• 약학회지
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• 제44권6호
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• pp.595-600
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• 2000

Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human cadaver skin was investigated in vitro. A mixture of ethanol/water (40/60) containing 0, 1, 3, 5, and 8 (w/v)% L-menthol were used as a vehicle and penetration enhancer respectively. The permeation of ketorolac through human cadaver skin from saturated drug solution was evaluated at $37^{\circ}C$ with modified Franz diffusion cell. The in vitro skin flux and lag time were $1.23\;{\pm}\;0.11\;{\mu}g/cm^2{\cdot}hr$ and $5.56\;{\pm}\;0.34\;hr$, respectively. The cumulative amount of penetrated ketorolac containing L-menthol in ethanol/water (40/60) binary system was increased by the following order; 3%, 5%, 8%, 1%, 0%, and the lag time was decresed by the following order; 3%, 5%, 8%, 0%, 1%. The results suggested that a potential use of 3% L-methol is an effective penetration enhancer of ketorolac tromethamine through the human cadaver skin.

• 복식
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• 제53권8호
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• pp.21-37
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• 2003

The purpose of this paper is to be studied the Devil's types and the special effect makeup's techniques expressed on horror movies. As the theoretical background, the researcher inquired the origin of Satan, Demon and Devil, and the shapes and meanings portrayed in the religion, philosophy art and literature. Also classified the Devil's types of the movies, and examined the factors, techniques and aesthetic characteristics of special effect makeup for each of them. The results are as follows. 1. The Devil's types are the Werewolf, the Zombie and the Vampire. The Werewolf is a kind of Devil that changes into a wolf when the full moon rises. It requires animatronics, rubber body suits, furs and fangs for special makeup effects. The Zombie is a dead body that the exorcist restored with a narcotic drug, and it nibbles on human's brain and flesh. So it needs decayed or pale skins, scars, bald heads, non-focus eyes and false teeth for making this character. The Vampire is a bloodsucking ghost. Therefore, it uses fangs, evil eyes, rubber body suits and dropping blood for special effect makeup. 2. They expresses Sadism, Masquerade and Cruelty as the aesthetic characteristics of the Devil's special effect makeup.

• 보건교육건강증진학회지
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• 제26권4호
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• pp.105-116
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• 2009

Objectives: In recent years, pregnancy rate among female adolescents has increased and caused a variety of physical and social problems. Therefore, this study aimed to investigate sexual behavior, delinquent behavior, and pregnancy rate among Korean female adolescents. Methods: In light of the growing interest in adolescent pregnancy, this study conducted a web-based survey, titled "The 2006 Youth Health Risk Behavior Survey." The Korean Center for Disease Control (KCDC) collected questionnaire responses from 34,200 young women. The collected data were analyzed through chi-square test and logistic regression using SPSS Win 14.0 version. Results: This study analyzed main factors, which can predict pregnant experience. The statistic results showed two types of the predicting factors: (1) personal factors: sexual relations after drinking (odds 25.1), Narcotic drug taking (odds 13.0), sexual violence act (odds 7.0), part-time job(odds 2.5), drinking, smoking ; and (2) environmental factors: stepfather(odds 4.2) and natural mother. Conclusion: The influential factor identification for predicting pregnancy rate is important to develop an effective education program for preventing the adolescent pregnancy. The education programs with referring to the identified factors can contribute to reducing the unwilling pregnancy rate of young woman.

• 대한치과마취과학회지
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• 제13권4호
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• pp.167-178
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• 2013

Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. Although developed in an attempt to improve on the existing opioids, the adverse effects of oxycodone are those that are typically found in opioids. In recent years, the use of the opioid oxycodone has increased markedly and replacing morphine as the first line choice of opioid in several countries. There are formulations for oral immediate, oral extended release and intravenous use. In 2013, intravenous oxycodone was approved for marketing by Ministry of Food and Drug Safety (MFDS), with the indication of postoperative intravenous patient-controlled analgesia (IV PAC). Simulation study of oxycodone demonstrated that minimum effective analgesic concentration (MEAC) of oxycodone was most quickly reached with higher loading dose and IV PCA with background infusion, which may reduce the necessity of rescue analgesics during immediate postoperative period. Previous studies for postoperative pain management with intravenous oxycodone are limited in sample size, mostly less than 100 patients, which may not be large enough to assess safety of intravenous oxycodone. The effectiveness and tolerability of IV PCA with oxycodone should, therefore, be evaluated in large scale clinical trials in Korean populations.

