• 한국응급구조학회지
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• 제26권3호
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• pp.161-184
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• 2022

연구 목적: 본 연구는 화재 현장에서 발생한 심정지 소방관의 소생률 향상을 위하여 화재진압대원을 위한 심폐소생술 훈련프로그램(FD-CPR)을 개발하고자 하였다. 연구 방법: 행동주의 이론을 전제로 한 FD-CPR 교수설계 모형을 3단계(분석, 설계, 개발) 절차에 따라 개발하였으며, 7명의 전문가 집단(응급의학과 교수 1인, 응급구조학과 교수 1인, 교육학과 교수 1인, 소방학교 교수 2인, 현장 활동 15년 이상 대원 2인)의 내용 타당도 검증(CVI)과 예비 실험을 거쳐 완성하였다. 연구 결과: 7개 절차로 구성된 시나리오 및 16개 항목으로 구성된 수행 능력 평가도구를 개발하였다. 평가도구의 난이도는 평균 41.16%, 변별도는 0.32로 나타나 난이도가 고르며, 변별도가 높은 것으로 확인되었다. 이후, 총 80분짜리 훈련프로그램을 개발하였고, 전문가 7인의 내용 타당도 검증 결과 1.0으로 높았다. 결 론: 본 연구를 통해 국내 처음으로 개발된 화재진압대원을 위한 기본 심폐소생술 훈련프로그램은 화재진압대원들의 심폐소생술 수행 능력 향상에 효과가 있는 것으로 나타났다. 이에 소방학교 신규 화재진압대원 교육과정에 본 프로그램을 넣게 된다면, 심폐소생술에 대한 반복훈련이 이뤄질 수 있으므로 심폐소생술의 수행 능력은 유지될 것이고, 나아가 심정지 동료의 소생률 향상에도 이바지할 수 있을 것으로 기대한다.

• 한국산업보건학회지
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• 제32권4호
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• pp.302-324
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• 2022

Objectives: The objective of this study is to investigate exposure to occupational carcinogens in the nationwide electronics industries and to establish a strategy for control of occupational carcinogens in South Korea. Methods: We evaluated occupational carcinogens as defined by International Agency for Research on Cancer (IARC) using a nationwide work environment measurement database on the electronics industry in South Korea measured between 2013 and 2017 in accordance with the Occupational Safety and Health Act. Results: The number of occupational carcinogens found in the electronics industry in South Korea were: 20 for IARC Group 1, 14 for Group 2A, and 30 for Group 2B. The occupational carcinogens (Group 1) most frequently exposed were strong-inorganic-acid mists containing sulfuric acid (sulfuric acid), welding fumes, mineral oils (untreated or mildly treated), nickel compounds, silica dust, crystalline substances in the form of quartz or cristobalite, formaldehyde, arsenic and inorganic arsenic compounds, chromium (VI) compounds, trichloroethylene, cadmium and cadmium compounds, vinyl chloride, ethylene oxide, wood dust, beryllium and beryllium compounds, 1,3 butadiene, benzene, and others. Among them, the carcinogens (Group 1) exceeding the acceptable standard were trichloroethylene, formaldehyde, and ethylene oxide. The working environment measurement system as regulated by Occupational Safety and Health Act is not properly assessed and managed for occupational carcinogens in South Korea. A component analysis for all materials used should be set up to practically reduce occupational carcinogens. A ban on the use of occupational carcinogens and the development of alternative materials are needed. The occupational carcinogens below the acceptable standards should be carefully examined and a new standard for exposure needs to be established. Conclusions: The Occupational Safety and Health Act should be improved to identify and monitor occupational carcinogens at work sites. A strategy for occupational safety and health systems should be provided to give direction to workers' needs and right to know.

• 대한본초학회지
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• 제33권2호
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• pp.1-7
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• 2018

