• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.127-131
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• 2021

Neuroendocrine tumor is one of popular diseases, and somatostatin receptor antagonists have been considered as promising agents for neuroendocrine tumors. Imaging of somatostatin receptor is useful approach on the diagnosis and therapy of neuroendocrine tumors. Thus, several radiolabeled somatostatin derivatives have been developed by scientists, and used for patients with neuroendocrine tumors. In particular, some radiopharmaceuticals for neuroendocrine tumors were approved by FDA. In this highlight review, the development of important radiolabeled somatostatin derivatives is described.

• The Korean Journal of Cytopathology
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• v.19 no.1
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• pp.9-15
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• 2008

The major categories of neuroendocrine tumors of lung are typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma. The histologic classification criteria of neuroendocrine tumors are well documented in the "WHO Classification of Tumors" based on mitotic figures and necrosis. Cytologic characteristics of neuroendocrine tumors are trabecular, acinar, and solid arrangement of tumor cells and occasional rosette formation. Nuclear chromatin patterns are characteristically described as "salt and pepper chromatin pattern". Many of cytologic classifications documented in the literature are before the "WHO Classification". In this review, the cytologic features of pulmonary neuroendocrine tumors are documented according to the WHO classification, and recent concepts of neuroendocrine tumors of lung are discussed.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1996.04a
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• pp.86-86
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• 1996

amine 전구물질을 흡수하며 신경분비과립을 함유하고 있는 것으로 밝혀진 neuroendocrine cell의 후두상피 내에서의 구조와 분포를 알기 위하여 고양이 후두 상피조직을 이용, 면역조직화학적 염색법으로 관찰하였다. neuroendocrine cell은 방추체 모양이었으며 후두강쪽의 첨부돌기는 미세돌기를 갖고 있었으며 기저막에 접하고 있는 세포질돌기에는 많은 수의 농심과립을 함유하고 있었다. neuroendocrine cell은 calcitonin gene-related peptide, substance P, 5-hydroxytryptamine들 함유하고 있었으며 protein gene product 9.5, neuron-specific enolase에 면역양성반응을 보였으며 성문하부에 가장 많이 분포하고 있었다. 이로 미루어 neuroendocrine cell은 고양이 성대에서 어떤 자극을 받으면 다양한 펩티드를 분비하여 내분비 혹은 paracrine 경로를 통하여 후두 기능 조절에 관여한다고 사료된다.

• Korean Journal of Head & Neck Oncology
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• v.35 no.2
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• pp.45-49
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• 2019

Large cell neuroendocrine carcinoma is a rare epithelial neuroendocrine malignancy and is preferentially located in gastrointestinal tract and pancreas. Cases of large cell neuroendocrine carcinoma have been reported in many other locations, including the thymus, gallbladder, prostate, larynx, salivary glands, nasopharynx, tonsil and mastoid. However, primary sinonasal large cell neuroendocrine carcinoma never have been reported in Korea. We experienced a case of primary large cell neuroendocrine carcinoma arising from left maxillary sinus recently. A 82-year-old male patient presented with nasal obstruction and epistaxis. The biopsy revealed large cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT3N0M0. The patient was treated by combined radiotherapy and chemotherapy. We report this rare case with literature review.

• Journal of Chest Surgery
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• v.35 no.12
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• pp.909-913
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• 2002

The large cell neuroendocrine carcinoma is uncommon and its diagnostic criteria was recently established as pulmonary neuroendocrine carcinoma. A 74-year-old man who was a heavy smoker without symptoms was presented with a lung mass in right lower lobe. He was diagnosed as having large cell neuroendocrine carcinoma by needle biopsy. He was treated with right lower lobe lobectomy and mediastinal lymph node dissection. We experienced one case of large cell neuroendocrine carcinoma of lung and report it with reference.

• Korean Journal of Head & Neck Oncology
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• v.20 no.2
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• pp.198-201
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• 2004

Neuroendocrine carcinomas are rare neoplasms of the hypopharynx. Neuroendocrine neoplasms are divided into four main types : carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. The diagnosis is primarily based on light microscopy and should be confirmed by immunohistochemical investigation. Small cell neuroendocrine carcinoma of the hypopharynx is extremely uncommon tumor and surgical results for this tumor have been disappointing. Chemotherapy and radiotherapy currently appear the most effective forms of therapy. We report our case of small cell neuroendocrine carcinoma of the hypopharynx with the brief review of literatures.

• Proceedings of the Zoological Society Korea Conference
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• 2001.10a
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• pp.185.2-186
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• 2001

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 2001.10a
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• pp.203.2-203
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• 2001

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.192.1-192
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• 2000

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.192.3-193
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• 2000

No Abstract, See Full Text