• Title/Summary/Keyword: Negative Side-Effects

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THE USE OF DEEP SEDATION FOR THE DENTAL MANAGEMENT OF PEDIATRIC PATIENTS WITH DEFINITELY NEGATIVE BEHAVIOR (행동조절이 어려운 소아환자의 Deep sedation을 이용한 치과치료)

  • Um, Hye-Sook;Yoon, Hyung-Bae
    • Journal of the korean academy of Pediatric Dentistry
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    • v.25 no.4
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    • pp.710-716
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    • 1998
  • It is one of difficulties to control children who show definitely negative behavior in dental clinic. In such a case, the pharmacologic management has been used to provide quality care, minimize the extremes of disruptive behavior, promote a positive psychologic response to treatment and patient welfare and safety. Deep sedation can be defined as a controlled, pharmacologically-induced state of depressed consciousness from which the patient is not easily aroused which may be accompanied by a partial loss of protective reflexes. In this retrospective report, the sedation records of 200 pediatric dental patients of ASA Class I & II who were not successfully treated under conscious sedation were used for analysis. Most frequently used regimen of deep sedation was the co-medication of midazolam(0.3mg/kg), enflurane(1.0-2.0 vol%) and 50-70% $N_2O_2$. The average age and weight of the patients was 4.6 yr (S.D: 2.72) and 18.7kg(S.D: 6.35) respectively. The average operative time was 52 minutes and midazolam (0.1-0.2cc) was additionally administered intranasally to prolong the operative time as needed. The episodes of untoward side effects were reported during and/or after the procedure in 58 patients. Serious adverse reactions such as cyanosis or laryngospasm were even reported in 7 patients but without mortality. Deep sedation is a very effective way of completing the dental treatments for those who failed to respond well to the conscious sedation. This technique has many practical advantages over general anesthesia case but the demands for the rigid monitoring criteria limit its use in general practice setting. The continuous efforts to improve the safety of the medication and the technique are required for the benefits of the patients and parent.

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Emotion Classification Method Using Various Ocular Features (다양한 눈의 특징 분석을 통한 감성 분류 방법)

  • Kim, Yoonkyoung;Won, Myoung Ju;Lee, Eui Chul
    • The Journal of the Korea Contents Association
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    • v.14 no.10
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    • pp.463-471
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    • 2014
  • In this paper, emotion classification was performed by using four ocular features extracted from near-infrared camera image. According to comparing with previous work, the proposed method used more ocular features and each feature was validated as significant one in terms of emotion classification. To minimize side effects on ocular features caused by using visual stimuli, auditory stimuli for causing two opposite emotion pairs such as "positive-negative" and "arousal-relaxation" were used. As four features for emotion classification, pupil size, pupil accommodation rate, blink frequency, and eye cloased duration were adopted which could be automatically extracted by using lab-made image processing software. At result, pupil accommodation rate and blink frequency were statistically significant features for classification arousal-relaxation. Also, eye closed duration was the most significant feature for classification positive-negative.

A Study on the Status of Information Dysfunction and Improvement Plan of Gifted Elementary School Students in Information Science (초등 정보과학영재들의 정보화 역기능 실태와 개선방안)

  • Ryu, Keun-Seong;Lee, Ae-Jung;Lee, Jae-Ho
    • Journal of The Korean Association of Information Education
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    • v.8 no.2
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    • pp.241-248
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    • 2004
  • Although communication technologies are developing day by day, moral and ethical attitude in using the technologies do not come up with thier development. Because of this, the negative side of development is getting worse. Recently, educational and social institutes are recoginizing the depth of the negative effects of development and are trying to teach communication etiquettes and ethics. However, a systemic education of communication ethics for the gifted students in the information technology field is absent. Education should be done appropriately according to the levels of its recipeints. Thus, it would be necessary that education of commuication ethics be performed suitable for the gifted students. In this paper, We analyze the actual state of Internet usage of the gifted students of elementary school and also to present a plan for teaching the ethics of communications to those students.

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The Preclinical and Clinical Effects of Herbal Product Containing Rosa mutiflora Roots Extracts as a Main Component on the Hair Growth Promotion (찔레뿌리 추출물을 주성분으로 하는 천연물 조성물의 발모촉진 효과에 관한 전임상 및 임상시험 연구)

