• Korean Journal of Veterinary Pathology
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• v.1 no.2
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• pp.91-96
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• 1997

General steps in the discovery and development of novel drugs in the United States are presented. The first step is the discovery of novel drugs. Brief histories and mechanisms of a few novel drugs in the American market are outlined. In this presentation preclinical animal toxicologic studies (drug safety evaluateion) are emphasized in regard to drug development. When preclinical animal studies have defined the toxicity and the doses at which it occurs an Investigational new Drug Application (IND) is submitted to the Food and Drug Administration (FDA) An IND notifies the FDA the intention to begin testing a novel drug in human subjects.

• English Language & Literature Teaching
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• v.11 no.1
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• pp.225-243
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• 2005

Korean students in English novel class read presentable papers about a novel, but if asked about some parts of the novel, they are helpless. How do they know the whole novel without knowing its parts? Because most Korean students cannot read through an English novel in a short time, they are awfully pressed with preparation for papers to be presented in the class. That makes their papers composed entirely of appropriated ideas from references. Being conscious of students' inability to read through a novel, some teachers select and read only some important parts or chapters of the novel. That makes students take a novel not as literary art, but as a prose work for abstract ideas. In order to solve the problem, I propose chapter analysis. Attentive reading new critics applied to poetry and short story is applicable to the chapter of a novel. Because no critic or scholar analyzes a novel chapter by chapter in his/her articles or books, students cannot wholly mosaic their papers with ideas from references. Chapter analysis will enable Korean students to interpret a novel with their own view point. This paper includes such sections as the theoretical background of fictional chapters, some items to be considered for chapter analysis in the class, and examples of analysis of a short story and two chapters from a novel.

• Transactions on Electrical and Electronic Materials
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• v.11 no.6
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• pp.243-248
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• 2010

The emergence of different and disparate materials together with the convergence of both the 'old' and 'emerging' technologies is paving the way for integration of heterogeneous technologies that are likely to extend the limitations of silicon technology beyond the roadmap envisaged for complementary metal-oxide semiconductor. Formulation of new information processing concepts based on novel aspects of nano-scale based materials is the catalyst for new nanoarchitectures driven by a different perspective in realization of novel logic devices. The memory technology has been the pace setter for silicon scaling and thus far has pave the way for new architectures. This paper provides an overview of the inevitability of heterogeneous integration of technologies that are in their infancy through initiatives of material physicists, computational chemists, and bioengineers and explores the options in the spectrum of novel non-volatile memory technologies considered as forerunner of new logic devices.

• International journal of advanced smart convergence
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• v.11 no.1
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• pp.36-41
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• 2022

Recently, to improve the performance of the strongest channel gain user in non-orthogonal multiple access (NOMA) with a non-uniform source and symmetric superposition coding (SSC), a novel bit-to-symbol (BTS) mapping have been proposed. However, only the performance of the user with the stronger channel gain was analyzed. Thus, we compare the bit-error rate (BER) of the new BTS scheme with that of uniform sources, especially for the user with weakest channel gain. First, we show that the performance of the novel BTS scheme for the user with weakest channel gain also improves, compared to that of the uniform sources. Furthermore, the signal-to-noise (SNR) gain of the new BTS scheme over the uniform sourcesis calculated. As a consequence, the novel BTS scheme would improve the performance of the user with weakest channel gain as well as that with the stronger channel gain for SSC NOMA with a non-uniform source.

• Journal of Marine Bioscience and Biotechnology
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• v.1 no.4
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• pp.225-231
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• 2006

The secondary metabolites from Taiwanese marine soft corals and sponges have attracted much attention because they possess considerable potential biological activities. To explore the origin of bioactivity, many cytotoxic natural products were isolated and characterized in the past few years. For examples, The lipophilic extracts from marine sponges Petrosia elastica and Ircinia formosana were found active against several human tumor cells. The investigation of the gorgonian Junceela has also resulted in the discovery of a series of new juncenolides. Bioassay-directed fractionation of Clavularia viridis yielded seven new prostanoids. These compounds have been tested and evaluated as potential antitumor agents. The soft corals of the genus Cespitularia produced novel secondary metabolites with diverse chemical structures and interesting biological activities. Four new norditerpenoids, designated cespitulactones and cespihypotins were isolated from Cespitularia hypotentaculata. Cespitulactones are novel structures having a bond cleavage between C-10 and C-11. In addition, three novel diterpenes were isolated from C. taeniata and designated cespitulactams A, B and C having a phenylethyl amino side chain.