• Natural Product Sciences
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• 제27권2호
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• pp.78-85
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• 2021

Through bio-guided isolation, two natural iron chelators were isolated from Mangifera indica L. leaves, identified as mangiferin (1) and iriflophenone-3-C-𝛽-D-glucoside (2). Their iron-chelating activity was compared to that of Desferal^® using bipyridyl assay and EDTA as a standard. Mangiferin showed the highest activity with IC₅₀ value of 0.385 mM (162.85 ㎍/mL). Furthermore, two combinations of mangiferin with Desferal^® (M-D) and iriflophenone-3-C-𝛽-D-glucoside (M-I) were evaluated. The results showed that mangiferin potentiated the iron chelation activity of Desferal^® about 46%, also that M-I combination is a promising candidate formula for iron chelation therapy. In addition, mangiferin and Desferal-iron complexes were prepared and characterized by IR, UV, and Mass spectra to compare their mode of chelation to iron. Their structural stability was studied by DFT calculations. Furthermore, they displayed increased ABTS antioxidant activity when bound to iron as compared to their free form, which enhances their pharmacological importance.

• The Korean Journal of Pain
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• 제35권4호
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• pp.361-382
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• 2022

The third opium war may have already started, not only due to illicit opioid trafficking from the Golden Crescent and Golden Triangle on the international front but also through indiscriminate opioid prescription and opioid diversion at home. Opioid use disorder (OUD), among unintentional injuries, has become one of the top 4 causes of death in the United States (U.S.). An OUD is defined as a problematic pattern of opioid use resulting in clinically significant impairment or distress, consisting of 2 or more of 11 problems within 1 year, as described by the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition. Observation of aberrant behaviors of OUD is also helpful for overworked clinicians. For the prevention of OUD, the Opioid Risk Tool and the Current Opioid Misuse Measure are appropriate screening tests before and during opioid administration, respectively. Treatment of OUD consists of 3 opioid-based U.S. Food and Drug Administration-approved medications, including methadone, buprenorphine, and naltrexone, and non-opioid-based symptomatic medications for reducing opioid withdrawal syndromes, such as α₂ agonists, β-blockers, antidiarrheals, antiemetics, non-steroidal anti-inflammatory drugs, and benzodiazepines. There are at least 6 recommendable guidelines and essential terms related to OUD. Opioid stewardship programs are now critical to promoting appropriate use of opioid medications, improving patient outcomes, and reducing misuse of opioids, influenced by the successful implementation of antimicrobial stewardship programs. Despite the lack of previous motivation, now is the critical time for trying to reduce the risk of OUD.

• 동의신경정신과학회지
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• 제16권2호
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• pp.135-148
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• 2005

Objective : The purpose of this study is to take around the oriental medical treatment about substance related disorder in china. Method : We review the studies which are published by six different journal in China since 1992 to 2002 involved in substance related disorders. Result 1. The kinds of substance which is the subject of each study. It suggest that the narcotics-withdrawal patients in china take kinds of opium many more than phillopon or barbiturate, cocain etc. especially the heroine takes the most portion in the kinds of opium. 2. The type of chinese medicine demonstration which is about the addiction and withdrawal. There are many symptoms in the each period of withdrawal, According to the each period demonstration, the herbal formula must be different. 3. The formula used in treatment and the substance which is used in common Codonopsis radix is widely used, and pinellia ternata, aractylodes japonica, citrus nobilis, vegetable worms, angelica gigas, zizyphus jujuba, panax ginseng, astragalus membranaceus etc are also used in treatment. 4. The methods of acupunture treatment Hapkok(LI-4), Naegwan(PC6), and Sanyinjiao(SP6) are the widely used acu-points. in addition to these acupoints, there are waegwan(TE5) choksamli(ST36) hanggan(LR2)etc. Conclusion : We expect that this review about substance related disorders in TCM help the clinical study of substance related disorders in Korean medicine.

