• 제목/요약/키워드: Neural implant

검색결과 42건 처리시간 0.028초

증가된 기계적 강도 및 양방향 신호 검출이 가능한 3차원 폴리이미드 기반 뉴럴 프로브 개발 (Development of 3-Dimensional Polyimide-based Neural Probe with Improved Mechanical Stiffness and Double-side Recording Sites)

  • 김태현;이기근
    • 전기학회논문지
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    • 제56권11호
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    • pp.1998-2003
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    • 2007
  • A flexible but implantable polyimide-based neural implant was fabricated for reliable and stable long-term monitoring of neural activities from brain. The developed neural implant provides 3-dimensional (3D) $3{\times}3$ structure, avoids any hand handling, and makes the insertion more efficient and reliable. Any film curvature caused by residual stress was not observed in the electrode. The 3D flexible polyimide electrode penetrated a dense gel whose stiffness is close to live brain tissue, because a ${\sim}1{\mu}m$ thick nickel was electroplated along the edge of the shank in order to improve the stiffness. The recording sites were positioned at both side of the shank to increase the probability of recording neural signals from a target volume of tissue. Impedance remained stable over 72 hours because of extremely low moisture uptake in the polyimide dielectric layers. At electrical recording test in vitro, the fabricated electrode showed excellent recording performance, suggesting that this electrode has the potential for great recording from neuron firing and long-term implant performance.

Transfer learning in a deep convolutional neural network for implant fixture classification: A pilot study

  • Kim, Hak-Sun;Ha, Eun-Gyu;Kim, Young Hyun;Jeon, Kug Jin;Lee, Chena;Han, Sang-Sun
    • Imaging Science in Dentistry
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    • 제52권2호
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    • pp.219-224
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    • 2022
  • Purpose: This study aimed to evaluate the performance of transfer learning in a deep convolutional neural network for classifying implant fixtures. Materials and Methods: Periapical radiographs of implant fixtures obtained using the Superline (Dentium Co. Ltd., Seoul, Korea), TS III(Osstem Implant Co. Ltd., Seoul, Korea), and Bone Level Implant(Institut Straumann AG, Basel, Switzerland) systems were selected from patients who underwent dental implant treatment. All 355 implant fixtures comprised the total dataset and were annotated with the name of the system. The total dataset was split into a training dataset and a test dataset at a ratio of 8 to 2, respectively. YOLOv3 (You Only Look Once version 3, available at https://pjreddie.com/darknet/yolo/), a deep convolutional neural network that has been pretrained with a large image dataset of objects, was used to train the model to classify fixtures in periapical images, in a process called transfer learning. This network was trained with the training dataset for 100, 200, and 300 epochs. Using the test dataset, the performance of the network was evaluated in terms of sensitivity, specificity, and accuracy. Results: When YOLOv3 was trained for 200 epochs, the sensitivity, specificity, accuracy, and confidence score were the highest for all systems, with overall results of 94.4%, 97.9%, 96.7%, and 0.75, respectively. The network showed the best performance in classifying Bone Level Implant fixtures, with 100.0% sensitivity, specificity, and accuracy. Conclusion: Through transfer learning, high performance could be achieved with YOLOv3, even using a small amount of data.

신경모델링을 이용한 인공와우 전기자극 패턴 연구 (Study on Electric Stimulus Pattern in Cochlear Implant Using a Computer Model)

  • 양혜진;우지환
    • 전자공학회논문지
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    • 제49권12호
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    • pp.249-255
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    • 2012
  • 청각 신경의 정상적 기능 회복을 위해 사용하는 인공와우는 인체 조직에 손상을 주는 단상파 방식의 펄스 대신 전하량 균형을 이루는 이상파 방식의 전기적 펄스를 사용한다. 본 논문에서는, Hodgkin-Huxley 신경 모델에 기반하여 다양한 전기적 펄스 방식의 자극이 신경 반응에 미치는 영향에 대하여 연구하였다. 전기적 펄스의 펄스 폭, 펄스간 간격 등을 변화시키면서, 청각신경의 역치, 반응 범위, 반응 시간 등을 측정하였다. 이러한 결과는 인공와우 시스템의 효과적인 자극 방식을 디자인 하는데, 활용 될 수 있으리라 기대된다.

체내 이식 신경 신호 기록 장치를 위한 저전압 저전력 아날로그 Front-End 집적회로 (A Low-Voltage Low-Power Analog Front-End IC for Neural Recording Implant Devices)

  • 차혁규
    • 전자공학회논문지
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    • 제53권10호
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    • pp.34-39
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    • 2016
  • 본 논문에서는 체내 이식용 신경 신호 기록 장치를 위한 저전압 저전력 아날로그 front-end 집적회로를 설계하였다. 제안된 집적 회로는 1 Hz에서 5 kHz 주파수 대역에 존재하는 신경 신호를 처리하기 위해 저잡음 neural 증폭기와 대역폭 조절이 가능한 능동 bandpass 필터로 구성되어 있다. Neural 증폭기는 우수한 잡음 특성을 위해 source-degenerated folded-cascode 연산증폭기를 기반으로 하여 설계하였고, 능동 필터의 경우 저전력의 current-mirror 연산증폭기를 이용하여 설계하였다. 능동 필터의 high-pass cutoff 주파수는 1 Hz에서 300 Hz까지 제어가 가능하며, low-pass cutoff 주파수는 300 Hz에서 8 kHz까지 제어가 가능하다. 전체 아날로그 front-end 회로는 53.1 dB의 전압 이득 성능과 1 Hz에서 10 kHz 대역에 대해서 $4.68{\mu}Vrms$의 입력 잡음 성능과 3.67의 noise efficiency factor 성능을 보인다. $18-{\mu}m$ CMOS 공정을 이용하여 설계를 하였고 1-V 전원에서 $3.2{\mu}W$의 전력 소모 성능을 갖는다. 칩 레이아웃 면적은 $0.19 mm^2$ 이다.

