• 대한화장품학회지
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• 제35권3호
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• pp.193-202
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• 2009

본 연구에서는 in vivo 광독성 시험을 대체할 수 있는 방법에 관한 연구를 수행하였다. 인체 유래의 섬유아세포를 활용하여 광독성 물질(promethazine, chlorpromazine chlortetracycline, 8-methoxypsoralen, neutral red, bithionol)과 비광독성 물질(cinnamic aldehyde, p-aminobenzoic acid, sodium lauryl sulfate, L-cysteine)을 평가하였다. 세포 생존율은 neutral red uptake (NRU)로 평가하였다. NRU 광독성 시험 결과 bithionol를 제외한 화합물에서 모두 in vivo 실험결과와 유사한 결과를 보였다. 같은 방법으로 화장품 성분인 $Medimin^{(R)}$ A, $Medimin^{(R)}$ D, $LG^{(R)}$ 106W, $Phytoclear^{(R)}$ EL-1, 단삼동 추출물, 미인초 추출물, 산거울 추출물, $Parsol^{(R)}$ MCX와 $Parsol^{(R)}$ 1789를 평가 하였다. 평가 결과 단삼동 추출물을 제외한 원료에서 광독성이 없는 것으로 평가되었다.

• 동의생리병리학회지
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• 제20권2호
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• pp.328-332
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• 2006

This study aims to provide definitions and standardization for necessities that elderly people can use conveniently and properly in their daily lives and classify necessities for different purposes. First, standard terminologies were defined by reviewing the literature and the relevant laws related to daily necessities for the elders. Secondly, a concept for necessities for the elders was also defined through consultation with experts. Lastly, the elderly's necessities were selected and classified. The elderly's necessities are defined as aids that ordinary elderly people in normal aging process need for the purpose of the convenience of life and aids they wear or use to maintain or improve their health. In this study, the elderly's necessities are divided into three categories: necessities of health, necessities of Oriental medical aids and necessities of daily living. Each category is further classified as follows: Necessities of health include aids for personal medical treatment, aids for personal care and protection and aids for recreation. Necessities of Oriental medical aids include aids for personal medical treatment, aids for personal care and protection and others. Necessities of daily living include aids for personal care and protection, aids for personal mobility, aids for housekeeping, furnishings, aids for communication, information and signalling, aids for handling products and goods and aids for recreation. The classification of the elderly's necessities in this study can be used as basic information for further studies of demand for necessities for the elderly. The results will lay the foundation for a standardization system for the elderly's necessities and the development of silver industry.

• 한국생활과학회지
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• 제13권2호
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• pp.301-316
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• 2004

In this study, 2,238 incidents from History of the Three States, Prehistory of the Three States, History of Koryo, True Records of Chosun Dynasty had been analyzed in order to examine the bathing styles of Koreans. The results were as follows. In the period of Three States, baths were taken for the purposes of cleanness, remedy, and beauty culture as well as etiquettes. And spa, rainwater, rivers, streams, and bath tubs were used. In the period of Koryo, it included not only reasons for etiquettes as in the period of the Three States but also reasons for medical care and daily life. In spa, temples, and homes, baths were taken by using perfumes and towels. In Chosun Dynasty, daily baths were for hygiene, health, and bodily charms. Before religious ceremonies, they made sure that they took baths, and spa baths were popular for the medical care. The ways to take baths included the order which area was the first to be washed, time, and areas concretely, and seasons, weather, and conditions of body were considered before taking baths. Moreover, the places included natural places such as streams, reservoirs, rivers, as well as artificial places such as temples, places for envoys, and palaces. Especially, in spa areas, bathing buildings were constructed. Considering all these, baths were taken for the purposes of ceremonies and medical care in the period of the Three States, and daily baths took down their roots in the period of Koryo. In the period of Chosun Dynasty, spa baths for cures, prays and rituals, hygiene and bodily charms were considered as a reason. How to take baths and means were decided carefully. Therefore, the results above demonstrated that baths took down their roots in people's daily life in Korea since the period of Koryo.

• 대한화장품학회지
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• 제24권3호
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• pp.6-16
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• 1998

Ceramides are currently emerging as the major skin care ingredients due to !heir barrier properties in the stratum corneum of the human skin. Thus, major cosmetic companies have developed synthetic ceramide analogs for their own use. In this study, several ceramide mimic compounds , new skin barrier lipids, were designed and synthesized, and their physical and biological properties were investigated to evaluate their skin care capability. Several structures were designed from the variation of hydrophobic alkyl chain and hydrophilic moiety by the use of molecular modeling software. The selected targets were synthesized, and their properties and activities were studied as the pure form, in the emulsion, or in the lamellar mixture containing cholesterol and fatty acid. Some compounds, such as 1,3-bis(N-(2-hydroxyethyl)-palmitoylamino)-2-hydroxypropane, enhanced the restoration of skin barrier damaged by SDS(sodium dodecyl sulfate), and by acetone treatment. The rate of restoration was comparable to that of natural ceramides. The synthesized compounds alleviated SDS induced skin irritation and facilitated lamellar phase liquid crystal formation. The treatment of 1,3-Dis(N-(2-hydroxyethyl)-palmitoylam ino)-2-hyd roxypropane on the acetone damaged skin revealed that the compound promoted the recovery of intercellular lipid lamellar structure of stratum corneum layer. The replacement of palmitoyl groups of the compound with shorter alkyl chain gave lower emulsion viscosity and liquid crystal density, suggesting easier formulation and poorer barrier activity. Most of the synthesized compounds were non-irritable in various toxicological tests proving that they can be safely introduced to the skin care formulations.

