• IMMUNE NETWORK
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• v.16 no.1
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• pp.44-51
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• 2016

Dendritic cells (DCs) are professional antigen presenting cells, and play an important role in the induction of antigen-specific adaptive immunity. However, some DC populations are involved in immune regulation and immune tolerance. These DC populations are believed to take part in the control of immune exaggeration and immune disorder, and maintain immune homeostasis in the body. Tolerogenic DCs (tolDCs) can be generated in vitro by genetic or pharmacological modification or by controlling the maturation stages of cytokine-derived DCs. These tolDCs have been investigated for the treatment of rheumatoid arthritis (RA) in experimental animal models. In the last decade, several in vitro and in vivo approaches have been translated into clinical trials. As of 2015, three tolDC trials for RA are on the list of ClinicalTrial.gov (www.clinicaltrials.gov). Other trials for RA are in progress and will be listed soon. In this review, we discuss the evolution of tolDC-based immunotherapy for RA and its limitations and future prospects.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12A
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• pp.1309-1318
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• 2004

The rapid growth of the mobile Internet has enabled its application area to expand, and its users want services that require more bandwidth for multimedia services. There are limits to support the various multimedia service to mobile station provided by existing mobile communications. The wireless MAN called the IEEE 802.16 Broadband Wireless Access systems which the IEEE 802.11 wireless LAN is similar to wireline Internet service being able to supper a various contents is used and is designed to consider a handoff is studying. Especially, TG(Task Group)e of IEEE 802.16 is in progress discussion to support a handoff to higher layer using BS(Base Station) or unit of sector, to UC. Yet a scheme is not detail. This thesis proposes the network model for IEEE 802.16e to support a soft handoff between BSs to use a mobile communication network called cdma2000 Ix EV-DO network. The proposed network model supports soft handoff to add a management skill in MA of each BS for MC(Mobility Controller). The proposed network model has merits that is able to apply existing systems as it is and that is able to use a various multimedia service, when using a wireless Internet.

• Journal of the Korea Society of Computer and Information
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• v.11 no.5 s.43
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• pp.39-52
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• 2006

As accelerates the technical evolution of high-speed network and progresses the digitalization of broadcasting network, TV channel service through satellite/cable/terrestrial networks becomes more stable and mature. However, TV channel service using IP network such as IPTV is recently emerging. Especially, when it comes to current mosaic EPG(Electronic Program Guide) as a channel guide, the implementation of EPG via IP network is under developing. Furthermore, the personal target mosaic EPG is not provided at all in the IPTV. This paper proposes a construction method of mosaic system which can support fixed and personalized mosaic EPG using IP network for viewers. The fixed mosaic EPG is made several steps as follows ; First, H/E generates several mosaic A/V streams. Then, which are transmitted to the STB in terms of multicasting via IP network. Finally, mosaic EPG is displayed on TV through STB. In addition, this paper describes a construction model of the personalized A/V mosaic EPG that represents each person's favorite channels according to their tastes and interests. As for the contributions. The TV channel guide using IP network enable viewer to select channel more easily with practical adaptation of multi-channel expansibility and sufficient usability. In addition, through personal mosaic EPG, a number of viewers can compose their own mosaic EPG and enjoy a variety of channel easily in accordance with their preferences. Finally, the personal mosaic EPG can prohibit non-adult users from connecting adult-only contents more efficiently.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.1
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• pp.193-198
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• 2020

The various uses of the Convolutional Neural Network technology are accelerating the evolution of the computing area, but the opposite is causing serious hardware performance shortages. Neural network accelerators, next-generation memory device technologies, and high-bandwidth memory architectures were proposed as countermeasures, but they are difficult to actively introduce due to the problems of versatility, technological maturity, and high cost, respectively. This study proposes DRAM-based main memory technology that enables read operations to be completed without waiting until the end of the refresh operation using pre-stored XOR bit values, even when the refresh operation is performed in the main memory. The results showed that the proposed technique improved performance by 5.8%, saved energy by 1.2%, and improved EDP by 10.6%.

• Journal of Ecology and Environment
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• v.31 no.3
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• pp.233-241
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• 2008

Functional feeding groups (FFGs) of benthic macroinvertebrates are guilds of invertebrate taxa that obtain food in similar ways, regardless of their taxonomic affinities. They can represent a heterogeneous assemblage of benthic fauna and may indicate disturbances of their habitats. The proportion of different groups can change in response to disturbances that affect the food base of the system, thereby offering a means of assessing disruption of ecosystem functioning. In this study, we used benthic macroinvertebrate communities collected at 650 sites of 23 different water types in the province of Overijssel, The Netherlands. Physical and chemical environmental factors were measured at each sampling site. Each taxon was assigned to its corresponding FFG based on its food resources. A multilayer perceptron (MLP) using a backpropagation algorithm, a supervised artificial neural network, was applied to evaluate the influence of environmental variables to the FFGs of benthic macroinvertebrates through a sensitivity analysis. In the evaluation of input variables, the sensitivity analysis with partial derivatives demonstrates the relative importance of influential environmental variables on the FFG, showing that different variables influence the FFG in various ways. Collector-filterers and shredders were mainly influenced by $Ca^{2+}$ and width of the streams, and scrapers were influenced mostly with $Ca^{2+}$ and depth, and predators were by depth and pH. $Ca^{2+}$ and depth displayed relatively high influence on all four FFGs, while some variables such as pH, %gravel, %silt, and %bank affected specific groups. This approach can help to characterize community structure and to ecologically assess target ecosystems.

