• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.241-262
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• 2021

This paper reviewed the necessity of a information and communication technology (ICT)-based smart livestock system as a development strategy for the animal life industry in the future. It also predicted the trends of livestock and animal food until 2050, 30 years later. Worldwide, livestock raising and consumption of animal food are rapidly changing in response to population growth, aging, reduction of agriculture population, urbanization, and income growth. Climate change can change the environment and livestock's productivity and reproductive efficiencies. Livestock production can lead to increased greenhouse gas emissions, land degradation, water pollution, animal welfare, and human health problems. To solve these issues, there is a need for a preemptive future response strategy to respond to climate change, improve productivity, animal welfare, and nutritional quality of animal foods, and prevent animal diseases using ICT-based smart livestock system fused with the 4th industrial revolution in various aspects of the animal life industry. The animal life industry of the future needs to integrate automation to improve sustainability and production efficiency. In the digital age, intelligent precision animal feeding with IoT (internet of things) and big data, ICT-based smart livestock system can collect, process, and analyze data from various sources in the animal life industry. It is composed of a digital system that can precisely remote control environmental parameters inside and outside the animal husbandry. The ICT-based smart livestock system can also be used for monitoring animal behavior and welfare, and feeding management of livestock using sensing technology for remote control through the Internet and mobile phones. It can be helpful in the collection, storage, retrieval, and dissemination of a wide range of information that farmers need. It can provide new information services to farmers.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.14 no.4
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• pp.257-268
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• 2021

As the variety and scale of facilities increase due to industrialization and urbanization, blind spots for facility safety management have occurred, resulting in numerous casualties.To meet safety and security needs of citizens living in smart cities, we present a procedure for establishing an integrated platform for facility safety management by combining 5G and digital twin technologies. It can be used to perform inspection according to risk factors and aging of facilities. In this paper, the current status of facility management and application directions of new 5G digital twin-based smart city technologies are reviewed and digital twin implementation procedures are presented. Five cities were selected as target areas: Osan, Gwangmyeong, Guri, Uijeongbu, and Anyang. Old and emergency facilities of each local government were selected. A total of 33 digital twin facilities reflecting policy directions of each city were selected. Focusing on facilities determined by each city, the purpose of this study was to define information technology infrastructure elements for the application of the 5G digital twin facility safety management integrated platform, define categories of implementation services, and suggest a concrete integrated platform configuration plan.

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.808-823
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• 2021

This study was conducted to explore the experience and its meaning of the elderly residents in long-term care facilities(LTCFs). It is aimed to find the role of family and society for the qualitative care of elderly living in LTCF and to seek social welfare measures. For this purpose, qualitative research data was collected by conducting in-depth interviews and participation observations on 8 elderly residents at 4 LTCFs in Seoul, Incheon, and Gyeonggi Province. The collected data were analyzed using Giorgi's phenomenological research method. The analysis results show that 33 semantic units, 14 subcomponents, and 4 upper components. The 4 upper components showed up as 「Crumbling my existence」, 「The life thrown into an unfamiliar environment」, 「New relationship where discomfort and gratitude coexist」 and 「My life I want to find」. Among them, 「My life I want to find」 was the essence of the living experiences of elderly residents in LTCF. Through this study, it was suggested creating an environment to provide facilities access preparation program for the elderly, developing and activating various family participation programs, providing conditions of Aging in place for the elderly, and developing and activating community resource linkage programs.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.40 no.3
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• pp.169-175
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• 2022

Korea's construction industry has a shortage and aging of construction manpower, low productivity compared to other industries, and a high rate of industrial accidents. The Ministry of Land, Infrastructure and Transport is preparing for the 4th industrial revolution and is expanding investment in construction automation and innovative growth engines to improve productivity in the construction industry. In order for new technologies to be utilized in the road construction field, the accuracy of the technologies and the applicability of each type of work must be evaluated. In this study, the accuracy of the mobile mapping system was tried to verify based on the relevant work regulations, and to suggest the applicability of the mobile mapping system to high-speed driving tracks through data acquisition and analysis on road construction sites. The accuracy of the equipment used in the study was verified in accordance with the relevant work regulations, and the possibility of applying the mobile mapping system used for the study to road construction surveying was presented with a maximum error of less than 10cm in the horizontal and vertical directions. In addition, the possibility of utilizing the road construction survey using the mobile mapping system was presented through comparison with the existing method for data acquisition time for construction surveying, production of construction status survey results, and calculation of heatmap and earthworks. In the future, the use of construction status surveying of the mobile mapping system will greatly improve the efficiency of construction work.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.5
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• pp.94-101
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• 2021