• 치위생과학회지
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• 제21권3호
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• pp.140-149
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• 2021

Background: The aim of these two (pre COVID-19 pandemic) public health studies in Amsterdam were to promote the profession of the oral hygienist and to increase oral health care awareness among (pregnant) women and young mothers, who were visitors of public consumer's exhibitions. Methods: Two cross-sectional studies were carried out. In 2018, during the first study, 1,765 visitors of the Household Fair completed a questionnaire. In 2020, during Study 2, 304 visitors of the Nine-Month Fair completed a semi-structured online questionnaire. At both fairs a team of 'outspoken' oral hygienists, i.e., members of the Foundation 'Goed Gebekt', provided the visitors with tailored advices about general health related to adults, mothers', and their children' oral health, using natural routine interviewing, that was based on their own professional daily practical experience. Results: In Study 1, just over half (53.5%) of a total of 1,742 visitors, (85.7% female) was younger than 45 years old. In Study 2, 210 visitors with a mean age of 30.7 years were included. Most women reported their self-perceived oral health as 'good' (mean=8.0, standard deviation=1.3; range 3~10). Qualified (self) employed oral hygienists seem to be known among the visitors, but still only visited upon referral of the dentists. Up to the age of 18 reimbursements by the basic insurance is still unknown to the public. Conclusion: The Foundation 'Goed Gebekt' encourages other oral hygienists to make their own initiatives and experiences public and to share it. Public awareness is needed for oral health promotion and the development of optimally targeted interventions among (pregnant) women and young mothers by oral hygienists.

• 한국엔터테인먼트산업학회논문지
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• 제13권4호
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• pp.63-70
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• 2019

상황 인식 환경에서 공황장애의 증상을 추출하고자 일상생활을 통해 자연스런 음직임에서 발생하는 신체 상황정보를 추출하여 공황장애의 구성요소를 찾아내고 온톨로지 이론을 적용하여 의미를 추론 과정을 거쳐 공황장애에 증상의 정도에 대해 정보를 제공할 수 있다. 온톨로지 기반의 정보 처리를 위해 공황장애의 구성요소는 클래스로 정의하고 공황장애의 상태를 이해할 수 있도록 온톨로지 모델링을 통해 공황장애지수를 도출하였다. 공황장애 구성요소와 공황장애 지수의 도출은 공황장애에 대한 상황 인식 기반의 정보 서비스를 가능할 것이며, 상황인식 기반 디바이스와 결합되어 상황정보는 주기적으로 동기화된다. 공황장애 지수의 결과를 관찰할 수 있으며 공황장애의 요인이 되는 생활습관을 개선하는데 적용할 수 있을 것이다.

• 대한화장품학회지
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• 제43권3호
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• pp.223-230
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• 2017

본 연구는 순채 점액질 다당체의 인체 피부와 in vitro에서의 피부 보습효과를 확인하고 화장품 원료로서의 가능성을 평가하기 위한 것이다. 다양한 환경적 스트레스와 노화로부터 피부를 보호하기 위해서는 피부의 수분 보유량을 증가시키고 수분의 손실을 예방해야 한다. 본 연구진은 순채의 점액질로부터 추출한 다당체를 인체 피부에 도포했을 때, 특이적인 윤활성으로 피부에서의 거칠기(roughness)를 개선시켰다는 것을 확인했다. In vitro에서 각질형성세포에 순채 점액질 다당체를 처리했을 때, 피부장벽의 가교 역할을 하는 transglutaminase 1 (TGM1) 유전자의 발현이 증가하였다. 또한 물과 글리세롤의 이동을 조절하는 막관통 단백질 aquaporin 3 (AQP3)와 수분 보유 기질 히알루론산을 합성하는 효소인 hyaluronan synthase 3 (HAS3) 유전자의 발현 또한 증가함을 확인했다. 추가적으로 화장품 원료로서의 가능성을 평가하기 위한 실험에서, 항염증과 콜라겐 합성 촉진 효능을 보였다. 결과적으로 순채의 점액질 다당체는 기존에 없는 새로운 천연 원료로서, 피부에 보습 효과와 항염증, 콜라겐 합성 촉진 효능이 있음을 밝혔다.

