• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4589-4594
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• 2014

The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers, including colorectal cancer (CRC). DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. However, the role of DEPTOR in the development of CRC is not known. The aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival. Here, Immunohistochemical expression of P-S6 (S235/236) and DEPTOR were evaluated in 1.5 mm tumor cores from 90 CRC patients and in 90 samples of adjacent normal mucosa by tissue microarray. The expression of P-S6 (S235/236) was upregulated in CRC, with the positive rate of P-S6 (S235/236) in CRC (63.3%) significantly higher than that in control tissues (36.7%, 30%) (p<0.05). P-S6 (S235/236) also correlated with high tumor histologic grade (p=0.002), and positive nodal metastasis (p=0.002). In contrast, the expression level of DEPTOR was correlated with low tumor histological grade (p=0.006), and negative nodal metastasis (p=0.001). Interestingly, P-S6 (S235/236) expression showed a significant negative association with the expression of DEPTOR in CRC (p=0.011, R= -0.279). However, upregulation of P-S6 (S235/236) (p=0.693) and downregulation of DEPTOR (p=0.331) in CRC were not significantly associated with overall survival. Thus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC. DEPTOR is a potential marker for prognostic evaluation and a target for the treatment of CRC.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.5
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• pp.1054-1065
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• 1993

A computer simulation is performed on the effectiveness of the active minimization of harmonically excited enclosed sound fields for producing global reduction in the amplitude of the pressure fluctuations. In this study for the appreciable reductions in total time averaged acoustic potential energy, $E_{pp}$, the transducer location strategies for three dimensional active noise control is presented based on a state space modal which approximates the closed acoustic field.In this study, the above theoretical basis is used to investigate the application of active control to sound fields of low modal density. By the used of room-like 3-dimensional rectangular enclosure it is demonstrated that the reductions in $E_{pp}$ can be achieved by using a single secondary source, provided that the source is placed within the half a wavelength from the primary source and placed away from nodal line of the sound field. Concerning the reductions in $E_{pp}$ by minimzing the pressure in sound fields by the use of 3-dimensional rectangular enclosure, the effects of the number of sensors and the locations of these sensors are investigated. When a few modes dominate the response it is found that if only a limited number of sensors are located away from nodal line and located at the pressure maxima of the sound field such as at each corner of a rectangular enclosure.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.3
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• pp.531-539
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• 2017

The strut-tie model approach has been recognized as an efficient methodology for the design of all types of concrete members with D-regions, and the approach has been accepted in design codes globally. However, the design of concrete members with the approach requires many iterative numerical structural analyses, numerous graphical calculations, enormous times and efforts, and designer's subjective decisions in terms of the development of appropriate strut-tie model, determination of required areas of struts and ties, and verification of strength conditions of struts and nodal zones. In this study, a computer graphics program, that enables the design of concrete members efficiently and professionally by overcoming the forementioned limitations of the strut-tie model approach, is developed. In the computer graphics program, the numerical programs that are essential in the strut-tie model analysis and design of concrete members including finite element analysis programs for the plane truss and solid problems with all kinds of boundary conditions, a program for automatic determination of effective strengths of struts and nodal zones, and a program for graphical verification of developed strut-tie model's appropriateness by displaying various geometrical shapes of struts and nodal zones, are loaded. Great efficiency and convenience during the application of the strut-tie model approach may be provided by the various graphics environment-based functions of the proposed program.

• Korean Journal of Head & Neck Oncology
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• v.26 no.1
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• pp.14-18
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• 2010

Objectives : We evaluated the use of FDG PET/CT for the identification of cervical nodal metastases of SCC of the oral cavity and oropharynx with histological correlation. Material and Methods : We reviewed 46 medical records, from January 2004 to July 2007, of patients who underwent FDG PET/CT and CT/MRI for SCC of the oral cavity and oropharynx before surgery. We recorded the lymph node metastases according to the neck level affected and the system used for the imaging-based nodal classification. Results : The FDG PET/CT had a sensitivity of 75.6% and a specificity of 96.7% ; it had a higher sensitivity than the CT/MRI for identification of cervical metastases on the side of the neck(26/28 vs. 20/28, p=0.031) and at each of the cervical levels(34/45 vs. 26/45, p=0.008). There was a significant difference in the $SUV_{max}$ between the benign and malignant cervical lymph nodes($3.31{\pm}3.23$ vs. $4.22{\pm}2.57$, p=0.028). The receiver-operating-characteristic (ROC) curve analysis for differentiating the benign from the malignant cervical lymph nodes, showed that the area under the curve(AUC) of the FDG PET/CT was 0.775. The cut-off value for the $SUV_{max}$ was 2.23 based on the ROC curve. There was a significant correlation between the $SUV_{max}$ and the size of the cervical lymph nodes(Spearman r=0.353, p=0.048). Conclusion : FDG PET/CT images were more accurate than the CT/MRI images. In addition, the $SUV_{max}$ cut-off values were important for evaluating cervical the cervical nodes in the patients with SCC of the oral cavity and oropharynx.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8425-8430
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• 2016

