• Advances in Traditional Medicine
• /
• 제7권1호
• /
• pp.51-64
• /
• 2007

Mucus is an aqueous gel complex with a constitution of about 95% water, high molecular weight glycoprotein (mucin), lipid, salts etc. Mucus appears to represent a significant barrier to the absorption of some compounds. Natural mucoadhesive agent was isolated and purified from the aqueous extract of the seeds of prosopis pallida (PP). Formulated tablet with the isolated material by wet granulation method. Some natural edible substances are in consideration for candidates as mucoadhesive agents to claim more effective controlled drug delivery as an alternative to the currently used synthetic mucoadhesive polymers. Subjected the materials obtained from natural source i.e. PP and standard synthetic substance, sodium carboxymethyl cellulose for evaluation of mucoadhesive property by various in vitro and in vivo methods. Through standard dissolution test and a model developed with rabbit, evaluated in vitro controlled release and bioadhesive property of theophylline formulation. Mucoadhesive agent obtained from PP showed good mucoadhesive potential in the demonstrated in vitro and in viνo models. The results suggest that the mucoadhesive agent showed controlled release properties by their application, substantially. In order to assess the gastrointestinal transit time in vivo, a radio opaque X-ray study performed in healthy rabbit testing the same controlled release formulation with and without bioadhesive polymer. Plasma levels of theophylline determined by the HPLC method and those allowed correlations to the in vitro mucoadhesive study results. Better correlation found between the results in different models. PP may acts as a better natural mucoadhesive agent in the extended drug delivery system.

• Toxicological Research
• /
• 제35권1호
• /
• pp.1-7
• /
• 2019

Mycotoxin contamination is a global phenomenon and causes a wide array of negative effects and other complications. This study focused on commonly found mycotoxins in Africa and the possible means of prevention or reduction of their contaminating effects. Mycotoxins are secondary metabolites of mold and fungi; they are generally toxic to living organisms. Hundreds of mycotoxins have been identified thus far, with some, such as aflatoxins, ochratoxins, trichothecenes, zearalenone, fumonisins, and patulin, considered agro-economically important. Several factors contribute to the presence of mycotoxins in food, such as climatic conditions, pest infestation, and poor harvest and storage practices. Exposure to mycotoxins, which occurs mostly by ingestion, leads to various diseases, such as mycotoxicoses and mycoses that may eventually result in death. In light of this, this review of relevant literature focuses on mycotoxin contamination, as well as various methods for the prevention and control of their prevalence, to avert its debilitating consequences on human health. Clear evidence of mycotoxin contamination is present in Africa, and it was therefore recommended that adequate prevention and control of these toxic substances in our food system should be encouraged and that appropriate measures must be taken to ensure food safety as well as the enhanced or long-lifespan of the African populace. Governments, research institutions, and non-governmental organizations should tailor the limited resources available to tackle mycotoxin prevalence, as these will offer the best prospects for successful development of a sustainable food system in Africa.

• 상하수도학회지
• /
• 제21권4호
• /
• pp.395-407
• /
• 2007

Disinfection by-products(DBPs) are formed through the reaction between chlorine and natural organic matter(NOM) in water treatment. For reducing the formation of chlorinated DBPs in the drinking water treatment, there is a need to evaluate the behavior of NOM fractions and the occurrence of DBPs for each fraction. Among the six fractions of NOM, the removal of HPOA and HPIN got accomplished through coagulation and sedimentation processes. Advanced water treatment processes were found to be most significant to remove the HPOA and HPON. It was found that HPOA made the most THMFP level than any other fractions and HPIA and HPOA formed higher HAAFP. The fraction of NOM with MW less than 1k Da was 32.5~54.3% in intake raw water. Mostly the organic matter with MW more than 1k Da was removed through coagulation and sedimentation in the drinking water treatment processes. In case of advanced water treatment processes, the organic matter with MW 1k~100k Da decreased by means of ozone oxidation for high molecular weight substances. As the result low molecular organic matter increased. In the BAC and GAC processes, the organic matter with MW less than 100k Da decreased.