Objectives : This study was conducted to evaluate the antioxidant activity and inhibitory activity of pancreatic lipase in vitro using natural products sangju dungsi, chungdo bansi, kabju baekmok three kind of young persimmon fruit extracts and to develop a high - functional anti - obesity substance with reduced body fat. Methods : The antioxidative effect of the three kind of young persimmon fruit extracts was determined by hot water extraction, 30% EtOH extraction and 70% EtOH extraction. The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. Furthermore, we examined total phenol and flavonoids contents. And the pancreatic lipase inhibition was measured by selecting the sangju dungsi extract with antioxidant effect. Results : The yield of water, 30% and 70% EtOH extract from young persimmon fruit was sangju dungsi (water 8.3%, 30% EtOH 18.1%, 70% EtOH 16.9%), chungdo bansi (water 16.2%, 30% EtOH 16.1%, 70% EtOH 11.6%), kabju baekmok (water 16%, 30% EtOH 16.8%, 70% EtOH 11.5%). The sangju dungsi 30% EtOH extract eminent DPPH ($IC_{50}$, $19.25{\pm}2.94{\mu}g/m{\ell}$) and ABTS ($IC_{50}$, $19.94{\pm}4.07{\mu}g/m{\ell}$) radical scavenging activity, and total phenol $52.37{\pm}0.78mg/g$ and flavonoid $7.97{\pm}0.13mg/g$ contents were also excellent. It also showed excellent pancreatic lipase inhibition efficacy. Conclusion : The extracts from the three kind of young persimmon fruit extracts showed excellent antioxidant activity. sangju dungsi 30% EtOH extract may be a new anti-obesity material by reducing fat absorption through the inhibition of pancreatic lipase.

• 한국버섯학회지
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• 제20권3호
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• pp.178-182
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• 2022

버섯의 오랜 역사에도 불구하고 버섯의 유전적 기능과 분자유전학을 응용한 신품종 개발에 대한 연구는 크게 부족한 상황이다. 그러나 최근 유전자 가위인 CRISPR/Cas를 이용한 새로운 유전자 교정 기술이 개발됨에 따라 버섯 연구에서 이 기술을 이용한 다양한 시도가 이루어지고 있다. 특히 선택의 용이성을 위해 외래 유전자 삽입 없이도 고효율로 유전자 편집이 가능한 RNPs를 활용한 연구가 활발히 진행되고 있다. 그러나 RNPs는 원형질체의 세포막을 통과하기에 Cas9이 너무 거대하고 guide RNA가 쉽게 파괴된다는 단점을 가지고 있다. 이러한 단점을 극복하기 위하여 세포막 통과에 용이한 미네랄 성분인 CaP와 PAA를 조합하여 Nanoparticle을 형성함으로써 극복하고자 했다. 표고버섯 단핵 균주인 산조705-13을 이용하여 원형질체 분리에 적합한 Osmotic buffer를 찾기 위하여 0.6M과 1.2M의 Sucrose, Sorbitol, Mannitol, KCl을 처리하였고 그 결과 0.6M Sucrose가 가장 적합한 osmotic buffer임을 확인하였다. 또한 CaP으로 RNPs와 Nanoparticle 복합체를 형성하고 이 복합체가 RNase A로부터 RNPs의 기능을 온전히 보호하는 것을 확인할 수 있었다.

• 문화기술의 융합
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• 제8권6호
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• pp.479-486
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• 2022

중년기는 현재 자신의 위치에서 삶을 돌아보고 평가를 하게 되는 중요한 시기이다. 중년기는 성취에 대한 만족감과, 현실과 기대에 대한 위기감이 공존하는 양면성이 있다. 위기냐 기회냐의 전환기 과정에서 일어나는 문제와 갈등의 최소화를 위한 중년기 목회상담 연구는 의의 있는 일이다. 목회상담은 성경적 원리에 입각하여 지금-여기 현존 하시는 하나님과의 사실적 만남을 기본 전제로 내담자의 요구와 발달과제를 의미 있는 삶으로 재생산이 되도록 도울 수 있어야 한다. 이에 문헌 고찰을 통하여 중년기 연구의 선구자인 융, 에릭슨, 레빈슨의 중년기 발달적 견해를 살펴 보았다. 중년기 내담자들의 욕구와 위기감을 무조건적으로 말씀과 기도로 헤쳐나가라고 하는 것은 무리가 있다. 이러한 관점에서 목회상담과 현실치료의 통합은 자신이 선택한 실현 가능한 현실적 행동과 책임을 통해 내적 대화와 행동의 어우러짐이 함께 출발하도록 할 때 활용도가 매우 높다고 본다. 현실치료의 자신에 대한 통찰과 구체적 상담 방법은 목회상담과의 통합을 통해 새로운 상담유형을 제시할 수 있다. 따라서 본 연구는 현실치료의 이론적 배경과 특징을 살펴본 후 목회상담과 현실치료의 만남을 통해 중년기 위기를 극복하는데 일조하는 의미가 있다.

