• MALSORI
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• no.53
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• pp.17-35
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• 2005

A New Method of Extracting the Filter Characteristics of the Nasal Cavity Using Homorganic Nasal-Stop Sequences: A Preliminary R eportHansang ParkThis study provides a new method of extracting the filter characteristics of the nasal cavity. Korean lenis stops are realized as voiced in the homorganic nasal-lenis stop sequences between vowels. Since the only difference between the two members of the homorganic nasal- lenis stop sequences, such as [mb], [nd], and [ g], is whether the passage to the nasal cavity is open or not, the subtraction of the LPC spectrum of the voiced stop from that of the preceding nasal leads to the filter characteristics of the nasal cavity of an individual speaker regardless of place of articulation. The results suggest that various attempts should be made to extract a robust filter characteristics of the nasal cavity by giving variation to LPC coefficients and by paying particular attention to speech samples. This study is significant in that it provides a preliminary report about a new method of extracting the filter characteristics of the nasal cavity.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.498-501
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• 2008

Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal, abnormal, and deformed nasal cavity models cavity models by PIV under both constant and periodic flow conditions. In this time normal and several deformed nasal cavity models, which simulate surgical operation, Turbinectomy, are investigated numerically by the FVM general purpose code and PIV analysis. The comparisons of these results are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticated cavity models. The Davis (LaVision Co.) code is used for PIV flow analysis. Average and RMS distributions have been obtained for inspirational and expirational nasal airflows in the normal and deformed nasal cavities.

• 한국가시화정보학회:학술대회논문집
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• 2004.12a
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• pp.135-140
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• 2004

Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. With our experiences of experimental investigations on nasal airflows in normal and abnormal nasal cavity models, we are going to deal with the topic that may contribute to the diagnosis and treatment of nasal diseases. In this paper, airflows in the normal and artificially deformed models, which simulate surgical treatment, are investigated experimentally by PIV. High-resolution CT data and careful surface rendering of computational model with the help of the ENT doctor provide more sophisticated nasal cavity models. The CBC PIV (Correlation Based Correction PIV) algorithm with window offset is used for PIV flow analysis. Average and RMS distributions in sagittal and coronal sections are obtained for inspiratory and expiratory nasal airflows. Comparisons in nasal airflows for both normal and deformed cases are also appreciated. In case of simulations of surgical operations, velocity and RMS distributions in coronal section changes locally, this may cause some difficulties in physiologic functions of noses and may hurt mucosal surface.

• Journal of Mechanical Science and Technology
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• v.18 no.10
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• pp.1799-1808
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• 2004

Knowledge of airflow characteristics in nasal cavity is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. Since the final goal of these works is their contribution to the diagnosisand treatment of nasal diseases, the next step on this topic is naturally studies for disordered nasal cavities. In this paper, as the first application, airflows in the normal and abnormal nasal cavities with adenoid vegetation are investigated experimentally by PIV, and comparisons of both cases are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticatedcavity model. The CBC PIV algorithm with window offset is used for PIV flow analysis. Average and RMS distributions are obtained for inspirational and expirational nasal airflows. Airflow characteristics that are related with the abnormalities in nasal cavity are presented.

• YAKHAK HOEJI
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• v.38 no.2
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• pp.114-122
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• 1994

A study on the absorption mechanism of cefixime(CF), an oral ${\alpha}-amino$ group deficient cephalosporin antibiotic, has been undertaken through the rat jejunum and nasal cavity using an in situ simultaneous perfusion technique developed in our laboratory. CF was well absorbed in the jejunum and nasal cavity of rats at pH 5.0, but not at pH 7.0. CF absorption was studied over four orders of magnitude in concentration to determine saturability. Disappearance of CF in the perfusate followed first-order kinetics at all tested concentrations. The apparent first-order absorption rate constant was found to be dependent on the concentration over the range of $0.1\;mM{\sim}3\;mM$ in the jejunum and nasal cavity of rats. Inhibitors were added to determine the competitive inhibition of CF absorption. The presence of L-tyrosine, L-phenylalanine, alanine-alanine, glycine-glycine and cefadroxil produced the significant inhibition of CF absorption in the nasal cavity and jejunum. However, there was no evidence of the inhibition in the presence of cefazolin. In addition, The CF absorption in the nasal cavity and jejunum was inhibited significantly by ouabain and 2,4-dinitrophenol(DNP). This study suggested that CF is absorbed across the rat nasal cavity and jejunum by carrier-mediated transport mechanism and energy consuming system.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.6
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• pp.811-816
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• 2002

