• Journal of Haehwa Medicine
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• v.20 no.2
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• pp.1-16
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• 2012

In order to study the effect of CPS in the treatment of atopic dermatitis (AD), its role on various immune related cytokines were tested. Levels of liver and kidney function markers such as ALT, AST, BUN in NC/Nga mice were all normal indicating no toxicity in CPS treated group. Significant recovery from AD could be observed in CPS treated group through naked eye observation. Dermatitis index was significantly decreased after 11, 12, and 13 weeks of treatment. CD4+, CD8+, CD3+ /CD69+ immune cell ratio in DLN were decreased significantly by 37.2%, 49%, 20.8% in CPS treated group. CD4+ and CD11b+ /Gr-1+ immune cell ratio in dorsal skin were decreased significantly by 50.8% and 59.2% in CPS treated group. Expression of IL-4, IL-5, IL-6, IL-13 and TNF-${\alpha}$ in spleen were decreased by 78.8%, 97.8%, 64.7%, 73.6%, and 68.4%, respectively in CPS treated group. The results above strongly indicated the significant immune modulatory effect of CPS and thus clinical application of CPS on AD treatment.

• Journal of Haehwa Medicine
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• v.17 no.2
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• pp.51-68
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• 2008

The effect of combinational treatment of oral HTGMB and topical CSGMB ("H&C" hereinafter) on the changes of dermal inflammation index and immune system were studied using NC/Nga atopic dermatitis animal model. 1. Through naked eye examination, H&C ameliorated atopic dermatitis compared to the control group. Significant reduction of dermal inflammation index was observed after 12 weeks of treatment. 2. The H&C treated group showed 51% increase in the number of immune cells in DLN, and 59% increase in the number of immune cells is dorsal skin. 3. The H&C treated group showed decrease of 26%, 8%, 59% in CD19+, CD3+/CD69+, B220+/IgE+ cells in DLN respectively. On the other hand, CD3+, CD8+, CD4+ cells were increased by 8%, 31%, 12%, respectively. 4. The H&C treated group showed significant decrease of 38% and 47% in B220+/IgE+, CD11b+/Gr-1+ cells within dorsal skin respectively. Also, a decrease in CCR3+ cells by 21% was observed. 5. Significant decrease of the production of IL-4, IL-5, GM-CSF by 39%, 65%, 60% respectively, in spleen cells activated with CD3 and CD28 were observed in the H&C treated group. The results above strongly suggest significance of anti-atopic dermatitis effect of combinational treatment of oral HTGMB and topical CSGMB through immune modulation. Further applications in clinical use of the treatment are anticipated.

• Restorative Dentistry and Endodontics
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• v.26 no.2
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• pp.180-187
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• 2001

The structure of current guides is largely illogical and without any rational use of color ordering. The shade guides are generally made of plastic (rather than the actual composite material) and do not accurately depict the true shade. translucency. or opacity of the composite resin after polymerization. To solve this problem, information based on evaluations of natural teeth and material that use the same method and experimental conditions is necessary. The present investigation measured the color of natural maxillary anterior teeth in vivo and compared the results with those of composite resins. 269 Korean subjects were selected for this study. Intact central incisor. lateral incisor. and canine were selected. The clinical crowns were free of caries or restorations. The middle site of the coronal portion on the labial surface of the tooth was measured by Chroma Meter. The five light activated. resin-based materials (Amelogen, Denfil, Elitefil, Spectrum, Z100) were used in this study. Resin composite was condensed into plastic mold with a diameter of 8mm and a thickness of 4mm. pressed between glass plates to flatten the surfaces. and polymerized using a Visilux II visible light activation unit. The surfaces were polished sequentially on wet sandpaper. Color measurements of each specimen were accomplished by Chroma Meter. A computer program that compares each tooth color with each composite resin color was written and the minimum CIELAB color difference ($\Delta$E$^*$) between tooth and each material was calculated. Under the conditions of this study: 1. Teeth tend to become darker with advancing age. 2. Canines were darker. more yellow. and less green than incisors. 3. The teeth from the women were lighter. more green. and less yellow than the male teeth. 4. In general. composite resins were lighter. more green. and less yellow than teeth. Deficiencies were noted in Hues in YR range. 5. Mean color differences between the five composite resin products and teeth were detectable to the naked eye($\Delta$E$^*$>1.0). 6. In comparing the mean $\Delta$E$^*$ values of materials. Spectrum showed the least followed by Z100, Elitefil, Amelogen, Denfil in increasing order.

