• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.1
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• pp.23-28
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• 1999

ALP (alkaline phosphatase) is a membrane-bound metalloenzyme that is expressed in osteoblasts, hepatocytes, lung, kidney, endothelial cells, leukocytes and other cells. Normal soft tissue and skin show little tissue nonspecific ALP (TN-AP), However, scar tissue contains high levels of TN-AP activity, and in fact, TN-AP is expressed intensely in regenerating connective tissue after the wounding. The purpose of this study was to evaluate the change of ALP expression in hypertrophic scar model in rabbits and the effect of triamcinonolone on ALP expression. Adult male New Zealand white rabbits, weighing about 2.5 kg, were used. After full-thickeness wounding over the ventral surface of each ear, either saline (control ear) or triamcinolone (contralateral ear) was injected on day 16. Rabbits were sacrificed on day 3, 7, 15, 17, 19, 23, and the specimens were retrieved en bloc. Histologic and immunohistochemical examinations of tissue samples were done. The results obtained were as follows: On day 3, ALP reaction was observed on fibroblasts and inflammatory cells in wound margin. On day 7, ALP reaction was more intense than day p in capillaries, inflammtory cells, and fibroblasts behind newly formed epithelium. On day 15, ALP reaction was lessened in both groups and appeared mainly in subepidermal capillary network, Since day 17, ALP reaction was lessened in both groups and weaker in triamcinolone-injected group than in saline-injected group. These results suggest that ALP reaction isn't increased in triamcinolone-injected scar and triamcinolone reduces scar not by increasing TN-AP expression but other mechanism.

• Geophysics and Geophysical Exploration
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• v.18 no.1
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• pp.21-30
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• 2015

Induced seismicity has been observed in the relation with lots of anthropogenic influence and at variety of geological conditions over the last several decades. This paper reviews those induced earthquakes and compares with each other as well as with natural tectonic earthquakes. Hydraulic fracturing is commonly used to enhance the permeability through new cracks in the rock formation. The process triggers the induced seismicity, which can give crucial information on the fracture network and oil/gas migration. In the similar way, unintentionally induced events during the production procedure of the field, dam reservoir, minig activity, or wastewater injection can be used to give insight into various hydrodynamic processes and changes of reservoir properties at a various scales. The general conclusion summarizes the uncertainty or limitations of knowledge up to date and presents some issues to be dealt with in the future research.

• Journal of the Korea Society of Computer and Information
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• v.23 no.4
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• pp.175-182
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• 2018

In this paper, we propose a software education ecosystem model for activating software education donation. First, in order to investigate current software education donation status, we will conduct a survey on software education donors and analyze the results. 39.6% of the software education donors responded that they were introduced to software education donation activities through their affiliated companies, institutions, organizations. Therefore, it can be seen that the promotion of software education donation activities is the most effective by promoting through software companies, organizations, and organizations and using human networks. The subjects of software education donation activities were the highest at middle school students (73.9%), and the contents of software education donations were the highest at programming practice (63.3%). Donors' satisfaction with software education donation activities was 57.9%. The social support for SW education donors was in the order of software education contents support, activity cost support, equipment and network support, and place sponsorship. 87.4% of donors were willing to continue to donate to software education. The reason why they did not want to continue donating software education was 'lack of personal time' (65.4%). Therefore, it is necessary to develop appropriate social support and incentive system to overcome shortage of personal time in order to activate software education contribution. In order to promote sustainable software education donations, it is essential to establish a virtuous circle of software education donation ecosystem based on cooperation and solidarity with various organizations such as government, corporations, institutions, universities and civil society organizations.

