• 한국전문물리치료학회지
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• 제27권4호
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• pp.233-240
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• 2020

Background: Cross-culturally adapted questionnaires may not be comparable to their original version. Objects: To examine concurrent validity of two health-related quality of life (HRQOL) instruments for the Korean versions of EuroQOL-5 Dimension (EQ-5D) and the abbreviated version of the World Health Organization Quality of Life (WHOQOL-BREF) instrument. Methods: A total of 139 cancer survivors from two rehabilitation institutes was recruited. All participants were registered for palliative rehabilitation care. Both instruments were concurrently administered by health care providers following the second bout of the rehabilitation cares. Rasch partial credit model and Spearman's correlation analysis were used to investigate: 1) dimensionality, 2) hierarchical item difficulty, and 3) concurrent validity using correlations between two instruments. Results: For the WHOQOL-BREF, all items except negative feeling, pain, dependence of medical aid, were found to be acceptable, while all items of EQ-5D were acceptable. There was an evidence of negative correlations between EQ-5D and 4 domains of WHOQOL-BREF. Two correlations were strong (EQ-5D vs. physical health domain, ρ = -0.610, 95% CI = -0.716 to -0.475) and moderate (EQ-5D vs. psychosocial domain, ρ = -0.402, 95% CI = -0.546 to -0.236). Other two correlations were weak (EQ-5D vs. social relationship and environmental domains, ρ = -0.242, 95% CI = -0.401 to -0.075 and ρ = -0.364, 95% CI = -0.514 to -0.207, respectively). Item difficulty calibrations of the two measurements were ranged from -0.84 to 0.86 for the EQ-5D and -1.07 to 1.06 for the WHOQOL-BREF. Conclusion: The study provides some supports for the concurrent validity of the two Korean versions of HRQOL instrument, with evidences of weak to strong correlations between the EQ-5D and four domains of the WHOQOL-BREF applied to various cancer survivors. Additionally, the cancer survivors appeared to have more of a tendency to view the EQ-5D items as being slightly more challenging than the WHOQOL-BREF items.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6397-6401
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• 2012

Background: No factor has thus far been identified to predict the efficacy of bevacizumab therapy for colorectal cancer. We here therefore studied PTEN, VEGF, HER2 and p53 by immunohistochemistry as possible prognostic and predictive factors. Materials and Methods: A total of 34 retrospectively collected tumor samples were evaluated, all from patients receiving bevacizumab-based regimens. VEGF-A, PTEN, HER2, p53 were assessed and data was compared with clinicopathologic characteristics of patients and the bevacizumab response rate. Results: In this study, the median age of the 34 metastatic colorectal cancer patients was 55.5 (24-75), twelve (35.3%) being women and 22 (64.7%) men. PTEN, VEGF, HER2, p53 expressions were compared with bevacizumab response and other chacteristics of disease. Statistical significant differences were not found between bevacizumab response rates and different expression levels of VEGF, PTEN, HER2 and p53 (respectively p=0.256, p=0.832, p=0.189, p=0.131). However, a survival difference was noted in the VEGF expression negative group (median OS:55 months; 95%CI, 22-88 months) (p=0.01). There was no statistically significant OS difference in other groups (PTEN p=0.6, HER2 p=0.189, p53 p=0.13). Conclusions: We did not find any predictive factor for BV therapy in our study. VEGF negative expression could be an important prognostic factor in metastatic colorectal carcinoma.

