• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.987-992
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• 2005

Manufacturing companies should perform process planning and its evaluation concurrently with new product developments so that they can be highly competitive in the modern market. Process planners should make decisions in the manner of concurrent and collaborative engineering in order to reduce the manufacturing preparation time and cost when developing new products. Automated generation of analysis models from the integrated database, which contains process and material information, reduces time to prepare analyses and makes the models reliable. In this research, we developed a web-based system for concurrent and collaborative system for production flow analysis, using web, database, and simulation technology. An integrated database is designed to automatically generate analysis models from process and material plans without reworking the data. This system enables process planners to evaluate their decision fast and share their opinions with others easily. With this system, it is possible to save time and cost for assembly process and material planning, and reliability of process plans can be improved

• Reproductive and Developmental Biology
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• v.40 no.1
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• pp.7-13
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• 2016

Effectiveness of transgene transfer into genome is crucially concerned in mass production of the bio-pharmaceuticals using genetically modified transgenic animals as a bioreactor. Recently, the mammary gland has been considered as a potential bioreactor for the mass production of the bio-pharmaceuticals, which appears to be capable of appropriate post-translational modifications of recombinant proteins. The mammary gland tissue specific vector system may be helpful in solving serious physiological disturbance problems which have been a major obstacle in successful production of transgenic animals. In this study, to minimize physiological disturbance caused by constitutive over-expression of the exogenous gene, we constructed new retrovirus vector system designed for mammary gland-specific expression of the hEPO gene. Using piggyBac vector system, we designed to express hEPO gene under the control of mammary gland tissue specific and lactogenic hormonal inducible goat ${\beta}$-casein or mouse Whey Acidic Protein (mWAP) promoter. Inducible expression of the hEPO gene was confirmed using RT-PCR and ELISA in the mouse mammary gland cells treated with lactogenic hormone. We expect the vector system may optimize production efficiency of transgenic animal and reduce the risk of global expression of transgene.

• Proceedings of the KIEE Conference
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• 1996.07b
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• pp.793-796
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• 1996

This study proposes a new algorithm which performs a production simulation under various constraints and maintains computational efficiency. In order to consider the environmental and operational constraints, the proposed algorithm is based on optimization techniques formulated in LP form In the algorithm, "system characteristic constraints" reflect the system characteristics such as LDC shape, unit loading order and forced outage rate. By using the concept of Energy Invariance Property and two operational rules i.e. Compliance Rule for Emission Constraint, Compliance Rule for Limited Energy of Individual Unit, the number of system characteristic constraints is appreciably reduced. As a solution method of the optimization problem, the author uses Karmarkar's method which performs effectively in solving large scale LP problem. The efficiency of production simulation is meaningful when it is effectively used in power system planning. With the proposed production simulation algorithm, an optimal expansion planning model which can cope with operational constraints, environmental restriction, and various uncertainties is developed. This expansion planning model is applied to the long range planning schemes by WASP, and determines an optimal expansion scheme which considers the effect of supply interruption, load forecasting errors, multistates of unit operation, plural limited energy plants etc.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.116-128
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• 2020

In the shipbuilding industry, three-dimensional (3D) templates play a key role in the completeness evaluation of shell plates with a large curvature in the shell-plate fabrication process. Currently, the information of 3D templates from a ship computer-aided design system is limited; thus, manufacturers depend on their experience to produce the templates manually. This results in the inaccuracy of templates in addition to increased production time. Therefore, if the pieces of the 3D templates can be produced automatically with accurate information, the lead time of the fabrication process can be reduced. In this study, we define a new type of template piece and develop methods for extending a boundary template and converting manufacturing information into numerical control machine input. In addition, based on the results of the study, we propose a production automation system for 3D template pieces. This system is expected to reduce the lead time of the fabrication process.

• Journal of Microbiology and Biotechnology
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• v.16 no.12
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• pp.1947-1953
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• 2006

There have been a number of studies of methods for recycling animal wastewater to provide new bioresources. In the present work, a marine algal culture medium, designated KEP II, was prepared by adding swine waste (3% v/v) fermented by soil bacteria to a dilution of f/2 culture medium (CT). When Phaeodactylum tricornutum was grown in batch culture in KEP II, the cells lasted long at the exponential phase producing the specific growth rate and biomass; the production of total amino acids and secondary metabolites rose up to 5-fold. It also substantially enhanced the maximum quantum yield of photo system (PS) II of P. tricornutum, greatly increased the level of thylakoid membranes containing PS, and stimulated the production of pyrenoids, including enzymes for $CO_2$ fixation in chloroplasts. KEP II should improve the cost efficiency of industrial mass batch cultures and the value of microalgae for long-term preservation of fresh aquaculture feed as well as production of anticancer and antioxidant agents. Specifically, a low-cost medium for growing the diatoms of aquaculture feed will be economically advantageous.