Purpose: To study the safety of prophylactic level VII nodal dissection regarding hypoparathyroidism (temporary and permanent) and vocal cord dysfunction (temporary and permanent) and its impact on disease free survival. Materials and Methods: This prospective study concerned 63 patients with papillary thyroid carcinoma with N0 neck node involvement (clinically and radiologically) in the period from December 2009 to May 2013. All patients underwent total thyroidectomy and prophylactic central neck dissection including levels VI and VII lymph nodes in group A (31 patients) and level VI only in group B (32 patients). The thyroid gland, level VI and level VII lymph nodes were each examined histopathologically separately for tumor size, multicentricity, bilaterality, extrathyroidal extension, number of dissected LNs and metastatic LNs. Follow-up of both groups, regarding hypoparathyroidism, vocal cord dysfunction and DFS, ranged from 6-61 months. Results: The mean age was 34.8 and 34.3, female predominance in both groups with F: M 24:7 and 27:5 in groups A and B, respectively. Mean tumor size was 12.6 and 14.7mm. No statistical differences were found between both groups regarding age, sex, bilaterality, multicentricity or extrathyroidal extension. The mean no. of dissected level VI LNs was 5.06 and 4.72 and mean no. of metastatic level VI was 1 and 0.84 in groups A and B, respectively. The mean no. of dissected level VII LNs was 2.16 and mean no. of metastatic LNs was 0.48. Postoperatively temporary hypoparathyroidism was detected in 10 and 7 patients and permanent hypoparathyroidism in 2 and 3 patients; temporary vocal cord dysfunction was detected in 4 patients and one patient, and permanent vocal cord dysfunction in one and 2 patients in groups A and B, respectively. No significant statistical differences were noted between the 2 groups regarding hypoparathyroidism (P=0.535) or vocal cord dysfunction (P=0.956). The number of dissected LNs at level VI only significantly affected the occurrence of hypoparathyroidism (<0.001) and vocal cord dysfunction (<0.001).The DFS was significantly affected by bilaterality, multicentricity and extrathyroidal extension. Conclusions: Level VII nodal dissection is a safe procedure complementary to level VI nodal dissection with prophylactic central neck dissection for papillary thyroid carcinoma.

• Korean Journal of Plant Tissue Culture
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• v.28 no.1
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• pp.1-6
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• 2001

The timing for the determination in root formation from nodal and internodal explants of cassava (Manihot esculenta Crantz, cv. MCol 22) was investigated. Nodal explants about 10 mm with an axillary bud formed adventitious roots directly on MS basal medium for 8 days of cultures. But internodal segments without an axillary bud did not develop the adventitious roots on the same medium, and most internodal segments excised from nodal explants after cultures of 5 days on MS basal medium developed adventitious roots. On the other hand, the internodal segments rooted at 90% after cultures on medium with 0.5 mg/L IBA for 5 days, with 1 mg/L IBA for 2.5 days, and with 2 mg/L IBA for 1.5 days respectively. Thus the period of culture on medium with IBA and its IBA concentration affected the rooting rate. Therefore, it is suggested that the determination for root formation occurred before the differentiation of root primordia on medium with IBA, and root inducing factors in medium were absorbed and accumulated during the period of determination for root primordium differentiation in internodal segment of cassava.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.2
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• pp.131-136
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• 2008

Using ultrasonic standing waves, micro particles submerged or flowing in fluid can be manipulated. Due to acoustic radiation force of ultrasound, particles are forced to move to pressure nodal or antinodal lines. In this work, we propose a method to control the position of micro particle in a flow by adjusting the frequency of the standing wave. To this end, standing wave field generation system including a few millimeter thick micro channel was established using an immersible ultrasonic transducer. The present generation system works valid in a frequency range between 2.0 MHz and 2.5 MHz. We observed the SiC particles in water moved to pressure nodal lines by the standing wave. The effect of the channel thickness and operating frequency was also investigated. Interestingly, it was shown that the operating frequency have a close relation with the location of the pressure nodal line. Consequently, it fan be said that the position of particle movement rail be controlled by adjusting the ultrasound frequency. The maximum range of the controllable position was about 261 micrometers under the given condition. The resulted observations reveal the possibility of various applications of the ultrasonic standing wave to the manipulation of particles submerged in a fluid.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6267-6272
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• 2015

