• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.6
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• pp.903-910
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• 2016

In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women's health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman's index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women's health.

• KSBB Journal
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• v.24 no.3
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• pp.259-266
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• 2009

AfsR2 in Streptomyces lividans, a 63-amino acid protein with limited sequence homology to Streptomyces sigma factors, has been known for a global regulatory protein stimulating multiple antibiotic biosynthetic pathways. Although the detailed regulatory mechanism of AfsK-AfsR-AfsR2 system has been well characterized, very little information about the AfsR2-dependent down-stream regulatory genes were characterized. Recently, the null mutant of afsS in S. coelicolor (the identical ortholog of afsR2) has been characterized through DNA microarray system, revealing that afsS deletion regulated several genes involved in antibiotic biosynthesis as well as phosphate-starvation. Through comparative DNA microarray analysis of afsR2-overexpressed S. lividans, here we also identify several afsR2-dependent genes involved in phosphate starvation, morphological differentiation, and antibiotic regulation in S. lividans, confirming that the AfsR2 plays an important pleiotrophic regulatory role in Streptomyces species.

• BMB Reports
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• v.46 no.4
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• pp.201-206
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• 2013

Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane] is an isothiocyanate found in some cruciferous vegetables, especially broccoli. Sulforaphane has been shown to display anti-cancer properties against various cancer cell lines. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment. TPA substantially increased NF-${\kappa}B$ and AP-1 DNA binding activity. Pre-treatment with sulforaphane inhibited TPA-stimulated NF-${\kappa}B$ binding activity, but not AP-1 binding activity. In addition, we found that sulforaphane suppressed NF-${\kappa}B$ activation, by inhibiting phosphorylation of $I{\kappa}B $ in TPA-treated MCF-7 cells. In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells.

• Korean Journal of Remote Sensing
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• v.34 no.6_1
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• pp.1025-1032
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• 2018

Snow Cover is a form of precipitation that is defined by snow on the surface and is the single largest component of the cryosphere that plays an important role in maintaining the energy balance between the earth's surface and the atmosphere. It affects the regulation of the Earth's surface temperature. However, since snow cover is mainly distributed in area where human access is difficult, snow cover detection using satellites is actively performed, and snow cover detection in forest area is an important process as well as distinguishing between cloud and snow. In this study, we applied the Normalized Difference Snow Index (NDSI) and the Normalized Difference Vegetation Index (NDVI) to the geostationary satellites for the snow detection of forest area in existing polar orbit satellites. On the rest of the forest area, the snow cover detection using $R_{1.61{\mu}m}$ anomaly technique and NDSI was performed. As a result of the indirect validation using the snow cover data and the Visible Infrared Imaging Radiometer (VIIRS) snow cover data, the probability of detection (POD) was 99.95 % and the False Alarm Ratio (FAR) was 16.63 %. We also performed qualitative validation using the Himawari-8 Advanced Himawari Imager (AHI) RGB image. The result showed that the areas detected by the VIIRS Snow Cover miss pixel are mixed with the area detected by the research false pixel.

• Journal of the Korea Computer Graphics Society
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• v.27 no.3
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• pp.31-42
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• 2021

We propose a deep learning-based method that can estimate an appropriate lighting of both indoor and outdoor images. The method consists of two networks: Crop-to-PanoLDR network and LDR-to-HDR network. The Crop-to-PanoLDR network predicts a low dynamic range (LDR) environment map from a single partially observed normal field of view image, and the LDR-to-HDR network transforms the predicted LDR image into a high dynamic range (HDR) environment map which includes the high intensity light information. The HDR environment map generated through this process is applied when rendering virtual objects in the given image. The direction of the estimated light along with ambient light illuminating the virtual object is examined to verify the effectiveness of the proposed method. For this, the results from our method are compared with those from the methods that consider either indoor images or outdoor images only. In addition, the effect of the loss function, which plays the role of classifying images into indoor or outdoor was tested and verified. Finally, a user test was conducted to compare the quality of the environment map created in this study with those created by existing research.