• IMMUNE NETWORK
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• v.13 no.2
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• pp.63-69
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• 2013

IL-12 is a secretory heterodimeric cytokine composed of p35 and p40 subunits. IL-12 p35 and p40 subunits are sometimes produced as monomers or homodimers. IL-12 is also produced as a membrane-bound form in some cases. In this study, we hypothesized that the membrane-bound form of IL-12 subunits may function as a costimulatory signal for selective activation of TAA-specific CTL through direct priming without involving antigen presenting cells and helper T cells. MethA fibrosarcoma cells were transfected with expression vectors of membrane-bound form of IL-12p35 (mbIL-12p35) or IL-12p40 subunit (mbIL-12p40) and were selected under G418-containing medium. The tumor cell clones were analyzed for the expression of mbIL-12p35 or p40 subunit and for their stimulatory effects on macrophages. The responsible T-cell subpopulation for antitumor activity of mbIL-12p35 expressing tumor clone was also analyzed in T cell subset-depleted mice. Expression of transfected membranebound form of IL-12 subunits was stable during more than 3 months of in vitro culture, and the chimeric molecules were not released into culture supernatants. Neither the mbIL-12p35-expressing tumor clones nor mbIL-12p40-expressing tumor clones activated macrophages to secrete TNF-${\alpha}$. Growth of mbIL-12p35-expressing tumor clones was more accelerated in the $CD8^+$ T cell-depleted mice than in $CD4^+$ T cell-depleted or normal mice. These results suggest that $CD8^+$ T cells could be responsible for the rejection of mbIL-12p35-expressing tumor clone, which may bypass activation of antigen presenting cells and $CD4^+$ helper T cells.

• Journal of Korean Academy of Nursing Administration
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• v.15 no.1
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• pp.91-105
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• 2009

Purpose: The aim of this study was to analyze the needs of HIV/AIDS care and to develop the job description of HIV/AIDS Counselling nurse in Korea. Methods: The needs assessment was done by focus group interview with HIV/AIDS care recipients who are 16 persons living with HIV/AIDS and four their family members, seven persons from HIV/AIDS high risk group, and five nurses working on HIV/AIDS clinics. Based on the result of needs assessment, job description was developed using the DACUM. Mail survey was done to identify the frequency, importance, and difficulty of duties, tasks, and task elements. Results: The job description was classified under 8 duties, 36 tasks, and 290 task elements. Duties were categorized as needs assessment, health promotion and quality of life, improvement of treatment compliance, symptom care, health education, resource network, administrative activity, and career development. The importance of all duties and tasks showed high score from the survey, but the frequency and the performance level were middle range. Conclusion: It is suggested that the special training program based on the job description needs to be developed. In the political aspects, the introduction of HIV/AIDS nurse specialist certification could be considered.

• Nuclear Engineering and Technology
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• v.52 no.10
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• pp.2250-2261
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• 2020

Accurate localization of radioactive materials is crucial in homeland security and radiological emergencies. Coded-aperture gamma camera is an interesting solution for such applications and can be developed into portable real-time imaging devices. However, traditional reconstruction methods cannot effectively deal with signal-independent noise, thereby hindering low-noise real-time imaging. In this study, a novel reconstruction method with excellent noise-suppression capability based on a multi-layer perceptron (MLP) is proposed. A coded-aperture gamma camera based on pixel detector and coded-aperture mask was constructed, and the process of radioactive source imaging was simulated. Results showed that the MLP method performs better in noise suppression than the traditional correlation analysis method. When the Co-57 source with an activity of 1 MBq was at 289 different positions within the field of view which correspond to 289 different pixels in the reconstructed image, the average contrast-to-noise ratio (CNR) obtained by the MLP method was 21.82, whereas that obtained by the correlation analysis method was 5.85. The variance in CNR of the MLP method is larger than that of correlation analysis, which means the MLP method has some instability in certain conditions.

• Korea journal of population studies
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• v.5 no.1
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• pp.4-16
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• 1982

