• 대한바이러스학회지
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• 제29권4호
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• pp.261-269
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• 1999

The relationship between second messenger cGMP and human cytomegalovirus (HCMV) replication was investigated. First, the intracellular level of cGMP ([cGMP]i) in HCMV-infected cells was measured. The [cGMP]i increased at early times after HCMV infection, reached maximum level at 12 hr and returned to basal level at 24 hr after virus infection, while [cGMP]i in mock-infected cells remained relatively unchanged. Increasing [cGMP]i resulted in enhanced transcription of HCMV major immediate early gene. For early gene expression, cGMP had varying effect. Expression of 1.2 kb RNA decreased and 2.2 kb RNA increased with increasing cGMP, while 2.7 kb RNA gene expression was not affected. HCMV early genes are regulated by immediate early gene, and the effect of cGMP on the regulatory effect of major immediate early gene on early genes was investigated. In the absence of cGMP, major immediate early gene repressed 2.7 kb RNA gene expression, while 1.2 kb RNA and 2.2 kb RNA early genes were not significantly affected. In the presence of $1\;{\mu}M$ cGMP, however, major immediate early gene stimulated the expression of three early genes.

• 공학교육연구
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• 제14권4호
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• pp.20-28
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• 2011

현재 이공계생을 위한 글쓰기 교육은 전공글쓰기 교육이 부재하고 교양글쓰기 교육에만 치중되어 있다. 이러한 문제의식으로 본고는 서울대학교의 이공계 전공글쓰기 교육 실태를 분석하고 MIT, Stanford University와의 사례 비교를 통해 전공글쓰기 교육의 현실적인 방안을 제시하였다. 서울대학교의 실태를 분석한 결과, 전공글쓰기 교육의 필요성에 대한 학생들의 높은 수요에 비해 전공글쓰기 교육을 담당할 교원과 그들의 인식이 해외대학에 비해 부족해 전공글쓰기 교육과정이 부재하다는 것을 알 수 있었다. 이를 해결하기 위해 현실적으로 적용가능한 전공글쓰기 교육방안으로서 <전공설계과목>의 과제물에 대해 기존의 교양글쓰기 교원이 투입되어 3~4회의 피드백을 줌으로써 전공글쓰기 교육을 집중적으로 받는 1학점을 추가하는 방안을 제안하였다.

• 생명과학회지
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• 제32권5호
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• pp.375-390
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• 2022

인수공통 호흡기바이러스인 인플루엔자바이러스 감염으로 인해 공중보건과 가축산업에 심각한 피해가 지속적으로 발생하고 있다. 인플루엔자 백신 접종을 통해 항원형이 일치하는 바이러스 감염에 대해 우수한 방어면역을 제공하고 있으나, 효과적인 바이러스 감염 제어에는 여전히 큰 공백이 존재하고 있다. 다양한 항원형을 갖는 바이러스에 동시방어가 가능한 범용인플루엔자백신 개발과 함께 바이러스 치료효과를 제공하는 항바이러스제의 개발도 중요한 접근법으로 고려되고 있다. 현재 널리 사용되고 있는 인플루엔자 항바이러스제의 불완전한 치료효과와 내성바이러스의 출현 등의 문제들로 인해 식물 유래 천연물의 항바이러스 활성에 대한 관심이 증가하고 있다. 특히, 현재 진행 중인 코로나-19 팬데믹은 범용적인 항바이러스 활성을 갖는 안전하고 효과적인 항바이러스제 개발의 필요성을 뚜렷이 보여준다. 본 리뷰는 현재까지 보고된 천연물의 항인플루엔자바이러스 활성을 요약하였다. 또한, 항바이러스 활성을 갖는 천연물의 바이러스 사멸활성과 면역증강활성을 이용하는 신규 백신개발과 면역증강제 개발 가능성에 대해서도 분석하였다.

• 한국잠사학회:학술대회논문집
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• 한국잠사학회 2001년도 제44회 추계 학술연구 발표회
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• pp.47-47
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• 2001

no Abstract, See Full Text

• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1079-1087
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• 2021

Gentisic acid (GA), a benzoic acid derivative present in various food ingredients, has been shown to have diverse pharmaceutical activities such as anti-carcinogenic, antioxidant, and hepatoprotective effects. In this study, we used a co-culture system to investigate the mechanisms of the anti-inflammatory and anti-adipogenic effects of GA on macrophages and adipocytes, respectively, as well as its effect on obesity-related chronic inflammation. We found that GA effectively suppressed lipopolysaccharide-stimulated inflammatory responses by controlling the production of nitric oxide and pro-inflammatory cytokines and modulating inflammation-related protein pathways. GA treatment also inhibited lipid accumulation in adipocytes by modulating the expression of major adipogenic transcription factors and their upstream protein pathways. Furthermore, in the macrophage-adipocyte co-culture system, GA decreased the production of obesity-related cytokines. These results indicate that GA possesses effective anti-inflammatory and anti-adipogenic activities and may be used in developing treatments for the management of obesity-related chronic inflammatory diseases.

