• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.205-213
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• 2018

The purpose of this study was to investigate the effect of somatosensory input on the gait ability and equilibrium sensory of elderly women. The subjects who participated in this study were 31 elderly women with a mean age of 75 years or older who no using a walking stick and had no abnormality in otolaryngology. The control group consisted of 30 elderly women who did not exercise regularly more than twice a week. Dependent variables consisted of 2.44m timed up and go test, 10m usual gait, 10m fast gait and 6minute gait. The equilibrium sensory test was performed using EquiTest (NeuroCom, USA). The results of the study on gait ability were not statistically significant for 2.44m timed up and go test, and 10m usual gait. However, 10m fast gait (P<.001) and 6min gait (P<.05) showed significant differences. According to the results of the study on equilibrium sensory ability, there was no significant difference between Condition 1 and Condition 5 however Condition 2 (P<.01), Condition 3 (P<.01), Condition 4(P<.01) and Condition 6 (P<.05) showed statistically significant differences. In conclusion, walking stick have beneficial effects on walking and equilibrium sensation, and elderly women need to actively use walking stick when going out and walking.

• Korean Journal of Radiology
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• v.24 no.3
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• pp.235-246
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• 2023

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27-82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrast-enhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46-4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01-2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.

• Smart Structures and Systems
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• v.20 no.1
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• pp.61-74
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• 2017

One of the most reliable and simplest tools for structural vibration control in civil engineering is Tuned Mass Damper, TMD. Provided that the frequency and damping parameters of these dampers are tuned appropriately, they can reduce the vibrations of the structure through their generated inertia forces, as they vibrate continuously. To achieve the optimal parameters of TMD, many different methods have been provided so far. In old approaches, some formulas have been offered based on simplifying models and their applied loadings while novel procedures need to model structures completely in order to obtain TMD parameters. In this paper, with regard to the nonlinear decision-making of fuzzy systems and their enough ability to cope with different unreliability, a method is proposed. Furthermore, by taking advantage of both old and new methods a fuzzy system is designed to be operational and reduce uncertainties related to models and applied loads. To design fuzzy system, it is required to gain data on structures and optimum parameters of TMDs corresponding to these structures. This information is obtained through modeling MDOF systems with various numbers of stories subjected to far and near field earthquakes. The design of the fuzzy systems is performed by three methods: look-up table, the data space grid-partitioning, and clustering. After that, rule weights of Mamdani fuzzy system using the look-up table are optimized through genetic algorithm and rule weights of Sugeno fuzzy system designed based on grid-partitioning methods and clustering data are optimized through ANFIS (Adaptive Neuro-Fuzzy Inference System). By comparing these methods, it is observed that the fuzzy system technique based on data clustering has an efficient function to predict the optimal parameters of TMDs. In this method, average of errors in estimating frequency and damping ratio is close to zero. Also, standard deviation of frequency errors and damping ratio errors decrease by 78% and 4.1% respectively in comparison with the look-up table method. While, this reductions compared to the grid partitioning method are 2.2% and 1.8% respectively. In this research, TMD parameters are estimated for a 15-degree of freedom structure based on designed fuzzy system and are compared to parameters obtained from the genetic algorithm and empirical relations. The progress up to 1.9% and 2% under far-field earthquakes and 0.4% and 2.2% under near-field earthquakes is obtained in decreasing respectively roof maximum displacement and its RMS ratio through fuzzy system method compared to those obtained by empirical relations.

• Korean Institute of Interior Design Journal
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• v.23 no.6
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• pp.115-124
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• 2014

This study has carried out scanning tests in order to figure out the features of scanning search by sex of space users, with the result of which the validity of data has been estimated. In this research, the scanning patterns were set up for verifying the typology of scanning paths and then the reason for determining scanning paths and the validity of estimation method were reviewed. Since the observation features depends on sex, the analysis of visual activities for acquiring any information in a space will reveal the intention and purpose of space users. The findings by analyzing the features of scanning pattern by sex which were found at the determination of scanning patterns can be defined as the followings. First, for estimating the process of space-information search, the movement distance at each point of continuative-observation data from the angle of eye-movement has been extracted, on the ground of which the fixation and movement of eye have been defined for the establishment of scanning-cut characteristics. Second, the scanning times were estimated for the extraction of effective observation data that would be used for comparative analysis, which showed that men had more data (3,398.2/64.4%) than women (2,998.2/55.6%). This enables the acknowledgment that the scanning cut of men was relatively less, which indicates that men will acquire more information on space than women in the process of observing any space. Third, men's scanning times (58.0 times/2.02 seconds) were less than those of women (71.9 times/1.39 seconds) while the scanning time of the former was longer than that of the latter, which shows the feature that it takes longer for men than women in scanning while the scanning times of the former is less than those of the latter. Fourth, the observation features can be determined that the combination of this result with the predominance character by sex for a general viewpoint to be employed indicates that while men employ mixed-scanning for observation activities to acquire space-information spending for longer time, women, by concentrated-scanning, focus on a single point for shorter time or stay at one location for a considerably long time for space-information acquirement.