• Food Science of Animal Resources
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• v.32 no.2
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• pp.149-154
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• 2012

It is known that lactic-acid bacteria (LAB) helps keeping the intestine healthy and to enhance its immunologic competence. In addition, it is known to control the composition of the enterobacteria and the intestinal inflammatory reaction by inducing immunological enhancement. This study was performed, in a mouse model, to test the treatment and preventive effects of LAB of inflammatory bowel disease (IBD), which was induced by a blend of LAB-administering trinitrobenzene sulfonic acid (TNBS). To obtain the animal model of IBD, 2% TNBS was rectally administered once to a five-week-old male Balbc/J mouse. A probiotic combination was administered to the prevention group five times a week for eight weeks before the inducement of enteritis, and the mixture was administered to the treatment group five times a week, after the administration of TNBS. The changes in the levels of the cytokines of the lymph nodes and the tissue of the large intestine were observed, both with the naked eye and with a microscope. The observation showed that the levels of inflammatory cells, infiltration, and necrosis were much lower in the LAB-administered groups than in that of the control group. In addition, the inflammatory cytokines (e.g., TNF-${\alpha}$, IL-17A) decreased in the lymph nodes and the tissues of the large intestine. The results indicated that the administration of the combination to the animal model suppressed the inflammatory cytokines in the large intestine and in the lymph nodes, which in turn suppressed the progression of colitis.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.344-348
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• 2008

During the last few years, the use of Pre-tensioned spun High strength Concrete(PHC) pile has been gradually increased in many construction sites such as super high-rise and large building construction. there is almost no specific code and/or standard described in the specifications to check verticality for Pre-tensioned Spun High Strength Concrete pile installation process. The most commonly used method for the vortical PHC pile installation is a naked-eye measurement or water level measurement conducted by assistant crew in the construction sites. And recent analysis results of the pile cutting work revealed that it frequently makes a lot of cracks which significantly reduce the strength of the pile and is very labor intensive work, thus requiring a large amount of additional time, costs, and efforts. The main objective of the research is to analize problems and to improvement. measure of PHC Pile Construction. The improvement measure present to the main problem with survey and discussion.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.6
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• pp.825-830
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• 2010

Generally, the copy protection mark and 2D bar-code techniques are widely used for forgery protection in printed public documents. But, it is hard to discriminate truth from the copy documents by using exisiting methods, because of that existing 2D-barcode is separated from the copy protection mark and it can be only recognized by specified optical barcord scanner. Therefor, in this paper, we proposed the forgery protection tehchnique for discriminating truth from the copy document by using watermark inserted 2D-barcord, which can be accurately distinguished not only by naked eye, but also by scanner. The copy protection mark consists of deformed patterns that are caused by the lowpass filter characteristic of digital I/O device. From these, we verified the performance of the proposed techniques by applying the histogram analysis based on the original, copy, and scanned copy image of the printed documents. Also, we suggested 2D-barcord confirmation system which can be accessed through the online server by using certification key data which is detected by web-camera, cell phone camera.

• Journal of Korean Society for Geospatial Information Science
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• v.14 no.1 s.35
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• pp.13-19
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• 2006

When investigating the damage of a forest fire, quite a few are depending on the naked eye observation. However, if the damage spreads to another area, it is easy to use the satellite images because it is hard to reach all the damaged areas on foot. From this research, we did a statistical interpretation of after fire using satellite image data to classify the damage on first and second factor analysis. As a result, it was more easier to classify the river's plants and ridges between rice fields that were in the forest fire damage area in the second observation then the first observation. Also, we could classify the area by areas that were damaged more or less using the second factor analysis. To verify this, we used the forest fire images collected from the satellite images and the actual survey data collected from spectral radiometer to see if these two datawere correlated and as a result we found out that they were highly involved.

