• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1111-1119
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• 2004

In this study, we investigated that the effects of corynoxeine on the apoptosis by inducible CT105 in PC 12 cells and neuronpathogenic agent as CT105 confirmed with apoptosis, DNA fragmentation, neurite outgrowth and immunocytochemistry analysis This study examines whether corynoxeine have an anti-alzhmeimer agent by inhibition of apoptosis by CT105 and induces neurite outgrowth. Cytotoxicity was assessed in PC12 cell cultures by DNA fragmentation and measuring lactate dehydrogenase (LDH) in the culture media. The treatment of corynoxeine in exposure of cultures to CT105 and provided complete protection against cytotoxicity. CT105-induced cytotoxicity was blocked by apoptotsis, repaired by DNA fragmentation, neurite outgrowth and exposure to CT105 expression and regenerated with neurite outgrowth and immunocytochemistry by corynoxeine. These results indicate that in neuronal cell cultures, damage of T105, repaired excitotoxicity by corynoxeine and CT105-induced cytotoxicity is blocked primarily by the activation of anti-apoptosis.

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.341-359
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• 2000

The following result are obtained through that comparative study on the psychotherapy of oriental and occidental medicine. 1. The shamanism(祝由) and active emotion therapy(移精變氣療法) are a primitive form of psychotherapy. It is an opinion that between active emotion therapy(移精變氣療法) and psychoanalytic therapy or supportive psychotherapy are similar. Also, the basic cognition pattern of shamanism(祝由) is projection. 2. Taoism is inseparably related to the psychotherapy of korean oriental medicine, the major thought has become the ideal base of oriental psychotherapy. 3. According to study of clinical document in relation to oriental psychotherapy, psychotherapy had been widely used by medical cure. 4. The five emotion restraint therapy is a high level psychotherapy of oriental medicine. Oriental psychotherapy that disease caused by surprising must be cure by surprising is like to systematic desensitization in western, and that pseudopsychosis must be cure by patient rely on doctor is like to suggestive therapy in western. 5. There are psychotherapy in western that Supportive psychotherapy, Short-term dynamic psychotherapy, Psychoanalytic therapy, Group psychotherapy, Family therapy, Morita therapy, Hypnotherapy, Autogenic training, Behavioral therapy, Milieu therapy, Occupational therapy, Psychodrama, the others. I think that they have wide application to the psychotherapy of korean oriental medicine.

• Journal of Oriental Neuropsychiatry
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• v.12 no.1
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• pp.67-79
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• 2001

This investigation is to make clear the feature of Zhangzihe's medical care. This investigation had used individual or mixture theory of which is Oriental medicine or Western medicine. I have come to some conclusion from the analysis of medical cases in ${\ulcorner}Rumenshiqin{\Ircorner}$. The conclusion is as followed: 1. Zhangzihe had recognized that the cause of disease's main factor is the internal fever from mental unrest. His such a thought is applied for all process of medical care. 2. He had emphasis on the environment of patients, social mood, individual grade and economic ability, personality and etc. 3. He had thought that the doctor should lead the patient in relationship between doctor and patient. He asked the patient for blind obelience to doctor without the patient's voluntary participation. 4. He had emphasis on the adaptation to medical circumstance.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1276-1282
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• 2008

This experiment was designed to investigate the effect of the ODTCMT and DDTCMT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants. The effects of the ODTCMT and DDTCMT extract on cell death of BV2 microglial cell line treated by $IFN-{\gamma}$ ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide (LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively. The ODTCMT and DDTCMT extract significantly increased cell viability in BV2 microglial cell line treated with $IFN-\nu$. The ODTCMT and DDTCMT extract suppressed the NO and RDS production in BV2 microglial cell line treated by LPS. The ODTCMT and DDTCMT extract groups also showed inhibition of AChE activity in PC-12 cell line. According to the above result, it is suggested that the ODTCMT and DDTCMT extract might be usefully applied for prevention and treatment of Alzheimer's disease. OnDam-TanghapChongMyoung-Tang (ODTCMT), DoDam-TanghapChongMyoung-Tang (DDTCMT), Microglia, acetylcholinesterase, ROS

• Korean Journal of Psychosomatic Medicine
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• v.15 no.1
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• pp.3-6
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• 2007

Anxiety disorders are common illness to general physician. The comorbidity between anxiety disorders and medical illness is not only a diagnostic issue, but also has implications of the course of the disease and its outcome. The comorbid condition requires consideration of each individual illness, their psychological and physiological condition. This article aims to review the literature on the prevalence of anxiety disorders in patients prescribing to psychiatrists and to discuss pharmacological treatment options for patients with a comorbid anxiety disorder and medical illness.

• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.175-181
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• 2014

Objectives It was the aim to examine the association of the thyroid-related hormones with cognitive function, depression, and subjective memory impairment in community-dwelling elders with questionable dementia. Methods The sample consisted of 399 community residents with 'questionable dementia' aged 60 or over in whom serum thyroid-related hormones [thyroid stimulating hormone (TSH) and thyroxine] had been assayed. Cognitive impairment was defined using the Korean version of the Consortium Establish a Registry for Alzheimer's Disease. Depression was diagnosed using the Korean version of Geriatric Depression Scale and subjective memory complaint (SMC) was checked using the subjective memory complaints questionnaire (SMCQ). Age, gender, education, and the presence of apolipoprotein E {\varepsilon}4 were included as covariates. Results There was a significant positive association between verbal fluency test (VFT) score and serum TSH levels (p = 0.01). There was a significant negative association between SMCQ total score and word list memory test (WLMT)(p = 0.002) or word list recall test (WLRT) score (p = 0.013). Conclusions Lower serum TSH levels were associated with semantic memory (VFT), and we found that SMC was associated with episodic memory (WLMT and WLRT) in this sample.

