Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

EFFECT OF SELENIUM COMPOUNDS ON CHEMOPREVENTION AND TUMOR INVASION

  • Chung, An-Sik (Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Uhee Jung (Dept. of Biological Sciences, Korea Advanced Institute of Science and Technolog) ;
  • Yoon, Sang-Oh (Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • Published : 2001.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Selenium is known to have both chemopreventive and therapeutic benefits of cancer. Recent studies have implicated that apoptosis is one of the most plausible mechanism of chemopreventive effects of selenium compounds and tumor invasion is a new factor involved in chemotherapy. In the present study, we demonstrate that Se-methylselenocysteine(MSC), one of the most effective selenium compound sat chemoprevention, induces apoptosis in HL-60 cells and that ROS plays a crucial role in MSC-induced apoptosis.(omitted)

Keywords