According to the Facility Management System (FMS) operated by the Korea Authority of Land & Infrastructure Safety, it is expected that the number of aging facilities that have been in use for more than 30 years will increase rapidly to 13.9% in 2019 and 34.5% in 2929, and end up with a social problem. In addition, with the revision of "Common Application of Seismic Design Criteria" by the Ministry of Public Administration and Security in 2017, it is mandatory to re-evaluate all existing road facilities and if necessary seismic reinforcement should be done to minimize the magnitude of earthquake damage and perform normal road functions. The seismic performance management-decision support technology currently used in seismic performance management practice in Korea only determines the earthquake-resistance reinforcement priority based on the qualitative index value for the seismic performance of individual facilities. However with this practice, normal traffic functions cannot be guaranteed. A new seismic performance management decision support technology that can provide various judgment data required for decision making is needed to overcome these shortcomings and better perform seismic performance management from a road network perspective.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.4
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• pp.121-136
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• 2022

Purpose : Marine therapy is an activity that promotes public health such as constitution improvement, immunity improvement, and anti-aging by utilizing marine therapeutic resources such as seawater, mud, seaweed, salt and sea climate. In Europe developed countries, the marine therapy industry has been developing for centuries, with France, Germany, and Israel leading the way. Currently, it has achieved great industrial achievements and is of great help in improving the human health. The purpose of this study is to investigate how marine therapeutic resources benefit to human health, as well as how to study and utilize their efficacy. We analyzed previous research articles related to the effects of marine therapeutic resources. Methods : The study included a total of 830 published literatures in the last 20 years from the Republic of Korea and other contries. PubMed and Google Scholar were utilized to collect the foreign source while the local scientific publications were accessed through the Korean Education and research Information Service (KERIS) and Korean studies Information Service System (KISS). The keywords used to search foreign literature were "marine therapy", "Thalassotherapy", "seawater", "deep seawater", "saline groundwater", "sand therapy", "mud therapy", "hydrotherapy", "seaweed", "Sun light", "sea salt", "marine animal", and "marine microorganisms" were combined, and for the domestic literature, the keywords were "marine therapy", "marine therapeutic resources", "seawater", and "sand". Results : A total of 830 research papers were found as a result of searching for domestic and international papers related to marine therapeutic resources. The collected documents were classified into 175 seawater resources, 259 marine mineral resources, 41 marine environment, and 355 marine organisms. The efficacy of each marine therapeutic resources was analyzed. By resources type, there were about 213 papers on the efficacy of seaweed, followed by about 175 papers on seawater, 142 on microorganisms, 124 on mud/peat, and sand, salt, minerals and others are appeared in order (Table 1). Conclusion : Korea has the highest marine biodiversity index, excellent tidal flats, four distinct seasons, and various sea environments of the East sea, Yellow sea, South sea and Jeju sea. For this reason, Korea has a much more diverse marine therapeutic resources than other advanced countries in the marine therapy industry. prebiously, we thought that the sea was only valuable as a shipping port and fishery industry. But now, it been shown that the ocean can become a new industrial field which can contribute to human health and well-being by providing healing and therapy to people through the gift of marine resources.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.73-81
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• 2023

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA damage and stress response, cellular metabolism, and aging. SIRTs also influence carcinogenesis, making them potential targets for anticancer therapeutic strategies. In this study, we investigated the anticancer properties and underlying molecular mechanisms of a novel SIRT1 inhibitor, MHY2251, in human colorectal cancer (CRC) cells. MHY2251 reduced the viability of various human CRC cell lines, especially those with wild-type TP53. MHY2251 inhibited SIRT1 activity and SIRT1/2 protein expression, while promoting p53 acetylation, which is a target of SIRT1 in HCT116 cells. MHY2251 treatment triggered apoptosis in HCT116 cells. It increased the percentage of late apoptotic cells and the sub-G1 fraction (as detected by flow cytometric analysis) and induced DNA fragmentation. In addition, MHY2251 upregulated the expression of FasL and Fas, altered the ratio of Bax/Bcl-2, downregulated the levels of pro-caspase-8, -9, and -3 proteins, and induced subsequent poly(ADP-ribose) polymerase cleavage. The induction of apoptosis by MHY2251 was related to the activation of the caspase cascade, which was significantly attenuated by pre-treatment with Z-VAD-FMK, a pan-caspase inhibitor. Furthermore, MHY2251 stimulated the phosphorylation of c-Jun N-terminal kinase (JNK), and MHY2251-triggered apoptosis was blocked by pre-treatment with SP600125, a JNK inhibitor. This finding indicated the specific involvement of JNK in MHY2251-induced apoptosis. MHY2251 shows considerable potential as a therapeutic agent for targeting human CRC via the inhibition of SIRT1 and activation of JNK/p53 pathway.

