• Environmental Mutagens and Carcinogens
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• v.18 no.2
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• pp.104-108
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• 1998

In the present study, we have evaluated cytotoxic effects of Taraxaci Herba extract in human oral epitheloid carcinoma cells. An antitumor activity was measured by colorimetric assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine protein B (SRB). The light microscopic study showed morphological changes, Ag-NOR (argyrophylic nucleolar organizer region) number and PAS positive reaction or the treated cells. These results obtained are as follows : MTT and SRB quantities were significantly decreased in cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations. The number of Ag-NORs were significantly decreased in cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations and the rate of Ag-NORs was shifted to left side (one Ag-Nounucleus was increased and five Ag-NORs/nucleus were decreased) by the high concentration. PAS reaction of cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations was negative. These results suggest that Taraxaci Herba retains a potential antitumor activity.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2883-2888
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• 2016

Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant source garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They were docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.

• Journal of The Korean Association of Information Education
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• v.8 no.1
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• pp.39-49
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• 2004

In this paper, We analysis actual condition of education about information communication ethics in elementary school and survey negative side effects of information communication ethics, such as, the circulation of unsound information, game addiction, the misuse and overuse of information. we survey recognition level of information communication ethics on the teachers who responsibles the education of the elementary school students and make some suggestions to develope education of information communication ethics based on research results.

• Archives of Plastic Surgery
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• v.42 no.1
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• pp.68-72
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• 2015

For recent years, use of autologous fat injection has increased significantly in facial contouring surgery. Along with such increase in use, complications like atypical mycoplasma infection have been also on the increasing trend. The authors report two cases of Mycobacterium chelonae infection that occurred after autologous fat injection. Patients were treated as infection that resistant to common antibiotics and results were negative to routine culture and Gram staining. Acid-fast bacillus stain, polymerase chain reaction (PCR) test and mycobacterial cultures were conducted for diagnosis under suspicion of atypical mycoplasma infection. Then, combination antibiotics therapy, surgical treatment, and steroid injection were performed for treatment. Both patients were diagnosed with Mycobacterium chelonae in PCR test. They were positive to mycobacterial cultures. Combination antibiotics therapy was repeated to improvement of symptom. However, they could not be free from side effects such as deformation in facial contour, scar and pigmentation even after full recovery. When chronic wound infections after autologous fat injection, we must suspect atypical or mycobacterial infection and conduct examinations for a early diagnosis and proper antibiotic therapy that is effective to the nontuberculous mycobacteria.

• Journal of Welding and Joining
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• v.29 no.2
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• pp.34-39
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• 2011

Nickel-based austenitic alloys such as Alloy 82 and 182 had been employed as the weld metals in nuclear power plants (NPPs) due to their high corrosion resistance as well as good mechanical properties. However, since the 2000s, the occurrence of primary water stress corrosion cracking has been reported in conjunction with these alloys in domestic and oversea NPPs. In the present work, we assumed an imaginary crack at the inner surface of a surge nozzle weld that had previously experienced the outside repair welding, and constructed its finite element model. Finite element analysis was performed with respect to the heat transfer, and then to the residual stress for obtaining the total applied stress distributions. These stress distributions were finally converted to the stress intensity factors for estimating crack growth rate. From the comparison of crack growth rate curves for the cases of no repair welding and outside repair welding, it was found that the outside repair welding did not exhibit negative effect on the crack growth for the surge nozzle under consideration in this work; in both cases, the cracks stopped growing before they became the through-wall cracks.

• Korean Journal of Health Education and Promotion
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• v.20 no.1
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• pp.61-76
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• 2003

As people get broader access to health information through the internet, there is a greater need for measure to maximize the social advantages of the internet and to minimize negative side-effects. With this concern, this paper classifies internet health information services sites into : on-line supply of health information, on-line consultation, on-line diagnosis, and on-line sales. As well this paper analyzes domestic laws supporting and/or regulating these services. The efficient provision of internet health services requires comprehensive laws on individual privacy protection, prevention and handling of medical accidents, an electronic prescription form for internet diagnosis, electronic signing, payment for medical expenses, qualifications for internet medical practitioners. Additional laws are required to establish internet pharmacies and internet health goods stores. These new laws can be prepared either separately or through revision of existing laws governing medical practice, pharmacies, and public health promotion. However, as the legal control by the government on cyber processes and entities has a fairly minimal effect, consumers should be encouraged to improve their own capacity for wisely using internet health services and health-service providers should be encouraged to promote voluntary supervision and control of their own services and practices.

