• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.227-239
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• 2023

Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and lack of responses are major reasons for the need to develop faster and more efficient antidepressants. Studies show that ketamine (KET), a PCP analog, produces antidepressant effects within a few hours of administration that lasts up to a week. However, the use of KET has raised concerns about side effects, as well as the risk of abuse. 4 -F-PCP analog is a novel PCP analog that is also an NMDA receptor antagonist, structurally similar to KET, and might potentially elicit similar antidepressant effects, however, there has been no study on this subject yet. Herein, we investigate whether 4-F-PCP displays antidepressant effects and explored their potential therapeutic mechanisms. 4-F-PCP at 3 and 10 mg/kg doses showed antidepressant-like effects and repeated treatments maintained its effects. Furthermore, treatment with 4-F-PCP rescued the decreased expression of proteins most likely involved in depression and synaptic plasticity. Changes in the excitatory amino acid transporters (EAAT2, EAAT3, EAAT4) were also seen following drug treatment. Lastly, we assessed the possible side effects of 4-F-PCP after long-term treatment (up to 21 days). Results show that 4-F-PCP at 3 mg/kg dose did not alter the cognitive function of mice. Overall, current findings provide significant implications for future research not only with PCP analogs but also on the next generation of different types of antidepressants.

• Journal of Life Science
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• v.33 no.8
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• pp.605-611
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• 2023

Recently, sporadic cases of human infection by genetic reassortants of H7Nx influenza A viruses have been reported; such viruses have also been continuously isolated from avian species. In this study, A/wild bird/South Korea/sw-anu/2023, a novel reassortant of the H7N1 avian influenza virus, was analyzed using full-genome sequencing and molecular characterization. Phylogenetic analysis showed that A/wild bird/South Korea/sw-anu/2023 belonged to the Eurasian lineage of H7Nx viruses. The polymerase basic (PB)2, PB1, polymerase acidic (PA), and nucleoprotein (NP) genes of these viruses were found to be closely related to those of avian influenza viruses isolated from wild birds, while the hemagglutinin (HA), neuraminidase (NA), matrix (M), and nonstructural (NS) genes were similar to those of avian influenza viruses isolated from domestic ducks. In addition, A/wild bird/South Korea/sw-anu/2023 also had a high binding preference for avian-specific glycans in the solid-phase direct binding assay. These results suggest the presence of a new generation of H7N1 avian influenza viruses in wild birds and highlight the reassortment of avian influenza viruses found along the East Asian-Australasian flyway. Overall, H7Nx viruses circulate worldwide, and mutated H7N1 avian viruses may infect humans, which emphasizes the requirement for continued surveillance of the H7N1 avian influenza virus in wild birds and poultry.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.131-138
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• 2019

The film enters the color film from black and white, and the screen image changes qualitatively. The color in the film not only has the reproduction function of the restoration object like the objective appearance, but also has the function of conveying different subjective emotions. It can express the color and can't express it. The artistic effect conveys the information content that the story itself can't convey, so the color of the film becomes an important part of the film language. The color in the film is presented on the screen in the form of single-screen color, scene color, full-color color tone, and various color chains designed according to different contradictions and conflicts. Because the film art and art means are assembled by montage, he colors in the picture also form a montage form. People call it "color montage". People's subjective nature of color criticism and acceptance of color language also depend on various local tones. The accurate expression of the relationship, the unique attribute of color determines that the color must enter the structural state in order to express its unique charm. The color of the film only has the real aesthetic value when it enters the level of "color structure". This paper studies the color of Chinese and Western films from the differences between the color thinking of Chinese and Western film directors and the cultural implication of Chinese and Western film colors. The western film director emphasizes the structure of color and pays attention to the use of tonal montage to convey the characters. Emotions reflect the characteristics of a subjective color. Beginning with the "fifth-generation" director of Chinese film, the new journey of film color language has been opened. In the process of blending love and scenery, the film style of "image-in-one" has been achieved.