• Journal of Korean Public Health Nursing
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• v.7 no.1
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• pp.81-97
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• 1993

This study was carried out to analyze the factors of the perieved symptoms of fatigue of the industrial workers, to examine the inter-relatisnship of the above factors with their general charactenstics and the environments of working area for the examination of their health status and the effective health management of them. This study was undertaken from December 1 to December 20, 1990. The subjets were 495 workers who had worked at the Industrial complex located in Chonbuk Province. The result of this study were as follows: 1. The worker's percieved symptoms of fatigue were classified to the following seven factors; A) Musculo-Skeletal Symptoms, B) Neuro-Psychial Symptoms, C) Optical Symptoms, D) Heart Symptoms, E) Head Symptoms, F) Respiratory Symptoms, G) Genital Symptoms 2. Analysis of the inter-relationship of their percieved symptoms of fatigue with general characteristics; 1) The difference of distribution to their percieved symptoms of fatigue according to sexuality was significant; Female were higher than Male $(p{\leqq}0.001$, p<0.005) 2) The difference of distribution to their percieved symptoms of fatigue according to age was significant; Age group under 24 years of age were higher than the other's group (p<0.001). 3) The difference of distribution to their percieved symptoms of fatigue according to the level of education was significant; Workers who stand on a low intellectual were higher than workers on a high intellectual level. 4) The difference of distribution to their percieved symptoms of fatigue for a week was the highest when worked at sunday. 5) The difference of distribution to their percieved symptoms of fatigue for seasons was high at spring. 3. Analysis of the inter-relationship of their percieved symptoms of fatigue with the environments of working area. 1) The difference of distribution of their percieved symptoms of fatigue according to the working department was significant; Production workers were higher than office workers. 2) The difference of distribution of their percieved symptoms of fatigue related with working posture was significant; Sitting: Musculo-Skeletal symptoms (p<0.05), Optical symptoms (p<0.005) 3) The more dissatisfied with their's own duty they were, the higher became the distribution of their percieved symptoms of fatigue (p<0.001. p<0.005, p<0.05) 4) The more dissatisfied with their working condition they were, the higher became the degree of their percieved symptoms of fatigue (p<0.001. P<0.05) 5) The difference of distribution of their percieved symptoms of fatigue according to kinds of job was significant: Workers who has handled heavy materials were higher than who had not handled $(p{\leqq}0.001$, p<0.05). Workers who has handled chemical materials: Optical, symptoms $(p{\leqq}0.001)$. Workers who has handled dusty materials: Respiratory symptoms (p<0.01) 6) The environment of working area was significantly affected to the distribution of their percieved symptoms of fatigue: Workers complains of a illumination problem; Optical symptoms (p<0.005), Heart symptoms (p<0.005) Workers complains of a ventilation problem: Heart symptoms (p<0.05), Optical symptoms, Heart symptoms (p<0.01) Musculo-skeletal symptoms ($p{\leqq}0.001$)

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.245-257
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• 2000