• Toxicological Research
• /
• 제14권2호
• /
• pp.171-176
• /
• 1998

The biological effects of the water extracts of Rhus Verniciflua Stokes (RVS) were evaluated by protection against hydroxyl radicals. Antioxidative activities were measured using both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and thiocyanate method. Also we used the Glucose oxidase (GO) 20 mU/$\textrm{m}{\ell}$ hydroxyl radical generating system in mouse forebrain cell culture. Water was used for ex-traction from RVS as a solvent which has high polarity especially. In DPPH method, the antioxidative activities of the crude water extract were stronger than any other extracts of low polar-solvents. In the antioxidative effects of mouse forebrain culture using 20 mU/$\textrm{m}{\ell}$ GO, cell viabilities were evaluated 65.6%, 68.8% at 1 $\mu\textrm{g}$. 5 $\mu\textrm{g}$ addition of crude water extracts (30 mg/$\textrm{m}{\ell}$) respectively. 10 $\mu\textrm{g}$ addition of crude water extracts had more than 86.1% cell viabilities, P<0.0l significantly, compared with the group treated with GO alone. In comparison with the antioxidative activities of several commercial antioxidants (ascorbic acid, $\alpha$-tocopherol, catalase, serum), 273 $\mu\textrm{g}$/$\textrm{m}{\ell}$ addition of crude water extracts (300 $\mu\textrm{g}$/$\textrm{m}{\ell}$) showed equivalent antioxidative effect to 25 uM ascorbic acid.

• 한국수정란이식학회지
• /
• 제33권3호
• /
• pp.159-168
• /
• 2018

Bovine colostrum is necessary for newborn calves to survive, grow and receive immunity from their mother. Cows in Korea produce about 35kg of colostrum, 4Kg of which is fed to the calf, and the rest is discarded. The bovine colostrum causes the harmful side effects to human, such as allergies and digestive problems; so, it is prohibited by law to consume colostrum itself as a food. However, many scientific research data have suggested that components in the colostrum can improve human health and has the ability to help treat diseases. In line with the trend of food and pharmacy industries using natural product materials, which attract positive attention, recently, some ingredients in colostrum have been used in the production of food supplements, and it has been used in its raw form in some cosmetics. This review introduces the active ingredients and physiologically active substances contained in bovine colostrum, summarizes the efficacy of physiological enhancement of the colostrum, which has been proven by scientific methods to date, and also suggests the possibility of industrial applications of colostrum as an animal-derived natural material.

• Journal of Nutrition and Health
• /
• 제2권1호
• /
• pp.29-34
• /
• 1969

The nutrients such as protein, calcium, iron and all three of them, either by natural or chemical substances were added to the recipes of yeast breads. Acceptability test was carried for the each formulated bread before selecting eight experimental diets. Sixty albino rats were separated into ten dietary groups including eight enriched breads and two control diets of plain breads from the market, which were used as the carbohydrate sources of the each basal diet. Experimental regime was seven weeks. The growth rate, hematology, total serum protein and organ weights we compared. Generally animals on the enriched bread showed the better growth rate than the rats fed control diet. Diet H enriched protein, iron and calcium by natural foods, brought up the highest weight gain among all of the rats. Hemoglobin concentrations of the rats on the diet H and G (enriched with three nutrients by chemicals) were 14.3 and 14.2 gram % comparing with other two control groups (12.9 and 13.1 gram%). Rats on diet K (fed nothing but diet H enriched bread) showed the significantly higher growth rate, total serum protein and hemoglobin level than these on the diet L (fed only plain bread from the market).

• 생약학회지
• /
• 제34권1호통권132호
• /
• pp.40-44
• /
• 2003

Antler has been used as one of the important traditional oriental medicines for many years. It contains many biochemical components including lipids, peptides, carbohydrates, and inorganic substances. The various biological activities of antler are being considered owing to such biochemical components. The purpose of this research is to compare the biochemical components of antlers after treatment of three different kinds of fodder. They are mulberry (group A), Lycii Fructus (group B) and the complex of herbs (group C). The chemical composition of each antler was determined in three sections (top, middle, and bottom) and compared with those of the control. The contents of sialic acid, uronic acid and glycosaminoglycans increased in the top antlers of the group B. Total lipids content increased in the top antlers of all groups (A, B, and C). The concentration of inorganic ions (Ca, Mg, and P) decreased in all groups. Fattyacid composition was also analyzed by GC-MS and expressed as percentage of total fatty acid concentration. The content of palmitic acid decreased in all groups. The content of 2-hydrox-yhexadecanoic acid, which has not been reported in aster, increased in the top antlers of all groups. These results suggest that the treatment of special fodder may affect the composition of the biochemical components of antlers.

