• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.506-513
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• 1996

The odor theory(氣味論) has been defined as the Nature(氣) and the Taste(味) of traditional herbal medicine to find the logic in treatment of various diseases by them. There is a strong possibility these Natures of the drug can be categorized according to yin(陰) and yang(陽). To understand the Hot and the Cold Natures of traditional herbal drugs in scientific approaches, changes in skin, rectal temperature of rats have been measured at 0, 30, 60, 90 min after a 5, 10, 20g/Kg oral administration each of Coptidis Rizoma(Ranunculaceae, Coptis chinesis, $F_{RANCH}$), Aconiti Lateralis Preparata Radix(Ranunculaceae, Aconitum carmichaeli $D_{EBX}$). From this study, we obtained as follows. 1. We can categorize the four Natures of drug according to yin(陰) - Cool and Cold Natures and yang(陽) - Warm and Hot Natures. 2. The relation between the four Natures of drug and the changes of body temperature can be studied as the considertion of the dosage and the preparation of crude medicines. 3. Herbs containing toxicant should be studied carefully without the side effects.

• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.8-11
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• 1997

The odor theory (기미론) has been defined as the Nature (기) and the Taste(미) of traditional herbal medicine to find the logic in treatment of various diseases by them. There is a strong possibility these Na1ures of the drug can be categorized according to yin (음) and yang (음). There is a neutral Nature which does not fit into one of these four categories. To understand the Natures of traditional herbal drugs in modern scientific approaches, changes in rectal temperature of rats have been measured at 0,30, 60, 90 min after a 10 g/Kg oral administration each of 34 different drugs. Following the classification of the four Natures of drugs, only the temperatures of warm group at 30, 60, and 90 min were elevated significantly from the control and the rest groups. Following a modified classification of 3 groups such as cold and cool, warm and hot, and neutral Nature, changes in temperatures after administration of Hot and Warm drugs were also increased significantly from the control (P<0.01). Thus, the measurement of rectal temperature can be a tool to define the Nature (기) of traditional herbal drugs, but the modified classification is another way to do.

• The Journal of Korean Medicine
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• v.18 no.2
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• pp.148-154
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• 1997

In the pharmacology of traditional Korean medicine, each drug has its own specific characters. The different characters of drugs are employed to treat diseases, rectify the hyperactivity or hypoactivity of yin or yang, and help the body restore its normal physiological functions, consequently curing the diseases and restoring health. The various characters and functions of these drugs concerning medical treatment include drugs' properties, flavours, actions of lifting, lowering, floating and sinking, channel tropism, toxicity, etc. Among these theories, theory of properties and flavours of drugs provides the basis for drug analysis and application. 'Property' refers to the cold, hot, warm or cool nature of a drug. These properties of drugs are so sorted out according to the different actions of the drugs on the human body and thier therapeutic effects. Drugs which cure heat syndrome(yang syndrome) have a cold or cool property, whereas drugs which cure cold syndrome (yin syndrome) have hot or warm property Drugs of cold and cool-natured and drugs of warm and hot natures are of opposite properties. A cold-natured drug is different from a cool-natured on only in degree, and so is a warm-natured drug from a hot-natured drug. Most of the cool- or cold- natured drugs have the effects of clearing heat, purging fire, removing toxic substances, and nourishing yin, and are uese to cure heat syndromes. On the contrary, drugs of warm or hot nature usually have the effects of dispersing cold, warming up the interior, supporting yang, and treating collapse, and are therefore used to treat cold syndromes. We thought that the property of drug may be related to the autonomic nervous system in western medicine. In other words, drugs of warm or hot nature increase heart rate or acts like sympathomimetics, and drugs of cool or cold nature decrease heart rate or acts like para sympathomimetics . According to this hypothesis, we administrated some drugs to isolated rat right atrium in magnus tube. But there is no correlation between 'property' in traditional Korean medicine and autonomic nervous system in western medicine.

• Journal of Pharmaceutical Investigation
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• v.23 no.4
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• pp.187-206
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• 1993

Since the advent of recombinant DNA technology coupled with other biotechnology a variety of therapeutically effective proteins and peptides have been extensively invesitigated and many of them are now on clinical trial. They, however, suffer from some problems such as immunogenicity, antigenicity, instability and short half-life in circulation due to their proteinous natures. These drawbacks can be overcome successfully by conjugating proteins and peptides with hydrophilic polymers such as polyethylene glycol (PEG), albumin or dextran. The resulting soluble conjugates showed reduced antigenicity and immunogenicity, increased circulatory half-life, enhanced stability against proteolytic degradation. Comparing with the unmodified proteins and peptides, the therapeutic potential of conjugates is greatly enhanced. Clinical applications of these conjugates have shown promising results for the future use.

• Korean Journal of Oriental Medicine
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• v.7 no.1
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• pp.1-16
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• 2001

The Objective of this article is to make a bibliographical introduction and to discuss the historical value of several literatures on the Sasang constitutional medicine established by Jema Lee$(1837{\sim}1900)$. Literatures are as follows: 1. ${\ulcorner}$HamsanSachon Donguisusebowon(咸山沙忖 東醫壽世保元 甲午舊本)${\lrcorner}$; newly found draft of ${\ulcorner}$Donguisusebowon${\lrcorner}$ that contains an old edition written in 1894. 2. ${\ulcorner}$Bojeyeonseol-Supplement of Donguisusebowon(普濟演設-東醫壽世保元補編)${\lrcorner}$; a clinical book which is regarded as to had been published before the first edition of ${\ulcorner}$Donguisusebowon${\lrcorner}$ was printed. 3. ${\ulcorner}$Gyukchigo appendix(格致藁-附錄)${\lrcorner}$, ${\ulcorner}$Sasang Medicine-A Memorandom of the first edition(四象醫學草本卷備忘錄)${\lrcorner}$; which were aquired in Yanbian(China) several years ago. 4. ${\ulcorner}$Donguisusebowon${\lrcorner}$- The first edition published in 1901; owned by Mikki Sakae(三木榮) a Japanese medical historian. 5. ${\ulcorner}$Donguisusebowon${\lrcorner}$ - Manuscript; poetry on natures of herbal drugs are appended.