• Industrial Engineering and Management Systems
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• v.13 no.4
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• pp.369-382
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• 2014

This paper introduces a new multi-product multi-period multi-objective aggregate production planning problem. The proposed problem is modeled using multi-objective mixed-integer mathematical programming. Three objective functions, including minimizing total cost, maximizing customer services level, and maximizing the quality of end-product, are considered, simultaneously. Several constraints such as quantity of production, available time, work force levels, inventory levels, backordering levels, machine capacity, warehouse space and available budget are also considered. Some parameters of the proposed model are assumed to be qualitative and modeled using fuzzy sets. Then, a fuzzy goal programming approach is proposed to solve the model. The proposed approach is applied on a real-world industrial case study of a color and resin production company called Teiph-Saipa. The approach is coded using LINGO software. The efficacy and applicability of the proposed approach are illustrated in the case study. The results of proposed approach are compared with those of the existing experimental methods used in the company. The relative dominance of the proposed approach is revealed in comparison with the experimental method. Finally, a data dictionary, including the way of gathering data for running the model, is proposed in order to facilitate the re-implementation of the model for future development and case studies.

• Journal of Microbiology and Biotechnology
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• v.20 no.2
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• pp.346-349
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• 2010

Coenzyme $Q_{10}$ ($CoQ_{10}$) production from Rhizobium radiobacter T6102 was monitored under various oxygen supply conditions by controlling the agitation speeds, aeration rates, and dissolved oxygen levels. As the results, the $CoQ_{10}$ production was enhanced by limited oxygen supply. To investigate whether the $CoQ_{10}$ production is associated with its physiological functions of electron carrier and antioxidant, the effects of sodium azide and hydrogen peroxide on the $CoQ_{10}$ production were studied, showing that the $CoQ_{10}$ contents were slightly enhanced with increasing sodium azide (up to 0.4 mM) and hydrogen peroxide (up to $10\;{\mu}M$) concentrations. These results suggest the plausible mechanism where the limited electron transfer stimulating the environments of limited oxygen supply and oxidative stress could accumulate the $CoQ_{10}$, providing the relationship between the $CoQ_{10}$ physiological functions and its regulation system.

• New & Renewable Energy
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• v.8 no.1
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• pp.8-17
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• 2012

The Korean government pushed ahead various policies to disseminate photovoltaic (PV), wind power, small hydro, bio-fuel, etc. Renewable energy system (RES) budget of the Korean government increased from 118 billion won of 2003 to 876.6 billion won of 2010. The R&D budgetary supports for RES increased by 6.8 times in the period 2003-2010. It is necessary to confirm RES budget expenditure that renewable energy promotion policy makes good performance evaluated in quantity level. This paper made Input-Output Table 2009 contains photovoltaic power generation equipment industry as a dependent sector and analyzed induced production effect by demand of photovoltaic power generation equipment industry. From the empirical analysis result, additional demand in photovoltaic power generation equipment induced 1.932 times of induced production in Korea. Each of industry sector has positive induced production from the additional demand in photovoltaic power generation equipment. Renewable energy promotion in photovoltaic power generation is considered together with industry policy as the option to sustain economic growth.

• Journal of Korea Multimedia Society
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• v.17 no.12
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• pp.1484-1493
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• 2014

Recently, Industry 4.0 (next generation industrial revolution) designed by Germany to retain initiative in manufacturing business is actively studied. Goal of Industry 4.0 is 'Smart factory' which manages progress of production, supply logistics and services. To achieve the goal, we can construct value creation and new business model by integrating organically with production management systems which is existing and cyber-physical systems, Internet of Things, Services Internet and sensor, etc. However, if integration with production management systems does not work effectively by adding and developing new technologies, It does not have performance. Hence, in this research, we will analysis Industry 4.0 which is possible for small quantity batch production and one of the light and flexible manufacturing systems, and based on this, we will suggest methodology to horizontally integrate with production management systems.

• Journal of Distribution Research
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• v.2 no.1
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• pp.59-85
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• 1997

The automobile industry in Korea has grown to the fifth in the world in terms of production capacity. In spite of the production growth, the marketing aspects such as distribution and customer service in the auto industry are still behind the world-class. Thus, the major purposes of this paper are as follows. The first is to analyze competitive structure of the industry and to compare distribution strategies of the major auto firms(Hyundai, Daewoo, and Kia). The second is to theoretically explain the transition from the vertical marketing system to the dealer system using transaction cost analysis. The third is to compare auto distribution channels in Korea with those in the U.S. and Japan. Finally, an optimal channel stucture in the auto industry is suggested after reviewing five alternative channel structures such as corporate-owned VMS, sales-specializing firm, multiplex system(VMS+limited dealer system), dual sales channel, and advanced dealer system. In the short-run, sales-specilizing firm was suggested as an optimal channel system to enhance customer satisfaction by integrating sales and customer service. In the long-run, advanced dealer system through regional differentiation was desirable for an optimal channel structure by organically integrating new car sales, used car sales, and after service to provide total marketing service to customers.