• 가정과삶의질연구
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• 제33권2호
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• pp.135-148
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• 2015

The purpose of this study is to develop cognitive behavioral therapy(CBT) to improve the parenting efficacy of married immigrant women, and verify its effectiveness. In the CBT of this study, behavioral technique was added to cognitive reconstruction based on cultural context in order to improve parenting efficacy. The study selected 28 married immigrant women, and randomly divided them into a CBT group(10), a general treatment group(8) and a control group(10). The CBT and the general treatment programs consisted of 10 sessions, approximately 2 hours in duration. The results of the study were as follows. 1) The level of parenting efficacy was improved significantly in the CBT and the general treatment group. 2) The level of negative automatic thoughts and dysfunctional parenting thoughts was significantly decreased only in the CBT group. 3) In the CBT and the general treatment group, the level of parenting stress and acculturative stress was decreased while the level of psychological well-being improved. On the other hand, the level of parent-adolescent communication was improved significantly only in the CBT group. 4) In comparison with the general treatment group, the CBT group showed higher parenting efficacy and lower automatic thoughts and dysfunctional parenting thoughts. This study has significance in its attempt to develop a parent training program to improve the parenting efficacy of married immigrant women by integrating behavioral modification and communication skills training focused on cognitive reconstruction of parenting-related negative thoughts and beliefs in application of the CBT paradigm.

• The Journal of Korean Physical Therapy
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• 제29권5호
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• pp.281-286
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• 2017

Purpose: The purpose of this study was to examine the correlations among the resting physical factors related to a six-minute walk test (6MWT) and to determine the effects of the resting physical factors on the distance and intensity related to the 6MWT in healthy female subjects. Methods: A total of 43 healthy female subjects ($22.84{\pm}3.90yrs$) participated in this study. They performed the 6MWT, and the physical factors related to the 6MWT were assessed. SPSS 20.0 was used to analyze the data, and the mean and standard deviation were calculated, and the collected data were analyzed by the Pearson's correlation coefficient (among physical factors related to 6MWT) and independent t-test (between six-minute walk distance [6MWD] groups and six-minute walk intensity [6MWI] groups). Results: The 6MWD had a significant negative correlation with the resting HR (beat/min) in healthy female subjects (r=-0.49, p<0.05). The 6MWI had a significant negative correlation with the resting systolic blood pressure (SBP) (r=-0.45, p<0.01). A comparison of the 6MWD revealed the long distance group (LDG, 700-799 m) to be significantly higher than the middle distance group (MDG, 600-699 m) in the 6MWI (%), %predicted distance (%), predicted VO2max (mL/kg/min), resting HR (beat/min), and resting SBP (mmHg)(p<0.05). In the comparison of 6MWI, the moderate intensity group (MIG, 64-75%HRmax) was significantly lower than the low intensity group (LIG, 50-63%HRmax) in the resting SBP (mmHg) (p<0.05). Conclusion: These results suggest that the resting physical factors are related to the 6MWD and 6MWI of the 6MWT in healthy females. In particular, SBP is associated with not only the 6MWD but also the 6MWI in 6MWT.

• 한국융합학회논문지
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• 제10권10호
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• pp.33-41
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• 2019

본 연구의 목적은 뇌졸중 환자의 운동공포증과 낙상공포 사이에 융합적 관계를 조사하는 것이다. 총 113명의 뇌졸중 환자가 본 연구에 참여하였다. 참여자는 재활병원 입원환자로 낙상 효능감 척도(FES), 운동공포증을 위한 번역된 탐파 척도(TSK-13), 및 활동-특이성 균형 자신감 척도(ABC)를 포함한 3가지 다른 설문지를 작성하도록 요청하였다. TSK-13과 FES는 약한 음의 상관관계를 보였고(r=-0.226), TSK-13과 ABC는 중등도 음의 상관관계가 나타났다(r=0.838). FES는 ABC와 비교했을 때 매우 강한 양의 상관관계가 나타났다(r=0.838). 낙상을 경험한 환자는 낙상을 경험하지 않은 환자보다 유의하게 낮은 FES와 ABC 점수를 보였다(p<0.05). 이 결과는 뇌졸중 환자가 경증 운동공포증을 가지고 있으며, 운동공포증은 낙상공포와 관련이 있음을 제시하고 있습니다. 앞으로 뇌졸중 재활에 있어 운동공포증의 평가가 필요할 것으로 사료된다.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.115-120
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• 2019

