• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.3
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• pp.85-93
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• 2014

Purpose: Nodal metastasis is the main prognostic factor in the patients with oral squamous cell carcinoma (OSCC). We investigated the association between tumor-associated lymphatics and OSCC characteristics. Methods: Thirty-four specimens were used for the immunohistochemical staining with the antibody for vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, phosphorylated VEGFR-3, D2-40, and matrix metallproteinases (MMPs). We observed the distribution of the lymphangiogenic factors and quantified the degree of expression. We determined lymphatic vessel density (LVD) and lymphatic vessel dilatation with D2-40 immunostaining. We assessed the association of LVD or lymphatic vessel dilatation with tumor progression or tumor differentiation. Results: OSCC cells expressed lymphangiogenic ligands. Lymphangiogenic receptor, VEGFR-3, was expressed and activated in some tumor cells as well as in tumor-associated endothelial cells. LVD was not associated with tumor size or nodal status, but lymphatic vessel dilatation was higher in tumors with nodal metastasis, and also higher in poorly differentiated tumors. In stromal area of OSCC, MMP-1 and MMP-10 were up-regulated and the basement membrane of tumor-associated endothelial cells was destroyed by these collagenases. Conclusion: In the primary tumors with nodal metastasis, especially in poorly differentiated OSCC, tumor cells invaded the dilated lymphatic vessels via ruptured sites. MMP-1 and MMP-10 are important in the lysis of the glycocalyx inside the tumor-associated lymphatic endothelial cells.

• Molecules and Cells
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• v.37 no.5
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• pp.389-398
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• 2014

Siah acts as an E3 ubiquitin ligase that binds proteins destined for degradation. Extensive homology between siah and Drosophila Siah homologue (sina) suggests their important physiological roles during embryonic development. However, detailed functional studies of Siah in vertebrate development have not been carried out. Here we report that Siah2 specifically augments nodal related gene expression in marginal blastomeres at late blastula through early gastrula stages of zebrafish embryos. Siah2 dependent Nodal signaling augmentation is confirmed by cell-based reporter gene assays using 293T cells and 3TP-luciferase reporter plasmid. We also established a molecular hierarchy of Siah as a upstream regulator of FoxH1/Fast1 transcriptional factor in Nodal signaling. Elevated expression of nodal related genes by overexpression of Siah2 was enough to override the inhibitory effects of atv and lft2 on the Nodal signaling. In particular, E3 ubiquitin ligase activity of Siah2 is critical to limit the duration and/or magnitude of Nodal signaling. Additionally, since the embryos injected with Siah morpholinos mimicked the atv overexpression phenotype at least in part, our data support a model in which Siah is involved in mesendoderm patterning via modulating Nodal signaling.

• Journal of the Korean Geographical Society
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• v.48 no.4
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• pp.545-556
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• 2013

This study sets up nodal regions for shopping and leisure with 424 district units located in Seoul and examines the characteristics of the vertical structure and the regional system. According to the higher-order analysis result, the trip for leisure forms a greater part, and about each of the nodal regions of the first stratum, major spots for origin and destination are located in the center, and those spots are connected to adjacent district units located nearby. As the factor's eigenvalue is bigger, the spatial range gets greater, too, and is located in outsides. And in the third or higher strata, either linkage between Gangnam and Gangbuk or leapfrogging linkage according to the bipolar factors is distinctive. Linkage between nodal regions centering around Jongro-gu, Jung-gu, Gangnam-gu, or Yeoungdeungpo-gu is not distinct, and in particular, the nodal regions of Jongro Geumcheon are maintained as the upper strata being independent from other nodal regions from the second or higher strata.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4211-4214
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• 2015

