• 약학회지
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• 제50권6호
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• pp.386-392
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• 2006

Pramlintide, a synthetic analogue of human hormone amylin, is the first of a new class of amylinomimetic compounds. Present study was undertaken to compile and analyze the clinical trials of pramlintide, and thereby to facilitate the design of the bridging study for the earlier introduction of the drug, which might be needed by diabetes patients in Korea. Sixty-two articles from Pubmed and MEDLINE search were used to analyze the trials of pramlintide along with prescribing information and New Drug Application packet obtained form the manufacturer. The efficacy of the new drug was attributed to three mechanisms: delay of gastric emptying time, inhibition of post-prandial glucagon secretion, and reduction of food intake by enhanced satiety. Clinical trials consistently identified the effectiveness of the drug for the treatment of type 1and type 2 diabetes who have failed to achieve glycemic control despite optimal therapy with insulin. However, the six pivotal Phase III clinical trials were peformed with mostly caucasian and some black and hispanic people. None of the trials documented the proportion of either Asian or Korean participants. Since Korean diabetes patients show different epidemiology and characteristics in their disease state, it appears that the bridging study of pramlintide should be designed in the level of full scale Phase III clinical trial along with pharmacokinetic and pbarmacodynamic studies.

• 한국전자통신학회논문지
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• 제6권4호
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• pp.533-537
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• 2011

우리나라의 형사재판제도는 2008년 형사소송법이 개정되면서 공판중심주의로 커다란 전환점을 맞이하게 되었다. 배심원제도라고 할 수 있는 국민의 형사재판 참여제도가 본격화되면서 국민의 법 제도에 관한 수준이 향상되었고, 형사 재판에 참여하는 국민(배심원)들의 수준에 맞는 형사재판의 진행과 설명, 과학적인 증거의 제시를 통한 증거주의 재판이 실현되고 있는 것이다. 이에 검찰에서는 과학적 조사기법과 수사의 과학화를 위한 한 방편으로 영상녹화제도를 도입하게 되었고, 부가적인 지원절차로서 컴퓨터 속기사를 전국 검찰청에 상주시킴으로써 영상녹화를 통하여 진술된 내용의 문서화를 지원하고 있다. 이에 본 논문에서는 컴퓨터속기제도를 국내외적으로 살펴보고 우리나라에서 과학적 조사기법으로 전개되고 있는 영상녹화제도속의 컴퓨터속기의 미래를 전망 해본다. 본 논문을 통하여 검찰에서 지양하는 과학조사를 위한 영상녹화제도에서 컴퓨터 속기가 차지하는 역할과 전망을 살펴봄으로써 조사기법의 선진화를 촉진하고, 인권보호, 공개재판중심주의에서 컴퓨터속기의 중요성과 위치를 재조명할 수 있다.

• Journal of Acupuncture Research
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• 제23권1호
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• pp.165-177
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• 2006

Objectives : 1. Clinical trial for the efficacy evaluation of Korean acupuncture techniques in treating frozen shoulder. 2. Development of the standard clinical guidelines of the acupuncture treatment for the frozen shoulder. 3. Development of the new clinical protocol for the acupuncture treatments. 4. Verification of the hypothesis that treating at both the remote and the nearby acupoints according to the meridian theory is more effective than treating at only the nearby acupoints. Methods : 1. Research designed as Single blind, Randomized, Sham acupuncture controlled clinical Trial. 2. Assignment of 86 patients to one of three groups treated at nearby acupoints(group A), remote & nearby acupoints(group B), and sham points(group C) respectively. 3. Trial conducted at KIOM CRC of Dunsan oriental medical hospital, Daejeon Univ. 4. Estimation of the recovery rate of the frozen shoulder in subjects aged over 40. 5. Efficacy evaluation using VAS, SPADI, ROM and Improvement rate. Results : 1. There was no significant difference in VAS among the three groups. 2. Pain related scores in SPADI of the group B were significantly lower than those of the group A. 3. There was no significant difference in disability related scores of SPADI among the three groups. 4. External rotation of upper arm in the group B was significantly improved in comparison with that in the group C. 5. Abduction of upper arm in group A was improved with weak statistical significance in comparison with that in the group C. Conclusion : Acupuncture at both the remote and the nearby acupoints according to the meridian theory is effective to improve external rotation of frozen shoulder, and acupuncture at the nearby acupoints is effective to improve adduction of frozen shoulder. However it is not clear that acupuncture treatment at both the remote and the nearby acupoints according to the meridian theory is more effective than treating at only the nearby acupoints in the treatment of frozen shoulder. Since our study was a short term trial, a long term trial for a more precise evaluation of acupuncture treatment for frozen shoulder will be needed in the future.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2000년도 춘계 학술대회 및 국제 감성공학 심포지움 논문집 Proceeding of the 2000 Spring Conference of KOSES and International Sensibility Ergonomics Symposium
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• pp.157-162
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• 2000

