• Nuclear Engineering and Technology
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• 제54권10호
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• pp.3949-3956
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• 2022

Kori Unit 1 is planning a system decontamination project to reduce radiation exposure of decommissioning workers, prevent the spread of contamination and down-grade the level of classification of radioactive waste. The system decontamination range for Kori Unit 1 will be the entire primary system, including RCS, CVCS and RHRS. Some system design modifications are required for the system decontamination operation. In this paper, major system design modifications were evaluated based on the conditions that system restoration is needed after completion of system decontamination. The major system design modifications are CIDF connection location to system, system decontamination operating pressure control, RCP seal water injection and formation of letdown flow. It was evaluated that there was no negative effect on the system due to the system design modifications. However, as the RCP seal water is injected into the system in the oxidation process, the concentration of the oxidizing agent is diluted. Therefore, the oxidizing agent injection and system decontamination operation procedures should be developed to address the dilution effect of the oxidizing agent. The system design modifications dealt in this paper will be finally confirmed through on-site investigation in the future, and if necessary, the system design modifications will be re-evaluated.

• Nuclear Engineering and Technology
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• 제56권3호
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• pp.1116-1123
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• 2024

-In recent years, unmanned underwater vehicles (UUV) have been vigorously developed, and with the continuous deepening of marine exploration, traditional energy can no longer meet the energy supply. Nuclear energy can achieve a huge and sustainable energy supply. The heat pipe reactor has no flow system and related auxiliary systems, and the supporting mechanical moving parts are greatly reduced, the noise is relatively small, and the system is simpler and more reliable. It is more favorable for the control of unmanned systems. The use of heat pipe reactors in unmanned underwater vehicles can meet the needs for highly compact, long-life, unmanned, highly reliable, ultra-quiet power supplies. In this paper, a heat pipe reactor scheme named UPR-S that can be applied to unmanned underwater vehicles is designed. The reactor core can provide 1 MW of thermal power, and it can operate at full power for 5 years. UPR-S has negative reactive feedback, it has inherent safety. The temperature and stress of the reactor are within the limits of the material, and the core safety can still be guaranteed when the two heat pipes are failed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5437-5442
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• 2014

Esophageal squamous cell carcinoma (ESCC) is one of the most malignancies with a poor prognosis. The phospholipase $C{\varepsilon}$ gene (PLCE1) encodes a novel ras-related protein effector mediating the effects of R-Ras on the actin cytoskeleton and membrane protrusion. However, molecular mechanisms pertinent to ESCC are unclear. We therefore designed PLCE1-special small interfering RNA and transfected to esophageal squamous cell (EC) 9706 cells to investigat the effects of PLCE1 gene silencing on the cell cycle and apoptosis of ESCC and indicate its important role in the development of ESCC. Esophageal cancer tissue specimens and normal esophageal mucosa were obtained and assayed by immunohistochemical staining to confirm overexpression of PLCE1 in neoplasias. Fluorescence microscopy was used to examine transfection efficiency, while the result of PLCE1 silencing was examined by reverse transcription (RT-PCR). Flow cytometry and annexin V apoptosis assays were used to assess the cell cycle and apoptosis, respectively. Expression of cyclin D1 and caspase-3 was detected by Western-blotting. The level of PLCE1 protein in esophageal cancer tissue was significantly higher than that in normal tissue. After transfection, the expression of PLCE1 mRNA in EC 9706 was significantly reduced, compared with the control group. Furthermore, flow cytometry results suggested that the PLCE1 gene silencing arrested the cell cycle in the G0/G1 phase; apoptosis was significantly higher than in the negative control group and mock group. PLCE1 gene silencing by RNAi resulted in decreased expression of cyclin D1 and increased expression of caspase-3. Our study suggests that PLCE1 may be an oncogene and play an important role in esophageal carcinogenesis through regulating proteins which control cell cycling and apoptosis.

• 한국환경생태학회지
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• 제34권2호
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• pp.121-129
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• 2020

본 연구는 강원도 원주시에 설치된 사방댐을 대상으로 장마 전·후의 자료를 비교·분석하여 사방댐에 의한 저서성 대형무척추 동물의 군집 변화를 파악하고자 하였다. 조사시기는 2019년 3월부터 9월까지 총 4회 조사를 실시하였으며, 조사지점은 불투과형 사방댐(전석), 투과형 사방댐(버트리스), 대조지역을 선정하여 사방댐을 기준으로 상류 2지점, 하류 2지점을 조사하였다. 유속은 불투과형, 투과형, 대조지역의 지점에서 대부분 증가하였으며, 불투과형은 St. 3에서 장마 이후 감소하는 것으로 나타났다. 저서성 대형무척추동물의 종수 및 개체수는 장마 이후 대부분 감소하는 것으로 나타났으며, 투과형과 대조지역의 개체수 감소율은 전석에 비해 비교적 유사한 것으로 나타났다. EPT 그룹의 종수 및 개체수는 장마 이후 대부분 감소하는 것으로 나타났다. 유사도 분석 결과, 장마 이전에는 불투과형 및 투과형이 대조지역과 38.4%로 구분되었으나, 장마 이후에는 투과형과 대조지역이 불투과형과 51.3%로 구분되었다. PCA 분석 결과, Axis 1을 기준으로 불투과형은 장마 전·후로 양의 값을 나타내었으며, 투과형과 대조지역은 장마 전·후 음의 값을 나타내어 불투과형 보다는 투과형이 대조지역과 상관성이 높은 것으로 분석되었다. EPT 그룹은 불투과형에서 하루살이목, 투과형과 대조지역에서 날도래목이 분포하는 것으로 분석되었다. 본 연구결과, 사방댐 설치는 저서성 대형무척추동물 군집에 변화를 초래할 수 있으며, 불투과형 보다는 상대적으로 투과형이 대조지역과 장마 이후 군집 차이가 적은 것으로 분석되었다.

