• Title/Summary/Keyword: New Development Component

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Development of the 3rd Generation Anticancer Platinum Complex as New Drug

  • Cho, Yong-Baik;Ph. D.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2002.07a
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    • pp.97-102
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    • 2002
  • Life Science Research Center of SK Chemicals has developed a 3rd-generation anticancer platinum drug for the first time in the nation′s 100-year-old pharmaceutical industry. The Korea Food and Drug Administration (KFDA) approved the sale of "Sunpla" (code name SKI 2053R, general name : Heptaplatin) on July 14, 1999 for the treatment of advance, metastatic gastric cancer. Cisplatin, the 1 st-generation anticancer drug, which was developed by Bristol-Myers of the United States in 1976, is one of the most potent anticancer drugs and is a major component of combination chemotherapy for a variety of human cancers. However its clinical usefulness has frequently been limited not only by undesirable side effects such as severe renal toxicity, nausea, vomiting, ototoxicity, and neurotoxicity but also by the development of resistance. Carboplatin, the 2nd-generation anticancer platinum drug, which was also developed by Bristol-Myers in 1986, has modified the problems of the renal and gastrointestinal toxicities of cisplatin. Carboplatin, however, has no enhanced therapeutic efficacy over cisplatin and does not possess the property to overcome cross-resistance to cisplatin.

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SOA Development Methodology Based on Service Ontology (서비스 온톨로지 기반 SOA 개발 방법론)

  • Choi, Ko-Bong;Park, Sei-Kwon;Ryu, Sung-Wan
    • Journal of Information Technology Services
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    • v.9 no.2
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    • pp.193-203
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    • 2010
  • Service-Oriented Architecture (SOA) is a new trend for the design of application architecture to enhance the degree of share and reuse with the concept of service. It comes from the current situation where the business environments are changing rapidly and therefore competitions are getting bitter. To cope with such business challenges, business (and/or applications) architecture needs considerably flexibility and reusability, and that's why SOA is accepted as one of the most effective framework for the business applications in these days. In this paper we propose an analysis and design methodology for the applications of SOA. To implement the proposed methodology, the service ontology needs to be defined first, and the tasks such as service profiling, workflow design and service orchestration need to be followed. To validate the expected effects on flexibility and reusability, the proposed methodology was compared with CBD (Component Based Development).

한강하류지형면의 분류와 지형발달에 대한 연구 (양수리에서 능곡까지)

