• Journal of Distribution Science
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• v.21 no.6
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• pp.119-129
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• 2023

Purpose: The study is developed in order to describe the trends of scientific production of blockchain technologies for sustainability within the supply chains. Research design, data and methodology: This study is developed from the documentary field from the application of bibliometric techniques to analyze the trends of scientific production indexed in the Scopus database, for which processing is carried out in the R and VOS Viewer software. Results: The results show a total of 461 documents, of which 58% of the articles, 17% are conference articles and the remaining 25% are made up of other formats. Conclusions: 78% of the articles are concentrated in the years 2020, 2021 and 2022. India, United Kingdom, China, United States and Italy are the countries where 70% of all the publications were published. 23% of the articles have been published in four journals: Sustainability (Switzerland), Journal of Cleaner Production, Computers and Industrial Engineering and Business Strategy and the Environment. Sarkis, J. is the author with the most published articles with fifteen publications and, finally, 13% of the total publications were concentrated in: Uttaranchal University, Yasar University, Malaviya National Institute of Technology, Centro Di Ricerca Ingegneria e Trasformazioni Agroalimentari and University of Hong Kong.

• Journal of the Korean Society for Library and Information Science
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• v.41 no.1
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• pp.105-123
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• 2007

The aim of this paper is to analyse correlation between the national competitiveness and research competitiveness in OECD countries. As the result of correlation analysis there are positive correlations among competitiveness indicators(GERD, SCI articles, average citation counts, JCR journal titles, patents). And SCI articles and peer-reviewed journals emanating from the developed countries or the OECD is essential to maintaining national and research competitiveness in Korea. This study also calls for further correlation analysis between research competitiveness and academic libraries.

• Journal of the Korean Geographical Society
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• v.50 no.6
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• pp.641-657
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• 2015

Nowadays research collaboration between the business, academic and governmental community is high on the policy agenda in all over the world, especially with regard to science-based technological innovation. The aim of this paper is to explore some of the changing spatial patterns of research collaboration by carrying out bibliometric analysis of co-authorship publications in major international and scientific journals that are jointly realized by Korean scientists and researchers in the seven science-based technologies for the period 2002~2012. Using the co-authored papers as an indicator of research collaboration with the institutional address of each co-authoring researcher and the geographic location of their affiliation, this paper describes some trends and patterns of domestic and international research collaborations. Identifying a rapid increase in the volume of co-authored papers and the trend towards multiple authorships over the last decade, the paper finds collaborative scientific research to be geographically dispersed at the different spatial scales. Despite the rising geographic dispersion of research collaboration within the nation, this paper finds that there were empirical evidences for the presence of localized knowledge production processes at regional level, and biased knowledge flows towards core areas with advanced research resources.

• Journal of Korean Society of Archives and Records Management
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• v.22 no.3
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• pp.125-141
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• 2022

This study aims to suggest measures for handling copyright information on government publications during records and archives management to use them freely as public works according to Article 24-2 of the Copyright Act in Korea. Through email interviews with 17 records managers, persons in charge of government publication management, and government staff with experience in production from April 4 to June 13, 2022, this study determined the current situations and problems related to producing and managing copyright information on government publications. Based on the interview findings, this research suggested the following. First, Article 24-2 of the Copyright Act must be revised to apply the Korea Open Government License (KOGL) type 1 mandatorily to all public works. Second, a cooperative system for managing copyright information on government publications should be established to improve their production and management effectiveness. Third, copyright information, such as authors, copyright holders, copyright duration, information on the copyright property transfer, public works status, and reasons for nonpublic works, must be managed through records and archives management systems. Fourth and last, information on public works must be provided during the registration number application for government publication so that everyone can access the full texts of the publications on the National Archives of Korea website.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.4
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• pp.396-416
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• 2021

