• Clinical and Experimental Reproductive Medicine
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• v.32 no.4
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• pp.315-324
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• 2005

Objectives: To compare the efficacy of GnRH antagonist multiple dose protocol (MDP) with that of GnRH agonist long protocol (LP) in controlled ovarian hyperstimulation for in vitro fertilization in patients with high basal FSH (follicle stimulating hormone) level or old age, a retrospective analysis was done. Methods: Two hundred ninety four infertile women (328 cycles) who were older than 41 years of age or had elevated basal FSH level (> 8.5 mIU/mL) were enrolled in this study. The patients had undergone IVF-ET after controlled ovarian hyperstimulation using GnRH antagonist multiple dose protocol (n=108, 118 cycles) or GnRH agonist long protocol (n=186, 210 cycles). The main outcome measurements were cycle cancellation rate, consumption of gonadotropins, the number of follicles recruited and total oocytes retrieved. The number of fertilized oocytes and transferred embryos, the clinical pregnancy rates, and the implantation rates were also reviewed. And enrolled patients were divided into three groups according to their age and basal FSH levels; Group A - those who were older than 41 years of age, Group B - those with elevated basal FSH level (> 8.5 mIU/mL) and Group C - those who were older than 41 years of age and with elevated basal FSH level (> 8.5 mIU/mL). Poor responders were classified as patients who had less than 4 retrieved oocytes, or those with $E_2$ level <500 pg/mL on the day of hCG injection or those who required more than 45 ampules of exogenous gonadotropin for stimulation. Results: The cancellation rate was lower in the GnRH antagonist group than in GnRH agonist group, but not statistically significant (6.8% vs. 9.5%, p=NS). The amount of used gonadotropins was significantly lower in GnRH antagonist group than in agonist group ($34.8{\pm}11.3$ ampules vs. $44.1{\pm}13.4$ ampules, p<0.001). The number of follicles > 14 mm in diameter was significantly higher in agonist group than in antagonist group ($6.7{\pm}4.6$ vs. $5.0{\pm}3.4$, p<0.01). But, there were no significant differences in clinical pregnancy rate (24.5% in antagonist group vs. 27.4% in agonist group, p=NS) and implantation rate (11.4% in antagonist group vs. 12.0% in agonist group, p=NS) between two groups. Mean number of retrieved oocytes was significantly higher in GnRH agonist LP group than in GnRH antagonist MDP group ($5.4{\pm}3.5$ vs. $6.6{\pm}5.0$, p<0.0001). But, the number of mature and fertilized oocytes, and the number of good quality (grade I and II) and transferred embryos were not different between two groups. In each group A, B, and C, the rate of poor response did not differ according to stimulation protocols. Conclusions: In conclusion, for infertile women expected poor ovarian response such as who are old age or has elevated basal FSH level, a protocol including a controlled ovarian hyperstimulation using GnRH antagonist appears at least as effective as that using a GnRH agonist, and may offer the advantage of reducing gonadotropin consumption and treatment period. However, much work remains to be done in optimizing the GnRH antagonist protocols and individualizing these to different cycle characteristics.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.66-66
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• 2003

The aim of this study was to investigate effect of different energy substrates on embryonic development of mouse embryos. Two cell embryos, recovered from ICR female mice (4 weeks old) at 44~52hrs after hCG injection (mated just after hCG injection), were cultured fur 72 hrs in the medium (MEM) supplemented with the three different energy substrates [glucose(G), pyruvate(P) and lactate(L)] and combinations (Control: 0 mM: group A: G 0.5; B: G 3.15; C: P 0.1; D: P 0.32; E: L 5.87; F: L 10.5; G: G0.5+P0.32+L10.5; H: G3.15+P0.1+L5.87; I: G0.5+P0.1+L5.87; J: G3.15+P0.32+L10.5). Blastocysts were stained differentially using PI and bisbenzimide. The 69.8% of the 2 cell embryos cultured in group F were developed the blastocysts. This was the highest (NS) than all other tested groups (44.2~62.8%). Blastocysts, cultured in the group E (60.4$\pm$26.9) and G (58.1$\pm$26.3), had significantly(p<0.05: group E vs. control, B, C, D; G vs. control, A, B, C, D) higher mean cell number compared with the other (42.6$\pm$25.8 ~ 55.2$\pm$31.3) and control (42.6$\pm$25.8) was at the basal level. The proportion of ICM (% ICM of total cells) in blastocysts cultured in group B (26.0$\pm$9.5%), C (29.6$\pm$22.8%) and J (26.0$\pm$11.8%) were significantly higher (p<0.05: control vs. group B, C, J: A vs. C, J; C vs. D, E, I) than those of other tested groups (15.0$\pm$10.6 ~ 23.8$\pm$ 12.9％) and control (15.0$\pm$10.6％) was at the basal level. These results showed that energy substrates supported the development of mouse 2 cell embryos, especially with greater embryo development in high dose of lactate added to media.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.2
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• pp.281-287
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• 1999