• The Journal of Korean Philosophical History
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• no.27
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• pp.417-446
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• 2009

This study was to review the features of the preventive dimension in connection with adolescent deviation on the basis of the morality and ethics held by Confucian doctrine. To find solutions to the problems of adolescent deviation is never easy. As adolescent deviation always does occur, it is important to consider the methods that can minimize and prevent it. The traditional society of Korea laid weight on the education and training in the aspect of preventive measure against such adolescent deviation by emphasizing moral edification and realization of spiritual understanding for it. In this paper, the researcher tried to understand the problem situations by examining the image of such deviation and its type as well as the method on response thereto targeting the young generation of Korea. In addition, the researcher analyzed how the adolescent was recognized in the traditional society that was established on the Confucian values, and moral standards that applied to them, and the process of education as well. Through the moral concepts of Confucianism that were revealed in the Doctrine of the Mean (中庸, pronounced 'Jungyong' in Korean) in particular, the researcher sought the possibility of education on morality and ethics that will be able to prevent adolescent deviation. This study suggests that the morality and ethics held by Confucian doctrine can prevent adolescent deviation and open a new horizon of ethics education.

• (The) Research of the performance art and culture
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• no.42
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• pp.321-359
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• 2021

This paper examines the unique features of Korean farmer's music-or nongak-in Hawaii by exploring three nongak groups from different decades beginning in the 1970s. The first community-based nongak group began in the 1970s, with the establishment of the Wahiawa Korean Seniors Club. In the 1980s, there was another group supported by the Kalihi-Palama Immigrant Service Center. And in the 1990s, the Hawaii Korean Farmer's Music Assoiation, which is still active, was founded. I ullustrate the overall changes made by the three nongak groups as follows. First, they show a shift from social groups playing music to a music group doing social activities. Second, from a group of people negotiating their music, through a group led by musical leadership, to a group with a leader who created his own musical leadership. Third, from a music group began out of a pseudo-shaman ritual, through a group purely playing music, to a group adding samulnori and further creating a new rhythmic pattern. These changes occurred because, while the members are all first-generation immigrants, their experience of nongak in the motherland was different because of their age differences. In addition, they emerged because the level of awareness and acceptance of samulnori-which has gained huge popularity in Korea-were different.

• Journal of the Korean Geotechnical Society
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• v.25 no.6
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• pp.17-29
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• 2009

There has been an increase in the investigation of deep sea sediments with a consequent increase in the amount of energy required to undertake these investigations. The geotechnical characteristics of Ulleung Basin sediment are explored by using depressurized specimens following methane production tests carried out on pressured core samples obtained at 2,100 m water depth and 110 m below sea floor. Geotechnical index tests, X-ray diffraction, and scanning electron microscope are conducted to identify the geotechnical index parameters, clay mineralogy, chemical composition, and microstructure of the sediments. Compressibility, and elastic and electromagnetic wave parameters are investigated for two samples by using a multi sensing instrumented oedometer cell. The strength chatracteristics are obtained by the direct shear tests. The dominant clay minerals are mostly kaolinite, illite, chlorite, and calcite. The SEM shows a well-developed flocculated structure of the microfossil. Void ratio, electrical resistivity, real permittivity, conductivity, and shear wave velocity show bi-linear behavior with the effective vertical stress: as the vertical effective stress increases. The friction angle obtained by the direct shear test is about $21^{\circ}$, which is similar to the value observed in the Ulleung Basin sediments. This study shows that the understanding of the behavior acting on the diatomaceous marine sediment is important because it often maintains the useful energy resources such as gas hydrate and so will be the new engineering field in the next generation.

• Journal of the Korea Society of Computer and Information
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• v.14 no.3
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• pp.93-101
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• 2009

This paper suggests a new algorithm automatically searching for Region-of-Interest(ROI) with high speed, using the edge information of high frequency subband transformed with wavelet. The proposed method executes a searching algorithm of 4-direction object boundary by the unit of block using the edge information, and detects ROIs. The whole image is splitted by $64{\times}64$ or $32{\times}32$ sized blocks and the blocks can be ROI block or background block according to taking the edges or not. The 4-directions searche the image from the outside to the center and the algorithm uses a feature that the low-DOF image has some edges as one goes to center. After searching all the edges, the method regards the inner blocks of the edges as ROI, and makes the ROI masks and sends them to server. This is one of the dynamic ROI method. The existing methods have had some problems of complicated filtering and region merge, but this method improved considerably the problems. Also, it was possible to apply to an application requiring real-time processing caused by the process of the unit of block.

