• Journal of KIISE:Information Networking
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• v.30 no.2
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• pp.270-281
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• 2003

ETF made the RFCs of MPLS technologies for providing the QoS of ATM or Frame Relay and the flexibility&scalability of IP on the Internet services. IETF has been expanding MPLS technologies as a common control component for supporting the various switching technologies called GMPLS. Also, IETF has standardized the signaling protocols based on such technologies, such as LDP, CR-LDP and RSVP-TE. ETRI developed the MPLS system based on ATM switch in order to provide more reliable services, differentiated services and value-added services like the VPN and traffic engineering service on the Korea Public Sector network. We are planning on deploying model services and commercial services on that network. This paper explains the basic functions of LDP, design and development of LDP on our system, and compares with LDP development and operation on other MPLS systems made by Cisco, Juniper, Nortel and Riverstone. In conclusion, this paper deduces the future services and applications by LDP through these explanation and comparison.

• Journal of KIISE:Information Networking
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• v.34 no.1
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• pp.73-80
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• 2007

This paper presents an approach to support dynamic QoS(Quality of Service) requirements of largely emerging SIP(Session Initiation Protocol) multimedia applications in broadband access networks. The topology of QoS-enabled broadband access networks and its operational model to support SIP QoS are firstly suggested. And then the procedures to bind QoS-enabled SIP signaling into an IP QoS mechanism are presented. In this paper, DiffServ-based IP QoS architecture is deployed due to the complexity problem of the other IntServ architecture, and COPS(Common Open Policy Service) and COPS-PR protocol based signaling mechanisms are used to support dynamic DiffServ QoS, correspondent with dynamic SIP QoS. The broadband access network is assumed to support rapidly expanding Metro Ethernet 802.1 D/Q QoS, and how to translate SIP QoS parameters into IP DiffServ classes and DiffServ classes into 802.1 D/Q QoS parameters is also presented in this paper.

• Journal of KIISE:Information Networking
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• v.36 no.3
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• pp.204-211
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• 2009

Proxy Mobile IPv6(PMIPv6) is that network-based mobility management protocol that network supports mobile node's mobility on behalf of the Mobile Node(MN). In PMIPv6 network, data packets from a Correspondent Node(CN) to a MN will always traverse the MN's Local Mobility Anchor(LMA). Even though, CN and MN might be located close to each other or within the same PMIPv6 domain. To solve this problem, several PMIPv6 Route Optimization(RO) schemes have been proposed. However, these RO schemes may result in a high signaling cost when MN moves frequently between MAGs. For this reason, we propose an adaptive route optimization(ARO) scheme. We analyze the performance of the ARO. Analytical results indicate that the ARO outperforms previous schemes in terms of signaling overhead.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6485-6488
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• 2014

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3359-3362
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• 2014

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

• Journal of Communications and Networks
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• v.18 no.5
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• pp.784-795
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• 2016

In this paper, we investigate the resource allocation problem in time-varying heterogeneous wireless networks (HetNet) with multi-homing user equipments (UE). The stochastic optimization model is employed to maximize the network utility, which is defined as the difference between the HetNet's throughput and the total energy consumption cost. In harmony with the hierarchical architecture of HetNet, the problem of stochastic optimization of resource allocation is decomposed into two subproblems by the Lyapunov optimization theory, associated with the flow control in transport layer and the power allocation in physical (PHY) layer, respectively. For avoiding the signaling overhead, outdated dynamic information, and scalability issues, the distributed resource allocation method is developed for solving the two subproblems based on the primal-dual decomposition theory. After that, the adaptive resource allocation algorithm is developed to accommodate the timevarying wireless network only according to the current network state information, i.e. the queue state information (QSI) at radio access networks (RAN) and the channel state information (CSI) of RANs-UE links. The tradeoff between network utility and delay is derived, where the increase of delay is approximately linear in V and the increase of network utility is at the speed of 1/V with a control parameter V. Extensive simulations are presented to show the effectiveness of our proposed scheme.

• Journal of Internet Computing and Services
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• v.13 no.3
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• pp.1-16
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• 2012

Cost-effective mobility management for the roaming mobile users is very important in the seamless services on next-generation wireless network (NGWN). MIPv6 (Mobile IPv6) is one of the mobility management schemes proposed by the IETF (The Internet Engineering Task Force) and various IPv6-based mobility management schemes have been developed. They are directly involved with data transfer from MN (Mobile Node). In this paper, two kinds of schemes in analyzing of mobility management schemes are proposed. The signaling transfer and packet delivery procedures for each mobility management schemes are analyzed, respectively. The signaling cost for mobility management schemes are calculated, and the cost of each protocol are analyzed numerically. In other word, applying the sum of signaling cost and packet delivery cost to each mobility management scheme, their costs are analyzed. Finally, our performance evaluation results that the network-based mobility management scheme shows better performance in terms of overall cost.

• The KIPS Transactions:PartC
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• v.12C no.3 s.99
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• pp.409-418
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• 2005

This paper presents an efficient multicast method based on a locality in mobile IPv6 networks. We exploit the repetitive movement pattern of mobile node to reduce the total number of experience of graft and join procedure. We defined the locality scope by a movement pattern. While the network is included in the locality scope, the network should maintain a multicast tree even when the mobile node moves to the other network. In this way, the mobile host can receive a multicast service without a delay when it moves to the network in the locality scope later. We compare our scheme with existing schemes under the total signaling cost and the service delay time by using a discrete analytical model for cost analysis. Analytical results demonstrated that the total signaling cost and service delay time was significantly reduced through our proposed scheme.

• Journal of Internet Computing and Services
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• v.10 no.6
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• pp.27-36
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• 2009

PSTN (public switched telephone network) provides voice communication service, whereas IP network provides data oriented service, and we can use IP network for multimedia transport service (e.g. voice over IP service) with economic price. In this paper, we propose RoIP (robot on IP) service scenario, signaling call flow, and implementation to provide home automation and monitoring service for remote site users. In our scheme, we used a extended SIP (session initiation protocol) for signaling protocol between remote site users and home robots. For our bearer transport control, we implemented H.263 video codec over RTP (real-time transport protocol) and additionally DTMF (dual tone multi-frequency) transport for robot actuator control. We implemented our scheme on home robots and experimented with KTF operator network, and it shows good communication quality (average MOS = 9.15) and flexible robot controls.

• IMMUNE NETWORK
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• v.2 no.3
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• pp.125-132
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• 2002

In the past, bioinformatics was often regarded as a difficult and rather remote field, practiced only by computer scientists and not a practical tool available to biologists. However, the various on-going genome projects have had a serious impact on biological sciences in various ways and now there is little doubt that bioinformatics is an essential part of the research environment, with a wealth of biological information to analyze and predict. Fully sequenced genomes made us to have additional insights into the functional properties of the encoded proteins and made it possible to develop new tools and schemes for functional biology on a proteomic scale. Among those are the yeast two-hybrid system, mass spectrometry and microarray: the technology of choice to detect protein-protein interactions. These functional insights emerge as networks of interacting proteins, also known as "pathway informatics" or "interactomics". Without exception it is no longer possible to make advances in the signaling/regulatory pathway studies without integrating information technologies with experimental technologies. In this paper, we will introduce the databases of protein interaction worldwide and discuss several challenging issues regarding the actual implementation of databases.