The turbulent natural convection in the membrane type LNG carrier cofferdam with heating points has been studied by numerical method. As the numerical methods, we introduced the three turbulence model, a standard $k-{\varepsilon}$ model and two case of a low Reynolds number models. The parameters considered for this study ore number and capacity of heating points i.e., $1{\leq}Ns{\leq}12$ and $1.0{\times}10^5{\leq}Qs(W/m^3){\leq}1.0{\times}10^8$. The results of the isotherms and velocity vectors have been represented for various parameters. The temperature and velocity at upper position in the space ore shown to be higher than those at lower position. For obtaining the optimal temperatures, $20{\sim}30^{\circ}C$ in the cofferdam space, the heating capacities show $2.0{\times}10^7W/m^3$ at g-heating points and $1.0{\times}10^7W/m^3$ at 12-points. The mean temperature in the cofferdam space can be expressed as a function of number and capacity of heating points.

• Ocean and Polar Research
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• v.29 no.4
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• pp.303-310
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• 2007

2-D wavelet analysis is applied to bathymetric data from the KR1 area of Korea Deepsea Mining Area. The wavelet analysis is one of the quantitative methods to analyze the topography. The wavelet allows us to create filters to select for topography in a continuous variety of shapes, sizes, and orientation. The 2-D Linear B-spline filter, 100 BS and 100 NF, is convolved with bathymetric data to identify the location of abyssal hills and abyssal troughs in bathymetry. In addition, the 2-D derivative of Cubic B-spline filter, 60 BS and 60 NF, is applied to bathymetric data to find the slope of abyssal hill in bathymetry. These filters were rotated $5^{\circ}$ counterclockwise from NS to match the dominant orientation of seafloor lineament. Both filters result in good match with abyssal hills, troughs, and slopes. This method can apply to fault, fold, and other lineament structures description with variable size. The result of application shows that wavelet analysis of bathymetric data could be used with fundamental data of geophysical analysis.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.379-381
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• 2002

A single CdZnTe detector is tested for suitability in a prototype CT/ SPECT system designed to acquire both emission and transmission data. The detector has the size of 1${\times}$l-cm$^2$ with 4${\times}$4 1.5${\times}$l.5mm$^2$ pixellated anodes. Since the detector is smaller than imaged object, we translated it in an arc centered at the x-ray tube to image larger objects. Pulse counting electronics with very short shaping time (50 ns) are used to satisfy high photon rates in x-ray imaging, and response linearity up to 3${\times}$10$\^$5/ counts per second per detector element is achieved. The energy resolution of 122-keV gamma-ray is measured to be 14%. We have characterized the system performance by scanning a radiographic resolution phantom .and the Hoffman brain phantom. The spatial resolution of CT and SPECT are about 1 mm and 7 mm, respectively.

• Journal of electromagnetic engineering and science
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• v.16 no.1
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• pp.7-12
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• 2016

This paper presents the design of a negative group delay circuit (NGDC) using the filter synthesis approach. The proposed design method is based on a frequency transformation from a low-pass filter (LPF) to a bandstop filter (BSF). The predefined negative group delay (NGD) can be obtained by inserting resistors into resonators. To implement a circuit with a distributed transmission line, a circuit conversion technique is employed. Both theoretical and experimental results are provided for validating of the proposed approach. For NGD bandwidth and magnitude flatness enhancements, two second-order NGDCs with slightly different center frequencies are cascaded. In the experiment, group delay of $5.9{\pm}0.5ns$ and insertion loss of $39.95{\pm}0.5dB$ are obtained in the frequency range of 1.935-2.001 GHz.