• 한국산학기술학회논문지
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• 제14권3호
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• pp.1350-1358
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• 2013

본 연구는 발 반사마사지를 받는 이용자들의 발 반사요법에 대한 인식수준을 알아보고 그에 관련된 요인을 규명하고자 2011년 09월 01일부터 10월 30일까지의 기간 동안에 대전지역에 소재하고 있는 전문 발 관리실 3곳의 이용자 181명을 대상으로 구조화된 자기기입식 설문지를 이용한 설문조사를 실시하였다. 연구결과, 전체 조사대상자의 발 반사마사지요법 인식수준에 대한 평균점수는 $32.19{\pm}5.32$점(11개 항목의 점수범위; 0-44점)으로 나타났으며, 일반적 특성별 발 반사마사지요법 인식수준은 학력이 높을수록 유의하게 높았다(p=0.020). 조사대상자의 발 반사마사지 요법에 대한 태도 및 실천도에 따른 발 반사마사지요법 인식수준은 "질병치유를 위해서 한다"는 군에서(p=0.034), 발 반사마사지 시작 시 "질병이 있었다"는 군에서(p=0.030). 발 마사지 이용기간이 길수록(p=0.000), 발 반사마사지를 타인에게 "권유 하겠다"는 군에서 유의하게 높았다(p=0.004). 다중회귀분석 결과 발 반사마사지요법 인식수준에 영향을 미치는 관련요인으로는 발 반사마사지 이용 이유, 발 반사마사지 시작 시 건강상태, 발 반사마사지 이용기간 및 발 반사마사지의 타인에의 권유여부가 유의한 변수로 선정되었으며 이들 변수에 대한 설명력은 26.1%이었다. 위와 같은 결과를 볼 때, 전문 발 관리실 이용자들의 발 반사마사지요법 인식수준은 일반적 특성 변수들보다는 발 반사마사지에 대한 태도 및 실천도를 설명하는 변수들과 관련성이 높은 것을 알 수 있었다.

• 대한화장품학회지
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• 제47권3호
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• pp.219-226
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• 2021

천마(Gastrodia elata, G. elata)는 자연상태에서 수분율이 매우 떨어지고 인공재배에서도 자마의 퇴화로 꽃을 피는 개체가 드물어 연구가 거의 이루어지지 못하고 있다. 따라서 본 연구는 천마꽃을 인공개화시켜, DPPH radical 소거 활성 평가를 통한 항산화 효능, nitric oxide (NO) 생성 억제 효과를 통한 항염증 효과, hyaluronic acid 생성 촉진 효능을 통한 보습 효과를 평가하여 화장품 소재로서의 가능성을 확인하고자 하였다. 봄에 수확한 천마가 출현율과 개화율이 높게 나타났고 gastrodin은 0.36% 함유함을 확인하였다. 천마꽃 추출물의 DPPH radical 소거 활성에서 IC₅₀ 값은 0.045%로 나타났으며, 천마꽃 추출물이 천마뿌리 추출물에 비해 radical 소거능이 더 높음을 확인하였다. 천마꽃 추출물에 대한 NO 생성 억제 활성은 1%에서 83.2%로 유의적인 억제 효과를 나타내었다. Hyaluronic acid 생성 촉진 효능은 천마뿌리 추출물에서는 확인되지 않았으나, 꽃 추출물에서는 농도의존적으로 생성율이 증가하였으며, 0.02% 처리시 46.9%로 가장 높게 나타났다. 이상의 연구 결과를 바탕으로 천마꽃 추출물이 항산화, 항염, 피부 보습 화장품 소재로써 활용 가능성이 높을 것으로 판단된다.

• Nutrition Research and Practice
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• 제9권1호
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• pp.22-29
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• 2015

BACKGROUND/OBJECTIVES: Recently, anthocyanins have been reported to have various biological activities. Furthermore, anthocyanin-rich purple corn extract (PCE) ameliorated insulin resistance and reduced diabetes-associated mesanginal fibrosis and inflammation, suggesting that it may have benefits for the prevention of diabetes and diabetes complications. In this study, we determined the anthocyanins and non-anthocyanin component of PCE by HPLC-ESI-MS and investigated its anti-diabetic activity and mechanisms using C57BL/KsJ db/db mice. MATERIALS/METHODS: The db/db mice were divided into four groups: diabetic control group (DC), 10 or 50 mg/kg PCE (PCE 10 or PCE 50), or 10 mg/kg pinitol (pinitol 10) and treated with drugs once per day for 8 weeks. During the experiment, body weight and blood glucose levels were measured every week. At the end of treatment, we measured several diabetic parameters. RESULTS: Compared to the DC group, Fasting blood glucose levels were 68% lower in PCE 50 group and 51% lower in the pinitol 10 group. Furthermore, the PCE 50 group showed 2-fold increased C-peptide and adiponectin levels and 20% decreased HbA1c levels, than in the DC group. In pancreatic islets morphology, the PCE- or pinitol-treated mice showed significant prevention of pancreatic ${\beta}$-cell damage and higher insulin content. Microarray analyses results indicating that gene and protein expressions associated with glycolysis and fatty acid metabolism in liver and fat tissues. In addition, purple corn extract increased the phosphorylation of AMP-activated protein kinase (AMPK) and decreased phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6pase) genes in liver, and also increased glucose transporter 4 (GLUT4) expressions in skeletal muscle. CONCLUSIONS: Our results suggested that PCE exerted anti-diabetic effects through protection of pancreatic ${\beta}$-cells, increase of insulin secretion and AMPK activation in the liver of C57BL/KsJ db/db mice.