• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.2
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• pp.145-151
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• 2019

Fluorine-18 is considered to be the radionuclide of choice for positron emission tomography (PET). Thus, the development of small molecule-based radiopharmaceuticals for use in diagnostic imaging relies heavily on efficient radiofluorination techniques. Until the early 2000s, diaryliodonium salts and aryliodonium ylides were widely employed as labeling precursors to yield aromatic PET radiotracers with cyclotron-produced [¹⁸F]fluoride ion. Rapid recent progress in the development of efficient borylation methods has led to a paradigm shift in ¹⁸F-labeling methods. In addition, deoxyfluorination has attracted a great deal of interest as an alternative approach to aryl ring activation with ¹⁸F^-. In this review, methods for radiolabel development are discussed with a specific focus on the progress made in the last 5 years. Other interesting ¹⁸F-based protocols are also briefly introduced. New methods for exploiting ¹⁸F^- are expected to increase the number of ¹⁸F-labeling methods, to allow applications in a range of chemical environments.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.2
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• pp.900-905
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• 2012

The researches and discussion for regenerating the deprived urban residential areas are proceeding actively. But urban agriculture is regard as a simple tool for participation of resident and its value as primary industry is discussed in part. Now discussion about increasing the place capital is needed to overcome the existing urban development methods that maximizes the space capital as a new alternative. So this research is to give a theoretical basis for sustainable urban regeneration. It studies the place value improvement through urban agriculture which is applied creative industry convergence. For these, it indicates problems of the methods of existing urban development, reveal the strengths of urban agriculture applied creative industry convergence in the aspect of place value improvement, and suggests a new paradigm for urban regeneration.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.10a
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• pp.51-70
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• 2003

In recent years, Korean rice must compete with the rice of advanced countries under Doha Development Agenda(DDA) and free Trade Agreement(FTA). Therefore we should find more active and positive solution in rice industry according to the inncreasing power of international pressure. Increasing rice production was the most important policy during the past food-deficient days, but recently, with overproduction of rice, various circulation system by the brand(price)-differentiation should be settled in a recent market of Korea. Nowadays, some advanced rice farmers and Rice Processing Complex(RPC) managers developed new brands of rice with high-quality, adding healthy materials and environment-friendly farming methods. Therefore, the future strategy of making a new brand rice should be planned including selection of rice variety, cultural and post-harvest techniques, circulation and processing methods to compete against foreign rice. And environment-friendly farming is also recommendable for food safety and differentiate from imported rice. For the purpose of successful brand-rice, the following points might be considered. Firstly, selection of good quality rice and continual development of good variety must be conducted for the differentiation of Korean rice from foreign rice. Secondly, a special contract between producer and consumer with functional-rice, organic filming-rice, specific-rice will be recommendable. Thirdly, improvement of post-harvest management and milling system are necessary for the production of differentiated-rice. Fortunately, standard of inspection, rules of description for brand-rice must be developed by a more scientific examination in order to settlement of trust for consumer. Finally, provincial or regional-representative brand rice must be settled and conducted for the development of agreement market system between producer and consumer.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.23 no.3
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• pp.111-116
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• 1987

The accurate prediction of the ship wave resistance is very important to design ships which operate satisfactorily in a wave environment. Thus, work should continue on development and validation of methods to compute ship wave patterns and wave resistance. Research efforts to improve the prediction of ship waves and wavemaking resistance are categorized in two major areas. First is the development of higher-order theories to take account of the nonlinear effect of the free surface condition and improved analytical treatment of the body boundary condition. Second is the development of direct numerical methods aimed at solving body and free-surface boundary conditions as accurately as possible. A new formulation of the slender body theory for a ship with constant speed is developed by Maruo. It is quite different from the existing slender ship theory by Vossers, Maruo and Tuck. It may be regarded as a substitute for the Neumann-Kelvin approximation. In present work, the method of asymptotic expansion of the Kelvin source is applied to obtain a new wave resistance formulation in fluid of finite depth. It takes a simple form than existing theory.

• Proceedings of the KOR-KST Conference
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• 1999.10a
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• pp.47-52
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• 1999

The methods currently in use to evaluate traffic impacts on the transportation network involve some fundamental shortcomings. First, the methodss do not properly take into account regional and local traffic impacts on the transportation network simultaneously. Second, temporal distribution of traffic, a major contributor to transportation problems, is not accurately accounted for. Third, traffic impact studies require costly and labor-intensive efforts to collect necessary data and to establish to collect necessary data and to establish traffic impact models. In this research, a new method called AMIS is developed for congestion management, access control, and impact simulation to overcome the shortcomings involved in the current methods. The new method is designed for a variety of scenarios such as access management strategies, land use policies, traffic impacts, and other congestion management strategies. This method can effectively be used, with little modification, anywhere in the United States. It is an improvement over the current traffic impact simulation methods that produces more reliable and accurate traffic impact estimates. The case studies conducted in this research have offered evidence that the new method, AMIS, is a credible congestion management tool. Most importantly, a case study presented in this paper illustrates how the new method can be used not only to estimate regional and local impacts of alternate supply management policies in the course of a day, but virtually on an hour-by-hour basis.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.777-784
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• 2010

In the current Korean seismic design guide, the site classification and the corresponding site coefficients were determined based on the UBC-1997 (Uniform Building Code). In order to develop the current site classification system, it is important to compare the local site conditions in Korea to other countries which have similar seismic design guides. In the eastern United States, New York City(40degrees 45minutes north latitude, 73degrees 59minutes west longitude) suggested that current design guidelines are unsuitable to shallow bedrock depth sites. So the 3-parameter methods are performed for new criteria in New York City. In this study, site response analyses were performed at 181 study sites using one-dimensional equivalent linear to evaluate the site-specific earthquake ground motions at inland areas in the Korean peninsula and reclassify the results according to similar ground motions using the 3-parameter methods. It is effective that multi-parameter methods for Korean site characteristics in comparison with single parameter method.