For the first time, airflow in the nasal cavity of a normal Korean adult is investigated experimentally by PIV measurement. Nasal airflow can be subdivided into two interrelated categories; nasal airflow resistance and heat and mass transfer between the air stream and the walls of the nasal cavity. In this study, thanks to a new method for the model casting by a combination of the rapid prototyping and curing of clear silicone. a transparent rectangular box containing the complex nasal cavity can be made fur PIV experiments. The CBC PIV algorithm is used for analysis. Average and RMS distributions are obtained for inspirational and expiration nasal airflows. Data fer the airflow at the end of meatuses are obtained for the first time. Comparisons between western and Korean nasal airflows are appreciated. Due to the difference in geometry of the frontal part of nasal cavity, the flow near nares shows the difference.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.1 s.232
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• pp.103-109
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• 2005

Airflow in the nasal cavity of a normal Korean adult is investigated experimentally by tomographic PIV measurement. Knowledge of airflow characteristics in nasal cavities is essential to understand the physiology and pathology aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. All of these researches on nasal airflow are under the condition of constant flow-rate. In this study, nasal cavity flow with the physiological period is investigated by tomographic PIV, for the first time. A pumping system that can produce the periodic flow is created. Thanks to a new method for the model casting by a combination of the rapid prototyping and curing of clear silicone, a transparent rectangular box containing the complex nasal cavity can be made for PIV, The CBC PIV algorithm is used for analysis. Phase-averaged mean and RMS velocity distributions are obtained for inspirational and expiration nasal airflows. The comparison with the constant flow case is appreciated. There exist many flow patterns depending on each phase.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.4
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• pp.518-523
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• 2003

Airflow in the nasal cavity of Korean adults is investigated experimentally by PIV measurement. Quantitative data for normal and abnormal nasal cavities with adenoid vegetation are obtained. The CBC PIV algorithm with window offset is used for PIV flow analysis. Average and RMS distributions are obtained for inspirational and expirational nasal airflows. Comparisons between western and Korean nasal airflows are appreciated. Due to the difference in geometry of the frontal part of nasal cavity, the flow near nares shows the difference. For the joint research on nasal deceases, PIV measurements of nasal airflow for nasal cavities with 50% and 70% adenoid vegetation are conducted for the first time. Comparisons in nasal airflows for both normal and abnormal cases are also appreciated.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.6
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• pp.461-467
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• 2009

Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal, abnormal, and deformed nasal cavity models by PIV under both constant and periodic flow conditions. In this time normal and several deformed nasal cavity models, which simulate surgical operation, Turbinectomy, are investigated numerically by the FVM general purpose code and PIV analysis. The comparisons of these results are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticated cavity models. The Davis (LaVision Co.) code is used for PIV flow analysis. Average and RMS distributions have been obtained for inspirational and expirational nasal airflows in the normal and deformed nasal cavities.

• Journal of Pharmaceutical Investigation
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• v.25 no.4
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• pp.353-363
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• 1995

The purpose of this study was to investigate the intestinal and nasal absorption enhancement of cefotaxime (CTX) by ion-pairing with counterions and to design an effective oral and intranasal drug delivery system for antibiotics. Counterions for absorption promotion were cationic surfactants [cetylpyridinium chloride (CP), cetrimide (CT) and benzalkonium chloride (BA)]. In the presence of counterions, the apparent partition coefficient of cefotaxime was increased depending on the molar concentration of the counterions. Anion interference was observed for ion-pairing of cefotaxime with counterions because of the counterbalance between an anion and counterions. The present study employed the in situ simultaneous nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of cefotaxime were $1.43{\pm}0.04{\times}10^{-5}\;cm/sec(mean{\pm}S.E)$ in the nasal cavity and 0 in the jejunum, respectively, which indicated that the intrinsic absorptivity of cefotaxime was greater in the nasal cavity than in the jejunum. When ionupairing formers were used, the decreasing order of apparent cefotaxime permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was as followings: $BA\;(7.50{\pm}0.36)\;>\;CT\;(4.92{\pm}0.24)\;>\;CP\;(3.01{\pm}0.17)$ in the jejunum and $BA\;(22.31{\pm}1.36)\;>\;CP\;(18.24{\pm}0.81)\;>\;CT \;(16.22{\pm}1.87)$ in the nasal cavity. The increase in permeability of cefotaxime was about 13-fold in the rat nasal cavity and was marked in the rat jejunum for ion-pairing with counterions as compared to those without ion-pairing. The damages of jejunal and nasal mucosal membrane by counterions were observed within approximately 2hrs after removal of ion-pair of cefotaxime with counterions from the nasal cavity and jejunum. These results suggest that CP can be used as an ion-pairing former in the jejunum and CP and CT can be used as ion-pairing formers in the nasal cavity for cefotaxime, as well as for poorly absorbed drugs with a negative charge due to ionization.