본 연구는 경증 알츠하이머 치매 노인의 베타 아밀로이드 및 혈중 지질 수준과 인지기능 간의 상관관계를 알아보고자 실시하였다. 연구의 대상자는 경증 알츠하이머 치매 노인 45명을 대상으로 실시하였다. 2018년 12월 베타 아밀로이드 및 혈중 지질 수준을 측정하기 위해 혈액 분석을 실시하였으며, 인지기능의 측정을 위해 MMSE-K 검사를 이용하여 측정하였다. 베타 아밀로이드 및 혈중 지질 수준과 인지기능 간의 상관관계를 알아보기 위해 Pearson's correlation analysis를 사용하여 분석하였다. 연구 결과 베타 아밀로이드 수준과 인지기능 간의 상관관계에서는 -.604로 유의한 음의 상관관계를 보였으며(p<.05), 혈중 지질 수준과 인지기능 간의 상관관계에서는 TC(total cholesterol)와 LDL(low density lipoprotein) 수준에서 각각 -.601, -.403로 유의한 음의 상관관계를 보였다(p<.05). 이와 같은 결과는 베타아밀로이드 및 TC, LDL 수준이 증가할수록 인지기능이 감소하는 음의 상관관계가 나타나는 것을 알 수 있었다. 이처럼 치매 환자의 예방 및 인지기능의 증진을 위해서 치매 관련 병리학적 인자의 관리가 중요하다고 사료된다.

• 국제물리치료학회지
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• 제5권2호
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• pp.723-729
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• 2014

The purpose of this study is to understand the relationship between female college students' stress level and premenstrual syndrome so that it can provide baseline data on how to cope with the syndrome. The study subjects are 250 female college students in Gyungbook area. This study chose 199 appropriate subjects and collected data. As per general menstrual phases, this study investigated the age when one had her first period, regularity and duration of period, and amount of bleeding. It used a measurement tool to measure stress level and premenstrual syndrome. Most of the subjects experienced their first period before the age of 13. The menstrual period was irregular with the duration of less than 7 days. 123 subjects had normal amount of bleeding. 121 subjects were experiencing high level of stress over 2.4. The correlation between the level of stress and premenstrual syndrome factors showed significant static correlation for each factor. Especially, the correlation between digestive system and response of autonomic nervous system was .996 and negative emotion and behavioral change was .635, and negative emotion and pain was .614 which were relatively high. The regression analysis of factors of premenstrual syndrome depending on the subjects' stress level indicated that response of autonomic nervous system had the biggest effect in the low stress group while behavioral change, negative emotion, pain, decreased concentration, water congestion, response of autonomic nervous system, and skin change had the biggest effect in the high stress group with statistical significance. Based on the result, it can be said that higher premenstrual stress is closely related to the premenstrual syndrome one experiences for some female college students.

• Tuberculosis and Respiratory Diseases
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• 제81권2호
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• pp.148-155
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• 2018

Background: Although targeted therapy and immuno-oncology have shifted the treatment paradigm for lung cancer, platinum-based combination is still the standard of care for advanced non-small cell lung cancer (NSCLC). Pemetrexed continuation maintenance therapy has been approved and increasingly used for patients with nonsquamous NSCLC. However, the efficacy of this strategy has not been proven in patients without driving mutations. The objective of this study was to compare the clinical benefit of pemetrexed continuation maintenance to conventional platinum-based doublet in epidermal growth factor receptor (EGFR)-negative lung adenocarcinoma. Methods: A total of 114 patients with EGFR-negative lung adenocarcinoma who were treated with platinum doublet were retrospectively enrolled. We compared the survival rates between patients received pemetrexed maintenance after four-cycled pemetrexed/cisplatin and those received at least four-cycled platinum doublet without maintenance chemotherapy as a first-line treatment. Results: Forty-one patients received pemetrexed maintenance and 73 received conventional platinum doublet. Median progression-free survival (PFS), which was defined as the time from the day of response evaluation after four cycles of chemotherapy to disease progression or death, was significantly higher in the pemetrexed maintenance group compared to conventional group (5.8 months vs. 2.2 months, p<0.001). Median overall survival showed an increasing trend in the pemetrexed maintenance group (22.3 months vs. 16.1 months, p=0.098). Multivariate analyses showed that pemetrexed maintenance chemotherapy was associated with better PFS (hazard ratio, 0.73; 95% confidence interval, 0.15-0.87). Conclusion: Compared to conventional platinum-based chemotherapy, premetrexed continuation maintenance treatment is associated with better clinical outcome for the patients with EGFR wild-type lung adenocarcinoma.

