• The Korean Journal of Physiology and Pharmacology
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• v.22 no.4
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• pp.419-425
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• 2018

The superficial dorsal horn of the spinal cord plays an important role in pain transmission and opioid activity. Several studies have demonstrated that opioids modulate pain transmission, and the activation of ${\mu}$-opioid receptors (MORs) by opioids contributes to analgesic effects in the spinal cord. However, the effect of the activation of MORs on GABAergic interneurons and the contribution to the analgesic effect are much less clear. In this study, using transgenic mice, which allow the identification of GABAergic interneurons, we investigated how the activation of MORs affects the excitability of GABAergic interneurons and synaptic transmission between primary nociceptive afferent and GABAergic interneurons. We found that a selective ${\mu}$-opioid agonist, [$D-Ala^2$, $NMe-Phe^4$, Gly-ol]-enkephanlin (DAMGO), induced an outward current mediated by $K^+$ channels in GABAergic interneurons. In addition, DAMGO reduced the amplitude of evoked excitatory postsynaptic currents (EPSCs) of GABAergic interneurons which receive monosynaptic inputs from primary nociceptive C fibers. Taken together, we found that DAMGO reduced the excitability of GABAergic interneurons and synaptic transmission between primary nociceptive C fibers and GABAergic interneurons. These results suggest one possibility that suppression of GABAergic interneurons by DMAGO may reduce the inhibition on secondary GABAergic interneurons, which increase the inhibition of the secondary GABAergic interneurons to excitatory neurons in the spinal dorsal horn. In this circumstance, the sum of excitation of the entire spinal network will control the pain transmission.

• Journal of the Korean Society of School Health
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• v.22 no.2
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• pp.157-167
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• 2009

Purpose : The purpose of this study is to explore the students injuries by analyzing the data which has been inputted by the emergency center of the cooperated hospitals and the 119 rescue party through the injury surveillance system in Cheonan city. Method : Students were divided into the elementary, middle, high school students with the 776 cases of children and teenagers(7-19years old) of injury surveillance system in Cheonan area from january to june in 2009. Frequency analysis and $x^2$-test was done to recognize the features of students injuries among the groups. The program to be used for the statistical analysis is SPSS 17.0. Result : Out of the injury incidence rate, the elementary school students(52.1%) are first, the high school students (24.9%) are second, the middle school students appear to be 23.1%. Male is about two times higher than female by 66.6% in the injury incidence. In terms of the injury mechanism, the injury(22.2%) by hit is the first, the traffic accident(21.5%) is the second, the slippery(16.8%) is followed. The injuries were occurred most largely at 16:00-20:00(33.4%), and the 33.6% of injury by daily leisure activity occurs at 16:00-20:00 chiefly. Conclusion : Analysis using the data of the injury surveillance system has some advantages compared to the previous research such as reliability and specification. To prevent the students injuries, not the individual problem but the social dimension should be acknowledged so that we can secure and promote the safety from the risk. Therefore, we must organize the role assignment and the cooperative network in the school, home and community.

• Journal of Internet Computing and Services
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• v.11 no.4
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• pp.143-158
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• 2010

The illegal leakage of enterprise digital confidential information will threaten the enterprise with bankruptcy. Today since most small-and-medium companies have no capability to fight against illegally compromising their critically confidential documents in spite of knowing the leakage of them, strongly safe distribution system of the digital confidential documents should be designed so in secure as to prevent any malicious intent of embezzlement from accessing the critical information. Current DRM-based protection system is not always perfect to protect the digital secrets, even seems to leave the secrets open. Therefore our study has analyzed the illegal leakage paths that hackers attack against and the vulnerability of the current protection systems. As result, we study the group communication based system architecture satisfying the security conditions to make even legitimate working employee keep out of the confidential documents, without performance degradation. The main idea of this architecture is to stay every secrets in encrypted form; to isolate the encrypted documents from the crypto-key; to associate every entity with one activity and to authenticate every entity with DSA-based public key system; multiple authentication method make hackers too busy to get a privilege to access the secrets with too many puzzle pieces. This paper deal with the basic architectural structure for the above issues.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.10
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• pp.708-714
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• 2014

Wireless sensor networks (WSNs) generally consist of densely deployed sensor nodes that depend on batteries for energy. Having a large number of densely deployed sensor nodes causes energy waste and high redundancy in sensor data transmissions. The problems of power limitation and high redundancy in sensing coverage can be solved by appropriate scheduling of node activity among sensor nodes. In this paper, we propose a cellular automata based node scheduling algorithm for prolonging network lifetime with a balance of energy savings among nodes while achieving high coverage quality. Based on a cellular automata framework, we propose a new mathematical model for the node scheduling algorithm. The proposed algorithm uses local interaction based on environmental state signaling for making scheduling decisions. We analyze the system behavior and derive steady states of the proposed system. Simulation results show that the proposed algorithm outperforms existing protocols by providing energy balance with significant energy savings while maintaining sensing coverage quality.

• Journal of Digital Contents Society
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• v.7 no.1
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• pp.15-23
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• 2006

The hamonious development of human brain has been an indigenous objective of each age. A variety of training programs related to the purpose have turned up at an educational market and a commercial market, as well. I'd like to indicate, however, that these training methods are somewhat prejudiced and have some elements, inherently, which are against the development of human brain for one's whole personality. Therefore, the most desirable brain training program is to induce it to respond to various stimuli, to educate for itself and to generate continuously, to create and strengthen an innumerous synapse among brain cells, so as to form a nero-network. In this study, I have used a brain training program with multimedia which have been produced for a specific purpose. With this method, by measuring directly the effectiveness of human brain development, I have analysed more objectively and more quantitatively.