  • Park, No-Sik
    • Journal of the Speleological Society of Korea
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    • no.68
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    • pp.23-73
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    • 2005
  • Purpose of study; The purpose of this study is specifically classified as two parts. The one is to attempt the chronological annals of Quaternary topographic surface through the study over the formation process of alluvial surfaces in our country, setting forth the alluvial surfaces lower-parts of Han River area, as the basic deposit, and comparing it to the marginal landform surfaces. The other is to attempt the classification of micro morphology based on the and condition premising the land use as a link for the regional development in the lower-parts of Han river area. Reasons why selected the Lower-parts of Han river area as study objects: 1. The change of river course in this area is very serve both in vertical and horizontal sides. With a situation it is very easy to know about the old geography related to the formation process of topography. 2. The component materials of gravel, sand, silt and clay are deposited in this area. Making it the available data, it is possible to consider about not oかy the formation process of topography but alsoon the development history to some extent. 3. The earthen vessel, a fossil shell fish, bone, cnarcoal and sea-weed are included in the alluvial deposition in this area. These can be also valuable data related to the chronological annals. 4. The bottom set conglometate beds is also included in the alluvial deposits. This can be also valuable data related to the research of geomorphological development. 5. Around of this area the medium landform surface, lower landform surface, pediment and basin, are existed, and these enable the comparison between the erosion surfaces and the alluvial surfaces. Approach : 1. Referring to the change of river beds, I have calculated the vertical and horizontal differences comparing the topographic map published in 1916 with that published in 1966 and through the field work 2. In classifying the landform, I have applied the method of micro morphological classification in accordance with the synthetic index based upon the land conditions, and furthermore used the classification method comparing the topographic map published in 1916 and in that of 1966. 3. I have accorded this classification with the classification by mapping through appliying the method of classification in the development history for the field work making the component materials as the available data. 4. I have used the component materials, which were picked up form the outcrop of 10 places and bored at 5 places, as the available data. 5. I have referred to Hydrological survey data of the ministry of Construction (since 1916) on the overflow of Han-river, and used geologic map of Seoul metropolitan area. Survey Data, and general map published in 1916 by the Japanese Army Survbey Dept., and map published in 1966 by the Construction Research Laboratory and ROK Army Survey Dept., respectively. Conclusion: 1. Classification of Morphology: I have added the historical consideration for development, making the component materials and fossil as the data, to the typical consideration in accordance with the map of summit level, reliefe and slope distribution. In connection with the erosion surface, I have divided into three classification such as high, medium and low-,level landform surfaces which were classified as high and low level landform surfaces in past. furthermore I have divided the low level landform surface two parts, namely upper-parts(200-300m) and bellow-parts(${\pm}100m$). Accordingly, we can recognize the three-parts of erosion surface including the medium level landform surface (500-600m) in this area. (see table 22). In condition with the alluvial surfaces I have classified as two landform surfaces (old and new) which was regarded as one face in past. Meamwhile, under the premise of land use, the synthetic, micro morphological classification based upon the land condition is as per the draw No. 19-1. This is the quite new method of classification which was at first attempted in this country. 2. I have learned that the change of river was most severe at seeing the river meandering rate from Dangjung-ni to Nanjido. As you seee the table and the vertical and horizontal change of river beds is justly proportionable to the river meandering rate. 3. It can be learned at seeing the analysis of component materials of alluvial deposits that the component from each other by areas, however, in the deposits relationship upper stream, and between upper parts and below parts I couldn't always find out the regular ones. 4. Having earthern vessel, shell bone, fossil charcoal and and seaweeds includen in the component materials such as gravel, clay, sand and silt in Dukso and Songpa deposits area. I have become to attempt the compilation of chronicle as yon see in the table 22. 5. In according to hearing of basemen excavation, the bottom set conglomerate beds of Dukso beds of Dukso-beds is 7m and Songpa-beds is 10m. In according to information of dredger it is approx. 20m in the down stream. 6. Making these two beds as the standard beds, I have compared it to other beds. 7 The coarse sand beds which is covering the clay-beds of Dukso-beds and Nanjidobeds is shown the existence of so-called erosion period which formed the gap among the alluvial deposits of stratum. The former has been proved by the sorting, bedding and roundness which was supplied by the main stream and later by the branch stream, respectively. 8. If the clay-beds of Dukeo-bed and Songpa-bed is called as being transgressive overlap, by the Eustatic movement after glacial age, the bottom set conglomerate beds shall be called as being regressive overlap at the holocene. This has the closest relationship with the basin formation movement of Seoul besides the Eustatic movement. 9. The silt-beds which is the main component of deposits of flood plain, is regarded as being deposited at the Holocene in the comb ceramic and plain pottery ages. This has the closest relationship with the change of river course and river beds.

Concept and Development of Resident Training Program for General Competencies (전공의 공통역량의 개념과 개발)

  • Lee, Sun Woo
    • Korean Medical Education Review
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    • v.19 no.2
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    • pp.63-69
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    • 2017
  • Resident training programs in South Korea lag far behind that of advanced countries. Given the problems the current system in South Korea has, it is time to consider a new resident training system, resident training for general competencies. Training for the general competencies was practiced in medical fields in advanced countries such as the USA, Canada, and the UK as early as 20 years ago. This system has rendered itself a key component of resident training. Although a few theoretical procedures on general competencies have been practiced in South Korea, the awareness of this concept is still very weak, and the application of the theory to actual training is a long way off from becoming effective. It is urgent for South Korea to adopt competency- and outcome-based training for general competencies. To this end, the knowledge of the concept of this type of training should be improved. Also, the system should be carefully designed to cover a doctor's whole career, and be applied immediately. The competency- and outcome-based training for general competencies is a system that assures high level qualifications. It reflects the needs of our society under the recognition that a professional organization should be committed and accountable in order to respond to social demands. As the benefits of the new training system reach the public and medical care consumers, training-related expenses should be borne by social costs.

