• 대한두경부종양학회지
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• 제8권2호
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• pp.63-71
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• 1992

After analysis according to age, sex, site of origin, nodal involvement, perineural invasion. histopathology and treatment modality. authors had reached the following conclusion about the 28 cases of adenoid cystic carcinoma of the salivary gland, which were, histopathologically, diagnosed at Yonsei University Severance Hospital and Yongdong, Severance Hospital during the 8-year period from Apr. 1983 to Mar. 1991. Among the 28 cases, 13 were females and 15 were males, which implies that there isn't any sigificant distinction of gender. The age range was 24 years to 69 years with a mean age of 49 years, and the most common site of origin in order was 6 cases(21.4%) of maxillary sinus, 5 cases(17.8%) of submandibular gland, each 4 cases(14.4%) of parotid gland, palate, 3 cases(10.4%) of nasal cavity and each 2 cases(7.1%) of mouth floor, nasopharynx with each one case(3.6%) of buccal mucosa and retromolar trigone. With clinical staging by UICC, the 5-year survival of adenoid cystic carcinoma was 100% in stage I and II, 87.5% in stage III. In stage IV, all of the patient were died within 3 years. We have known that the prognosis was poorer in following cases; the cases with higher clinical stage, primary site other than the major salivary gland especially maxillary sinus and positive neural or nodal invasion.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4853-4858
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• 2015

Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of $2^{nd}$ line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3037-3046
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• 2012

The diffuse large B-cell lymphoma (DLBCL) encompasses two major groups of tumors with uneven survival outcomes - germinal center B-cell (GCB) and non-germinal center B-cell (non-GCB). In the present study, we investigated the expression of GCB markers (BCL-6 and CD10) and non-GCB markers (CD138 and MUM-1) in an effort to evaluate their prognostic value. Paraffin-embedded tumor biopsies of 46 Jordanian DLBCL patients were analyzed, retrospectively, by immunohistochemistry to investigate the expression of BCL-6, CD10, CD138 and MUM-1. In addition, survival curves were calculated with reference to marker expression, age, sex and nodal involvement. Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases, respectively, that of BCL-6 being associated with better overall survival (p = 0.02), whereas positive CD138 was linked with poor overall survival (p = 0.01). The expression of CD10 and MUM-1 had no impact on the overall survival. Among the clinical characteristics studied, diagnosis at an early age, nodal involvement and maleness were associated with a higher overall survival for DLBCL patients. Our results underline the importance of BCL-6 as a marker of better prognosis and CD138 as a marker of poor prognosis for DLBCL patients.

• 대한토목학회논문집
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• 제12권4_1호
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• pp.67-76
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• 1992

축대칭(軸對稱) 선형강성(線形彈性) 응력해석을 위해 p-version 유한요소법에 기초한 계층적(階層的) 정식화 과정이 제안되었다. 이 방식은 적분형 르장드르 다항식을 사용하여 절점좌표값을 갖지 않는 절점을 추가하여 형상함수의 조합형태로 변위함수(變位)를 근사시키는 방법이다. 형상함수(形狀函數)가 계층적 성질을 갖기 때문에 강성도(剛性度)행렬과 하중벡터도 계층적이 된다. 본 연구에서 제안된 요소(要所)의 장점(長點)은 다음과 같다. 첫째, 개선된 수치연산의 효율성이며 둘째, 요소간에 서로 다른 차수(次數)의 형상함수를 사용할 수 있고 셋째, p-세분화를 할 때 저차(低次)일 때 계산된 값을 그대로 사용할 수 있다. 수치예제를 통해 제안된 요소의 정확도(正確度), 효율성(效率性), 모델링의 간편성(簡便性), 적용성(適用性) 및 변위와 응력 그리고 에너지 Norm등을 사용하여 그 우월성을 입증하고 있다. 몇 가지 예제의 해석결과는 이미 발표된 논문과 아울러 해석적 방법에 의한 결과와 비교되었다.

