• BMB Reports
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• v.36 no.1
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• pp.60-65
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• 2003

Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising that the deregulation of the cell cycle is one of the most frequent alterations during tumor development. Cell cycle progression is a highly-ordered and tightly-regulated process that involves multiple checkpoints that assess extracellular growth signals, cell size, and DNA integrity. Cyclin-dependent kinases (CDKs) and their cyclin partners are positive regulators of accelerators that induce cell cycle progression; whereas, cyclin-dependent kinase inhibitors (CKIs) that act as brakes to stop cell cycle progression in response to regulatory signals are important negative regulators. Cancer originates from the abnormal expression of activation of positive regulators and functional suppression of negative regulators. Therefore, understanding the molecular mechanisms of the deregulation of cell cycle progression in cancer can provide important insights into how normal cells become tumorigenic, as well as how cancer treatment strategies can be designed.

• Proceedings of the KIEE Conference
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• 2007.04c
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• pp.100-102
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• 2007

In this paper, a modified multi-level convert for low cost high speed switched reluctance (SR) drive is proposed The proposed multi-level converter has reduced number of power switches and diodes than that of a conventional asymmetric converter for SRM, and lower voltage rating of the dump capacitor comparing with energy efficient c-dump converter. It can supply five operating modes that is boosted, DC-link, zero, negative bias and negative boosted voltage. The proposed multi-level converter has fast excitation and demagnetization modes of phase current, so dynamic response can be achieved. The proposed multi-level converter is verified by computer simulation and experimental results.

• Proceedings of the KSPS conference
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• 2006.11a
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• pp.11-13
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• 2006

The present paper focuses on the interaction between lexical-semantic information and affective prosody. More specifically, we explore whether affective prosody influence on evaluation of affective meaning of a word. To this end, we asked participants to listen a word and to evaluate the emotional content of the word which were recoded with affective prosody. Results showed that first, emotional evaluation was slower when the word meaning is negative than when they is positive. Second, when the prosody of words is negative, evaluation time is faster than when it is neutral or positive. And finally, when the affective meaning of word and prosody is congruent, response time is faster than it is incongruent.

• ETRI Journal
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• v.32 no.3
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• pp.406-413
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• 2010

In order to guarantee the proper operation of a recessed channel array transistor (RCAT) pseudo SRAM, the back-bias voltage must be changed in response to changes in temperature. Due to cell drivability and leakage current, the obtainable back-bias range also changes with temperature. This paper presents a pseudo SRAM for mobile applications with an adaptive back-bias voltage generator with a negative temperature dependency (NTD) using an NTD VBB detector. The proposed scheme is implemented using the Samsung 100 nm RCAT pseudo SRAM process technology. Experimental results show that the proposed VBB generator has a negative temperature dependency of -0.85 $mV/^{\circ}C$, and its static current consumption is found to be only 0.83 ${\mu}A$@2.0 V.

• Korean Journal of Child Studies
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• v.25 no.6
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• pp.153-170
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• 2004

This study explored age and sex differences in preschoolers' narrative representations of their mothers. Subjects were 120 3-, 4-, 5- and 6-year-old children, with 15 boys and 15 girls in each age group. Using the MacArthur Story Stem Battery(Bretherton et al., 1990), observations were made to obtain children's narrative representations of their mothers. content themes and emotional responses. Boys' representations were more negative and less positive than girls' regardless of their age. Boys talked about more aggressive themes and showed more anxiety and less joy. Five and 6-year-old children had less negative and disciplinary representations of their mothers than 3- and 4-year-olds. Six-year-olds showed less prosocial themes than 3- and 5-years, and fewer aggressive themes than 3-and 4-year while they showed less joy, distress and concern responses than 3-years.