• Journal of Technology Innovation
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• v.22 no.4
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• pp.117-143
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• 2014

Tracing an evolutionary technological trajectory in the macroscopic viewpoint is useful for technology policy, but not for corporate technology and intellectual property strategy. Tackling this issue, recent bibliometric studies using patents and papers have made efforts to identify more specific and detailed technological trajectory. However, these studies cannot go beyond simple description of the past trajectory. Also, identification of technology fusion and evolution relies on experts judgments. We suggest a way of identifying microscopic evolutionary technological trajectories by combining patent citation network analysis with dynamic technology tree. Also, using new indicators of generality, diversity and novelty, we can detect key technologies that can be a starting point of next generation technology and derivative technology. HVDC(High Voltage DC transmission) system technology is exemplified.

• Convergence Security Journal
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• v.15 no.2
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• pp.63-68
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• 2015

Current ICT(Information & Communication Technology) infrastructures (Internet and server/client communication) are struggling for a wide variety of devices, services, and business and technology evolution. Cloud computing originated simply to request and execute the desired operation from the network of clouds. It means that an IT resource that provides a service using the Internet technology. It is getting the most attention in today's IT trends. In the distributed cloud environments, management costs for the network and computing resources are solved fundamentally through the integrated management system. It can increase the cost savings to solve the traffic explosion problem of core network via a distributed Micro DC. However, traditional flooding methods may cause a lot of traffic due to transfer to all the neighbor DCs. Restricted Path Flooding algorithms have been proposed for this purpose. In large networks, there is still the disadvantage that may occur traffic. In this paper, we developed Lightweight Path Flooding algorithm to improve existing flooding algorithm using hop count restriction.

• Journal of the Korean Institute of Intelligent Systems
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• v.11 no.5
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• pp.426-432
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• 2001

This paper is implementation of cellular automata neural network system using evolving hardware concept. This system is a living creatures'brain based on artificial life techniques. Cellular automata neural network system is based on the development and the evolution, in other words, it is modeled on the ontogeny and phylogney of natural living things. The phylogenetic mechanism are fundamentally non-deterministic, with the mutation and recombination rate providing a major source of diversity. Ontogeny is deterministic and local physics. Cellular automata is developed from initial cells, and evaluated in given environment. And genetic algorithms take a part in adaptation process. In this paper we implement this system using evolving hardware concept. Evolving hardware is reconfigurable hardware whose configuration si under the control of an evolutionary algorithm. We design genetic algorithm process for evolutionary algorithm and cells in cellular automata neural network for the construction of reconfigurable system. The effectiveness of the proposed system if verified by applying it to Exclusive-OR.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.5
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• pp.925-933
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• 2003

Network is expected to be developed into optical Internet network collected IP layer and optical layer, but GMPLS is risen at the transitional evolution stage because of the present technology level. GMPLS that MPLS is extended and generalized is able to support not only the packet switching device but also the devices which perform switching in time, wavelength, and space domain. To implement the common control plane to these various switching types, GMPLS extends the existing MPLS signaling and routing protocol. In this paper, we describe the overview of GMPLS technology, and then we will refer to the OSPF(Open Shortest Path First), which was used to exchange the status information of link, as the plan of routing extension to exchange the information of various link type, bandwidth, link protection type etc. And also, we describe the definition of new protocol, so called, LMP that is a signaling protocol for solving complex problem which manages hundreds and thousands of links between two nodes. And we will examine and analyze the plan of signaling protocol extension to apply signaling protocol RSVP-TE(Resource Reservation Protocol) for traffic engineering in MPLS to network, and the message objects and formats associated with modified RSVP.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.8A
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• pp.618-624
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• 2009

In the evolution from wireless sensor networks(WSNs) to ubiquitous sensor networks(USNs), technologies that can support intensive data-traffic loads, large number of users, improved interoperability, and extreme longevity are required. Therefore, efficient communication time coordination control and low power consumption becomes one of the most important design goals for USN MAC protocols. So far several time division multiplexed (TDM) MAC protocols have been proposed. However, since the pros and cons of existing protocols are not easy to analyze, it becomes a challenging task to design improved TOM MAC protocols. Based on this objective, this paper provides a novel protocol analysis along with a message complexity derivation and comparison of the existing TDM MAC protocols.