Stamping process design to develop a urea tank cover for excavators based on sheet metal forming analysis (굴삭기 요소수 탱크 커버의 신규 모델 개발을 위한 CAE 기반 프레스 성형 공정 설계)

  • Jeon, Yong-Jun;Heo, Young-Moo;Yun, Seok-Hyun;Kim, Dong-Earn
    • Design & Manufacturing
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    • v.14 no.2
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    • pp.49-55
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    • 2020
  • Recently, when a new component of construction equipment is designed, a stamping process capable of producing parts having high appearance quality and precision has been gaining attention. However, in general, as it is developed based on existing parts made by welding metal sheets and tubes, frequent to die modification occurs, which increases the time and cost of developing new parts. Thus, it is necessary to reduce the cost by shortening the die development period. In this study, a stamping process was designed for the urea tank cover, which is a part for excavators, to reduce the die development period through sheet metal forming analysis. The stamping process was designed by determining the blank holding force after selecting the initial blank shape and size. The round value at the corner was modified such that formability is ensured. After selecting process parameters, the thickness reduction rate and spring-back effect were reviewed.

COMPASS - New modeling and simulation approach to PWR in-vessel accident progression

  • Podowski, Michael Z.;Podowski, Raf M.;Kim, Dong Ha;Bae, Jun Ho;Son, Dong Gun
    • Nuclear Engineering and Technology
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    • v.51 no.8
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    • pp.1916-1938
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    • 2019
  • The objective of this paper is to discuss the modeling principles of phenomena governing core degradation/melting and in-vessel melt relocation during severe accidents in light water reactors. The proposed modeling approach has been applied in the development of a new accident simulation package, COMPASS (COre Meltdown Progression Accident Simulation Software). COMPASS can be used either as a stand-alone tool to simulate in-vessel meltdown progression up to and including RPV failure, or as a component of an integrated simulation package being developed in Korea for the APR1400 reactor. Interestingly, since the emphasis in the development of COMPASS modeling framework has been on capturing generic mechanistic aspects of accident progression in light water reactors, several parts of the overall model should be useful for future accident studies of other reactor designs, both PWRs and BWRs. The issues discussed in the paper include the overall structure of the model, the rationale behind the formulation of the governing equations and the associated simplifying assumptions, as well as the methodology used to verify both the physical and numerical consistencies of the overall solver. Furthermore, the results of COMPASS validation against two experimental data sets (CORA and PHEBUS) are shown, as well as of the predicted accident progression at TMI-2 reactor.

Daughters' Mourning Experience from Loss of their Mothers (엄마를 상실한 중년여성의 애도 경험)

  • Choi, Seung-Yee
    • The Korean Journal of Community Living Science
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    • v.22 no.4
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    • pp.637-653
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    • 2011
  • Over the last 20 years, women's development has been ambiguous. According to Freud, the mother-daughter relationship has been considered as an essential component of women's development. This study investigated how the mourning experience from daughters who were separated from their mothers by death offers any meaningful idea to women's life. For Hermeneutic phenomenology, researchers collected data from three women who have lost their mothers through in-depth interviews and drawing pictures with each of them. As a result, this study found that daughters started to fight with their mothers' death from the moment when they were informed. They also experienced a symbolic death until the moment of their mothers' death and even after the confirmation of their mothers' death. Daughters experienced symbolic death, both emotionally and physically as well as familiar experiences with their mothers through the repeated confirmation of death. However, these experiences encouraged daughters to adapt to the reality that was the absence of their mothers through the processes such as "Reflection," "Living in the Center of My life," and "Another Embrace." Through this new perspective, attempts, and relationships, daughters form a new identity and experience 'rebirth'. These daughters' changes were paradoxically strengthened through their resistances towards changes of reformation of themselves.