• The Korean Journal of Pain
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• 제31권2호
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• pp.102-108
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• 2018

Background: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes causes side effects such as nausea, vomiting, somnolence, hyperhidrosis and injection-related pain, manufacturers are advised to infuse it slowly, over a duration of 15 minutes. Nevertheless, pain at the injection site is very common. Therefore, we investigated the effect of warmed carrier fluid on nefopam injection-induced pain. Methods: A total of 48 patients were randomly selected and allocated to either a control or a warming group. Warming was performed by diluting 40 mg of nefopam in 100 ml of normal saline heated to $31-32^{\circ}C$ using two fluid warmers. The control group was administered 40 mg of nefopam dissolved in 100 ml of normal saline stored at room temperature ($21-22^{\circ}C$) through the fluid warmers, but the fluid warmers were not activated. Results: The pain intensity was lower in the warming group than in the control group (P < 0.001). The pain severity and tolerance measurements also showed statistically significant differences between groups (P < 0.001). In the analysis of vital signs before and after the injection, the mean blood pressure after the injection differed significantly between the groups (P = 0.005), but the heart rate did not. The incidence of hypertension also showed a significant difference between groups (P = 0.017). Conclusions: Use of warmed carrier fluid for nefopam injection decreased injection-induced pain compared to mildly cool carrier fluid.

• The Korean Journal of Pain
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• 제37권1호
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• pp.41-50
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• 2024

Background: Recognizing the seriousness of the misuse and abuse of medical narcotics, the South Korean government introduced the world's first narcotic management system, the Narcotics Information Management System (NIMS). This study aimed to explore the recent one-year opioid prescribing patterns in South Korea using the NIMS database. Methods: This study analyzed opioid prescription records in South Korea for the year 2022, utilizing the dispensing/administration dataset provided by NIMS. Public data from the Korean Statistical Information Service were also utilized to explore prescription trends over the past four years. The examination covered 16 different opioid analgesics, assessed by the total number of units prescribed based on routes of administration, type of institutions, and patients' sex and age group. Additionally, the disposal rate for each ingredient was computed. Results: In total, 206,941 records of 87,792,968 opioid analgesic units were analyzed. Recently, the overall quantity of prescribed opioid analgesic units has remained relatively stable. The most prescribed ingredient was oral oxycodone, followed by tapentadol and sublingual fentanyl. Tertiary hospitals had the highest number of dispensed units (49.4%), followed by community pharmacies (40.2%). The highest number of prescribed units was attributed to male patients in their 60s. The disposal rates of the oral and transdermal formulations were less than 0.1%. Conclusions: Opioid prescription in South Korea features a high proportion of oral formulations, tertiary hospital administration, pharmacy dispensing, and elderly patients. Sustained education and surveillance of patients and healthcare providers is required.

• Clinical and Experimental Pediatrics
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• 제49권10호
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• pp.1042-1049
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• 2006

목 적 : 건강위험행동은 만성질환의 가장 큰 원인으로 보건교육의 예방 목표이다. 예방을 위한 적절한 개입이 필요한 시점인 후기 청소년기에서 각 위험행태에 대한 현황과 그 위험행동을 지속하게 할 수 있는 위험요인을 찾아 청소년의 건강한 생활습관을 형성할 수 있는 인자들을 규명하고자 하였다. 방 법 : 2006학년도 고려대학교 신입생들을 대상으로 한 건강검진에 참여한 학생 중 자발적으로 설문지에 응답한 1,297명을 대상으로 비공개 설문지를 통한 조사를 실시하였으며, 설문지는 기본 정보와 4가지의 건강 위험행태(흡연, 음주, 약물사용, 성 행태)에 대한 문항으로 구성되었다. 결 과 : 친구의 흡연과 주변 사람의 흡연하는 정도가 흡연 경험에 영향을 주는 것으로 나타났고, 흡연경험자가 현재흡연자로 이행할 위험요인들은 남성, 도시출신, 친구의 흡연, 니코틴 의존도로 나타났다. 고 위험 음주군의 위험요인들로 남성, 만취하는 회수, 음주한 기간, 과음에 대한 위험성 인식이 낮은 경우가 있었다. 부적절한 약물 사용 경험자는 1.0%로 비교적 낮은 편이었으나 처방 없이 약물을 구하는 경우가 많은 것으로 나타났다. 성 행태 조사 결과 성교육을 받은 경우는 68.1%이나 성교육을 받은 사람에서 피임여부가 유의한 차이를 보이지 않았다. 자신이 양성애를 포함하여 동성애적인 성향을 가진다고 대답한 경우는 1.6%로 나타났으며 거의 이성애로 인식하는 경우는 여성의 비율이 유의하게 높았다. 결 론 : 향후 후기 청소년들의 보건 교육의 목표는 건강위험행동의 시작단계에서 습관적 행동으로의 이행을 막고 건강위험행태에 대한 감시체계 확립에 있다. 고려대학교 신입생들의 건강위험행태에 대한 조사 결과는 후기 청소년들의 건강 위험행태의 위험요인을 규명하는 데 이용될 수 있을 것이다.