• Journal of the Economic Geographical Society of Korea
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• v.11 no.3
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• pp.492-507
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• 2008

Many classical network analysis methods approach networks in aspatial perspectives. Measuring network reliability and finding critical nodes in particular, the analyses consider only network connection topology ignoring spatial components in the network such as node attributes and edge distances. Using local network autocorrelation measure, this study handles the problem. By quantifying similarity or clustering of individual objects' attributes in space, local autocorrelation measures can indicate significance of individual nodes in a network. As an application, this study analyzed internet backbone networks in the United States using both classical disjoint product method and Getis-Ord local G statistics. In the process, two variables (population size and reliability) were applied as node attributes. The results showed that local network autocorrelation measures could provide local clusters of critical nodes enabling more empirical and realistic analysis particularly when research interests were local network ranges or impacts.

• Journal of Chest Surgery
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• v.36 no.7
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• pp.489-496
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• 2003

To clarify the prognostic implication of the location and number of the metastatic mediastinal nodes in resected stage IIIA N2 non-small cell lung cancer. Material and Method: One hundred and seventy-four patients with resected non-small cell lung cancer who eventually proved to have pathologic stage IIIA N2 disease were studied. Patients who received preoperative induction therapy, non-curative operation or defined as operative mortality were excluded from this study. Result: In upper lobe tumors, there was no difference in 5-year survival according to the involvement of lower mediastinal nodes (32.3% vs 25.6%, p＝0.86). In lower lobe tumors, no difference was found in 5-year survival according to the involvement of upper mediastinal nodes (25.1% vs 14.1%, p＝0.33). There was no significant difference in 5-year survival between patients with or without metastatic subcarinal node (20.9% vs 25.6%, p＝0.364). In terms of the number of metastatic mediastinal nodes, 5-year survival was better in single station group (26.3%) than multiple station group (18.3%) (p＝0.048). In multiple station N2 group, the patients who received postoperative chemotherapy and radiation therapy had better 5-year survival (34.2%) (p＝0.01). Cox's proportional hazards model revealed that the age $\geq$60 (O.R: 1.682, p＝.006), multiple station N2 (O.R: 1.503. p＝0.021), pneumonectomy (O.R: 1.562, p＝0.018), postoperative chemotherapy and radiation therapy (O.R: 0.625, p＝0.012) were the factors affecting the postoperative survival. Conclusion: Multiple station N2 disease was the important prognostic factor for postoperative survival in resected stage IIIA N2 non-small cell lung cancer. Postoperative chemotherapy and radiotherapy were thought to improve the survival in case of multiple station N2 disease.

• Tuberculosis and Respiratory Diseases
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• v.49 no.1
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• pp.60-71
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• 2000

Backgrounds : Cathepsin D, an aspartic lysosomal proteinase, is believed to be involved in local invasion and metastasis of tumor cells by its proteolytic activity and has been described to be associated with tumor progression and prognosis in some human malignancies including breast cancer. But, its prognostic value for human lung cancer remains to be determined. The purpose of this study is to determine clinicopathological and prognostic significance of cathepsin D expression in non-small cell lung cancer. Method : Using a polyclonal antibody, immunohistochemical analysis of cathepsin D was performed on paraffin embedded sections of tumors obtained surgically from 54 patients with non-small cell lung cancer (37 squamous cell carcinoma, 14 adenocarcinoma, 2 large cell carcinoma, and 1 undifferentiated carcinoma). Results : Eighteen patients (33.3%) showed positive immunoreactivities of cathepsin D in tumor cells. No significant correlation of cathepsin D expression in tumor cells was found in p-stage (surgical-pathologic stage), tumor size, tumor factor, nodal involvement, and differentiation. Of 54 patients, 29 (53.7%) patients showed moderate to massive cathepsin D-positive stromal cells within the tumor tissues, while the rest (46.3%) showed few cathepsin D-positive stromal cells within the tumor tissues. Cathepsin D expression in stromal cells was significantly associated with p-stage in non-small cell lung canær (p=0.031). No significant correlation of the degree of cathepsin D-positive stromal cells was found in tumor size, T -factor, nodal involvement, differentiation Cathepsin D expression status in tumor cells and stromal cells was not significantly associated with prognosis expressed by survival rate. The results of multivariate analyses of variables possibly associated with prognosis showed that nodal involvement was the only independent prognostic factor in all patients. Conclusion : Cathepsin D expression in stromal cells was significantly associated with p-stage in non-small cell lung cancer. However, it was not related to other clinicopathologic features and prognosis, and Cathepsin D expression in tumor was not related to p-stage and prognosis.

• Tuberculosis and Respiratory Diseases
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• v.49 no.3
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• pp.290-297
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• 2000

Background : Current non-invasive methods for evaluating the mediastinum by computed tomographic (CT) scan have limited sensitivity and specificity. The recently introduced PET was reported to be a more sensitive and specific method for the mediastinal staging of NSCLC (sensitivity : 76-100 %, specificity : 81-100%) than CT or MRI. We assessed the usefulness of PET in the mediastinal staging of NSCLC. Methods : We reviewed the medical records of NSCLC patients that had undertaken staging work-up by both CT and PET before thoracotomy between January 1997 and December 1998. A total of 23 patients were enrolled in the study (14 males and 7 females) with a mean age of 61$\pm$9 years. By comparing the clinical(CT and PET) and pathologic stagings, we evaluated the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET in thoracic nodal staging. Results : Sensitivity, specificity, positive predicted value and negative predicted value were 38%, 40%, 25% and 50% respectively for computed tomography, and 50%, 60%, 30% and 69% for PET. The accuracy of FDG-PET in our study was lower than that reported by previous other studies. Conclusion : The addition of FDG-PET to CT scanning has limited benefit for the thoracic nodal staging of NSCLC, but its value in our study was lower than that observed by others.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.6A
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• pp.789-798
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• 2008

