• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.135.1-135.1
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• 2003

We have previously reported three new oleanene-type glycosides and kudzusaponin $A_3$ methyl ester and subproside II methyl ester from the roots of Echinosophora koreensis. Further study has now led to the isolation of three known oleanen-type glycosides. sophoraflavoside I, azukisaponin V, and kudzusaponin $SA_3$ as their methyl esters. The structures of theses compounds were characterized by spectroscopic and chemical methods.

• 약학회지
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• 제37권5호
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• pp.476-482
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• 1993

For the investigation of medicinal resources in Crataegus species, the present study was carried out to evaluate the pharmaco-constituents in the leaves of Crataegus Pinnatifida var. psilosa (Rosaceae). Fruits has folk medicine in Korea. From the $Et_{2}$O fraction of MeOH extract, a new compound, apigenin-8-C-(6"-acetyl)-$\beta$-D-glucopyranoside, named psilosin and three known compounds, ursolic acid, phytosterol complex and (-)-epicatechin were isolated and identified on the basis of their physico-chemical properties and spectroscopic evidences (UN, IR, NMR and mass etc.) in comparison with authentics, respectively.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.52-55
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• 1998

During a survey of new antitumor substances from higher plants, we have found that the crude extract of Simaba cedron Planchon (Simaroubaceae) showed cytotoxic activity (IC$\sub$50/ 0.7 $\mu\textrm{g}$/mL) against P388 leukemia cells. Activity-guided chromatographic purification using P388 cells led to the isolation of five novel quassinoids, cedronolactones A-E (1-5) and nine known quassinoids, simalikalactone D (6), chaparrinon (7), chaparrin (8), glaucarubolone (9), glaucarubol (10), samaderine Z (11), guanepolide (12), ailanquassin A (13), and polyandrol (14). In this seminar, the structural elucidation of 1-5 and the cytotoxic activity of the isolated compounds are discussed.

• Bulletin of the Korean Chemical Society
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• 제28권5호
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• pp.827-831
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• 2007

Bioassay-directed fractionation of Draba nemorosa led to the isolation of two new phenolic glycosides, 1-O- (sinapoyl)-glucitol (2) and 1,3-disinapoylgentiobiose (5) along with five known phenolic glycosides (1, 3, 4, 6, and 7). Their structures were characterized based on spectroscopic methods (2D NMR, HRTOFMS, IR, and UV). The isolated compounds showed antioxidant activities (IC50) in the range of 14-98 mM which were estimated by DPPH radical-scavenging assay.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.246.1-246.1
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• 2003

Hetero chain compounds have high possibilities of being good medicinal candidate because of their well-known medicinal activity and relatively low subtitled carbon. By constructing the method of making this compound library, this research has the purpose to create a new medicinal candidate materials based on an easy medicinal search. The first step is to construct an Indole library in a compounding process with the design of a linker connecting a solid-state resin and a substrate. (omitted)

• 약학회지
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• 제22권1호
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• pp.1-7
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• 1978

Two yellowish oily liquid compounds, $C_{6}H_{6}O_{3}$(A) bp $189^{\circ}$, $n^{20}_{D}$ 1.3697 and $C_{7}H_{8}O_{3}$(D) bp $164^{\circ}$, $n^{20}_{D}$1.5075, were isolated from root of Codonopsis pilosula (Franch.) Nannfeldt (Campanulaceae). Their structures were identified as 5-(hydroxymethyl)-2-furaldehyde(A) and 5-(methoxymethyl)-2-furaldehyde(D). The latter is a new compound among the known natural products.

• Natural Product Sciences
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• 제3권1호
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• pp.8-10
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• 1997

A new flavonol glycoside, quercetin 3-rhamnosyl $(1{\rightarrow}3)$ galactoside [5] was isolated from the leaves of M. africana. The known compounds kaempferol 3-rutinoside [1], 3'-O-methylquercetin 3-rutinoside [2], quercetin 3-rutinoside [3], and quercetin 3-rhamnosyl $(1{\rightarrow}6)$ galactoside [4] were also isolated for the first time from this plant. Their structures were determined by chemical and spectroscopic methods.

• Archives of Pharmacal Research
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• 제28권10호
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• pp.1127-1130
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• 2005

A new phenolic glucoside (1), pursargentoside, was isolated from the leaves of Prunus serrulata var. spontanea, along with three other known compounds, orobol 7-O-glucoside (2), $1{\beta}$, $2{\alpha}$, $3{\alpha}$, 24-tetrahydroxy-urs-12-en-28-oic acid (3), and chlorogenic acid (4). The structure of pursargentoside (1) was identified by spectroscopic data analysis including 1D and 2D NMR spectroscopy, as 2-O-${\beta}$-(6'-benzoyl)-glucopyranosyl o-(Z)-coumaric acid. Compounds 1, 2, and 4 exhibited ONOO- scavenging activity, whereas compound 3 was determined to be virtually inactive.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.11-12
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• 2001

Selenium is known to have both chemopreventive and therapeutic benefits of cancer. Recent studies have implicated that apoptosis is one of the most plausible mechanism of chemopreventive effects of selenium compounds and tumor invasion is a new factor involved in chemotherapy. In the present study, we demonstrate that Se-methylselenocysteine(MSC), one of the most effective selenium compound sat chemoprevention, induces apoptosis in HL-60 cells and that ROS plays a crucial role in MSC-induced apoptosis.(omitted)

• Natural Product Sciences
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• 제20권1호
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• pp.22-28
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• 2014

A new natural product, tetrastigmol A (1), and several known compounds as flavonoids (2 - 8), steroids (9 - 10), bergenin and its derivative (11 - 12), stilbens (13 - 15), lignan (16), benzenecarboxylic derivative (17) and two norisoprenoid (18 - 19) were isolated from the stem of Tetrastigma erubescens Planch. (Vitateae). Their structures were determined on the basis of NMR spectroscopic data. This is the first report on chemical constituents of this plant. Compounds 1, 6 - 8 and 12 - 15 showed strong antioxidant activity using two methods including DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging and lipid peroxidation inhibitory assays.