• Journal of Chest Surgery
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• 제29권10호
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• pp.1076-1080
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• 1996

허혈후 재관류시 일산화질소의 전구체인 L-arginin에 심근기능에 미치는 영향은 각 연구의 조건에 따라 일정하지 않다. 저자들은 L-arginine의 농도에 의한 심근보호효과의 차이를 알아보고자 본 연구를 시행하였다. 란겐돌프 관류장치하의 흰쥐 적출심장에 37.5$^{\circ}C$에서 30분의 허혈과 30분의 재관류를 실시하면서 재관류시 관류액에 L-arginine을 첨가하여 농도를 1, 2, 3, 4 mm/L로 하였고 대 조군에는 L-arginine을 첨가하지 않았다. 허혈기 직전과 재관류 30분에 좌심실 수축기능(좌심실 발생압, 좌심실압 최대 순간 증가율), 이완기능(좌심실압 최대 순간 감소율)과 관상관류량을 측정하였다. L-arginine 농도가 1mm/L, 2 mm/L인 실험군은 좌심실 발생압, 좌심실압 최대 순간증가율, 좌심실압 최대 순간감소율 및 관상관류량의 회복률이 대조군에 비해 통계적 유의성은 없었으나 우수한 경향을 보였다. 그러나 L-arginine의 농도가 증가함에 따라 회복률은 감소하여 4 mM/L농도의 실험군은 대조군보다 유의하게 낮은 회복률을 보였다(p(0.05). 이러한 연구결과를 통해 심근허혈후 재관류시 심근기능 및 관상관류량 회복을 향상시키기 위해서는 L-arginine을 2mM/ 이하의 농도로 투여 해야 하며 향후 그 이상의 높은 농도에서 나타난 회복 저하에 관한 연구가 필요할 것으로 생각된다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제23권2호
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• pp.63-72
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• 2017

Purpose: The purpose of this study is to review the material handling system of the Airborne Infection Isolation Hospitals which is the one of the key elements of infection control and to improve the basic data for the planning and design of those facilities. Methods: Research was conducted by literature reviews and case studies for the material handling system of domestic and foreign Isolation hospitals. Results: The result of this study can be summarized into three points. First, a general isolation unit and a high level isolated unit need to be distinguished in terms of efficiency and safety. In particular, it is desirable that a high level isolated unit have to completely separate clean and soiled circulations, and soiled corridor should be installed by those means. By doing this, the medical staff can observe patient rooms and supply clean materials directly in the clean zone without wearing PPE, so that safety and work efficiency can be improved at the same time. Second, for the safe disposal of wastes, it is desirable to install a dedicated sterilizer per ward and sterilize it at least in the ward. In addition, It is desirable to install a central waste treatment room and a dedicated soiled corridor in consideration of the inadequate handling capacity and emergency situation. Third, the characteristics of material flow chart in the negative pressured isolation hospitals and the corresponding material handling system have been presented. Implications: Infection control is very important in safety, but it is necessary to respond to the symptoms of the patient.

• Archives of Plastic Surgery
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• 제32권6호
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• pp.727-732
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• 2005

The treatment of wounds of the lower extremity caused by diabetes or vascular dysfunction remains a difficult problem for the plastic surgeon. The use of negative pressure in wound healing is a relatively new method to facilitate chronic wound healing by secondary healing. The use of vacuum-assisted closure(VAC) system is purposed to reduce local edema, increase regional blood flow, enhance epithelial migration, preserve a moist wound environment, reduce bacterial colonization, promote granulation tissue formation, and mechanically enhance wound closure. The VAC also can be used as a dressing for anchoring an applied split thickness skin graft. We reviewed the data from 20 consecutive patients with non-healing wound in lower extremity at Dong-A University from March 2002 to December 2004. We used the VAC in 20 patients and compared the results with the control group. In the VAC using group, mean application duration was about 3 weeks and dressing change was done every other day. The follow-up period of patients ranged from 3 months to 30 months with a mean of 17 months. The points of comparison with control group are wound size, granulation tissue proliferation rate, operation method, preoperative time, postoperative healing time, complication, and cost. With those points, we propose to approve the efficiency of the VAC in non-healing wound. As a result, the VAC used in non-healing wound decrease wound size, accelerate granulation tissue formation, do a wound closure with less invasive operation method, make less postoperative complication, can make operation time shorter. Therefore it is cost effect. Our results demonstrate the usefulness of VAC as an adjunct in management of chronic wounds with other extrinsic factors.