The Korean Population Control Program has been implementing under the jurisdiction of the Ministry of Health and Social Affairs through an existing network of health centers. This arrangement was successful in bringing population growth down to targeted level by the end of the Fourth Five Year Economic Planning, 1981. It is expected, however, that future goal will be harder to reach due to difficulty of reducing traditional family size norms further and to the projected increasing the number of eligible couples as the past Korean war baby boom generation enters the reproductive activity in the next few years. The recognition of the need for modification of population policy is increasing. The 1980 census shows that the total number of population reached approximately 38.5 million with 1.57 per cent of the growth rate. It was projected that the size of Korean Population will reach around 42 million and 51 million in 1986 and 2000 respectively. Furthermore, there is some argument as to whether decline in the birth rate in Korea is too slow to meet government target. Hence, a new development of population policy and greatly increased amount of effort will be needed in order to achieve Zero Population Growth Rate before the year 2050. The development of future national population policy and its related area are recommended as follow: 1. It is highly recommended that the population planning law governing both vital events of birth and death and population migration should be legislated. 2. The National Population Policy Council, Chaired by Deputy Prime Minister should be activated to implement and coordinate population program within ministries. 3. Responsible organization of population and family planning program should be established as a Bureau unit at central government level. 4. For the improvement of national vital registration, an existing system should be studied and developed.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.50-57
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• 2020

Background: The cellular senescence of primary cultured cells is an irreversible process characterized by growth arrest. Restoration of senescence by ginsenosides has not been explored so far. Rg3(S) treatment markedly decreased senescence-associated β-galactosidase activity and intracellular reactive oxygen species levels in senescent human dermal fibroblasts (HDFs). However, the underlying mechanism of this effect of Rg3(S) on the senescent HDFs remains unknown. Methods: We performed a label-free quantitative proteomics to identify the altered proteins in Rg3(S)-treated senescent HDFs. Upregulated proteins induced by Rg3(S) were validated by real-time polymerase chain reaction and immunoblot analyses. Results: Finally, 157 human proteins were identified, and variable peroxiredoxin (PRDX) isotypes were highly implicated by network analyses. Among them, the mitochondrial PRDX3 was transcriptionally and translationally increased in response to Rg3(S) treatment in senescent HDFs in a time-dependent manner. Conclusion: Our proteomic approach provides insights into the partial reversing effect of Rg3 on senescent HDFs through induction of antioxidant enzymes, particularly PRDX3.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.52 no.5
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• pp.201-205
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• 2003

We synthesized dendrimers containing light switchable units, azobenzene group. And the dendrimer containing 48 pyridinepropanol functional end group, which could form a complex structure with metal ions was synthesized. To apply to the molecular level devices or data storage system using Langmuir-Blodgett(LB) film, we firstly investigated the monolayer behavior using the surface pressure-area($\pi$-A) isotherms at air-water interface. And then the surface pressure shift of monolayer by light irradiation was also measured to the dendrimer with azobezene group. As a result, the monolayer of dendrimer with azobenzene group showed the reversible photo-switching behavior by the isomerization of azobenzene group in their periphery. The samples for electrical measurement were fabricated to two types which were pure dendrimer with pyridinepropanol group and its complexes with $Pt^4+$ ions by LB method. We have studied the electrical properties of the ultra thin dendrimer LB films investigated by the current-voltage(I-V) characteristics of Metal/Dendrimer LB films/Metal(MIM) structure. And we have investigated different results in the surface activity at the air-water interface as well as the electrical properties for the monolayers of pure dendrimer with pyridinevopanol group and its complex with $Pt^4+$ ions. In conclusion, it is demonstrated that the metal ion around dendrimer with pyri야nepropanol group can contribute to make formation of network structure among dendrimers and it result from the change of electrical properties. This results suggest that the dendrimers with azobenzene group and pvridinedropanol group can be applied to high efficient nano-device of molecular level.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.4
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• pp.725-732
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• 2020

This paper uses variables following as : to follow me well(0-9), it takes a lot of time to make a decision (0-9), lethargy(0-9) during physical activity in the exercise learning program of the children in the marginalized class. This paper classifies 'gender', 'physical education classroom', and 'upper, middle and lower' of age, and observe changes in ego-resiliency and self-control through sports rehabilitation therapy to find out changes in mental health. To achieve this, the data acquired was merged and the characteristics of large and small numbers were removed using the Label encoder and One-hot encoding. Then, to evaluate the performance by applying each algorithm of MLP, SVM, Dicesion tree, RNN, and LSTM, the train and test data were divided by 75% and 25%, and then the algorithm was learned with train data and the accuracy of the algorithm was measured with the Test data. As a result of the measurement, LSTM was the most effective in sex, MLP and LSTM in physical education classroom, and SVM was the most effective in age.