• Journal of Electrical Engineering and Technology
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• v.11 no.4
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• pp.878-888
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• 2016

Cogging torque has a negative impact on the operation of permanent magnet machines by increasing torque ripple, speed ripple, acoustic noise and vibration. In this paper Magnet Shifting Method has been used as a tool to reduce the cogging torque in inset Line Start Permanent Magnet Synchronous Motor (LSPMSM). It has been shown that Magnet Shifting Method can effectively eliminate several lower-order harmonics of cogging torque. In order to implement the method, first the expression of cogging torque is studied based on the Fourier analysis. An analytical expression is then introduced based on Permanent Magnet Shifting to reduce cogging torque of LSPMS motors. The method is applied to some existing machine designs and their performances are obtained using Finite Element Analysis (FEA). The effect of magnet shifting on pole mmf (magneto motive force) distribution in air gap is discussed. The side effects of magnet shifting on back-EMF, core losses and torque profile distortion are taken into account in this investigation. Finally the experimental results on two prototypes 24 slot 4 pole inset LSPMS motors have been used to validate the theoretical analysis.

• Analyses & Alternatives
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• v.4 no.2
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• pp.71-102
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• 2020

This study analyzes the effect of demographic changes on economic growth. We use the supply-side output identity to forecast the growth potential of the Korean economy. According to the results, even based on optimistic assumptions and prospects, the economic growth rate is likely to fall drastically starting in 2020. Of course, to maintain growth potential, efforts to increase productivity are necessary. However, given the historical experience of developed countries, it is not clear whether the huge trend of demographic change can be offset by efforts to increase productivity. In the so-called '30-50 club' countries, both labor productivity and growth rate tend to fall after reaching the per capita income of $30,000. The degree of decline in the growth rate is closely related to changes in the working age population and the prime-age workforce. The results are similar when tracking the path of changes in total factor productivities of the economy. When a certain level of income is reached, the increase in total factor productivity also tends to slow down. The ripple effects of rapid changes in demographics will indeed be extensive. The negative impact is likely to be concentrated at a time when the working age population, the prime-age workforce, and the total population shrink simultaneously. Above all, it is necessary to use the government's fiscal space to block the possibility of a rapid fall in the growth rate. In addition, it is important to continuously implement various reform tasks that should be promoted, such as improving the education system and strengthening the social safety net.

• Journal of Forest and Environmental Science
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• v.39 no.4
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• pp.254-260
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• 2023

A sensor system has been developed that uses an ultrasonic sensor to detect the downhill slope on the side of a forest road and prevents a vehicle-type forest machine from rolling down a mountainside. A specular reflection of ultrasonic wave might cause severe issues in measuring distances to targets. By investigating the installation angle of the sensor to minimize the negative effects of specular reflection, the installation angle of lateral monitoring ultrasonic sensor could be determined based on the width of road shoulder. Obstacles such as small rocks or piece of log in a forest road may cause the forest machine to be overturned while the machine riding over due to excessive its posture change. It was determined that the laser sensor could be a part of a sensor system capable of specifying the location and size of small obstacles. Not only this sensor system including ultrasonic and laser sensors can issue a warning of dangerous sections to drivers in forest forwarders currently in use, but also it can be used as a driving safety sensor in autonomous forest machine or remote-control forest machine in the future.

• Journal of Information Processing Systems
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• v.20 no.1
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• pp.93-104
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• 2024

China is playing more predominant role in the liquefied natural gas (LNG) market worldwide and LNG import price is subject to various factors both at home and abroad. Nevertheless, previous studies rarely heed a multiple of factors. A time-varying parameter factor augmented vector auto-regression (TVP-FAVAR) model is adopted to discover the determinants of China's LNG import price and their dynamic impacts from January 2012 to December 2021. According to the findings, market fundamentals have a greater impact on the import price of natural gas in China than overall economic demand, financial considerations, and world oil prices. The primary determinants include domestic gas consumption, consumer confidence and other demand-side information. Then, there are diverse and time-varying spillover effects of the four common determinants on the volatility of China's LNG import price at different intervals and time nodes. The price volatility is more sensitive and long-lasting to domestic natural gas pricing reform than other negative shocks such as the Sino-US trade war and the COVID-19 pandemic. The results in this study further proves the importance of domestic natural gas market liberalization. China ought to do more to support the further marketization of natural gas prices while working harder to guarantee natural gas supplies.