A Study on the Development of Railway Logistics Business Model and Track Capacity

  • GyuBae KIM;SungWook KANG
    • Journal of Distribution Science
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    • v.21 no.9
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    • pp.93-102
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    • 2023
  • Purpose: This study attempts to analyze the current status of the railway logistics business and to seek ways to improve it by using the business model as an analytical framework. It was intended to reflect practical implications that could be applied to the field, by dealing with issues at the industrial site related to each component in the business model. Research design, data and methodology: This study was conducted through literature review and field research. We analyzed academic papers and industrial reports on the development of the railway logistics industry and interviewed various stakeholders in the railway logistics industry. Results: This study determined the factors that could be eliminated, raised, reduced, or created from the customer and product perspective, infrastructure management perspective, and financial perspective. Conclusions: The growth of existing business can be achieved by lowering service prices, improving service quality, and securing large-scale transportation capacity. The additional transportation of high value goods and cold chain commodities will be promising business opportunities. Existing services can be provided to new customers (large pre-shippers, forwarding customers, etc.) in order to increase the size of sales Urban delivery services and comprehensive logistics services based on complex logistics centers may open an avenue for new market. A more timetable and track capacity need to be assigned to logistics, which significantly improve the flexibility and the competency of railway logistics.

Development of a model to forecast the external migration rate in development projects reflecting city characteristics

  • Kim, Ki-Bum;Park, Joon;Seo, Jee-Won;Yu, Young-Jun;Hyun, In-Hwan;Koo, Ja-Yong
    • Environmental Engineering Research
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    • v.23 no.4
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    • pp.406-419
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    • 2018
  • In planning public service systems such as waterworks, the design population is very important factor. Owing to the limitations of the indirect method, two new models, which take into consideration urban characteristics, were developed to accurately predict external migration rate (EMR), which is an essential component in estimating reliably the design population. The root mean square error (RMSE) between the model values and observed values were 10.12 and 15.58 for the metropolitan cities and counties respectively and were lower compared to RMSE values of 27.31 and 28.79 obtained by the indirect method. Thus, the developed models provide a more accurate estimate of EMR than the indirect method. In addition, the major influencing factors for external migration in counties were development type, ageing index, number of businesses. On the other hand, the major influencing migration factors for cities were project scale, distance to city center, manufacturing size, population growth rate and residential environment. Future medium and long-term studies would be done to identify emerging trends to appropriately inform policy making.

Location Selection Factors for International Distribution Center in Port Hinterland - A Review of Busan New Port Hinterland from User's Perspective -

  • Kim, Si Hyun;Shin, Gun Hoon
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.64
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    • pp.187-210
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    • 2014
  • As port functions change to act as an economic catalyst and take on a central position in industries engaged in international trade, port hinterland has become a significant component in international shipping. The success of port hinterland as a strategic base of logistic activities critically depends on location selection factor for international distribution center that links elements of global supply chain management. By examining multi-measurement items empirically, this paper analyzed location selection factor for international logistics distribution center in port hinterland, and evaluated Busan new port hinterland from the user's perspective. Employing exploratory factor analysis, the results revealed that the model structured around five factors incorporating geo-location and accessibility, availability, political supports, cost factors, and quality of business environment is valid and reliable in the context of the location selection factors for logistics distribution center in the context of port hinterland operations. The evaluation of Busan new port hinterland provides useful insights for strategic improvement to accommodate the users' expectation. Further, the model offers both a descriptive and diagnostic strategic management tool for port hinterland development and operations, to guide future improvement.

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