• Transactions of the Korean hydrogen and new energy society
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• v.19 no.5
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• pp.417-422
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• 2008

In this paper, a novel DC/DC low-voltage high-current converter circuit is proposed to improve the efficiency of power converter used in the grid-connected fuel-cell generator system. We proposed a novel high efficiency grid-connected power conditioning system for RPG fuel cell. On the result of that, the loss of system was decreased rapidly by driving stack within the condition of maximum efficiency. The peak currents of the current-type inductor and the transformer's coil are reduced by synchronizing switching frequency of Buck-type converter is increased twice as the Push-Pull converter's switching frequency. The novel structure of DC/DC converter is able to realize ZVS-ZCS in fuel-cell system is proposed. The proposed switching component of Push-Pull converter has the ZVS and ZCS function by using the circuit of new passive clamp.

• Geomechanics and Engineering
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• v.18 no.2
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• pp.153-159
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• 2019

This paper examines the results from three-dimensional dynamic finite element analysis undertaken to develop a new dynamically installed anchor (DIA). Several candidate shapes of new DIAs were selected after an investigation into previous researches of existing DIA designs. The performances of selected DIAs during the installation and loading in non-homogeneous clay were investigated through large deformation finite element (LDFE) analyses. Findings were compared to the current anchors in operation (i.e., Torpedo and Omni-Max DIA) to assess the viability of the new designs in the field. Overall, the anchor embedment depths of the novel DIAs lied under the results of OMNI-Max DIA. And also, the tracked anchor trajectory confirmed that, the novel DIAs dove deeper with stiffer travelling angle, compared to the OMNI-Max DIA. These elements are more critical and beneficial especially in a field where the achieved embedment depths are generally low.

• Proceedings of the Korean Vacuum Society Conference
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• 2008.08a
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• pp.67-67
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• 2008

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.10
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• pp.4223-4249
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• 2015

A novel jamming detection technique to detect the presence of jamming in the downstream direction for cluster based wireless sensor networks is proposed in this paper. The proposed technique is deployed in base station and in cluster heads. The proposed technique is novel in two aspects: Firstly, whenever a cluster head receives a packet it verifies whether the source node is legitimate node or new node. Secondly if a source node is declared as new node in the first step, then this technique observes the behavior of the new node to find whether the new node is legitimate node or jammed node. In order to monitor the behavior of the existing node and new node, the second step uses two metrics namely packet delivery ratio (PDR) and received signal strength indicator (RSSI). The rationality of using PDR and RSSI is presented by performing statistical test. PDR and RSSI of every member in the cluster is measured and assessed by the cluster head. And finally the cluster head determines whether the members of the cluster are jammed or not. The CH can detect the presence of jamming in the cluster at member level. The base station can detect the presence of jamming in the wireless sensor network at CH level. The simulation result shows that the proposed technique performs extremely well and achieves jamming detection rate as high as 99.85%.

• Journal of English Language & Literature
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• v.55 no.5
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• pp.793-820
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• 2009

The studies of correspondence between novel and nation-state, among which The Rise of the Novel by Ian Watt is supposed to be the first book, have flourished for more than twenty years, encouraged by Benedict Anderson's and Cathy Davidson's works. According to them, the novel should come simultaneously with, or after the foundation of the nation-state, and testify to its production or the emergence of its subject/citizen. This paper questions about these prepositions, trying to introduce a new paradigmatical approach, "between global and transnational historical approach," to first novels in transatlantic areas including England and atlantic coastal areas. In its complex relation to a variety of colonial, post-colonial, and transnational geopolitics, various cultural practices such as history, traveler's tales and epistolary novels can be included in the genre of the novel. The idea of the sexual contract by Carole Pateman is very useful because it helps more clearly understand the nature of relation between men and women in the capitalist reproduction, while the social contract tells about the relation between men as citizens. Unlike Freud in Totem and Taboo, Zilboorg argues that there were primordial and violent scenes such as rape before the first sexual contract. This paper will illuminate that "the rise of the novel" corresponded with the emergence of the sexual contract. In the so-called first novel Pamela, the heroine Pamela was threatened to be violated by Mr. B., and was really even confined in his cottage. Mary Rowlandson's The Captive Narrative shows that her body was confined as an English female captive, and troubled with imaginary rape by Indians which resulted in the unequal sexual contract between her and her puritan community in America. However, Leonora Sansay's Secret History in an alternative communality, which was not a nation-state, was different from both novels mentioned above, in that it shows the possibility of emancipation from their unequal marriage, the sexual contract. Therefore, it can be argued that "between global and transnational historical approach" has a possibility to provide a new vision of global sisterhood and solidarity to recognize globalized women's violence, and free themselves from the unequal sexual contract.