• 대한기계학회논문집A
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• 제34권4호
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• pp.501-509
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• 2010

해상크레인은 크레인을 탑재한 선박으로서, 조선소에서 대형 블록이나 구조물의 탑재 및 해상 운송 작업에 사용된다. 본 논문에서는 해상크레인과 중량물의 전후 동요(Surge), 상하 동요(Heave), 종 동요(Pitch)에 대한 정적/동적거동을 분석하였다. 이 때, 유연 다물체계 동역학을 적용하여 해상크레인의 붐(boom)을 탄성으로 고려하였으며, 플로팅 프레임(floating frame)과 노드 좌표(nodal coordinates)를 사용하였다. 질량 행렬, 탄성 강성 행렬, 2 차 속도 벡터, 일반화 좌표 방향으로 작용하는 외력 등을 고려하여 모든 운동이 연성된 비선형 운동 방정식을 구성하였다. 외력으로는 비선형 유체정역학 힘, 선형화된 유체동역학 힘, wire rope 힘, 계류력이 고려되었다. 수치 해석을 위해 Hilber-Hughes-Taylor 방법을 비선형 운동방정식에 적용하였다. 정적 거동 분석을 통한 정적 평형 자세를 고려한 경우와 고려하지 않은 경우에 대해 결과를 비교하였으며, 수치 해석 방법에 대한 정적/동적 거동 분석 결과를 비교하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.887-890
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• 2014

This study was undertaken to compare surgical outcomes and survival rates of patients with the 2009 International Federation of Gynecology and Obstetrics (FIGO) stage IIA1 versus IIA2 cervical cancer treated with radical hysterectomy and pelvic lymphadenectomy (RHPL). Patients with stage IIA cervical cancer undergoing primary RHPL between January 2003 and December 2012 at Chiang Mai University Hospital were retrospectively reviewed. The analysis included clinicopathologic variables, i.e. nodal metastasis, parametrial involvement, positive surgical margins, deep stromal invasion (DSI)), lymph-vascular space invasion (LVSI), adjuvant treatment, and 5-year survival. The chi square test, Kaplan-Meier method and log-rank test were used for statistical analysis. During the study period, 133 women with stage IIA cervical cancer, 101 (75.9 %) stage IIA1, and 32 (24.1 %) stage IIA2 underwent RHPL. The clinicopathologic variables of stage IIA1 compared with stage IIA2 were as follows: nodal metastasis (38.6% vs 40.6%, p=0.84), parametrial involvement (10.9% vs 15.6%, p=0.47), positive surgical margins (31.7% vs 31.3%, p=1.0), DSI (39.6% vs 53.1%, p=0.18), LVSI (52.5% vs 71.9%, p=0.05) and adjuvant radiation (72.3% vs 84.4%, p=0.33). With a median follow-up of 60 months, the 5-year disease-free survival (84.6% vs 88.7%, p=0.67) and the 5-year overall survival (83.4% vs 90.0%, P=0.49) did not significantly differ between stage IIA1 and stage IIA2 cervical cancer. In conclusion, patients with stage IIA1 and stage IIA2 cervical cancer have comparable rates of locoregional spread and survival. The need for receiving adjuvant radiation was very high in both substages. The revised 2009 FIGO system did not demonstrate significant survival differences in stage IIA cervical cancer treated with radical hysterectomy. Concurrent chemoradiation should be considered a more suitable treatment for patients with stage IIA cervical cancer.

• International Journal of Industrial Entomology and Biomaterials
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• 제23권1호
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• pp.155-166
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• 2011

The leaf beetle, $Chrysolina$ $aurichalcea$ (Coleoptera: Chysomelidae), is a pest damaging plants of Compositae. In order to understand the genetic diversity and geographic variation we sequenced a portion of mitochondrial COI gene (658 bp) and complete nuclear internal transcribed spacer 2 (ITS2) of the species collected from seven Korean localities. A total of 17 haplotypes (CACOI01~CACOI17), with the maximum sequence divergence of 3.04% (20 bp) were obtained from COI gene sequence, whereas 16 sequence types (ITS2CA01~ITS2CA16), with the maximum sequence divergence of 2.013% (9 bp) were obtained from ITS2, indicating substantially larger sequence divergence in COI gene sequence. Phylogenetically, the COI gene provided two haplotype groups with a high nodal support (${\geq}87%$), whereas ITS2 provided only one sequence type group with a high nodal support (${\geq}92%$). The result of COI gene sequence may suggest the presence of historical biogeographic barriers that bolstered genetic subdivision in the species. Different grouping pattern between COI gene and ITS2 sequences were interpreted in terms of recent dispersal, reflected in the ITS2 sequence. Finding of unique haplotypes and sequence types only from Beakryeng-Islet population was interpreted as an intact remnant of ancient polymorphism. As more samples are analyzed using further hyper-variable marker, further fruitful inference on the geographic contour of the species might be available.

