is more effective than using each groups. The continuous study is needed for many interesting issues of iontophoretic transdermal drug delivery in new future.

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COMPARISON OF PHYSICAL PROPERTIES AND EVOLUTION OF AKARI AND SPITZER 24 ㎛-DETECTED GALAXIES AT z = 0.4 - 2

  • Fujishiro, Naofumi;Hanami, Hitoshi;Ishigaki, Tsuyoshi
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.313-315
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    • 2017
  • We present physical properties of $24{\mu}m$ galaxies detected by AKARI and Spitzer and their evolution between redshifts 0.4 < z < 2. Using multi-wavelength data from X-ray to radio observations in NEP Deep Field (for AKARI) and Subaru/XMM-Newton Deep Field (for Spitzer), we derive photometric redshift, stellar mass, star-formation rate (SFR), dust extinction magnitude and rest-frame luminosities/colors of the $24{\mu}m$ galaxies from photometric SED fitting. We infer the SFRs from rest-frame ultraviolet luminosity and total infrared luminosity calibrated against Herschel photometric data. For both survey fields, we obtain complete samples with stellar mass of > $10^{10}M_{\odot}$ and SFR of > $30M_{\odot}/yr$ up to z = 2. We find that specific SFRs evolves with redshift at all stellar masses in NON-power-law galaxies (non-PLGs) as star-formation dominant luminous infrared galaxies (LIRGs). The correlations between specific SFR and stellar mass in the Spitzer and AKARI galaxy samples are well consistent with trends of the main sequence galaxies. We also discuss nature of PLGs and their evolution.

Research on Investigation on the Spot in Relation to Electrical Safety of Electrical Installation in Elementary.Middle.High School (전기안전에 대한 초.중.고등학교 전기시설물의 현장조사 연구)

  • Gil, Hyoung-Jun;Choi, Chung-Seog;Lee, Ki-Yeon;Moon, Hyun-Wook
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.21 no.5
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    • pp.99-105
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    • 2007
  • This paper describes the investigation on the spot in relation to electrical safety of electrical installation in elementary middle high school. The investigation was carried out for power receiving system, classroom, chemistry room, music hall and so on. The investigation on the spot was performed by researcher, the related expert, engineer with over fifteen years of industry experience all over the country. As a result of investigation on the spot to 41 schools, common grounding methods at power receiving system were dominant. The risk factors include absence of control box of electric fan, non-installation of earth leakage circuit breaker to power source of experiment stand, use of non-grounding outlet.

Development and Application of Two-Dimensional Hydrogen Mixing Model in Containment Subcompartment Under Severe Accidents

  • Lee, Byung-Chul;Cho, Jae-Seon;Park, Goon-Cherl;Chung, Chang-Hyun
    • Nuclear Engineering and Technology
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    • v.29 no.2
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    • pp.110-126
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    • 1997
  • A two-dimensional continuum model for the hydrogen mining phenomena in the containment subcompartment under severe accident conditions has been developed to predict the spatial distribution of the hydrogen concentration. The model can predict the distribution of time-dependent hydrogen concentration for HEDL experiments well. For the simulation of these experiments, the hydrogen is mixed uniform within the test compartment. To predict the extent of non-uniform distribution, the dominant factors such as the geometrical shape of obstacle and velocity of source injection in mixing phenomena are investigated. If the obstacle disturbing the flow of gas mixture exists in the compartment, the uniform distribution of hydrogen might be not guaranteed. The convective circulation of gas flow is separately formed up and down of the obstacle position, which makes a difference of hydrogen concentration between the upper and lower region of the compartment. The recirculation flow must have a considerable mass flow rate relative to velocity of the source injection to sustain the well-mixed conditions of hydrogen. Finally, in order to account for non-uniform distribution of the hydrogen due to the geometrical configuration the maximum-to-average ratio is functionalized.

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Preliminary Estimation of National Emission Inventory for the Unintentionally Produced Polychlorinated Biphenyls (국내 부산물 다염화비페닐(PCBs) 배출량 예비 평가)

  • Kim Kyoung-Mi;Cho Kyu-Tak;Lee Jee-Yoon;Lee Jee-Eun;Lee Dong-Soo
    • Environmental Analysis Health and Toxicology
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    • v.19 no.2
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    • pp.227-233
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    • 2004
  • The main objectives of this study were to identify from literature review the potential sources and to provide a preliminary national emission inventory for the unintentionally produced polychlorinated biphenyls (PCBs) (i.e., by - product PCBs). In Korea, fuel combustion, waste combustion, thermal industrial processes, and transportation were identified as potential sources of by -product PCB s. According to the availability of the emission factors and/or activity data, emission inventory could be assessed only for fuel combustion, waste combustion, steel industry, non-ferrous industry, and non-metallurgical industry. The total national emission of by-product PCBs was estimated to be 1087kg for the year 2000. The preliminary estimation further indicated that the steel manufacturing was the single dominant emission category, contributing 93% to the total emission. Of the steel manufacturing processes, the contribution of the electric arc furnace was about 80% of the total emission. Due to high uncertainty associated with both the emission factors and activity statistics, the emission estimates in this study are likely to contain significant errors. However, the results of the present work could serve the first step toward future efforts to establish national source and emission inventories of by-product PCBs.