• Nuclear Engineering and Technology
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• v.50 no.5
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• pp.673-682
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• 2018

One of the most widely used methods to estimate core damage during a nuclear power plant accident is containment radiation measurement. The evolution of severe accidents is extremely complex, leading to uncertainty in the containment dose rate (CDR). Therefore, it is difficult to accurately determine core damage. This study proposes to conduct uncertainty analysis of CDR for core damage assessment. First, based on source term estimation, the Monte Carlo (MC) and point-kernel integration methods were used to estimate the probability density function of the CDR under different extents of core damage in accident scenarios with late containment failure. Second, the results were verified by comparing the results of both methods. The point-kernel integration method results were more dispersed than the MC results, and the MC method was used for both quantitative and qualitative analyses. Quantitative analysis indicated a linear relationship, rather than the expected proportional relationship, between the CDR and core damage fraction. The CDR distribution obeyed a logarithmic normal distribution in accidents with a small break in containment, but not in accidents with a large break in containment. A possible application of our analysis is a real-time core damage estimation program based on the CDR.

• International Journal of Costume and Fashion
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• v.6 no.2
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• pp.11-27
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• 2006

The purpose of this study is to develop highly valued fashion cultural items using Korean face and human images to enhance global competition. The methods of this study include: historical study on the face/human images which appear on the dress; design by stage according to Lamb & Kallal's apparel design process; development of products using digital textile printing technology; and case study by objective evaluation through Grant's alpha-beta model. The procedure and the results of this study are as follows: First, in the problem identification stage, the need to develop fashion cultural products of Korean face/human images which are symbolic, aesthetic, and functional was recognized in order to enhance global competition. Second, in the preliminary idea stage, the fashion cultural products and the components that meet the above 3 standards for design were determined and first design was drawn up. The source of the design was extrapolated from face/human images, which appeared on the murals of the ancient Korea, the portraits and custom paintings from the Chosun Dynasty. From these images, a total of 7 design series of T-shirts with an "ULGUL" logo, scarves, and artwalls were developed using "obangsaek" which are five Korean traditional colors including red, blue, black. white, and yellow on cottons and silks. Third, in the design refinement stage, based on the preference survey, more varying design methods were used to develop 25 new designs. Fourth, in prototype development stage, based on the preference survey conducted on fashion professionals and general public from the previous stage, which showed preference for T-shirts and scarves, 3 designs on T-shirts and 2 designs on scarves were printed and produced using the DTP (Digital Textile Printing). Fifth, in the evaluation stage, Grant's alpha-beta model was used to perform comparative evaluation on the symbolic, aesthetic, and functional criteria of the new designs over the existing ones. The new designs received excellent results in all three criteria and a special recognition was given to symbolism of the new designs.

• Nuclear Engineering and Technology
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• v.52 no.9
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• pp.2119-2129
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• 2020

Flow-accelerated corrosion (FAC), liquid droplet impingement erosion (LDIE), cavitation and flashing can cause continuous wall-thinning in nuclear secondary pipes. In order to prevent pipe rupture events resulting from the wall-thinning, most NPPs (nuclear power plants) implement their management programs, which include periodic thickness inspection using UT (ultrasonic test). Meanwhile, it is well known in field experiences that the thickness measurement errors (or deviations) are often comparable with the amount of thickness reduction. Because of these errors, it is difficult to estimate wall-thinning exactly whether the significant thinning has occurred in the inspected components or not. In the previous study, the authors presented an approximate estimation procedure as the first step for thickness measurement deviations at each inspected component and the statistical & quantitative characteristics of the measurement deviations using plant experience data. In this study, statistical significance was quantified for the current methods used for wall-thinning determination. Also, the authors proposed new estimation procedures for determining local wall-thinning to overcome the weakness of the current methods, in which the proposed procedure is based on analysis of variance (ANOVA) method using subgrouping of measured thinning values at all measurement grids. The new procedures were also quantified for their statistical significance. As the results, it is confirmed that the new methods have better estimation confidence than the methods having used until now.

• The Journal of Korean Medicine
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• v.30 no.6
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• pp.96-102
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• 2009

Objectives: Traditional Korean herbal formulae are composed of multiple medicinal plants. This situation of multiple-ingredient mixtures has been considered as a major obstacle to new drug development using herbal formulae in the world market, despite the effectiveness of such mixtures. This study reviewed Liv-52 as a representative model of successful drug development using a multiple-herb mixture. Methods: All articles for Liv-52 were collected from the PubMed database. The history, composition of Liv-52, its pharmaceutical efficacy and mechanisms, and data from clinical studies including its market size were analyzed. Results: Liv-52 is composed of seven herbal plants and it is the best known in Ayurvedic medicine for treating liver disorders. Since its 1955 introduction, forty four international papers have been published based on pre-clinical and clinical trials. The efficacy and mechanisms of Liv-52 were intensively studied. Currently, Liv-52 is one of the top-selling products, with over 10 million dollars sales annually, in the world market. Conclusions: These results indicate that Korean herbal formulae could be new global drugs if scientific evidence for efficacy and standardization are produced via literature researches.