• The Journal of the Korea Contents Association
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• v.22 no.5
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• pp.97-109
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• 2022

This study analyzed successful cases of using metaverse in a reality where interest in metaverse is increasing. The use of Metaverse is mainly used in companies to explore its industrial potential or government agencies strive for policy support, but the possibility of application in educational institutions has another meaning. We tried to find the success factors and future implications by analyzing actual cases of using metaverse at university entrance ceremonies. As a result of analyzing the case of S University in Asan, Chungcheongnam-do's metaverse entrance ceremony, it was determined that the university's first metaverse entrance ceremony could be counted as a very meaningful success story. Specifically, on the technical level, it stood out that the existing metaverse technology and the new technology for the event were properly harmonized. At the organizational level, it is meaningful that the internal organization's resources were efficiently utilized based on previous experiences. On the environmental level, the COVID19 environment and the MZ generation. It was analyzed that the social change of going to college contributed to the planning and success of the metaverse entrance ceremony. As a result, it is judged that the successful use of the resources possessed by a clear goal is the success factor of the metaverse entrance ceremony.

• Journal of the Korean Orthopaedic Association
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• v.54 no.6
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• pp.509-518
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• 2019

Purpose: Lymph node metastasis is a very important prognostic factor for all skin cancers and some sarcomas. A sentinel lymph node (SLN) biopsy is the most useful technique for identifying SLNs. Recently, a new generation of diagnostic tools, such as single photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) enabled the detection of SLNs. This study compared the efficacy of PET/CT for detecting lymph node metastases with a SLN biopsy in a single medical center. Materials and Methods: From 2008 to 2018, 72 skin cancers of sarcoma patients diagnosed with some lymph node involvement in a whole body PET/CT reading were assessed. Patients suspected of lymph node metastasis were sent to biopsy and those suspected to be reactive lesions were observed. The analysis was performed retrospectively using the medical records, clinical information, PET/CT readings, and pathology results. Results: The age of patients ranged from 14 to 88 years and the mean follow-up period was 2.4 years. Twenty-two patients were suspected of a lymph node metastasis and confirmed. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT images in sarcoma and non-sarcoma tumors were increased significantly when the expert's findings were considered together. Conclusion: PET/CT is effective in detecting lymph node metastases.

• Journal of Christian Education in Korea
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• v.72
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• pp.273-291
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• 2022

The Industrial Revolution brought great development to the whole human history by the improvement of productive capacity. However, high speed development absorbed just on growth gave rise to resource depletion attack and economical inequality. If it might be neglected human society will meet unsustainable development situation. So UN has made effort to make sustainable development(SD) through global band together. SD concept considers it important to promote current development not giving damage to next generation's development. Then economy, environment and social integration should be harmonized and it demands governance for its actualization. SD gets to be a matter of common interest in education. New Millenium development Goals make African poor countries that are in blind spots of development advance toward gradual sustainable development by supporting programmes to these countries. Thus sustainable development education(SDE) is for future. It has an aim to give suitable education for all people who are all over the world. SDE tries to make health society and successful economical life for all. The concept of SD is found in the essential aims of Christian school and Christian education seeking justice and shalom. Christians are called as transformers for servant mission giving recover in corrupt world. Firstly, Christian school practise this mission making students think on Christian perspectives. Then it makes students serve for environment, economical fairness, social integration with servant mission. Also Christian school has a mission to seek both justice and shalom as a praxis beyond the intellectual dimension of education until fulfilling justice and shalom for all who are all over the world. Thus it can be that Christian school is an important educational institution for realizing sustainable development in that it is always to seek justice and shalom through restoration on the Christian educational perspective.