Objectives: This study was conducted to analyze the trends of government R&D (R&D) projects related to laboratory safety over the past 20 years. Methods: We collected publications from various databases(DBs) with words such as laboratory(ies), lab(s), researcher(s), laboratory worker(s), safety, environment, hazard(s), risk(s), and so on. Selected publications were analyzed by the research funds and the number of projects according to the investment subject and research characteristics. Results: About 93% of the total R&D budget went to government policy projects, not scientific research. Second, from the perspective of 'safety management activities', most of the research is related to management and inspection at the organizational level. Issues that need to be discussed at the national level like policy governance are not included. Third, focusing on the 'safety management cycle', there were few studies related to 'prediction' or 'post-response'. Fourth, when an analysis framework combining the perspectives of 'safety management activities' and 'safety management cycle' is applied, most of the budget is spent on infrastructure such as digital management systems, whereas basic knowledge for prevention and production of evidence was very few. Conclusions: In order to prevent policy planning without policy evaluation, implementation without strategy, and evaluation without evidence, it is necessary to expand investment in empirical research on risks, research on the effectiveness of current application methods, and research on theory development. The government budget for laboratory safety-related projects should be managed separately from the R&D budget for scientific research. Although less than 5% of the budget allocated to scientific research is the total budget, an optical illusion occurs because both the project budget and the scientific research budget are counted as R&D budgets.

• Journal of Korean Society of Forest Science
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• v.99 no.5
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• pp.726-735
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• 2010

Publications with the data on allometric equation, biomass and productivity of major oak forests in Korea were reviewed. Different allometric equations of major oak species showed site- or speciesspecific dependences. The biomass of major oak forests varied with age, dominant species, and location. Aboveground tree biomass over the different oak species was expressed as a power equation of the stand age. The proportion of tree component (stem, branch and leaf) to total aboveground biomass differed among oak species, however, biomass ranked stem > branch > leaf in general. The leaf biomass allocation over the different oak species was expressed as a power equation of total aboveground biomass while there were no significant patterns of biomass allocation from stem and branch to the aboveground biomass. Tree root biomass continuously increased with the aboveground biomass for the major oak forests. The relationship between the root to shoot ratio and the aboveground tree biomass was expressed by a logarithmic equation for major oak forests in Korea. Thirteen sets of data were used for estimating the net primary production (NPP) and net ecosystem production (NEP) of oak forests. The mean NPP and NEP across different oak forests was 10.2 and 1.9 Mg C $ha^{-1}year^{-1}$. The results in biomass allocation, NPP and NEP generally make Korean oak forests an important carbon sinks.

• Journal of Dairy Science and Biotechnology
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• v.37 no.3
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• pp.155-166
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• 2019

Bacteria from the genus Lactobacillus are important for the production of fermented food and dairy products, and as symbionts in human and animals. Lactobacillus acidophilus has widely been used in the production of yogurt, health foods, and even medicines. The efficacy of L. acidophilus has been proven with regards to the reduction of cholesterol, prevention and treatment of diarrhea, modulation of the immune system, suppression of cancer, etc. Using molecular biology tools, Lactobacillus acidophilus has now been reclassified into six species: L. acidophilus, L. amylovorus, L. crispatus, L gallinarium, L. gasseri, and L. johnsonii. Thus, since L. acidophilus has now been marked as a newly defined species, caution is advised when reading future publications regarding this bacterium. In this article, the results of the reclassification of L. acidophilus are mentioned after an analysis of its field inheritance was performed by my research team. Especially, L. amylovorus KU4 (formerly named as L. acidophilus KU4; KCCM 10975P) is a novel probiotic strain that is isolated from humans; it has the ability to reduce cholesterol. It has also been reported as a microorganism that effectively inhibits the growth of pathogenic E. coli. However, this Korean patent (No 10-1541280) refers to a strain obtained from calves; the origin of this strain was incorrectly labeled. Furthermore, after the discovery of L. acidophilus in 1900, its role in intestinal microbiological research was described and its utilization as a probiotic was presented.