• Natural Product Sciences
• /
• 제17권4호
• /
• pp.279-284
• /
• 2011

Phytochemical studies on the whole extract of Sedum hybridum L., a Mongolian medicinal plant, has been undertaken to isolate active principles responsible for its anti-oxidative and antibacterial activities. Eighteen known compounds, i.e. (1) quercetin, (2) kaempferol, (3) herbacetin-8-O-${\beta}$-D-xylopyranoside, (4) myricetin, (5) gossypetin-8-O-${\beta}$-D-xylopyranoside, (6) gallic acid, (7) 2,4,6-tri-O-galloyl-D-glucopyranose, (8) 6-O-galloylarbutin, (9) myricetin-3-O-${\alpha}$-L-arabinofuranoside, (10) quercetin-3-O-${\alpha}$-L-arabinofuranoside, (11) caffeic acid, (12) ethylgallate, (13) (-) epigallocatechin-3-O-gallate, (14) palmitic acid, (15) stearic acid, (16) stearic acid ethyl ether, (17) ${\beta}$-sitosterol and (18) ${\beta}$-sitosteryl-O-${\beta}$-D-glucopyranose have been isolated and their molecular structures identified by spectroscopic analysis. Thirteen substances including seven flavonol components (1, 2, 3, 4, 5, 9 and 10), five gallic acid derivatives (6, 7, 8, 12 and 13) and caffeic acid (11) exhibited significant, dose-dependent, DPPH radical scavenging activity. Galloyl esters 12 and 13 were revealed to be main active principles for the antibacterial property of the extract of Sedum hybridum L.

• Natural Product Sciences
• /
• 제20권1호
• /
• pp.33-38
• /
• 2014

In recent times, the demand for edible medication for the treatment of hyperpigmentation has increased significantly. Therefore, the discovery of a stable, safe and inexpansive antimelanogenic component from natural substances, such as grains, is of particular interest. The levels and activities of some metabolites and/or enzymes can be increased. In the present study, we investigated the antimelanogenic effects of water-soluble extracts from barley (BE), malt (ME) and germinated barley (GBE) in melan-a cells. The inhibitory effects of ME and GBE on melanin production were significantly greater than that of BE. Interestingly, the content of ferulic acid, the proposed active component of barley, was also higher in ME and GBE than in BE by HPLC analysis. Western blot analysis of the expression of melanogenic enzymes in melan-a cells treated with BE, ME or GBE indicated the expression of both tyrosinase and tyrosinase-related protein 2 (TRP-2) significantly decreased after treatment with BE, ME or GBE. These results suggest that besides BE, ME and GBE also inhibit melanin production most likely through suppression of tyrosinase and TRP-2 expression. ME and GBE were more efficacious at inhibiting melanin production than BE was and may also represent potential skin-whitening agents.

• Advances in Energy Research
• /
• 제5권2호
• /
• pp.129-145
• /
• 2017

In this study, the use of a micro gas turbine system using biogas to supply heating, cooling and electricity loads of a rural building located in rural area around Tehran has been studied. Initially, the amount of energy needed by the farmhouse was calculated and then the number of needed microturbines was determined. Accordingly, the amount of substances entering biogas digester as well as tank volume were determined. The results of this study showed that village house loads including electrical, heating and cooling and hot water loads can be supplied by using a microturbine with a nominal power of 30 kW and $33.5m^3/day$ of biogas. Digester tank and reservoir tank volumes are $67m^3$ and $31.2m^3$, respectively. The cost of electricity produced by this system is 0.446 US$/kWh. For rural area in Iran, this system is not compatible with micro gas turbine and IC engine system use urban natural gas due to low price of natural gas in Iran, but it can be compatible by wind turbine, photovoltaic and hybrid system (wind turbine& photovoltaic) systems.