• Nutrition Research and Practice
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• 제16권5호
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• pp.589-603
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• 2022

BACKGROUND/OBJECTIVES: Previous studies have reported that protein supplementation contributes to the attenuation of inflammation. Serious trauma such as burn injury usually results in the excessive release of inflammatory factors and organs dysfunction. However, a few reports continued to focus on the function of protein ingestion in regulating burn-induced inflammation and organ dysfunction. MATERIALS/METHODS: This study established the rat model of 30% total body surface area burn injury, and evaluated the function of blended protein (mixture of whey and soybean proteins). Blood routine examination, inflammatory factors, blood biochemistry, and immunohistochemical assays were employed to analyze the samples from different treatment groups. RESULTS: Our results indicated a decrease in the numbers of white blood cells, monocytes, and neutrophils in the burn injury group administered with the blended protein nutritional support (Burn+BP), as compared to the burn injury group administered normal saline supplementation (Burn+S). Expressions of the pro-inflammatory factors (tumor necrosis factor-α and interleukin-6 [IL-6]) and chemokines (macrophage chemoattractant protein-1, regulated upon activation normal T cell expressed and secreted factor, and C-C motif chemokine 11) were dramatically decreased, whereas anti-inflammatory factors (IL-4, IL-10, and IL-13) were significantly increased in the Burn+BP group. Kidney function related markers blood urea nitrogen and serum creatinine, and the liver function related markers alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were remarkably reduced, whereas albumin levels were elevated in the Burn+BP group as compared to levels obtained in the Burn+S group. Furthermore, inflammatory cells infiltration of the kidney and liver was also attenuated after burn injury administered with blended protein supplementation. CONCLUSIONS: In summary, nutritional support with blended proteins dramatically attenuates the burn-induced inflammatory reaction and protects organ functions. We believe this is a new insight into a potential therapeutic strategy for nutritional support of burn patients.

• 한방안이비인후피부과학회지
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• 제36권2호
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• pp.60-75
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• 2023

Objectives : A bibliometric approach using network analysis was applied to explore the global trends of research on herbal medicine for atopic treatment. Methods : Articles related to herbal medicine on atopic treatment from 2003 to 2022 were retrieved from Web of Science Core Collection. Extracted records were analyzed according to the publication year, research area, journal title, country, organization, author and keyword. The VOSviewer program was used to visualize the trends and the research hotspots in herbal medicine for atopy. Results : Analysis of 406 articles indicated the consistent increase of using herbal medicine for atopic treatment over the last 20 years. The most productive country and research organization in issuing articles were South Korea and Kyunghee university. Many articles have been published in research areas such as 'integrative complementary medicine' and 'pharmacology pharmacy'. By evaluating the total link strength, the average publication year and the average citations of countries and authors, the influential countries and authors were identified. A network analysis based on the co-occurrence and the publication year of keywords revealed the relevant characteristics and trends of herbal medicine for atopy. The most up-to-date keywords were 'topical application', 'skin barrier' and 'care'. Conclusions : This bibliometric study examined the overall trends and the time-based development of herbal medicine for atopic treatment. The current study would be useful not only for grasping the global network hub of research on herbal medicine for atopic treatment, but also to explore the new directions for future research.

• Journal of Korean Neurosurgical Society
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• 제66권5호
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• pp.573-581
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• 2023

Objective : Due to the implementation of vaccinations and the development of therapeutic agents, the coronavirus disease 2019 (COVID-19) pandemic that started at the end of 2019 has entered a new phase. As a result, neurosurgeons should reconsider the way they treat their patients. As the COVID-19 situation prolongs, the change in neurosurgical emergency patients according to the number of confirmed cases is no longer clear. Outpatient treatment by telephone was permitted according to government policy. In addition, visits to caregivers in the intensive care unit were limited. Methods : The electronic medical records of patients who had been treated over the phone for a month (during April 2020, while the hospital was closing) were reviewed. Meanwhile, according to the limited visits to the intensive care unit, a video meeting was held with the caregivers. After the video meeting, satisfaction was evaluated using a questionnaire. Results : During April 2020, 1021 patients received non-face-to-face care over the telephone. Among the patients, no critical medical problem occurred due to non-face-to-face care. From July 2021 to December 2021, 321 patients were admitted to the neurosurgical intensive care unit and 107 patients (33.3%) including their caregivers agreed to video visits. Twice a week, advance notice was given that access would be made through a mobile device and the nurse explained to caregivers how to use the mobile device. The time for the video meeting was approximately 20 minutes per patient. Based on the questionnaire, 81 respondents (75.7%) answered that they agreed, and 26 respondents (24.3%) answered that they strongly agreed that was easy to communicate through video meetings. Fifty-two (48.6%) agreed and 55 (51.4%) strongly agreed that they were easy to understand the doctor's explanation. For overall satisfaction with this video meeting, three respondents (2.8%) gave 4/5 points and 95 respondents (88.8%) gave 5/5 points, and nine (8.4%) gave 3/5 points. Their reason was that there was not enough time. Conclusion : In situations where patient visits are limited, video meetings through a mobile device can provide sufficient satisfaction to caregivers. Telemedicine will likely become common in the near future. Health care professionals should prepare and respond to these needs and changes. Therefore, establishing a system with institutional support is necessary.