A Multi-photodiode Array-based Retinal Implant IC with On/off Stimulation Strategy to Improve Spatial Resolution

  • Park, Jeong Hoan;Shim, Shinyong;Jeong, Joonsoo;Kim, Sung June
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제17권1호
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    • pp.35-41
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    • 2017
  • We propose a novel multi-photodiode array (MPDA) based retinal implant IC with on/off stimulation strategy for a visual prosthesis with improved spatial resolution. An active pixel sensor combined with a comparator enables generation of biphasic current pulses when light intensity meets a threshold condition. The threshold is tuned by changing the discharging time of the active pixel sensor for various light intensity environments. A prototype of the 30-channel retinal implant IC was fabricated with a unit pixel area of $0.021mm^2$, and the stimulus level up to $354{\mu}A$ was measured with the threshold ranging from 400 lx to 13120 lx.

Neurogram을 이용한 인공와우 자극기법 평가 연구 (Evaluation of Stimulus Strategy for Cochlear Implant Using Neurogram)

  • 양혜진;우지환
    • 대한의용생체공학회:의공학회지
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    • 제34권2호
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    • pp.47-54
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    • 2013
  • Electrical stimulation is delivered to auditory nerve (AN) through the electrodes in cochlear implant system. Neurogram is a spectrogram that includes information of neural response to electrical stimulation. We hypothesized that the similarity between a neurogram and an input-sound spectrogram could show how well a cochlear implant system works. In this study, we evaluated electrical stimulus configuration of CIS strategy using the computational model. The computational model includes stochastic property and anatomical features of cat auditory nerve fiber. To evaluate similarity between a neurogram and an input-sound spectrogram, we calculated Structural Similarity Index (SSIM). The results show that the dynamic range and the stimulation rate per channel influenced SSIM. Finally, we suggested the optimal configuration within the given stimulus CIS. We expect that the results and the evaluating procedure could be employed to improve the performance of a cochlear implant system.

신경회로망을 이용한 다중 전극 와우각 이식 시스템용 음성처리 알고리즘 (A Neural Speech Processing Algorithm for Multielectrode Cochlear Implant System)

  • 최진영;조진호;이건일
    • 대한의용생체공학회:의공학회지
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    • 제11권1호
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    • pp.83-88
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    • 1990
  • A New speech processing algorithm using neural networks is proposed. We transform input data into frequency domain and process them by neural networks of 22 output neurons which have Bark scale on the ground that the Bark scale is similiar with that of the characteristics of human cochlea. An utilized neural network is multilayer perceptron, and the characteristics of cochlea have it trained by error back propagation learning algorithm. The trained neural networks suffices functions of human cochlea including the effects of automatic gain control, compression and equalization. Simulation results show that the proposed speech processing algorithm has good performance in automatic gain control, compression and equalization.

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이식형 전자의료기 연구동향과 기술개발의 과제 (Research Trends and Challenges in Technology Development of Medical Electronic Implant Devices)

  • 조진호
    • 대한의용생체공학회:의공학회지
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    • 제29권6호
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    • pp.415-430
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    • 2008
  • The technologies in medical electronic implant(MEI) devices are developing rapidly, and already, there are various kinds of the MEI devices in the current medical equipments market. Recently, the global market scale of MEI devices have been increased about 13% year by year, and the import amount of MEI devices in Korea is increasing rapidly. In the near future, the demands of MEI devices will be magnificently increasing by the continuous development of the biomedical electronics devices which coupled with neural, brain and other organs will bring us to tremendous effects, such as providing new therapeutic solutions to patients, extension and saving human life, and an important clue of medical development. However, the investment of the research and the activity of developments in this field are still very weak in the Korea. Consequently, this paper introduces about the research trends of MEI devices, and technological problems those must be solved, and then concludes with the suggestions in order to be the leading country in this field.

전기 자극 청신경 복합활동전위: 변인 영향 (Electrical Compound Action Potential: Effects of different parameters)

  • 허승덕
    • 재활복지공학회논문지
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    • 제8권1호
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    • pp.9-17
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    • 2014
  • 전기 자극 청신경 복합활동전위(electrical compound action potential; ECAP)는 인공와우로 청신경을 자극하고 동시에 반응을 기록한다. 이 연구는 인공와우에서 ECAP의 효용성을 높이기 위하여 자극과 기록에 대하여 연구하고자 한다. 대상은 문헌 또는 사례 연구를 제외한 연구 논문 34 편으로 하였다. 연구는 펄스 및 자극 조건, 잡파 억제 및 기록 조건 등을 분석하였다. 효과적인 신경 발화, 안정적인 역치 확인, 신경 퇴행 방지 등을 위해서는 펄스폭과 위상 간격이 가급적 짧고, (-)위상이 앞선 양위상 펄스를 사용하였다. 자극은 펄스 간격, 자극비율, 자극 방식 등을 정하여 와우의 첨부, 중간, 기저회전으로 C-level 정도로 하였다. 잡파는 전방차폐법, 거푸집소거법으로 제거하였고, 분명한 파형을 획득하기 위해서는 전극 간격, 증폭 정도, 평균 가산 회수 등의 추가 조절이 필요하다.

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