• Journal of Korean Medical Ki-Gong Academy
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• v.3 no.2
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• pp.87-107
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• 1999

This study is about saliva from a GIGONG's point of view, it's importance, and it's funtion that recently medical world proved. And here is GIGONG training with saliva. The results were summarized as follows. 1. It is detected that saliva have function to prevent symptoms of senility and have effect of an $anti{\sim}cancer$ medically in recent years. So it is said that science proved narrowly that so called a predecessor speak of salive interms of high praise and they already experienced. 2. Similar substance to saliva exist in human body besides nature food, but human body have materials that deal with all situation to occur from every kind of environment and disease. And exactly saliva is an example of it. 3. We cannot turn back sweat, blood, tears and sperm again that is out of human body once, but we can swallow again only saliva. Therefore, we must experience training that swallow saliva to make us healthy by ourselves, and we don't have to commit a foolish act to cough up saliva at random that a predecessor speak of in terms of high praise, and to be second to JUNG(精). 4. Saliva is a kind of antibody or hormone, so I think that we need to make a study of using saliva with a GUIGONG that is an example of way to strengthen immunity of human body.

• Journal of Oriental Neuropsychiatry
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• v.3 no.2
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• pp.97-106
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• 1992

The literature which was written about manual technique of 'Four method of conducting the Qi(氣)'suggest the following results. 1. Four method of conducting the Qi(氣) is a total method based on the basic manual method, lifing and thrusting, twisting and rotating(捻轉), timing the insertion and withdrawal(呼吸) ect. 2) Cheongryongphami method(靑龍擺尾法) come to understanding channels and conducting and Qi(氣), Paekhoyodu method(白虎搖頭法) using a channels understanding and Qi(氣) introducing, Changkuthamhyeol method(蒼龜探穴法) using a channels understanding, Ceokpongyeongweon method(赤鳳迎源法) using a collaterals understanding. 3) Cheongryongphami(靑龍擺尾) and Changkuthamhyeol method(蒼龜探穴法) were used on disease like insufficiency symptom-complex(盧證), Paekhoyodu(白虎搖頭) and Ceokpongyeongweon method(赤鳳迎源法) were used on excessivess symptom-complex(實證) of pathogenic factors selectively. But all of them often used on C.V.A. 4) The Yang Channel's points, under the elbow and knee point, are often used as points which are used in "Four method of conducting the Qi(氣), and the Yin, Ren(任) Du(督) channels are used less than the former. 5) The manual techniques of 'Four method of conducting the Qi(氣)' are often used in clinically. "Four method of conducting the Qi(氣)"has been studies as above, but there weren't a lot of literature which is about total manual technique of acupuncture. So there is a need study about it.

• Journal of Oriental Neuropsychiatry
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• v.19 no.1
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• pp.71-81
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• 2008

Objective: Obesity threatens not only the problem of beauty but also health. Furthermore, it could be harmful a chronic disease to increase mortality rate. A purpose of this study is to show a effect of obesity control as developing a herbal medicine, Gyeongshingangjeehwan16 (GGEx16), in order to control obesity that is a harmful factor for healthy. Method : In order to prove the effect of GGEx16, BMI, fat distribution, fat control and fitness score which are closely related with obesity are considered as variables. Each variable is measured, for statistical analysis, using measurement implement of InBody 3.0 which applied a theory of bioimpedence analysis. Result and Conclusion : As a result of statistical analysis for four variables, it was improved that there are the improved effect for obesity because GGEx16 is statistically meaningful better than prior to taking.

• Korean Journal of Psychosomatic Medicine
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• v.5 no.2
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• pp.176-184
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• 1997

Abnormal illness behavior in patients with somatoform disorders were known formed by their traditional disease concepts and somatization-prone socio-cultural factors. The authors evaluated the characteristics of abnormal illness behavior in patients with somatoform disorders(who had somatization) by using abnormal illness behavior questionnaire. Methods : 29 somatoform disorders(SD) and 57 disease controls were compared by clinical characteristics, severity of pain, state anxiety(by Spielberger's State & Trait Anxiety Inventory), depression(by Beck's Depression Inventory) and level of psychosocial stess(by DSM-III-R). The illness behavior was measured by illness Behavior Questionnaire(IBQ). Results SD group had longer period of somatic symptoms with less severity in pain. The degree of anxiety and depression were higher in SB compared with controls. However, the degree of psychosocial stress was almost same between both groups. In IBQ, SD showed higher scores in general hypochondriasis, disease conviction, and affective disturbance subscales compared to control group. Conclusion: High disease conviction and hypochondriacal nature revealed by IBQ seemed to be a role in making somatization by way of somatic focusing and hypervigilance. And those tended to lead patients visit hospital frequently and report various somatic complaints. Evaluating abnormal illness behavior in somatoform disorders would be not only helpful in understanding the natures of somatoform disorders but also useful differentiating SD with other psychiatric conditions.