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Bayesian Estimation in Bioequivalence Study

  • Lee, Seung-Chun
    • The Korean Journal of Applied Statistics
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    • v.24 no.6
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    • pp.1095-1102
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    • 2011
  • The classical two-period, two-sequence crossover design is no longer sufficient to assess various demands in a bioequivalence study. For instance, to estimate the within-subject and between-subject variances of test and reference formulations separately, it is necessary to use a replicate design in which each subject receives at least the reference formulation in two periods. Several designs were studied to satisfy the demands. It is provided a unified Bayesian approach applicable to those study designs. The benefit of the method in the bioequivalence study is discussed.

AN EXTENSION OF TELCI, TAS AND FISHER'S THEOREM

  • Lal, S.N.;Murthy, P.P.;Cho, Y.J.
    • Journal of the Korean Mathematical Society
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    • v.33 no.4
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    • pp.891-908
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    • 1996
  • Let (X,d) be a metric space and let T be a mapping from X into itself. We say that a metric space (X,d) is T-orbitally complete if every Cauchy sequence of the form ${T^{n_i}x}_{i \in N}$ for $x \in X$ converges to a point in X.

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