• 대한기관윤리심의기구협의회지
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• 제5권1호
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• pp.14-20
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• 2023

Purpose: To obtain fundamental data on selection tools for an internal audit and develop a new guideline. We scored the indicated points from the internal audit, identified the research progress and problems that occurred, and confirmed the validity of the risk factors involved. Methods: Of the 63 internal audits conducted by Keimyung University Dongsan Hospital from 2014 to 2021, we analyzed 55 clinical trials with an inspection checklist. We excluded 8 that failed to transfer data and refused to comply with the internal audit. The statistical summary of the collected data was verified and interpreted by using frequency analysis and a chi-square test. Result: Of total 55 cases included in the internal audit, sponsor-initiated trial (SIT) was 63.6% (vs. investigator-initiated trial [IIT]), clinical trial for investigational drug was 71.0% (vs. nonclinical or clinical trial for investigational device), domestic multicenter trial was 60.0% (vs. single center or multinational multicenter trial), and trial requisition for MFDS approval was 69.1% (vs. exception for MFDS approval). The 10 areas of the clinical trial inspection checklist (reports, protection of subjects, compliance with protocols, records, management of investigational drug and/or device, delegation of duties, qualification of investigators, management of specimen, contract-agreement and approval of protocols, and preservation of recorded documents) were weighted between 2 to 5 points. The average of the total points was 16.09±13.2 and 20 clinical trials were above the average. As a result of comparing the average of the total points weighted by year, the highest score was in 2020. The 4 factors that play significant roles in determining the internal quality were (1) principal subjects that initiated the clinical trials (p=0.049), (2) type (p=0.003), (3) phase of clinical trials (p=0.024), and (4) number of registered subjects reported at the time of continuing deliberation (p=0.019). Of the 10 areas of the clinical trial inspection checklist, 'record' was the most inappropriate and insufficient. We found more indicated points; the quality of performance declined in IIT, nonclinical trials, and other clinical trials that were not in phase I1-IV4, and the study of more than 30 registered subjects at the time of continuing review. Conclusion: If an institution has an internal audit selection tool that reflects the aforementioned risk factors, it will be possible to effectively manage high-risk studies; thereby, contributing to an efficient internal audit and improving the quality of clinical trials.

• 한국콘텐츠학회논문지
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• 제22권5호
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• pp.620-632
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• 2022

본 연구는 인류세를 대비하기 위해 포커스그룹 인터뷰(FGI) 분석 방법을 활용하여 학부생을 대상으로 인류세 인식에 대한 경험을 공유함으로써 인류세 교양교육의 방향에 대한 기초자료를 제공하고자 한다. 2021년 10월부터 2022년 1월까지 약 4개월에 걸쳐 교양교육튜터링에 참여한 14명을 대상으로 인터뷰를 실시하였고, 질적분석 방법에 따라 의미있는 개념을 확인한 결과, 새로운 지질시대의 도래, 인류세 재구성과 책임, 인류세 교양교육의 방향 등 총 3개 주제, 8개 하위범주, 16개 하위단위가 도출되었다. '새로운 지질시대의 도래'에서는 인류세가 우리의 삶과 가까이 있음을 인식하였으며, 인류세의 의미, 심각성, 발전가능성을 통해 미래를 예측해 보는 시간이 되었고, '인류세 재구성과 책임'에서는 인류세 인식을 계기로 개인, 기업, 정부의 의식전환의 재구성과 책임감을 강조하였다. '인류세 교양교육의 방향'에서는 미래형 기초교양교육으로 기후변화를 위한 행동실천과 ICT기술을 활용한 인류세 극복방안 그리고 긍정적인 인류세를 위한 다양한 교양교육의 내용을 제안하였다. 이러한 점에서 본 연구는 교양교육 차원에서 인류세를 심층적으로 탐색함으로써 인류의 생존에 대한 경각심을 불러 일으키고, 인류세 시대에 필요한 미래형 교양교육의 방향을 제시하였으며, 나아가 인류세 교양교육을 위한 교육내용과 방법에 관한 시사점을 제공하였다.