Discriminant analysis is a method to relate whether the objects have a specific characteristic or not with their 'continuous' attribute values and, for given objects, to estimate whether they have a specific characteristic or not by their values of discriminant scores gotten from their attribute values. The author developed the new 'computational' method of discriminant analysis without specific hypotheses or assumptions and, by this new method, we can find 'feasible' solutions under the conditions required by our actual problems. In this paper, the author tried to apply this new method to the discrimination of logical relations. If this trial could be a success, we can apply this new method of discriminant analysis to the problems about relating the specific characteristic of the objects with their 'discrete' attribute values. The result was successful and the applicability of discriminant analysis could be expanded as a method for constructing the models for "estimating impressions".

• 한국군사과학기술학회지
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• 제16권6호
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• pp.752-761
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• 2013

A new gun fire control system has been developed for the Korean next generation frigate class. The engineering requirement was far more tightened than the PKG-A class for the firing range availability and gun control function since 5 inch gun is adopted for the new ship. We mention about the principal technologies required to build a generic gun fire control system and proposed methods for the new gun fire control system. The new system has been designed based on the proposed methods in order to satisfy the requirement and functionality has been proved to be acceptable through the sea trial by Korean navy.

• 복식
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• 제59권1호
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• pp.77-93
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• 2009

The purpose of this study is to analyze on the fashion collection of Hussein Chalayan who has changed the concept of fashion design in the 21st century and has pioneered in the new vision of fashion. This study will give a new perspective and perception of fashion as a conceptual and ideological art. The conclusions of this study are as follows. First, Hussein Chalayan's multicultural ideas and interdisciplinary approaches which based in national speciality are the unique elements in his works. Second, Hussein Chalayan intends to present his works as an expression of conception. He has expressed the clothes which speaks the form of nature, symbolizes the combination of culture, visualizes time and space and investigates the existence of human being. Third, Hussein Chalayan has asked an endless question about existence of the human being. Furthermore, He has put a question about the relationship between time, space, history, nature and the human being. His trial to visualize the metaphysical conception of 'ego' and 'self' through his works of art makes him as the designer who represents the 21st century. Forth, Hussein Chalayan pursues the communication between the human being and the world. His works is made for human being and makes the human life as valuable thing. Because the clothes is completed when the human wears it, it can not exist without the relationship of human being. Fifth, Hussein Chalayan makes a various attempt to combine with different artistic field. Fashion has developed to new direction with diverse trial and combination beyond fashion field and this has to be a direction in the 21st century fashion. Fashion is not just making clothes, but accepting and delivering the history and culture, expressing and communicating empathy, and combining the different fields harmoniously.

• Clinical and Experimental Pediatrics
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• 제50권7호
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• pp.601-605
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• 2007

The cure rate of acute lymphoblastic leukemia (ALL) in children dramatically improved over past 5 decades from zero to about 80%. The main cause of improvement is owing to the development of chemotherapy by multicenter clinical trial of large study groups with the understanding of leukemia biology. Recently, pediatric ALL protocols were applied to the treatment of adolescent and even adult ALL patients. For nearly 30 years, clinical factors have been used to risk-stratify therapy for children with ALL, so that the most intensive therapies are reserved for those patients at the highest risk of relapse. The risk groups of ALL are divided as standard- (low- plus intermediate-), high- and very high-risk group according to the prognostic factors, and treatment results improved by this risk based treatment. The factors used to risk-stratify therapy include age, gender, presenting leukocyte count, immunophenotype, cytogenetic aberrations including ploidy and translocations, and initial response after 1 to 2 weeks of therapy. But treatment efficacy is the most important determinant and can abolish the clinical significance of most, if at all, prognostic factors. Today, in the era of intensive, multiagent regimens, there is increasing evidence that we have reached the limits of prognostic significance of currently applied clinical risk factors in childhood ALL. As the cure rate of ALL is about 80%, introducing new prognostic factors such as new molecular prognostic markers, new methods of assessment about minimal residual disease, and pharmacogenetic study, with the development of stem cell transplantation and molecular targeted therapy are needed to cure residual 20% of childhood ALL patients without short and long term complications.