A clinical study was done 40 patients of chronic prostatitis who was treated in Dept. of Internal Medicine, Oriental Medicine Hospital, Taejon University, from 1 Mar. 1999 to 31 Oct. 1999. The results were as follows. 1. In distribution of age, 30's and 40's were 57.5% the most, 20's and 60's were 35.0%, 50's was 7.5%. 2. In distribution of past history, the urethritis(45.0%) was the most. 3. In distribution of ocupation, a white-collar worker was 35.0%, a business man was 22.5%, a public servant was 12.5%, etc. 4. Sitting the mean time of day were distributed 5~7 hours, above 7 hours, 3~5 hours, under 3 hours, etc. 5. The resting interval of a long distance drive were distributed 2 hours(35.0%), 3 hours(32.5%), etc. 6. The habit of enduring ejaculation during sexual intercourse was showed 45.0%. 7. The habit of enduring urination was showed 20.0%. 8. Influency of mental stress was showed 90.0%. 9. Ten cases(25.0%) were showed riding horse or riding bicycle. 10. Four cases(10.0%) were showed wearing tight trousers. 11. The habit of put a wallet his hip pocket was showed 57.5%. 12. The most common symptom was distributed the others symp-tom(66.8%) and the voiding symptom(63.3%) more than pain-neuro-logical symptom(37.5%) and symptom related with sexual function (26.6%). 13. In distribution of palpation, lower abdominal pain, lumbar pain, perineal or parascrotal pain were mostly showed right side. Moreover diagnosis of pulsation was weakly showed chi pulse of right. 14. Duration of disease were distributed above 1 year(82.5%), under 1 year(17.5%). Degree of prostatitis was severe showed adove 1 year. 15. The distribution of WBC count of the prostatic secretion, com-paring with before therapy and after therapy, were showed from 5 cases to 0 case in very many/HPF, from 23 cases to 13 cases in many/HPF, from 12 cases to 13 cases in 10~30/HPF, from 0 case to 13 cases in under 10/HPF. 16. Therapeutic improvement of symptom were distributed pain-neurological symptom(94.8%), the others symptom(90.8%), the void-ing symptom(89.6%) and symptom related with sexual function(67.5%). 17. Differentiation of symptoms and signs were distributed dificiency of spleen-lung vital energy, wetness-heat of lower warmer, dificiency of spleen-kidney yang, dificiency of kidney yin, wetness-phlegm, dificiency of vital energy and blood. The prescriptions were Bojungikgitang(44.6%), Yukmijihwangtang(20.7%), Palmijihwangtang(12.0%), etc.

• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.1-11
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• 1998

Ameliorating mechanisms of red ginseng on learning deficits were investigated in the following 3 experiments; its effects on 1) place learning deficits in aged rats and in young rats with selective hippocampal lesions (behavioral study), 2) long-term potentiation in the hippocampal formation (neuro- physiological study), and 3) ChAT (choline acetyl transferase) activity in various brain regions of aged rats (pharmacological study). In the behavioral study, first, performance in the place learning tasks were compared among 3 groups of young and aged rats; control young intact rats (10-12 week old) treated with water, aged rats (28-32 month old) treated with water, and aged rats (28-32 month old) treated with red ginseng (100 mghglday) suspended in water. Second, performance in the place learning tasks was compared among 3 groups of young rats; control intact rats treated with water, rats with bilateral hippocampal lesions treated with water, and rats with bilateral hippocampal lesions treated with red ginseng (100 mg/kg/day). Each rat in these 2 behavioral experiments was tested with the 3 types of the place learning tasks in a circular open field using intracranial self-stimulation (ICSS) as reward. The ICSS reward was delivered if the rat (1) moved distance of 100-160 cm (DMT): (2) entered an experiment-determined reward place within the open field, and this place was randomly varied in sequential trials (RRPST); or (3) entered 2 specific places, and did a shuttle behavior between the 2 places (PLT). Performance of the aged rats in the ginseng group was not significantly different from that of control young rats in ICSS (current intensity, bar press rates), DMT and RRPST. However, treatment with red ginseng significantly ameliorated place-navigation learning deficits in aged rats in the PLT. Similarly, red ginseng ameliorated learning and memory deficits in young rats with hippocampal lesions in the same tasks. In the neurophysiological study using young rats, perfusion of hippocampal slices with non-sapon in fraction of red ginseng significantly enhanced magnitudes of the long-term potentiation (LfP) in the CA3 subfield. In the pharmacological study, treatment with red ginseng did not affect ChAT activity in aged rat brain including the hippocampal formation. These results strongly suggest that red ginseng ameliorates learning and memory deficits in aged rats through actions on the CA3 subfield of the hippocampal formation, which were independent of the presynaptic components of the cholinergic system

• Korean Journal of Digital Imaging in Medicine
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• v.13 no.2
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• pp.83-90
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• 2011