  • Kim, Joong-Hark;Hong, Sung-Kil;Hwang, Sung-Jue;Son, Sang-Wook;Choi, Yong-Soon
    • Korean Journal of Medicinal Crop Science
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    • v.20 no.2
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    • pp.108-116
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    • 2012
  • In this study, to develop hair growth agents using natural products which has excellent ability to promote hair growth effect and fewer side effect, animal experiment and clinical trials was performed to evaluate hair growth promotion effect of herbal product containing $Rosa$ $mutiflora$ roots extracts as a main component (RMHP). 4-week-old male C57BL/6 mice were removed the dorsal hair using thioglycolate, and applied 15% EtOH solution as a negative control, 5% minoxidil as a positive control and RMHP to dorsal skin. In the results of macroscopy and photo-interpretation, RMHP group recorded 100% (+++++) of hair growth was proved to significantly stimulate hair growth against 80% (++++) negative control group. 37 patients were treated with RMHP and evaluated the therapeutic effect at 16 weeks. Hair density was significantly increased at 16 weeks after applying RMHP ($125.0{\pm}4.9\;FU/cm^2$) compared to before treatment ($104.3{\pm}4.7\;FU/cm^2$, p < 0.05), and hair thickness were also significantly increased ($0.066{\pm}0.003$ mm) than before treatment ($0.055{\pm}0.002$ mm, p < 0.05). The result of clinical photo-interpretation using 7-point rating scale assessment, after 16 weeks clinical symptoms were evaluated to significantly improve with $1.23{\pm}0.05$ (p < 0.05). Therefore, the results of this study were observed that RMHP have hair loss prevention effect and hair growth promotion effect to hair loss patients.

A High Performance Co-design of 26 nm 64 Gb MLC NAND Flash Memory using the Dedicated NAND Flash Controller

  • You, Byoung-Sung;Park, Jin-Su;Lee, Sang-Don;Baek, Gwang-Ho;Lee, Jae-Ho;Kim, Min-Su;Kim, Jong-Woo;Chung, Hyun;Jang, Eun-Seong;Kim, Tae-Yoon
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.11 no.2
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    • pp.121-129
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    • 2011
  • It is progressing as new advents and remarkable developments of mobile device every year. On the upper line reason, NAND FLASH large density memory demands which can be stored into portable devices have been dramatically increasing. Therefore, the cell size of the NAND Flash memory has been scaled down by merely 50% and has been doubling density each per year. [1] However, side effects have arisen the cell distribution and reliability characteristics related to coupling interference, channel disturbance, floating gate electron retention, write-erase cycling owing to shrinking around 20nm technology. Also, FLASH controller to manage shrink effect leads to speed and current issues. In this paper, It will be introduced to solve cycling, retention and fail bit problems of sub-deep micron shrink such as Virtual negative read used in moving read, randomization. The characteristics of retention, cycling and program performance have 3 K per 1 year and 12.7 MB/s respectively. And device size is 179.32 $mm^2$ (16.79 mm ${\times}$ 10.68 mm) in 3 metal 26 nm CMOS.

In vivo and In vitro hair growth promotion effects of extract from Glycine soja Siebold et Zucc

  • Yang, Jae Chan;Kim, Bo Ae
    • Journal of Applied Biological Chemistry
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    • v.59 no.2
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    • pp.137-143
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    • 2016
  • Hair is a dermal adjunctive organ that protects the body from external physical and chemical stimuli; hair undergoes anagen, catagen, and telogen phases, with hair-loss occurring during the telogen phase. Alopecia is a condition wherein a person undergoes hair-loss far exceeding the normal amount, owing to diverse external factors. Wild beans are rich in isoflavone and amino acids known to prevent hair-loss; compared to cultivated beans, many wild bean species have higher protein content. This study aimed to develop a hair growth promoting solution, with superior hair growth promoting effects and fewer side effects, using naturally obtained Glycine soja Siebold et Zucc (GSSZ) extracts. Seven-week-old C57BL/6N male mice were classified into different experimental groups. Hair growth was observed in GSSZ-treated mice, and compared against that seen in 3 % minoxidil (MXD, positive control)-treated mice. Visual observations revealed a greater reduction in hair-loss in MXD and GSSZ application groups, compared to that in TXN group (hair loss induction using 1 % testosterone). Evaluation using an image analysis software revealed that compared to the positive control, TXN + GSSZ group showed the highest hair growth. TXN + MXD and control groups exhibited similar follicular cell growth, while the hair growth promotion patterns were similar in the negative control (normal), TXN + GSSZ, and TXN groups, as observed via histological analysis. GSSZ did not induce cytotoxicity (even at 2 mg/mL) in keratinocytes and dermal papilla cells; alternately, dermal papilla cell proliferation was activated in a (GSSZ) concentration-dependent manner. Therefore, the GSSZ extract promoted hair growth and increased hair growth-related cell activity, and could therefore be utilized in alopecia treatment.