• 상하수도학회지
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• 제27권1호
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• pp.1-10
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• 2013

Major issues in water supply service have changed from expansion of service area to improvement of service quality, i.e., water quality and safety, and early response to emergency situation. This change in the service concept triggers the perceptions of limitation with the current centralized water supply system and of necessities of decentralized (distributed) water supply system (DWSS), which can make up the limitations. DWSS can reduce the possibility of water supply outage by establishing multiple barriers such as emergency water supply system, and secure better water quality by locating treatment facilities neighboring consumers. On the other hand, fluctuation of water demand will be increased due to the reduced supply area, which makes difficult to promptly respond the fluctuating demand. In order to supplement this, hybrid water supply system was proposed, which combined DWSS with conventional water supply system using distributing reservoir to secure the stability of water supply. The Optimal connection point of DWSS to existing water supply network in urban area was determined by simulating a supply network using EPANET. Optimal location of decentralized water treatment plant (or connection point) is a nodal point where changes in pressure at other nodal points can be minimized. At the same time, the optimal point should be selected to minimize hydraulic retention time in supply network (water age) to secure proper water quality. In order to locate the point where these two criteria are satisfied optimally, Distance measure method, one of multi-criteria decision making was employed to integrate the two results having different dimensions. This methodology can be used as an efficient decision-support criterion for the location of treatment plant in decentralized water supply system.

• 생물환경조절학회지
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• 제14권4호
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• pp.298-301
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• 2005

Potato (Solamum tuberosum 'Dejima') plantlets were investigated on culture type and initial quantity of inoculation in bioreactor and survival rate by hydroponics for mass production. rode stems (1 to 1.5cm in length) of potato plantlets multiplied in vitro were grown for 3 weeks in liquid Murashige and Skoog (MS) medium with sucrose $30 g\; L^{-1}$. When plantlets (80-node inoculation) were raised in 10L balloon type bubble (BB) bioreactor, the healthiest growth of plantlets was obtained from explants cultured in ebb & flow culture with medium supplied periodically 12 times per day. The suitable inoculation quantity of 20L BB bioreactor was 120 pieces of stem segments (mean 2.2g fresh weight) in ebb & flow culture. Number of nodal shoot was eight on the average. In controlled culture room, survival rate of plantlets at 7 days after stem cutting was above $70\%$ when they were acclimatized by hydroponics grown in deep flow and solid medium culture. The highest survival rate of the stem cutting plantlets was in nutrient solution adjusted to EC $1.4dS{\cdot}m^{-1}$. Stem cutting plantlets through one culture could be obtained $670\~900$, when plantlets were grown in ebb & flow culture during 3 weeks using a 20L bioreactor with initial 120 pieces of nodal segments. 11 is possible In do mass production of seedlings cultured in bioreactor and hydroponics.

• 한국공간구조학회논문집
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• 제3권2호
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• pp.85-90
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• 2003

If we use a third order approximation for the displacement function of beam element in finite element methods, finite element solutions of beams yield nodal displacement values matching to beam theory results to have no connection with the number increasing of elements of beams. It is assumed that, as the member displacement value at beam nodes are correct, the calculation procedure of beam element stiffness matrix have no numerical errors. A the member forces are calculated by the equations of $\frac{-M}{EI}=\frac{{d^2}{\omega}}{dx^2}\;and\;\frac{dM}{dx}=V$, the member forces at nodes of beams have errors in a moment and a shear magnitudes in the case of smaller number of element. The nodal displacement value of plate subject to the lateral load converge to the exact values according to the increase of the number of the element. So it is assumed that the procedures of plate element stiffness matrix calculations has a error in the fundamental assumptions. The beam methods for the high accuracy ratio solution Is also applied to the plate analysis. The method of reducing a error ratio of member forces and element stiffness matrix in the finite element methods is studied. Results of study were as follows. 1. The matrixes of EI[B] and [K] in the equations of M(x)=EI[B]{q} and M(x) = [K]{q}+{Q} of beams are same. 2. The equations of $\frac{-M}{EI}=\frac{{d^2}{\omega}}{dx^2}\;and\;\frac{dM}{dx}=V$ for the member forces have a error ratio in a finite element method of uniformly loaded structures, so equilibrium node loads {Q} must be substituted in the equation of member forces as the numerical examples of this paper revealed.