• Korean Journal of Biological Psychiatry
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• v.7 no.2
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• pp.115-122
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• 2000

The development of molecular biology has brought many changes in psychiatry. Molecular biology makes us possible to know the cause of mental disorders that provide the way to prevent the disorders, and to develop various accurate diagnostic and treatment methods for mental disorders. The author discusses the concept, cause, and treatment of mental disorders in the aspect of molecular biology. Importing the methods of molecular biology into psychiatry, we can anticipate to get a number of the goals of psychiatric genetics, including identification of specific susceptibility genes, clarification of the pathophysiological processes whereby these genes lead to symptoms, establishment of epigenetic factors that interact with these genes to produce disease, validation of nosological boundaries that more closely reflect the actions of these genes, and development of effective preventive and therapeutic interventions based on genetic counseling, gene therapy, and modification of permissive or protective environmental influences. In addition to their capacity to accelerate the discovery of new molecules participating in the nervous system's response to disease or to self-administered drugs, molecular biological strategies can also be used to determine how critical a particular gene product may be in mediating a cellular event with behavioral importance. Molecular biology probably enables us discover the environmental factors of mental disorders and allow rational drug design and gene therapies for mental disorders, by isolation of gene products that facilitate a basic understanding of the pathogenesis of these disorders. A specific genetic linkage may suggest a novel class of drugs that has not yet been tried. With respect to gene therapy, the hypothetical method would use a gene delivery system, most likely a modified virus, to insert a functional copy of a mutant gene into those brain cells that require the gene for normal function.

• Korean Journal of Psychosomatic Medicine
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• v.9 no.1
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• pp.93-102
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• 2001

The relaxation response is a state of profound rest, creates physiological responses directly opposite to the stress response. The relaxation response can be used to counteract the harmful effects of stress. The relaxation response can be elicited by a number of techniques such as diaphragmatic breathing, meditation, progressive muscle relaxation, autogenic training, biofeedback, etc. These relaxation methods in any mental or physical conditions associated with distress and even in normal people have useful benefits for stress control and health enhancement. These relaxation techniques are but one part of a comprehensive stress management program, through regular and continuous practice appropriate for each person, they will make an effective role in stress management. In this review, author reviewed how to practically use meditation, progressive muscle relaxation and autogenic training, in more detail. In the treatment of various stress-related disease, especially in psychiatric disorders, the relaxation technique may be a useful complement to conventional treatment and serves as an intervention between stress and disease.

• Korean Journal of Psychosomatic Medicine
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• v.2 no.1
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• pp.22-33
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• 1994

The author presented several points of experienced materials obtained from the joint meetings of consultation-liaison Psychiatric division with oncologic department in Kyung Hee University Hospital. The joint meetings which have been held regularly every other week were very helpful not only for the psychiatrist but also for the cancer department stags to manage the cancer patients actively. The joint meetings have been progressed into more cohesive and active communication as time goes by. Most of the subjects discussed in the meeting was focused on the psychological and behavioral problems of the cancer patients. Besides, the difficulties arising from the chemotherapy were discussed. Probably the most difficult task for the treatment team was to provide complete information while respecting the patient's right to deny their situation The liaison psychiatrist usually gave comments to the charge doctor and/or nusing staff how to evaluate the patient's behavior and what would be the influential factors in developing the doctor-patient relationship. It was found that many cancer patients and their family members had their own peculiar illness behavior and disease concept which led patients to take non-medical or moreover, anti-therapeutic care. The family members were found to play an influential role in the choice of treatment method and progression of the disease. Another role of the liaison psychiatrist in the oncology ward was to encourage the treatment team members. In the practical point of view, it was not easy for the liaison psychiatrist to have time regularly for the cancer patients to encourage the liaison activities. And it seems to be fundamental that the consultation fee for the liaison psychiatrist should be set up at the resonable level.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.14 no.1
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• pp.81-106
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• 2008

The ECG which used for this paper, is analysis result from alogrisms of arrythmia, and we have studied that how we could certain Cold(寒 )type or Heat(熱) type and that Deficiency(虛) type or Excess(實)type of organs from various special diseases, and we obtained like these results. 1. we depend on our examination about Pulse(脈) because we can't discriminate arrythmia using EKG analysis instruments. 2. We obtained that Cold(寒) type diseases had wave that prolonged above normal baseline and ST wave which had downward aptitude. 3. We obtained that Heat(熱) type diseases had the fibrillation which had shortend wave that compare to normal and had downward aptitude or negative aptitude. 4. We obtained that Respiratory system (肺) diseases had wave that is within normal or is short of normal range and had much fluctuation in potential difference or trans on P wave. 5. The character of EKG which presented about diseases of gastric systems is prolonged above narmal range of wave, and the EKG had represented mixed wave with Heat(熱) type when accompany inflammatory in gastric system. 6. The wave of Blood Stasis(瘀血) type had upward aptitude of QRS wave, and the wave of anemia or blood loss type(少血 ) had downward aptitude of QRS wave, the wave which had both Cold(寒) and Heat (熱) represented mixed waves. 7. The Knotted Pulse(結脈) and Intermittent Pulse(代脈) is corresponded with sinus brady cardia, and the Swift Pulsle(疾脈) is corresponded with fibrillation. 8. We pay attention to the relations of formations about pressures pulse from formations of EMD( electromechanical dissociation ). From these results, we will have to study about EKG which using in tests of change of Parkinsons disease.

• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.42-57
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• 2020

Electroconvulsive therapy (ECT) is indicated for various mental disorders (e.g., major depressive disorder, schizophrenia, and bipolar disorder) and the behavioral and psychological symptoms of dementia in elderly patients. Furthermore, ECT is a useful first-line treatment in emergency and crisis situations such as suicide risk, violent behavior, catatonia, and food refusal, which are more frequent in elderly patients. ECT is also effective in the treatment of the motor symptoms of neurological disorders, such as Parkinson's disease and Huntington's disease. Due to the high risk of various physical diseases, the comorbid physical conditions of elderly patients should be individually controlled to optimize ECT treatment. Compared to young adults, in elderly patients the seizure threshold is higher, the seizure duration is shorter, and the anesthetic dose is lower. On the contrary, the response rate in the elderly is both faster and higher. Considering potential cognitive decline and the prevention of further deterioration of cognitive function in elderly patients, in the absence of significant comorbidities, twice weekly sessions and right unilateral electrode placement with a lower seizure threshold and less cognitive effect are preferred to bilateral electrode placement, which has a high risk of adverse cognitive effects. After an acute course of ECT, continuation and maintenance of ECT, combined with prescription of therapeutic drugs, may prevent possible relapse or recurrence of mental disorders. In conclusion, ECT can be used to treat mental disorders in elderly adults, with safety and effectiveness comparable to that in young adults.

• The Journal of Internal Korean Medicine
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• v.21 no.3
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• pp.515-519
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• 2000

Developing of antibiotic, bacterial meningitis is one of the disease of high mortality. Especially in case of gram negative, pneumococal meningitis, they have high mortality and neurological disorders after treatment. Main symptoms of bacterial meningitis are fever, headache, vomit, neck stiffness and coma etc. In oriental medicine, acute feverish infectious diseases have been treated as wenbing(溫病). We can divide wenbing into 8 kinds. Bacterial meningitis is included as Chunwen(春溫), fengwen(風溫) in the sight of similarity on the symptoms and falling ill. Comparing with CVA, we have too rare cases of treating bacterial meningitis with oriental medicine. A case of sequelae of bacterial meningitis patient diagnosed as Chunon, pungon showed prominent improvement by herb med and acupuncture treatment etc.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.1
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• pp.37-48
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• 2020

Objective : In this article, we overviewed clinical Korean Medicine studies on dementia by analyzing papers published in Korea from 2010 to 2019. Methods : We explored research articles on dementia from 5 Korean research databases using the keyword 'dementia' and 'Korean Medicine'. We included original articles and reviews of clinical Korean Medicine and excluded single case study and experiment article of animal model. Then we analyzed them according to the published year, journal type, and research topics. Results & Conclusions : Research topics were classified into 'research trend', 'treatment', 'prevention', 'evaluation', 'medical expenses', 'collaborative practice' and 'others'. The largest number of articles were published in 2011(24.4%). 'Journal of Oriental Neuropsychiatry' was the journal with the most published articles(46.3%). In research topics, the analyses of research trend accounted for the largest portion(39.0%) and the articles about treatment for dementia or evaluation index in Korean medicine had the second largest proportion(14.6%). We hope that various researches for therapeutic effects, mechanisms and preventive effects of Korean Medicine in dementia would be conducted for future study.

• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.725-732
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• 2005

This study was designed to evaluate the effects of oriental medicine therapy on insomnia and diabetic pruritus. This clinical case was analysed on a patient with diabetus mellitus whose main symptom was sleep disorder, which was attributed to pruritus. The patient was admitted on July 16th, 2004, and departed on September 3rd, 2004. He was treated internally and externally with herbal medicine, acupuncture, and bloodletting therapy. After treatment, pruritus and sleep disorder decreased. The study suggests that orental medicime therapy is effective in treatment of diabetic pruritus accompanied by insomnia.

• The Journal of Internal Korean Medicine
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• v.26 no.2
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• pp.453-458
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• 2005

Epilepsy is a neurological condition that from time to time produces brief disturbances in the normal electrical functions of the brain, Normal brain function is made possible by millions of tiny electrical charges passing between nerve cells in the brain and to all parts of the body. They may affect a person's consciousness, bodily movements or sensations for a short time. These physical changes are called epileptic seizures. These clinical data, gathered an epileptic seizure whose main symptom was convulsion, was analyzed. This clinical report pertains to a 51 year-old man who suffered an epileptic seizure and after effects of weakness. He was treated with ChongsimOndamTang(淸心溫膽湯). The cheif symptom, epileptic seizure, disappeared and general conditions improved after Korean medical treatments, so this is reported as a potential treatment.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.2
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• pp.97-107
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• 2007

Objectives This experiment is about Jojoongikgi-tang(JIT) exerts anti-inflammatory effects in BV2 microglial cells, and the effect of JIT on Nitric oxide(NO) production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells were also demonstrated. Methods To investigate the anti-inflammatory effects of JIT, NO production, expression level of iNOS mRNA, PGE2 synthesis, expression COX-2 mRNA, cell viability, $TNF-{\alpha}$ mRNA expression were examined. Results The expression level of inducible nitric oxide synthase(iNOS) was decreased by JIT, and the production of Prostaglandin E2(PGE2) and the expression of Cox-2 mRNA also were inhibited by JIT. Proinflammatory mediators, such as $TNF-{\alpha}$, $IL-1{\beta}$, IL-12, were inhibited by JIT in a dose-dependent manner. Conclusions JIT have anti-inflammatory effects in BV2 microglial cells and could be used in inflammatory disease.