• Clinical and Experimental Pediatrics
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• 제55권1호
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• pp.11-17
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• 2012

Purpose: Early identification of neonatal sepsis is a global issue because of limitations in diagnostic procedures. The objective of this study was to compare the diagnostic accuracy of neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. Methods: A prospective study enrolled newborns with documented sepsis (n=11), clinical sepsis (n=12) and control newborns (n=14). CRP, neutrophil CD64, complete blood counts and blood culture were taken at the time of the suspected sepsis for the documented or clinical group and at the time of venipuncture for laboratory tests in control newborns. Neutrophil CD64 was analyzed by flow cytometry. Results: CD64 was significantly elevated in the groups with documented or clinical sepsis, whereas CRP was not significantly increased compared with controls. For documented sepsis, CD64 and CRP had a sensitivity of 91% and 9%, a specificity of 83% and 83%, a positive predictive value of 83% and 33% and a negative predictive value of 91% and 50%, respectively, with a cutoff value of 3.0 mg/dL for CD64 and 1.0 mg/dL for CRP. The area under the receiver-operating characteristic curves for CD64 index and CRP were 0.955 and 0.527 ($P$ <0.01), respectively. Conclusion: These preliminary data show that diagnostic accuracy of CD64 is superior to CRP when measured at the time of suspected sepsis, which implies that CD64 is a more reliable marker for the early identification of neonatal sepsis as a single determination compared with CRP.

• 환경생물
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• 제36권1호
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• pp.90-97
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• 2018

본 연구는 넙치 양식장 시설 내로 유입되는 병원 미생물을 효과적으로 관리하기 위한 오존 처리 기준을 마련하고자 수행되었다. 유수식 환경에서 오존 주입량을 $0.3{\sim}3.0mg\;O_3L^{-1}$의 범위로 주입하면서 3분의 반응시간을 가진 후 ORP 320~410 mV에서 TRO가 $0.01{\pm}0.01mg\;L^{-1}$가 검출되었으며, 600 mV와 700 mV에서 $0.07{\pm}0.02mg\;L^{-1}$와 $0.16{\pm}0.03mg\;L^{-1}$가 검출되었다. 오존 처리에 따라 총세균수는 80.6~97.9%의 제거율을 나타내어 오존 처리를 통한 미생물 제거효과는 분명하게 나타났다. 230 g 넙치를 $8.0kg\;m^{-2}$ 밀도로 사육한 300~400 mV 실험구에서는 총세균수는 가장 낮은 값을 보였다. 특히 400~500 mV에서 Vibrio spp.와 그램음성균은 거의 검출되지 않았다. 일간사료섭취율은 300~500 mV에서 0.7% 이상을 나타내어 대조구인 자연해수보다 감소하지 않아 부작용이 적은 것으로 나타났다. 넙치 양식장으로 유입되는 병원 미생물은 유입수의 ORP 400 mV 수준에서 효율적으로 제거되는 것으로 조사되었다.

• 생물환경조절학회지
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• 제19권4호
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• pp.195-202
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• 2010

수집 농산물의 세척, 선별, 포장 작업 등이 이루어지는 APC 작업장은 하절기에 작업자들이 고온의 환경에 노출되므로 작업환경 개선을 위한 냉방공조가 요구되고 있다. 기존의 전체 냉방 공조방식은 과도한 유지비로 인한 운용상의 어려움이 발생하고 있으므로 설비비 및 운용비가 상대적으로 저렴한 시스템을 적용할 필요가 있다. 본 연구에서는 하절기 APC 작업공간의 효율적 냉방을 위한 냉방시스템 설계의 기초 연구로써 CFD를 기반으로 하여 양압식 및 음압식 팬 앤 패드 시스템과 국소냉방 시스템에 대해 열유동 수치해석을 수행하여 각각의 냉방효과를 예측하였다. 그 결과, 음압식 팬 앤 패드 시스템은 고온 외기의 과도한 유업으로 인해 패드 하류의 일부 영역을 제외한 대부분의 작업영역에서 상대적으로 고온의 온도 분포를 보였으며 기류의 유속분포 역시 낮게 나타나 APC 냉방시스템으로 부적합한 것으로 판단되었다. 양압식 팬 앤 패드 시스템은 직업장의 중심부 및 각 작업영역에 비교적 균일한 저온환경을 조성하나 작업자 위치별로 기류의 유속편차가 크게 나타났다. 국소냉방 시스템의 경우 각 작업자 위치의 상부에서 냉기류가 공급되는 방식이므로 팬 앤 패드 시스템에 비해 작업자 위치에서의 온도분포와 기류 유속분포가 상대적으로 균일하게 나타났다. 양압식 팬 앤 패드 시스템은 냉방기를 사용하는 기존의 공조방식에 비해 설비비 및 유지비가 저렴하나, 실제 APC 작업장의 냉방공조에 적용시에는 팬 소음, 고습환경이 선별기 등 장비에 미치는 영향, 용수공급 및 패드교체 등을 고려하여 보다 신중한 검토가 요구된다.