• Journal of Digital Convergence
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• v.14 no.11
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• pp.201-224
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• 2016

The main objective of this study is to identify and analyze the factors affecting technology innovation of the innovative IT SMEs. A research model is established based on the previous studies on the technology innovation of SMEs. The model consists of independent variables (Adhocracy culture, R&D capability, IT capability, Leadership, and Appraisal & Reward), an intermediate variable (Knowledge management), and dependent variables (product/service innovation and process innovation). Major research results can be summarized as follows: IT SMEs pursuing technology innovation should: (1) pay attention to innovation oriented culture, IT capability, and evaluation & compensation systems of the company; (2) recognize that knowledge management is an essential activity performed by the company; (3) strengthen the R&D capabilities of the company by not only exerting internal efforts but establishing cooperative network with various parties; and (4) resolve the decoupling problem of the evaluation & compensation system.

• Bulletin of the Korean Chemical Society
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• v.28 no.8
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• pp.1335-1340
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• 2007

β-Ketoacyl acyl carrier protein synthase (KAS) III is a particularly attractive target in the type II fatty acid synthetic pathway, since it is central to the initiation of fatty acid synthesis. Enterococcus faecalis, a Grampositive bacterium, is one of the major causes of hospital acquired infections. The rise of multidrug-resistant of most bacteria requires the development of new antibiotics, such as inhibition of the KAS III. In order to block the fatty acid synthesis by inhibition of KAS III, at first, three dimensional structure of Enterococcus faecalis KAS III (efKAS III) was determined by comparative homology modeling using MODELLER based on x-ray structure of Staphylococcus aureus KAS III (saKAS III) which is a gram-positive bacteria and is 36.1% identical in amino acid sequences with efKAS III. Since His-Asn-Cys catalytic triad is conserved in efKAS III and saKAS III, substrate specificity of efKAS III and saKAS III and the size of primer binding pocket of these two proteins are expected to be similar. Ligand docking study of efKAS III with naringenin and apigenin showed that naringenin docked more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Also, only naringenin showed antibacterial activity against E. faecalis at 256 μg/mL. This study may give practical implications of flavonoids for antimicrobial effects against E. faecalis.

• Journal of Life Science
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• v.23 no.7
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• pp.947-954
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• 2013

The Wnt/${\beta}$-catenin signaling pathway is an evolutionarily conserved signaling network that is critical for embryonic development and adult tissue maintenance. In addition, aberrant activation of Wnt/${\beta}$-catenin signaling is implicated in the formation of various human diseases, including cancers. Thus, study of the underlying molecular mechanism of Wnt/${\beta}$-catenin signaling regulation is important to understand and treat diseases. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Recently, protein kinases have emerged as key regulating components of Wnt/${\beta}$-catenin signaling. In this review, we provide the most recent information on Wnt/${\beta}$-catenin signaling, describe protein kinases involved in Wnt/${\beta}$-catenin signaling, and discuss their potential as drug targets.

• Journal of Microbiology and Biotechnology
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• v.16 no.9
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• pp.1434-1440
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• 2006

The stable anchorage of pyridoxal 5'-phosphate (PLP) in the active site of D-amino acid transaminase (D-AT) is crucial for the enzyme catalysis. The three-dimensional structure of D-AT revealed that Glu32 is one of the active site groups that may playa role in PLP binding. To prove the role of Glu32 in PLP stability, we firstly checked the rate of the potential rate-limiting step. The kinetic analysis showed that the rate of the ${\alpha}$-deprotonation step reduced to 26-folds in E32A mutant enzyme. Spectral analyses of the reaction of D-AT with D-serine revealed that the E32A mutant enzyme failed to stabilize the key enzyme-substrate intermediate, namely a quinonoid intermediate (E-Q). Finally, analysis of circular dichroism (CD) on the wild-type and E32A mutant enzymes showed that the optical activity of PLP in the enzyme active site was lost by the removal of the carboxylic group, proving that Glu32 is indeed involved in the cofactor anchorage. The results suggested that the electrostatic interaction network through the groups from PLP, Glu32, His47, and Arg50, which was observed from the three-dimensional structure of the enzyme, plays a crucial role in the stable anchorage of the cofactor to give necessary torsion to the plane of the cofactor-substrate complex.

• Journal of Astronomy and Space Sciences
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• v.34 no.4
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• pp.303-314
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• 2017

With increased human activity in space, the risk of re-entry and collision between space objects is constantly increasing. Hence, the need for space situational awareness (SSA) programs has been acknowledged by many experienced space agencies. Optical and radar sensors, which enable the surveillance and tracking of space objects, are the most important technical components of SSA systems. In particular, combinations of radar systems and optical sensor networks play an outstanding role in SSA programs. At present, Korea operates the optical wide field patrol network (OWL-Net), the only optical system for tracking space objects. However, due to their dependence on weather conditions and observation time, it is not reasonable to use optical systems alone for SSA initiatives, as they have limited operational availability. Therefore, the strategies for developing radar systems should be considered for an efficient SSA system using currently available technology. The purpose of this paper is to analyze the performance of a radar system in detecting and tracking space objects. With the radar system investigated, the minimum sensitivity is defined as detection of a $1-m^2$ radar cross section (RCS) at an altitude of 2,000 km, with operating frequencies in the L, S, C, X or Ku-band. The results of power budget analysis showed that the maximum detection range of 2,000 km, which includes the low earth orbit (LEO) environment, can be achieved with a transmission power of 900 kW, transmit and receive antenna gains of 40 dB and 43 dB, respectively, a pulse width of 2 ms, and a signal processing gain of 13.3 dB, at a frequency of 1.3 GHz. We defined the key parameters of the radar following a performance analysis of the system. This research can thus provide guidelines for the conceptual design of radar systems for national SSA initiatives.