• Journal of Life Science
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• v.33 no.8
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• pp.612-622
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• 2023

T-cell deficiency may occur in various clinical conditions including congenital defects, cell/organ transplantation, HIV infection and aging. In this regard, the development of artificial thymus has recently been attracting much attention. To achieve this aim, the development of techniques for 3D culture of thymic stromal cells is necessary because thymocytes grown only in a 3D thymic microenvironment can be differentiated fully to become mature, immunocompetent T cells; the same cannot be achieved for thymocytes grown in 2D. This study aimed to develop a nanotechnology-based 3D culture technique using polymeric scaffolds for thymic epithelial cells (TECs), the main component of thymic stromal cells. Scanning electron microscopic observation revealed that the pores of both PCL and PCL/PLGA scaffolds were filled with TECs. Interestingly, TECs grown in 3D on polydopamine-coated scaffolds exhibited enhanced cell attachment and proliferation compared to those grown on non-coated scaffolds. In addition, the gene expression of thymopoietic factors was upregulated in TECs cultured in 3D on polydopamine-coated scaffolds compared to those cultured in 2D. Taken together, the results of the present study demonstrate an efficient 3D culture model for TECs using polymeric scaffolds and provide new insights into a novel platform technology that can be applied to develop functional, biocompatible scaffolds for the 3D culture of thymocytes. This will eventually shed light on techniques for the in vitro development of T cells as well as the synthesis of artificial thymus.

• The Korean Journal of Franchise Management
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• v.2 no.1
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• pp.100-118
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• 2011

Since 1990, income has been grown rapidly in Korea. Thus, concerns of environmental pollution and health have been increased among Korea's consumers. As a result of this concern, demand for safe food and agricultural products has been growing in Korea. Recently, purchasing patterns of Korea's consumers have been changed as Korea's society has changed to an aging society, growth of unmarried person, and low birthrate. Korea's consumers prefer to buy only volume that they need. Thus, the volume of agricultural products that they purchase became small. Therefore, retailers should reflect such needs of consumers to their business. The purpose of this study is to build up new strategies in order to make a high profit through customer's satisfaction when selling agricultural products. Using literature review, this study has drawn results. The results of this study is that retailers should lay products with brand in their store and establish trust with customers in oder to make loyal customers. In addition, retailers should prepare individual package of agricultural products for sales of a small volume to keep pace with social changes.

• 한국노년학
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• v.32 no.2
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• pp.649-668
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• 2012

The purpose of this study ahead of the aging society in Korea to prevent problems of the elderly aged new addiction Internet Addiction and identify factors affecting the quantitative increase and qualitative improvement beyond that aims to promote. To this end, residents in Seoul over the age of 60's targets, local welfare, cultural centers, senior centers and other research in the area through one-on-one interviews were conducted the survey. Findings The average degree of Internet addiction elderly 36.16 points (SD = 10.02) and the distribution of at least 20 points to 65 points, respectively. Factors affecting the degree of Internet addiction as a computer time (β = .248, p <.001), mon allowance (β = .180, p <.01), age (β = .139, p <.01) and social support (β = .087, p <.05), self-efficacy (β = - .078, p <.05), most used location (β = - .116, p <.05), degree of family relationship (β = - .147, p <.01), housing type (β = - .153, p <.01), were of the order, this factor was 17.6% of the variance. In other words, the more computer time, the higher the age, the more mon allowance, housing is not self, the lower the degree of family relationship, the house is not a place most used, lower self-efficacy, social support is high As increasing the degree of Internet addiction was thought to be the two predictor variables. Survey results to target the elderly through the Internet addiction group psychotherapy program implementation, and production and distribution of manuals related to Internet use and addiction-related factors, according to the case-by-case Case management services are tailored to be done, and the Internet in general for seniors potential risks related to use in training and preventive services for the elderly will need to be made.