Enzymatic N-glycan analysis of 31 kDa molecule in plerocercoid of Spirometra mansoni (sparganum) and its antigenicity after chemical oxidation

  • Chung, Young-Bae;Kong, Yoon;Yang, Hyun-Jong
    • Parasites, Hosts and Diseases
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    • v.42 no.2
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    • pp.57-60
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    • 2004
  • A highly specific antigenic protein of 31 kDa from plerocercoid of Spirometra mansoni (sparganum) was obtained by gelatin affinity and Mono Q anion-exchange column chromatography. The purified 31 kDa protein was subjected to N-glycan enzymatic digestion for structural analysis. The relative electrophoretic mobility was analyzed by SDS-PAGE, before and after digestion. On SDS-PAGE after enzymatic digestion, the 31 kDa protein showed a molecular shift of approximately 2 kDa, which indicated the possession of complex N-linked oligosaccharides (N-glycosidase F sensitive) but not of high-mannose oligosaccharides (endo-beta-N-acetylglucosaminidase H, non-sensitive). Chemically periodated 31 kDa protein showed statistically non-significant changes with human sparganosis sera by enzyme linked immunosorbent assay (ELISA). Therefore, the dominant epitopes of the 31 kDa molecule in human sparganosis were found to be mainly polypeptide, while N-glycans of the antigenic molecule in sparganum was minimal in anti-carbohydrate antibody production.

Genetic Background of Congenital Hearing Loss (선천성 난청의 유전적 배경)

  • Oh, Seung-Ha;Song, Jae-Jin
    • Journal of Genetic Medicine
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    • v.6 no.1
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    • pp.8-24
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    • 2009
  • Understanding the genetic background of hearing loss is important since almost 50% of the cases of profound hearing loss are caused by genetic factors. Until now, more than 150 causative genes have been identified. In this review, classification of genetic hearing loss (syndromic versus non-syndromic, recessive versus dominant, X-linked and mitochondrial), pitfalls in elucidating causative genes, anatomy of the inner ear, introduction of the most common syndromic hearing loss, introduction of the most common non-syndromic hearing loss-causing genes, mitochondrial and multifactorial hearing losses were discussed. Moreover, clinical approaches to the patients with hereditary hearing loss and genetic counseling were also explained briefly. Finally, future directions of the hereditary hearing loss research in Korean population were presented.

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An Efficient Assisted-GPS Acquisition Method in Weak Signal Environment (약 신호 환경에서 효율적인 A-GPS 초기동기 방법)

  • 박상현;이상정
    • Journal of Institute of Control, Robotics and Systems
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    • v.10 no.1
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    • pp.96-102
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    • 2004
  • For sensitivity enhancement, the general assisted-GPS acquisition method adopts not only the coherent accumulation technique but also the non-coherent accumulation technique since the long coherent accumulation period increases the number of frequency search cells. But the non-coherent accumulation technique causes tile squaring loss, which is a dominant factor among the acquisition losses of assisted GPS dealing with weak GPS signals. This paper derives the squaring loss of the previous assisted-GPS acquisition method and proposes an assisted-GPS acquisition method for solving the problem of squaring loss in weak signal environment. In this paper, it is explained that the proposed assisted-GPS acquisition method prevents the squaring loss using a coupled coherent accumulation technique and the number of search cells of the proposed assisted-GPS acquisition method is much smaller than that of the previous assisted-GPS acquisition method. Finally, through the simulation by the GPS simulator, the acquisition success rate of the proposed assisted-GPS acquisition method is compared with that of the previous assisted-GPS acquisition method and the acquisition improvements are shown in weak signal environment.

P-S Characteristics for End-bearing Pile in Granular Material (사질토 지반에서 선단지지말뚝의 P-S 특성)

  • Lee Yong Joo
    • Journal of the Korean Geotechnical Society
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    • v.21 no.2
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    • pp.85-91
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    • 2005
  • This paper investigates P-S (load-settlement) relationship for the end-bearing Pile in granular material using the CRISP FE Program with the laboratory 2D model pile load test. In order to simulate the effect of end-bearing pile problem in the FEA, the author adopts several forms of slip element around the pile length and the pile tip. Through this study it was found that e degree of non-associated Plastic flow rule incoporated into the Mohr-Coulomb model for the end-bearing pile with the slip elements was a dominant factor in terms of numerical solution convergence. In contrast, the roller boundary used along the pile shaft showed a smooth convergence with respect to the degree of non-associated plastic flow rule.

Application of wavelet transform for the impulse response of pile

  • Ni, Sheng-Huoo;Yang, Yu-Zhang;Lyu, Chia-Rong
    • Smart Structures and Systems
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    • v.19 no.5
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    • pp.513-521
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    • 2017
  • The purpose of this paper is to study the capabilities of the impulse response method in length and flaw detecting for concrete piles and provide a suggested method to find small-size flaws in piles. In this work, wavelet transform is used to decompose the recorded time domain signal into a series of levels. These levels are narrowband, so the mix of different dominant bandwidths can be avoided. In this study, the impulse response method is used to analyze the signal obtained from the wavelet transform to improve the judgment of the flaw signal so as to detect the flaw location. This study provides a new way of thinking in non-destructive testing detection. The results show that the length of a pile is easy to be detected in the traditional reflection time or frequency domain method. However, the small flaws within pile are difficult to be found using these methods. The proposed approach in this paper is able to greatly improve the results of small-size flaw detection within piles by reducing the effects of any noise and clarifying the signal in the frequency domains.