The stiffness method provides a framework to calculate the structural deformations directly from solving the equilibrium state. However, to use the displacement shape functions leads to approximate estimation of stiffness matrix and resisting forces, and accordingly results in a low accuracy. The conventional flexibility method uses the relation between sectional forces and nodal forces in which the equilibrium is always satisfied over all sections along the element. However, the determination of the element resisting forces is not so straightforward. In this study, a new fiber finite element mixed method has been developed for nonlinear anaysis of steel-concrete composite structures in the context of a standard finite element analysis program. The proposed method applies the Newton method based on the load control and uses the incremental secant stiffness method which is computationally efficient and stable. Also, the method is employed to analyze the steel-concrete composite structures, and the analysis results are compared with those obtained by ABAQUS. The comparison shows that the proposed method consistently well predicts the nonlinear behavior of the composite structures, and gives good efficiency.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.3 s.147
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• pp.351-361
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• 2006

The fatigue strength analysis of VLFS is carried out by using a 3-dimensional plate finite element model with a zooming technology which performs the modeling of wide portions of the structure by a coarse mesh but the concerned parts by a very fine mesh of t by t level. And a stepwise substructure modeling technique for global loading conditions is applied which uses the motion response of the global structure from 2-D plate hydroelastic analysis as the enforcing nodal displacements of the concern 3-D structural zooming model. Seven incident wave angles and whole ranges of frequency domains of wave spectrum are considered. In order to consider the effect of breakwater, the modified JONSWAP wave spectrum is used. Applying the wave data of installation region, the longterm spectrum analysis is done based on stochastic process and the fatigue life of the structure is estimated. Finally some design considerations from the view point of fatigue strength analysis of VLFS are discussed.

• Korean Journal of Optics and Photonics
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• v.17 no.4
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• pp.359-365
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• 2006

Wave-front error(WFE) is the main parameter that determines the optical performance of the opto-mechanical system. In the development of opto-mechanics, WFE due to the main loading conditions are set to the important specifications. The deformation of the optical surface can be exactly calculated thanks to the evolution of numerical methods such as the finite element method(FEM). To calculate WFE from the deformation results of FEM, another approximation of the optical surface deformation is required. It needs to construct additional grid or element mesh. To construct additional mesh is troublesomeand leads to transformation error. In this work, the moving least-squares approximation is used to reconstruct wave front error It has the advantage of accurate approximation with only nodal data. There is no need to construct additional mesh for approximation. The proposed method is applied to the examples of GOCI scan mirror in various loading conditions. The validity is demonstrated through examples.

• Journal of the Korea institute for structural maintenance and inspection
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• v.8 no.2
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• pp.147-158
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• 2004

For stiffened plates composed of composite materials, many researchers have used a finite element method which connected isoparametric plate elements and beam elements. However, the finite element method is difficult to reflect local behavior of stiffener because beam elements are transferred stiffness for nodal point of plate elements, especially the application is limited in case of laminated composite structures. In this paper, for analysis of laminated composite stiffened plates, 3D shell elements for stiffener and plate are employed. Reissner-Mindlin's first order shear deformation theory is considered in this study. But when thickness will be thin, isoparamatric plate bending element based on the theory of Reissner-Mindlin is generated by transverse shear locking. To eliminate the shear locking and virtual zero energy mode, the substitute shear strain field is used. A deflection distribution is investigated for simple supported rectangular and skew stiffened laminated composite plates with arbitrary orientation stiffener as not only variation of slenderness and aspect ratio of the plate but also variation of skew angle of skew stiffened plates.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.49 no.6
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• pp.322-329
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• 2000

BIST(Built-in Self Test) has been considered as the most promising DFT(design-for-test) scheme for the present and future test strategy. The most serious problem in applying BIST(Built-in Self Test) into a large circuit is the excessive increase in test time. This paper is focused on this problem. We proposed a new BIST construction scheme which uses a parallel divide-and-conquer method. The circuit division is performed with respect to some internal nodes called test points. The test points are selected by considering the nodal connectivity of the circuit rather than the testability of each node. The test patterns are generated by only one linear feedback shift register(LFSR) and they are shared by all the divided circuits. Thus, the test for each divided circuit is performed in parallel. Test responses are collected from the test point as well as the primary outputs. Even though the divide-and-conquer scheme is used and test patterns are generated in one LFSR, the proposed scheme does not lose its pseudo-exhaustive property. We proposed a selection procedure to find the test points and it was implemented with C/C++ language. Several example circuits were applied to this procedure and the results showed that test time was reduced upto 1/2151 but the increase in the hardware overhead or the delay increase was not much high. Because the proposed scheme showed a tendency that the increasing rates in hardware overhead and delay overhead were less than that in test time reduction as the size of circuit increases, it is expected to be used efficiently for large circuits as VLSI and ULSI.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.2
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• pp.191-198
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• 2010

This study investigated that the stress reduction of single edge cracked plates with patch repairs according to different type of patching such as material, size and thickness of patch and adhesive as well as single sided or double sided patches. As a numerical tool, the p-convergent partial layerwise model has been employed. The proposed model is formulated by assuming piecewise linear variation of in-plane displacement and a constant value of out-of-plane displacements across thickness. The integrals of Legendre polynomials are chosen to define displacement fields and Gauss-Lobatto numerical integration is implemented in order to directly obtain maximum values occurred at the nodal points of each layer without other extrapolation techniques. Also, total strain energy release rate method is adopted to obtain stress intensity factors. Numerical examples are presented not only to demonstrate the stress reduction effect in terms of non-dimensional stress intensity factor and deflection with respect to different type of patch repairs, but also the accuracy of proposed model.