• Asian Journal of Innovation and Policy
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• v.6 no.3
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• pp.313-331
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• 2017

This paper exhibits the concept of Triple Helix model to explain and link university-industry-government (Triple Helix) connections to national innovation systems theory. The driver of this paper is to test the dynamics of Triple Helix concept under national innovation system in the Association of South East Asian Countries (ASEAN)-5 economies. Panel econometric analysis with cross-sectional dependence (CD) test is applied to investigate the relationship amongst Triple Helix variables. The empirical analysis employs innovation indicators of five founding ASEAN countries namely Malaysia, Indonesia, Singapore, the Philippines and Thailand for the period of 2000-2015 from an existing WDI and WCY database. Econometric results support the two research questions of this study; firstly, there is a significant relationship between innovation outcome and its key drivers under Triple Helix context of National Innovation System in ASEAN-5 economies; secondly, the extent of the relationship among government R&D expenditure with high-tech productions are positive and significant while new ideas coming from universities as scientific publications and high-tech production have positive relationship but not significant yet in ASEAN-5 countries. Overall labor productivity is positive and significant with innovation outcomes in ASEAN-5.

• Molecular Medicine Reports
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• v.19 no.5
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• pp.3903-3911
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• 2019

Female sex steroid hormones, including estradiol (E2) and progesterone (P4), serve significant physiological roles in pregnancy. In particular, E2 and P4 influence placenta formation, maintain pregnancy and stimulate milk production. These hormones are produced by ovaries, adrenal glands and the placenta, of which the latter is a major endocrine organ during pregnancy. However, the mechanism of hormone production during pregnancy remains unclear. In the present study, the regulation of steroid hormones and steroidogenic enzymes was examined in human placenta according to gestational age. In human placental tissues, expression levels of steroidogenic enzymes were determined with reverse transcription-quantitative polymerase chain reaction and western blotting. The mRNA and protein expression of CYP17A1, HSD17B3 and CYP19A1, which are associated with the synthesis of dehydroepiandrosterone (DHEA) and E2, was elevated at different gestational ages in human placenta. In addition, to evaluate the correlation between serum and placental-produced hormones, steroid hormone levels, including pregnenolone (PG), DHEA, P4, testosterone (T) and E2, were examined in serum and placenta. Serum and placenta expression of DHEA and E2 increased with gestational age, whereas T and P4 were differently regulated in placenta and serum. To confirm the mechanism of steroidogenesis in vitro, placental BeWo cells were treated with E2 and P4, which are the most important hormones during pregnancy. The mRNA and protein expression of steroidogenic enzymes was significantly altered by E2 in vitro. These results demonstrated that concentration of steroid hormones was differently regulated by steroidogenic enzymes in the placenta depending on the type of the hormones, which may be critical to maintain pregnancy.

• International Journal of Oncology
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• v.54 no.2
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• pp.753-763
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• 2019

The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d- or l-forms of 2-hydroxyglutarate (2HG) from α-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. However, it is unclear whether the oncometabolite d-2HG increases angiogenesis in endothelial cells. Therefore, in this study, we analyzed the levels of various metabolites, including d-2HG, under hypoxic conditions and in IDH2R172K mutant breast cancer cells by mass spectrometry. We then further evaluated the effects of this metabolite on angiogenesis in breast cancer cells. The results revealed that treatment with d-2HG increased the levels of secreted vascular endothelial growth factor (VEGF) in cancer cells and enhanced endothelial cell proliferation in a concentration-dependent manner. Wound healing and cell migration (examined by Transwell assay) were significantly increased by d-2HG to a level similar to that induced by VEGF. Tube formation was significantly stimulated by d-2HG, and chick chorioallantoic membrane angiogenesis was also enhanced by d-2HG. d-2HG activated VEGF receptor (VEGFR)2 and VEGFR2 downstream signaling, extracellular signal-regulated kinase 1/2, focal adhesion kinase, AKT and matrix metalloproteinase (MMP)2. Taken together, the findings of this study suggested that d-2HG induced angiogenic activity via VEGFR2 signaling and increased MMP2 activity.