• 문화기술의 융합
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• 제4권4호
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• pp.387-392
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• 2018

새로운 의료기기 개발이나 신약 개발에 있어서 임상시험은 중요한 부분을 차지하고 있다. 하지만 임상시험을 진행하는데 시간과 비용이 많이 소요 된다. 이런 부분을 해결하기 위해서 해외 주요 국가들뿐만 아니라 우리나라에서도 임상시험에서 수집되는 데이터들의 표준 형식을 정의하고 있다. 한의학에서도 새로운 의료기기 개발을 위해서 임상시험을 진행하고 있다. 임상시험에서 수집하는 데이터들의 표준을 정의한다면 이를 활용할 수 있는 방법은 다양할 것으로 보인다. 다양한 임상시험 데이터를 하나의 표준화된 데이터로 수집 및 관리를 한다면 다양한 결과를 도출할 수 있을 것이다. 이런 내용을 바탕으로 임상시험 통합 데이터 수집 및 관리 체계를 구축하였다. 그리고 그 활용 방안에 대해서 모색하고자 한다.

• 펄프종이기술
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• 제47권4호
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• pp.96-101
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• 2015

In the previous study, we investigated the physical properties of new organic fillers made from major agricultural byproducts, including rice husks, peanut husks and garlic stems, and we estimated that rice husk was the best candidate for use as new organic fillers in paperboard. In this study, an organic filler prototype was produced with rice husk and the mill trials were carried out in a white liner chipboard (duplexboard) mill. The rice husk organic filler was added to the middle ply of SC $350g/m^2$ to determine the optimal conditions for the manufacture of rice husk organic fillers. The mill trials were performed three times and the bulk improvement and drying energy reduction were measured to identify the functionality of the rice husk organic filler compared to that of the commercial wood powder. In the first mill trial, the test failed because the surface roughness of the duplexboard had deteriorated after the rice husk organic filler was added to the OCC stock. As all of the particles remaining on the 60 mesh sieves were removed and the particle size was decreased by increasing the length of the grinding process, the surface roughness of the duplexboard did not be deteriorated in the second mill trial. However, the bulk improvement and drying energy reduction were not observed. In the final mill trial, as the particle size of the rice husk organic filler was controlled by increasing the portion of particles passing through the 60 mesh sieves and remaining 100 mesh sieves, higher bulk improvement and drying energy reduction were acquired compared to the commercial wood powder.

• 영재교육연구
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• 제23권4호
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• pp.567-592
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• 2013

효과적인 SSI 관련 의사결정 학습 방법의 모색을 위하여, 중학교 과학 우수학생들을 대상으로 지구온난화와 관련한 논쟁 상황을 주제로 자기주도적 협동학습을 강조한 SSI 의사결정 학습을 진행하였다. 자기주도적 협동학습을 강조한 SSI의사결정 학습은 (1) 교사가 제시하는 자료에 의존하지 않고 자기주도적으로 관련 자료를 수집하고, (2) 협동학습을 통해 찬성과 반대의 주장과 근거를 공유하며, (3) 마지막 글쓰기를 통해 자신의 의사결정과정을 정리하는 것을 강조하고 있다. 본 연구에서는 마지막 단계에서 이루어진 학생들의 의사결정 글쓰기를 분석하여 학습의 효과를 알아보았다. 학습의 효과를 알아보기 위하여 지구온난화 관련 논쟁 상황의 분석 및 설명을 교사 강의로 진행한 그룹 A, 분석 자료를 정리하여 교사가 제공하고 소그룹 토의와 프리젠테이션 과정을 진행한 그룹 B를 대조 그룹으로 설정하였다. 그리고 세 그룹의 수업 후 (1) 학생들의 의사결정 선택의 결과, (2) 학생들의 의사결정 글쓰기에 나타난 논증 구조의 수준, (3) 반성적 사고의 수준, (4) 과학의 본성을 포함한 과학적 정보의 활용 수준을 비교하였다. 그 결과 자기주도적 협동학습을 강조한 SSI 의사결정 학습이 학생들의 정보에 기반한 의사결정, 보다 높은 수준의 논증구조, 보다 높은 수준의 반성적 사고, 과학적 정보에 대한 평가 및 해석, 과학의 본성에 대한 이해에 긍정적인 효과가 있음을 확인할 수 있었다. 결론적으로 이 학습의 결과, 학생들은 관련된 과학적 정보에 기반하여 보다 과학적으로 의미있는 의사결정에 도달하게 되었음을 알 수 있었다.