Background: Prognostic value of prophylactic level VII nodal dissection in papillary thyroid carcinoma has been highlighted. Materials and Methods: A total of 27 patients with papillary thyroid carcinoma with N0 neck underwent total thyroidectomy with level VI and VII nodal dissection through same collar neck incision. Multicentricity, bilaterality, extrathyroidal extension, level VI and VII lymph nodes were studied as separate and independent prognostic factors for DFS at 24 months. Results: 21 females and 6 males with a mean age of 34.6 years old, tumor size was 5-24 mm. (mean 12.4 mm.), multicentricity in 11 patients 2-4 foci (mean 2.7), bilaterality in 8 patients and extrathyroidal extension in 8 patients. Dissected level VI LNs 2-8 (mean 5 LNs) and level VII LNs 1-4 (mean 1.9). Metastatic level VI LNs 0-3 (mean 1) and level VII LNs 0-2 (mean 0.5). Follow-up from 6-51 months (mean 25.6) with 7 patients showed recurrence (3 local and 4 distant). Cumulative DFS at 24 months was 87.8% and was significantly affected in relation to bilaterality (p-value <0.001), extrathyroidal extension (p-value <0.001), level VI positive ((p-value <0.001) and level VII positive ((p-value <0.001) LNs. No recurrences were detected during the follow-up period in the absence of level VI and level VII nodal involvement. Conclusions: Level VII prophylactic nodal dissection is an important and integral prognostic factor in papillary thyroid carcinoma. A larger multicenter study is crucial to reach a satisfactory conclusion about the necessity and safety of this approach.

• Nuclear Engineering and Technology
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• v.16 no.4
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• pp.202-216
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• 1984

The success of coarse-mesh nodal solution methods provides strong motivation for finding homogenized parameters which, when used in global nodal calculation, will reproduce exactly all average nodal reaction rates for large nodes. Two approximate theories for finding these ideal parameters, namely, simplified equivalence theory and approximate node equivalence theory, are described herein and then applied to the PWR benchmark problem. Nodal code, ANM, is used for the global calculation as well as for the homogenization calculation. From the comparative analysis, it is recommended that homogenization be carried out only for the unique type of fuel assemblies and for core boundary color-sets. The use of approximate homogenized cross-sections and approximate discontinuity factors predicts nodal powers with maximum error of 0.8% and criticality within 0.1% error relative to the fine-mesh KIDD calculations.

• Journal of Plant Biotechnology
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• v.6 no.2
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• pp.97-102
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• 2004

This study was carried out to establish The regeneration of healthy seedlings from the nodal segment culture of Chinese yam (Dioscorea opposita cv. Danma), cultivated in Korea. Different explants such as leaves, petioles, roots and nodal pieces, excised from the in vitro grown seedlings of Chinese yam, were cultured on MS medium supplemented with various combinations of growth regulators. All the growth regulators used induced plantlet regeneration from the nodal segments at a high frequency, while there was no induction of shoot or callus from leaf, petiole or root tissues. The medium supplemented with 0.01mg/L NAA, 0.5mg/L BA, 0.5-1.0mg/L kinetin and without plant growth regulator was effective for shoot development of buds from the nodal segment culture. The concentration of BA and NAA was an important factor in the bud induction of buds from the nodal segments of Chinese yam. Nodal segments cultured on the medium containing 1.0mg/L NAA and 0.5-1.0mg/L BA gave the best response to bud formation. The addition of GA$_3$ to the culture medium suppressed shoot induction and growth, while it increased microtuber formation. The shoot growth and microtuber formation were also affected by medium strength and solidity. The MS basal medium containing 1 g/L gelrite was suitable for microtuber formation from the nodal segment of Chinese yam.