• 한국노년학
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• v.39 no.2
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• pp.363-388
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• 2019

This study examined the influence of subjective age on subjective well-being and depression, and the mediating effect of meaning in life. A survey of 394 adults aged 40 or older completed a questionnaire concerning subjective age perception, meaning in life, subjective well-being, and depression. The main results are summarized as follows. First, the analysis of subjective age according to the sociodemographic variables showed that middle-aged and elderly people, who were highly educated and had good perceived health status, felt themselves younger than their counterparts did. Second, a young subjective age had a positive effect on meaning in life and subjective well-being while negatively influencing depression. Third, meaning in life significantly mediated the relationship among subjective age, subjective well-being, and depression. In other words, the younger the middle- and old-aged adults perceived themselves, the more meaning they found in life, which led to higher subjective well-being and lower depression. These findings suggest that, as people get older, perceiving themselves as younger than their chronological age can protect their mental health, and meaning in life plays an important role in the process.

• Journal of Technology Innovation
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• v.23 no.4
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• pp.1-31
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• 2015

Korea has continuously increased investment on R&D to improve global technology competitiveness through technology innovation. Korea's R&D expenditure as a percent of GDP is world's No. 1 as 4.15 and it accomplished 1 trillion won trade volume for 4 consecutive years. However, despite these efforts, technology balance of payment, which is an important factor that can measure nation's technology competitiveness is in a state of chronic deficit and the lowest level among OECD countries. In this paper, we studied methods to improve Korea's technology balance of payment We figured out concept and current state of technology trade and examined the importance of technology trade through making a comparison between commodity trade and technology trade. There have been studies regarding technology trade, but there was no study which tried to figure out cognition on technology trade from the point of view of companies which plays an important role in technology trade. For this, this study distinguished companies with experience in technology trade and which have not and conducted a survey to figure out cognition and current state of companies. The survey result showed noticeable difference on cognition of top decision makers between companies with experience in technology trade and which have not and there are serious shortage in department and staff which is exclusively responsible for technology trade. Also, despite their needs for education regarding technology trade, the ratio of employees who received education is below 10 % of the total respondents. This study suggested improvement methods such as reforming survey methods of technology trade statistics, enhancing social cognition, supporting to vitalize technology export, building infrastructure regarding technology trade, and opening education programs for cultivating experts based on preceding research and industry survey.

• Journal of Distribution Research
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• v.16 no.2
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• pp.95-118
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• 2011

The purpose of this study is as follows. First, we investigate empirically the effects of social network properties such as social network density and centrality of a franchisee on its information sharing with various subjects such as the franchisor and other franchisees in the franchise system. Second, we examine exploratively if tie strength between a franchisee and its franchisor plays a moderating role on the relationship between social network properties and information sharing. The study model was established as shown in

• Journal of Life Science
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• v.19 no.6
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• pp.735-743
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• 2009

The common word flavonoids is often used to classify a family of natural compounds, highly abundant in all higher plants, that have received significant therapeutic interest in recent years. Naringin is associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases; however the molecular basis of this effect remains to be elucidated. Thus we attempted to elucidate the anti-allergic effect of Naringin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic reactions in the airways. These included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of Naringin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that Naringin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of Naringin in terms of its effects on asthma in mice.

• Journal of Life Science
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• v.27 no.2
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• pp.139-148
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• 2017

The inhibition of tyrosinase, a key enzyme in mammalian melanin synthesis, plays an important role in preventing skin pigmentation and melanoma. Therefore, tyrosinase inhibitors are very important in the fields of medicine and cosmetics. However, only a few tyrosinase inhibitors are currently available because of their toxic effects on skin or lack of selectivity and stability. Therefore, we synthesized a novel series of (E)-2-(substituted benzylidene)-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one derivatives and evaluated their inhibitory effects on mushroom tyrosinase, with the aim of discovering a novel tyrosinase inhibitor. Among 19 derivatives, MHY3655 ($IC_{50}=0.1456{\mu}M$) showed the strongest inhibitory effect on tyrosinase activity compared to kojic acid ($IC_{50}=17.2{\mu}M$), a well-known tyrosinase inhibitor. In addition, MHY3655 showed competitive inhibition on Lineweaver-Burk plots. We confirmed that MHY3655 strongly interacts with mushroom tyrosinase residues through the docking simulation. Substitutions with a hydroxy group at both R2 and R4 in the phenyl ring indicated that these groups play a major role in the high binding affinity to tyrosinase. Further, MHY3655 did not show cytotoxicity at the concentrations tested in B16F10 melanoma cells. In conclusion, the novel compound MHY3655 potentially shows tyrosinase inhibitory activity, and it could be used as an ingredient in whitening cosmetics.