Background: Extra nodal lymphoma (ENL) constitutes about 33 % of all non-Hodgkin's lymphoma. 18-28% develops in the head and neck region. A multimodality treatment with multi-agent chemotherapy (CT) and radiotherapy (RT) is considered optimum. Materials and Methods: We retrieved the treatment charts of patients of HNENL treated in our institute from 2001-2012. The charts were reviewed and the demographic, treatment details and outcome of HNENL patients were retrieved using predesigned pro-forma. Results: We retrieved data of 75consecutive patients HNENL. Median age was 47years (Range: 8-76 years). Of the 75 patients 51 were male and 24 were female. 55patients were evaluable. The patient and tumor characteristics are summarized in Table 1. All patients were staged comprehensively with contrast enhanced computed tomography of head, neck, thorax, abdomen, pelvis and bone marrow aspiration and biopsy 66 patients received a combination multi-agent CT with CHOP being the commonest regimen. 42 patients received 4 or lesser number of cycles of chemotherapy whereas 24received more than 4 cycles chemotherapy. Post radiotherapy, 41 out of 42 patients had a complete response at 3 months. Only 21patients had a complete response after chemotherapy. All patients received radiation (mostly involved field radiation) as a part of the treatment. The median radiation dose was 45 Gray (Range: 36 Gray-50 Gray). The radiation was planned by 2D fluoro simulation based technique in 37cases and by 3 Dimensional conformal radiation therapy (3DCRT) in 36 cases. Two patients were planned by the intensity modulated radiation therapy (IMRT) technique. IMRT was planned for one thyroid and one nasal cavity primary. 5 patients experienced relapse after a median follow up of 19 months. The median survival was not reached. The estimated two and three year survival were 92.9% (95%CI- 68.6- 95.35) and 88% (95%CI- 60.82 - 92.66) respectively. Univariate analysis revealed higher stage and poorer baseline performance status to be significantly associated with worse progression free survival. 5 patients progressed (relapse or primary disease progression) after treatment. Of the 5 patients, two patients were primary orbital NHL, two patients had NHL nasal cavity and one was NHL thyroid. Conclusions: Combined modality treatment in HNENL confers excellent disease control with acceptable side effects.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5B
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• pp.321-329
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• 2012

Two regular progressive wave trains, the directions of which are slightly different from each other, develop a honeycomb pattern of wave crests due to their nonlinear interaction. In the honeycomb pattern of wave crest, the nodal line area, which has very low wave energy, is formed. When the honeycomb pattern is developed near the beach area, rip current evolves through the nodal line area formed in the cross shore direction. In this study, to confirm that the formation of honeycomb pattern of waves near the beach area is a dominant mechanism of rip current occurred at Haeundae beach, we performed a numerical simulation of nearshore circulation at Haeundae beach under an unidirectional and monochromatic wave condition by using a nonlinear Boussinesq equation model. As a result, wave refraction due to topographical characteristics (i.e., submerged shoal) of Haeundae gave rise to several wave trains propagating with slightly different directions toward the beach, and consequently rip currents well developed through the nodal line area of honeycomb patterns of wave crest. In addition, we found that a narrow-banded spectral wave condition (i.e., a swell spectrum) increases more likelihood of rip current than a broad-banded spectral wave condtion based on the simulations employing various wave spectra with an equivalent wave height and period.

• Radiation Oncology Journal
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• v.8 no.1
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• pp.59-64
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• 1990

From 1980 to 1986,26 patients with metastatic carcinoma of the neck node from an unknown primary site were seen in the Department of Therapeutic Radiology of Seoul National University Hospital. Among these, three patients were excluded from further analysis due to incomplete treatment. So a retrospective analysis was undertaken on 23 patients who had complete treat-ment with radiation therapy alone or in combination with surgical treatment and chemotherpay. The overall three year actuarial survival rate was $32\%$. According to the staging system of the American Joint Committee on Cancer, the three year survival rates with N2 and N3 patients were $43\%\;and\;13\%$, respectively. In 16 patients with squamous cell carcinoma and seven with non-squamous cell carcinoma, the three year survival rates were $34\%\;and\;29\%$, respectively. Analysis according to site of nodal involvement was also done. Patients with cervical node and supraclavicular node involvement recorded $44\%\;and\;17\%$ of three year survival, rate, respectively. In this study, six patients eventually manifested the primary sites (three in the lung, one in the esophagus, one in the stomach, one in the nasopharynx). Presence of the primary site seemed to influence the prognosis ($17\%\;vs\;38\%$). In analyzing the prognostic factors, the nodal stage and site of nodal involvement were important prognostic factors, and the presence of a primary site seemed to influence the patients' survival, but histology did not.