To prospectively determine the diagnostic performance a combination of standard bolus-chase magnetic resonance (MR) angiography and MR angiography with time-resolved imaging of contrast kinetics (TRICKS) for depicting severity of the head and neck vascular diseases. Over a period of two months, A total of 100 patients(average ages : $50{\pm}8$, male : 60, female : 40) with head and neck vascular diseases were performed on the GE excite 3.0 T units with 8-channel head coil and 4-channel NV coil. Imaging parameters for a typical study were as follow: SBC(TR/ TE/ FA/ SliceThicken./ Slab/ Freq./ FOV/ BW/Scan Time) = 5.4/ min/ 30/ 2/ zip2/ 70/ $224{\times}448$/ 30/ 62.50/ 28, TRICKS(TR/ TE/ FA/ Slice Thicken/Slab/ Freq./ FOV/ BW/ Temp Res./ Scan Time = 3.6/ min/ 25/ 4/ 30/ $160{\pm}384$, zip512/ 30/ 100/ 1 to 1.5/ 23). The analysis of all MR images, which have respect-ively classified two techniques into some diseases. The results of the former were divided into two groups(SBC, TRICKS)with 4 grading of two reader, respectively. Wilcoxon signed rank test was used to determine if a significant difference between imaging techniques existed(p < 0.05). In 33 of 100 patients, arterio-venous malformation was 11% at TRICKS, subclavian vein stenosis : 8%, fistular sinus : 4%, jugular vein stenosis:6%, Middle Cerebral Artery bypass surgery : 4%, p < 0.05). The rest of 67 patients were considered as the results of SBC(14% in the basilar artery stenosis, carotid stenosis : 16%, vertebral stenosis : 17%, central neuro-cytoma : 5%, meningioma : 5%, Not appliable : 10%, p < 0.05). Sensitivity and specificity of TRICKS MR angiography in SVS, FS, JVS, MCABS were improved compared with those at standard MR angiography. In SBS MR angiography which were improved in BAS, CS, VS, CN, Meningioma. In conclusion, TRICKS MR angiography of the SVS, FS, JVS, MCABS is superior to standard MR angiography regarding the number of diagnostic grading. The SBS MR angiography were improved in BAS, CS, VS, CN, Meningioma. and assessment of the degree of luminal narrowing on both TRICKS and SBS.

• Genomics & Informatics
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• v.14 no.2
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• pp.62-68
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• 2016

Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 ($p=6.42{\times}10^{-7}$), rs34594869 ($p=6.53{\times}10^{-7}$) and rs17124504 ($p=6.53{\times}10^{-7}$) in 14q31.3 and rs140155614 ($p=8.64{\times}10^{-7}$) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 ($p=6.35{\times}10^{-7}$) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.

• Korean Journal of Radiology
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• v.24 no.6
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• pp.553-563
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• 2023

Objective: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging-derived tractography (DTI-t) contribute to the localization of language areas, but their accuracy remains controversial. This study aimed to investigate the diagnostic performance of preoperative fMRI and DTI-t obtained with a simultaneous multi-slice technique using intraoperative direct cortical stimulation (DCS) or corticocortical evoked potential (CCEP) as reference standards. Materials and Methods: This prospective study included 26 patients (23-74 years; male:female, 13:13) with tumors in the vicinity of Broca's area who underwent preoperative fMRI and DTI-t. A site-by-site comparison between preoperative (fMRI and DTI-t) and intraoperative language mapping (DCS or CCEP) was performed for 226 cortical sites to calculate the sensitivity and specificity of fMRI and DTI-t for mapping Broca's areas. For sites with positive signals on fMRI or DTI-t, the true-positive rate (TPR) was calculated based on the concordance and discordance between fMRI and DTI-t. Results: Among 226 cortical sites, DCS was performed in 100 sites and CCEP was performed in 166 sites. The specificities of fMRI and DTI-t ranged from 72.4% (63/87) to 96.8% (122/126), respectively. The sensitivities of fMRI (except for verb generation) and DTI-t were 69.2% (9/13) to 92.3% (12/13) with DCS as the reference standard, and 40.0% (16/40) or lower with CCEP as the reference standard. For sites with preoperative fMRI or DTI-t positivity (n = 82), the TPR was high when fMRI and DTI-t were concordant (81.2% and 100% using DCS and CCEP, respectively, as the reference standards) and low when fMRI and DTI-t were discordant (≤ 24.2%). Conclusion: fMRI and DTI-t are sensitive and specific for mapping Broca's area compared with DCS and specific but insensitive compared with CCEP. A site with a positive signal on both fMRI and DTI-t represents a high probability of being an essential language area.