• Nuclear Engineering and Technology
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• v.51 no.5
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• pp.1195-1208
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• 2019

This paper introduces a new two-step procedure for PWR depletion analyses. This procedure adopts the albedo-corrected parameterized equivalence constants (APEC) method to correct the lattice-based raw cross sections (XSs) and discontinuity factors (DFs) by accounting for neutron leakage. The intrinsic limitations of the conventional two-step methods are discussed by analyzing a 2-dimensional SMR with the commercial DeCART2D/MASTER code system. For a full-scope development of the APEC correction, the MASTER nodal code was modified so that the group constants can be corrected in the middle of a microscopic core depletion. The basic APEC methodology is described and color-set problems are defined to determine the APEC functions for burnup-dependent XS and DF corrections. Then the new two-step method was applied to depletion analyses of the SMR without thermal feedback, and its validity was evaluated in terms of being able to predict accurately the reactor eigenvalue and nodal power profile. In addition, four variants of the original SMR core were also analyzed for a further evaluation of the APEC-assisted depletion. In this work, several combinations of the burnup-dependent and -independent XS and DF corrections were also considered. The results show that the APEC method could enhance the nodal equivalence significantly with inexpensive additional costs.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.3059-3072
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• 2022

A Jacobian-Free Newton Krylov Two-Nodal Coarse Mesh Finite Difference algorithm based on Nodal Expansion Method (NEM_TNCMFD_JFNK) is successfully developed and proposed to solve the three-dimensional (3D) and multi-group reactor physics models. In the NEM_TNCMFD_JFNK method, the efficient JFNK method with the Modified Incomplete LU (MILU) preconditioner is integrated and applied into the discrete systems of the NEM-based two-node CMFD method by constructing the residual functions of only the nodal average fluxes and the eigenvalue. All the nonlinear corrective nodal coupling coefficients are updated on the basis of two-nodal NEM formulation including the discontinuity factor in every few newton steps. All the expansion coefficients and interface currents of the two-node NEM need not be chosen as the solution variables to evaluate the residual functions of the NEM_TNCMFD_JFNK method, therefore, the NEM_TNCMFD_JFNK method can greatly reduce the number of solution variables and the computational cost compared with the JFNK based on the conventional NEM. Finally the NEM_TNCMFD_JFNK code is developed and then analyzed by simulating the representative PWR MOX/UO₂ core benchmark, the popular NEACRP 3D core benchmark and the complicated full-core pin-by-pin homogenous core model. Numerical solutions show that the proposed NEM_TNCMFD_JFNK method with the MILU preconditioner has the good numerical accuracy and can obtain higher computational efficiency than the NEM-based two-node CMFD algorithm with the power method in the outer iteration and the Krylov method using the MILU preconditioner in the inner iteration, which indicates the NEM_TNCMFD_JFNK method can serve as a potential and efficient numerical tool for reactor neutron diffusion analysis module in the JFNK-based multiphysics coupling application.

• Journal of Korean Association for Spatial Structures
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• v.13 no.1
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• pp.87-96
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• 2013

This study investigated characteristics of buckling load and effective buckling length by member rigidity of dome-typed space frame which was sensitive to initial conditions. A critical point and a buckling load were computed by analyzing the eigenvalues and determinants of the tangential stiffness matrix. The hexagonal pyramid model and star dome were selected for the case study in order to examine the nodal buckling and member buckling in accordance with member rigidity. From the numerical results, an effective buckling length factor of adopted models was bigger than that of Euler buckling for the case of fixed boundary. These numerical models indicated that the influence of nodal buckling was greater than that of member buckling as member rigidity was higher. Besides, there was a tendency that the bifurcation appeared on the equilibrium path before limit point in the member buckling model.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05a
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• pp.131-136
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• 1996

An analytic nodal expansion method has been derived for the multigroup neutron diffusion equation in 2-D cylindrical(R-Z) coordinate. In this method we used the second order Legendre polynomials for source, and transverse leakage, and then the diffusion eqaution was solved analytically. This formalism has been applied to 2-D LWR model. $textsc{k}$$_{eff}$, power distribution, and computing time have been compared with those of ADEP code(finite difference method). The benchmark showed that the analytic nodal expansion method in R-Z coordinate has good accuracy and quite faster than the finite difference method. This is another merit of using R-Z coordinate in that the transverse integration over surfaces is better than the linear integration over length. This makes the discontinuity factor useless.s.