The Influences of Driving Confidence Levels on Traffic Accidents: Research Using Path Analysis (운전확신수준이 교통사고에 미치는 영향: 경로분석을 이용한 연구)

  • Soon Chul Lee;Soon Yeol Lee ;Sun Jin Park
    • Korean Journal of Culture and Social Issue
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    • v.13 no.4
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    • pp.101-112
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    • 2007
  • We investigated the influences of 'Circumstance Insensibility', 'Unsafe Driving', 'Incautious Driving', and 'Self-efficacy of Driving', consisting of driving confidence level, on traffic accidents. 1055 drivers conducted Driving Confidence Level Questionnaire, items about their dangerous driving experience and traffic accidents. Among them, after checking the missing items, we analyzed data of 998 drivers. As a result, we found the relation between driving confidence levels and traffic accidents. Specially, 'Circumstance Insensibility' and 'Unsafe Driving' influenced traffic accidents. However 'Circumstance Insensibility' had negative effects, the other side 'Unsafe Driving' had positive effects on traffic accidents. This result means each factor of driving confidence levels have different relation with traffic accidents. 'Incautious Driving' and 'Self-efficacy of Driving' didn't have any effects on traffic accidents in this research. In future, it should be investigated 'Incautious Driving' and 'Self-efficacy of Driving'.

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Knowledge and Learning Needs Related to Cancer Treatment in Gynecological Cancer Patients (부인암환자의 항암치료에 대한 지식정도 및 교육요구도)

  • Seo, Mi-Sook;Choi, Euy-Soon
    • Journal of Korean Academy of Nursing
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    • v.36 no.6
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    • pp.942-949
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    • 2006
  • Purpose: This study was to investigate the knowledge and learning needs of chemotherapy in gynecological cancer patients. Method: The subjects consisted of 103 gynecological cancer patients receiving chemotherapy from April 2005 to August 2005. Data was collected using a questionnaire about knowledge and learning needs of chemotherapy. The data was analyzed by t-test, ANOVA, Scheffe test, and Pearson's correlation coefficient using SAS. Result: Average scores of knowledge and learning needs of general treatment and care were 2.74, and 3.30 respectively. Average score of knowledge and learning needs of chemotherapy were 2.54 and 3.23 respectively. Learning needs of general treatment and care and of chemotherapy were significantly different in relation to marital status, educational level, family support, the operation, and the amount of chemotherapy received. Items with the highest level of learning needs were the symptoms of recurring illness of general treatment, and minimizing side effects of chemotherapy. There were a negative correlation between knowledge and learning needs on general treatment and a positive correlation between knowledge and learning needs on chemothearpy but there were not significant statistically. Conclusion: The level of learning needs related to cancer treatment was high, whereas, that of knowledge was low. Therefore, when designing an educational program for gynecological cancer patients, understanding of learning needs is necessary. Also, consideration of a patient's characteristics, and a systematic and detailed educational program should be provided.

A Study on humanistic Imagination of Games using Oral Literature (구비문학을 활용한 게임의 인문학적 상상력에 관한 고찰)

  • Lee, Jae-Hong
    • Journal of Digital Convergence
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    • v.10 no.2
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    • pp.279-286
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    • 2012
  • Game contents are the driving force of the digital media era. As the gaming industry grows bigger, contents technologies are also rapidly developing in both their quality and quantity, while the story sources of the contents are depleting. Accordingly, digging out new stories that can support development of the cultural contents industry is emerging as an urgent issue. Since games took roots as a form of contents in our society, negative images have outweighed positive aspects. This study aims at finding cures for the side effects from storytelling. Important factors here are how to converge the technical nature of engineering imagination and the epic nature of humanities imagination. Recently, The excavations of the story is very important. This article demonstrates cases where the oral literature, an archetypical cultural genre, provides the sources of game storytelling.

A Review of Research on Acupuncture and Moxibustion Treatment for De Quervain's Stenosing Tenosynovitis

  • Kong, Hae Jin;Kang, Jae Hui;Yun, Gee Won;Oh, Seo Young;Lee, Hyun
    • Journal of Acupuncture Research
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    • v.34 no.3
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    • pp.71-90
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    • 2017
  • Objectives : This study was performed to review articles concerning acupuncture and moxibustion treatment for De Quervain's Stenosing Tenosynovitis. Methods : On-line databases including Cochrane Library, Pubmed, CNKI, NDSL and OASIS were searched to identify articles concerning acupuncture and moxibustion treatment for De Quervain's Stenosing Tenosynovitis (DQST). Several duplicated articles and those not relevant to this topic were excluded, as were review articles and commentaries. Results : Fifty-one studies were identified, which included 28 clinical case studies with 1,227 patients and 23 randomized controlled trials with 2,040 patients. In these studies, acupuncture, acupotomy, moxibustion, pharmacopuncture, and laser acupuncture were used as DQST interventions. Although DQST is a common disease seen in clinical practice, only four of the 51 studies we identified in our search were published in Korean academic journals, all of which used pharmacopuncture. Conclusion : Although the results of the studies to date provide evidence that acupuncture and moxibustion are effective treatments for De Quervain's Stenosing Tenosynovitis, the absence of a standard, objective evaluation tool, and a lack of reporting on the negative side-effects associated with treatment remain important factors that should be addressed in future studies.