• Korean Journal of Clinical Pharmacy
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• v.8 no.2
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• pp.147-158
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• 1998

The purpose of this study was to test the stability of TPN basic solutions containing amino acids and dextrose. Test solutions containing $4.25\%$ amino acids in $25\%$ dextrose (central TPN basic solution) or $4.25\%$ amino acids in $10\%$ dextrose (peripheral TPN basic solution) were prepared. Two different amino acids solutions $(Fravasol^{(R)}\;vs\;Freamine^{(R)})$ were tested. The samples were taken from each admixture and stored in the evacuated, sterile containers at $2{\sim}8^{\circ}C$ and ambient room temperature. Each sample was analyzed at 0, 3, 7, 14 and 30 days of storage. Each amino acid was analyzed by amino acid analyzer. Dextrose content was measured by polarimeter. The pH and chromagen formation were also monitored. The decomposition was measured by the changes in concentration of amino acids and dextroser TPN basic $solution-Freamine^{(R)}$ admixture stored at $2\sim8^{\circ}C$ were stable for 30 days. Central and peripheral TPN basic solutions stored at room temperature were stable for 7 days and 14 days, respectively. There were no changes in color for 30 days by naked eye. Amino acid concentrations in TPN basic $solution-Fravasol^{(R)}$ admixture stored at $2\sim8^{\circ}C$ or room temperature were stable for 30 days. But, significant color change was detected according to passing time. In conclusion, Peripheral TPN basic $solution-Fravasol^{(R)}$ admixture stored at room temperature and in refrigerator were stable for 3 days and 7 days, respectively. However, central TPN basic solution-Fravasol admixtures were unstable. Therefore, it is recommended that it should be admixed right before use.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.4
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• pp.17-30
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• 2020

Objectives The purpose of this study is to evaluate the healing effect of Yukmijihwang-tang (YM) on femur fractured mice. Methods Mice were randomly divided into 6 groups: normal, control, positive control, YM with low, medium, high dosage each. All groups were prepared with femur fracture and treated diffrently. In order to measure bone regeneration effects, we analysed the levels of cyclooxygenase-2 (COX2), bone morphogenetic protein-2 (BMP2), collagen type II alpha 1 chain (Col2a1), Sox9, runt-related transcription factor 2 (Runx2), and osterix genes expressed in bone. For morphological analysis, muscles were removed and femur was observed with naked eye. Results COX2 gene expression in bone marrow significantly decreased. BMP2 gene expression significantly increased. Col2a1 gene expression significantly increased. Sox9 gene expression increased as well. Runx2 gene expression in bone marrow increased, but there was no statistical significance. Osterix gene expression significantly increased. Union of the fracture site progressed more in YM group compared to the control group. The fracture union score was significantly decreased in YM group compared to the control group. Conclusions YM showed anti-inflammatory effect, promoted bone regeneration by stimulating the bone regeneration factor. In conclusion, YM can help fracture healing and it well be applied clinically to patients with fracture.

• Journal of Fisheries and Marine Sciences Education
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• v.24 no.1
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• pp.34-43
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• 2012

In order to establish order in fishing industry by cracking down on illegal fishing vessels effectively, it is an essential requirement to identify marking such as the name of fishing vessel and a port of register more easily. Accordingly, it is quite natural that markings on fishing vessels should be marked clearly in an appropriate size on an appropriate site in order for them to be distinguished on the air such as from planes as well as on the sea. Actually, when examining marks such as the name of a vessel which are operating in the country, marks of most fishing vessels are too small as they cannot be distinguished with the naked eye even very closely. There is no coastal fishing vessel which marks the name of fishing vessel on the upper part in order to distinguish it from planes. Fishing vessel law generally which regulates the basic laws about shipbuilding regulates marks on fishing vessel, and fisheries law only regulates sign boards of fishing vessels. Problems and improvement of the marking system on fishing vessels suggested by this paper are as follows. First, in order to contribute to establish order in fishing industry, it would be desirable to tighten standards in fisheries law besides the fishing vessel law. Second, it is difficult to distinguish marks such as the name of a vessel as relevant laws allow fishers to make such marks too small. It is necessary to set the standard for marks larger than those regulated by the international treaty. Third, the relevant laws do not regulate a letter form of marks. Therefore, it becomes a factor to make small marks hard to be distinguished more. It is necessary to decide a clear letter form. Fourth, there is insufficient detailed international standards about the marking system. It is necessary to regulate a detailed standard.