• 한국학교보건학회지
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• 제31권1호
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• pp.29-38
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• 2018

Purpose: The purpose of this study is to investigate the mediator effect of major satisfaction in relation to depression and job-seeking stress of university students according to the majors. Methods: This descriptive study was conducted in three universities randomly chosen from 47 universities in Seoul, Korea. Participants were 241 undergraduate students who were eligible and agreed to participate in the study. Data were collected from October 27 to November 10, 2014. The data were analyzed with descriptive statistics, $x^2$ test, Fisher's exact test, t-test, Kruskal-Wallis test, Pearson correlation coefficients, simple and multiple regression techniques with the PASW/WIN 20.0 program. Results: There were significant negative, negative, and positive correlations between job-seeking stress and major satisfaction, major satisfaction and depression, and job-seeking stress and depression regardless of major field, respectively. Moreover, in the major group in natural science and engineering, the link between job-seeking stress and depression was partially mediated by major satisfaction. Conclusion: The findings of this study contribute to providing basic data for the development of job-seeking stress and depression intervention programs and future study for university students.

• 한국토양비료학회지
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• 제50권3호
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• pp.179-186
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• 2017

This study was conducted to identify characteristics of domestic pine forest soils and to elucidate major soil influencing factors for natural regeneration. We analyzed the physico-chemical characteristics of the soil samples collected from 23 pine forests and confirmed the similar results with the forest soil characteristics. Soil pH, organic matter content, total nitrogen, exchangeable Ca, silt content, and exchangeable Al were selected as the major soil factors among the exposed soils through 10 days of pine seedlings exposure and cultivation experiments and statistical analysis. Multiple regression analysis showed that soil pH had a positive effect on specific root length (SRL) of red pine seedlings and exchangeable Al was a significant factor affecting negative change in SRL. Taken together, the reduction of exchangeable Al by soil pH adjustment would be helpful for natural regeneration by restoring the forest and improving the fine root and root integrity of pine seedlings. Therefore, soil pH and exchangeable Al could be recommended as a major soil factor to be carefully considered in the monitoring and management of soil in pine forests that need to be renewed in the future.

• 대한의생명과학회지
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• 제9권4호
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• pp.203-207
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• 2003

Protein aggregation could be problematic as causes of diseases and hindrance in the production of useful recombinant proteins. Aggregation of mutant tryptophan synthase $\alpha$-subunits was examined by treatment with urea and at high temperature. Large amorphous aggregate seemed to appear by heat treatment, while more various aggregates in size were formed by treatment with urea at low concentration. The result indicates that different aggregate in size could be formed depending on the treatment condition, suggesting different mechanisms underlying aggregation processes.

• 공학교육연구
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• 제20권5호
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• pp.59-73
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• 2017

This study aims to examine whether a gender works to make the difference on the university experiences of natural sciences and engineering major students; and the income and quality gap between the graduates. In this study, university experiences means job market and job searching related experiences such as job fair attending, The main research questions are as follows; fist, what are the significant university experiences related job preparation and application, and is there a gender gap on those experiences? Second, how is the job market performance of the national sciences and engineering graduates for their income level and quality job, and is there a gender gap on the job market performance of the sample? Third, which variables among the university experiences for job searching and application impacts the job quality and income level of the natural sciences and engineering graduates? To find out the research results, this study conducts a panel data analysis with GOMS (Graduates Occupational Mobility Survey) throughout survey year of 2006 to 2015, towards 568,264 as weighted value number. As analysis methods, this study carries out a descriptive analysis, ANOVA, discriminant analysis, linear regression and T-test. Therefore, here are the brief outputs of the study; first, for natural sciences and engineering students, the off-campus experiences such as job fair, job recruit festival and internship programs are more favored; second, female students are more likely to attend personal and self-driven job preparation programs; third, on job market performance, the graduates' income level and company scale rate are higher in the male but job stability is higher in the female; fourth, as a result of the linear regression, gender factor decides the income level in considerable degree; additionally, gender factor shows the difference of the job satisfaction and self-effectiveness on one's job as a qualitative variables. For obtaining strictness, university program factors are controlled through model fitness process. As above, this study finds out the main factors of university life of natural sciences and engineering graduates which are related their job searching and preparation experiences and figures out stronger factors in job market; and examines the statistically significance of the gender in this casual-effect relationship between job preparation and job quality of the graduates.

• 생명과학회지
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• 제14권1호
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• pp.14-16
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• 2004

트립토판 합성효소의 이소조절성에 작용하는 리간드가 알려져 있다. $\beta$반응의 기질인 세린만이 있는 조건에서 일가 양이온과 glycerophosphate의 리간드효과를 잔기치환체를 사용하여 조사하였다. 이들 리간드가 이 효소의 이소조절성에 관여하고 있음을 보여주고 있다.