• The Korean Journal of Applied Statistics
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• v.25 no.6
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• pp.1037-1047
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• 2012

The generalized linear mixed model(GLMM) is widely used in fitting categorical responses of clustered data. In the numerical approximation of likelihood function the normality is assumed for the random effects distribution; subsequently, the commercial statistical packages also routinely fit GLMM under this normality assumption. We may also encounter departures from the distributional assumption on the response variable. It would be interesting to investigate the impact on the estimates of parameters under misspecification of distributions; however, there has been limited researche on these topics. We study the sensitivity or robustness of the maximum likelihood estimators(MLEs) of GLMM for counts data when the true underlying distribution is normal, gamma, exponential, and a mixture of two normal distributions. We also consider the effects on the MLEs when we fit Poisson-normal GLMM whereas the outcomes are generated from the negative binomial distribution with overdispersion. Through a small scale Monte Carlo study we check the empirical coverage probabilities of parameters and biases of MLEs of GLMM.

• International Journal of High-Rise Buildings
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• v.8 no.4
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• pp.283-290
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• 2019

Corner cut, corner chamfered or a building shape change are adopted in the design of tall buildings to achieve aerodynamic superiority as well as response reduction. Kikuchi et.al pointed out that large negative peak external pressures can appear near the inside corner of set-back low rise buildings. It is therefore necessary to pay attention to facade design around steps in building surfaces. Peak wind pressures for corner cut or corner chamfered configurations are given in the AIJ code. However, they cannot be applied where there are many variations of vertical and horizontal steps. There has been no previous systematic research on peak wind pressures around steps in building surfaces. In this study, detailed phenomenon of peak wind pressures around steps in buildings are investigated focusing on vertical and horizontal distances from the building's corner.

• Journal of Information Technology Applications and Management
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• v.30 no.2
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• pp.59-66
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• 2023

This study aims to find the better working environment for the start-ups by tracking and analyzing the data from the firms that have occupied in the business incubator and also the firm that already left the business incubator. To do so, a total of the sixteen firms were responded and ten out of the sixteen were the firm that have occupied in the business incubator and the rest six were the firm already left. Based on the response, the positive things that they earned from the business incubator were renting an office or higher levels of technical skills; however, the negative things were low operating profit can be negative. The results of this study can contribute to the development of the business incubator for the future. The further study regarding satisfaction survey might help to build more creative and constructive environment for the business incubator.

• IMMUNE NETWORK
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• v.16 no.2
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• pp.134-139
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• 2016

Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of tumor-infiltrating T cells. Systemic blockade of PD-1 function using blocking antibodies has shown significant therapeutic efficacy in clinical trials. However, approximately 10 to 15% of treated patients exhibited serious autoimmune responses due to the activation of self-reactive lymphocytes. To achieve selective activation of tumor-specific T cells, we generated T cells expressing a dominant-negative deletion mutant of PD-1 (PD-1 decoy) via retroviral transduction. PD-1 decoy increased IFN-γ secretion of antigen-specific T cells in response to tumor cells expressing the cognate antigen. Adoptive transfer of PD-1 decoy-expressing T cells into tumor-bearing mice potentiated T cell-mediated tumor regression. Thus, T cell-specific blockade of PD-1 could be a useful strategy for enhancing both efficacy and safety of anti-tumor T cell therapy.

• The Korean Journal of Quaternary Research
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• v.13 no.1
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• pp.25-33
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• 1999

The relationships between climate (monthly precipitation and temperatures) and tree-ring growth of Korean fir (Abies koreana) growing at subalpine (1,600∼l,700m) zone on the south slope, Joong-Bong and the north slope, Changgun-Bong in the Cheonwang-bong area in Chiri mountains in the southern Korea were analyzed. Two cores from each of 10∼12 trees were extracted. The relationship between tree-ring(standardized) chronologies and climate was analyzed by the response-function method. Climate variables could explain 45.9∼53.8% of total variance in the chronologies. The precipitation response function of Korean fir were similar at both sites in overall ; positive for March∼May and August, and negative for February and July. The south-slope fir of Joong-Bong possessed higher negative temperature response function for February and August than north-slope one. The positive response function for April temperature was significant for both sites. In contrary to other subalpine species (e.g., Pinus koraiensis and Taxus cuspidata) in South Korea, whose growths are positively correlated with temperature in most seasons, the growths of Korean fir trees in Mt. Chiri appeared to be mainly limited by the moisture regime of spring prior to the cambial growth and early growing season.