• 대한통합의학회지
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• 제10권3호
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• pp.209-219
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• 2022

Purpose : The purpose of this study was two-fold: to investigate the effects of uncertainty and depression on the quality of life (QoL) of elderly people with chronic diseases and to provide basic data on the physical, emotional, and psychological factors affecting their QoL in the field of physical therapy. Methods : A questionnaire covering uncertainty, depression, and QoL was distributed among 320 elderly people. Pearson's correlation analysis was performed to examine the correlation between uncertainty (ambiguity, complexity, inconsistency, and unpredictability), depression, and QoL (physical, psychological, social, and living environment domains) of the respondents; furthermore, multiple regression analysis was performed to identify the factors affecting the QoL of the respondents with a chronic disease. Results : The sub-factors of uncertainty and QoL-"complexity and social domain" (r=-.295, p<.001), "complexity and living environment domain" (r=-.302, p<.001), and "inconsistency and living environment domain" (r=-.360, p<.001)-showed a negative (-) correlation, as did depression and the sub-factors of QoL-"depression and physical domain" (r=-.782, p<.001), "depression and psychological domain" (r=-.876, p<.001), "depression and social domain" (r=-.668, p<.001), and "depression and living environment domain" (r=-.731, p<.001). The factors affecting QoL were complexity (𝛽=-.122, p<.001), inconsistency (𝛽=-.102, p=.002), unpredictability (𝛽=.112, p<.001), and depression (𝛽=-.850, p<.001). The relative influence of the independent variables was in the order of depression, complexity, unpredictability, and inconsistency, and the explanatory power was 77.1 % (F=215.853, p<.001). Conclusion : It is important to help the elderly with chronic diseases reduce the negative impact on their quality of life by helping them gain support from their families and medical professionals and by increasing their understanding through communication so that they can transition from negative emotions to positive emotions of opportunity.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2729-2734
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• 2012

Despite clinical advances in anticancer therapy, there is still a need for novel anticancer metabolites, with higher efficacy and lesser side effects. Oroxylum indicum (L.) Vent. is a small tree of the Bignoniaceae family which is well known for its food and medicinal properties. In present study, the chemopreventive properties of O. indicum hot and cold non-polar extracts (petroleum ether and chloroform) were investigated with MDA-MB-231 (cancer cells) and WRL-68 (non-tumor cells) by XTT assay. All the extracts, and particularly the petroleum ether hot extract (PHO), exhibited significantly (P<0.05) higher cytotoxicity in MDA-MB-231 when compared to WRL-68 cells. PHO was then tested for apoptosis induction in estrogen receptor (ER)-negative (MDA-MB-231) and ER-positive (MCF-7) breast cancer cells by cellular DNA fragmentation ELISA, where it proved more efficient in the MDA-MB-231 cells. Further, when PHO was tested for anti-metastatic potential in a cell migration inhibition assay, it exhibited beneficial effects. Thus non-polar extracts of O. indicum (especially PHO) can effectively target ER-negative breast cancer cells to induce apoptosis, without harming normal cells by cancer-specific cytotoxicity. Hence, it could be considered as an extract with candidate precursors to possibly harness or alleviate ER-negative breast cancer progression even in advanced stages of malignancy.