• Journal of Acupuncture Research
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• v.19 no.5
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• pp.124-135
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• 2002

Objective : This study was done to observe the effects on the thermal changes of herbal acupuncture. There were remarkable local thermal changes between pre and post herbal acupuncture therapy on D.I.T.I. or not. If there are those, we examine how long changes of those were maintained, what is the adequate interval on herbal acupuncture therapy. Methods : D.I.T.I, was used to study the local thermal changes in herbal acupuncture therapy. Determination of this analysis periods are pre and post-therapy(1hour, 1day, 7days later). The study group was divided into six groups that are NS group(No.=20), CF group(No.=22), BU group(No.=23), BUM group(No.=19), HP group(No.=20) and BV group(No.=l9). The herbal acupuncture was injected by 0.2ml divided into 0.05ml at the Fengmen(風門: B12), Feishu(肺兪: B13), Fufen(附分: B41), Pohu(魄戶: B42) 4 points. Then, we checked the thermal changes of their point after performing. Results : The following results were obtained ; 1. In CF groups, significant dermatothermal difference between pre and post therapy was not checked, In BU group that continued until post-therapy 1day, in HP group until 1hour, in BV group until 2days. In BUM, HP and BV group, Most dermatothermal difference was checked at post-therapy 1hour, in BU group at post-therapy 1day. 2. At post-therapy 1 hour, significant dermatothermal different between pre and post therapy was checked among BU group, BUM group, HP group and BV group. At post-therapy 1day and 2days, checked among BU group, BUM group and BV group. At post-therapy 7days, not checked among all groups. The group that highest dermatothermal difference were checked is BV group.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.1
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• pp.28-35
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• 2010

In this paper, we designed and fabricated a ultra-wideband(UWB) bandpass filter with a good performance of a stopband, and a notched band in passband. The transformed equivalent circuit of the highpass filter was realized by distributed element. A wide-passband with 3-dB fractional bandwidth of more than 100 % was achieved by using optimum response of the HPF. For improving lower and upper stopband characteristic, a cross coupling between feed lines was employed, which was analyzed by desegmentation technique. In order to reject interference of Wireless LAN and Hyper LAN(5.15~5.825 GHz), the narrow notched(rejection) band was realized by a spurline. The fabricated BPF indicated the passband from 3.1 to 10.55 GHz and the flat group delay of less than 0.94 ns over the entire passband except the rejection band. The filter shown sharp attenuation both inside and outside the band and notched band from 5.2 to 6.12 GHz.

• The Korea Journal of Herbology
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• v.37 no.5
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• pp.27-35
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• 2022

Objectives : 3-Acetyl-11-keto-𝛽-boswellic acid (AKBA) is a major active compound in Boswellia serrata. We investigated the arthritic changes following AKBA administration in monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods : All rats were randomly divided into five groups: Normal, Control, INDO (indomethacin 2 mg/kg treated), AKBA30 (AKBA 30 mg/kg treated), and AKBA60 (AKBA 60 mg/kg treated); drugs were given 2 weeks before MIA injection. For all groups except the normal group, 50 µL of sterile saline with MIA (80 mg/mL) was injected into the right knee joint 2 weeks after drug administration. The drug administration was continued for 4 weeks from 1 week after osteoarthritis induction. The histomorphological changes of knee joint cartilage were observed by H&E staining. Also, the levels of glycosaminoglycan (GAG), cartilage oligomeric matrix protein (COMP), 5-lipoxygenase (5-LOX), 5-LOX-activating protein (FLAP), and leukotriene B₄ (LTB₄) in the knee joint were determined by the ELISA kits. The expressions of mitogen-activated protein kinases (MAPKs), inflammatory cytokines, and matrix metalloproteinases (MMPs) in knee joint were detected by Western blot. Results : Data show that levels of 5-LOX, FLAP, LTB4, and COMP were downregulated significantly in the AKBA treated groups when compared to those in the Control group. On the other hand, GAG levels were significantly elevated. As a result of Western blot, the AKBA-treated groups significantly inhibited phosphorylation of MAPKs. In addition, significant downregulation of the expression of inflammatory cytokines and MMPs was found in the AKBA-treated groups. Conclusion : Our findings suggest that administration of AKBA could exert better chondroprotective and anti-inflammatory effects for MIA-induced osteoarthritis rats.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2005.11a
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• pp.7-12
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• 2005

A compact microstrip band-selective filter for ultra-wideband (UWB) radio system is proposed. The filter combines the traditional short-circuited stub highpass filter and coupled resonator bandstop filter on both sides of the mitered 50-ohm microstrip line. To realize the pseudo-highpass filtering characteristic over UWB frequency band (3.1 GHz to 10.6 GHz), a distributed highpass filter scheme is adopted. Three coupled resonators are utilized to obtain the band stop function at the desired frequency band. By meandering the coupled resonators, there is 29% reduction in footprint compared to the traditional bandstop filter using L-shaped resonators. The measured results show that the filter has a wide passband of 146.7 % (2.1 GHz to 10.15 GHz) with low insertion loss and the stop band of 7.42 % (5.32 GHz to 5.73 GHz) for 3-dB bandwidth. The measured group delay is less than 0.7 ns within the passband except the rejection band.