• Title/Summary/Keyword: NQ304

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Inhibition of Growth Factor-induced MAP kinase and Akt Activation by NQ304, a 1,4-Naphthoquinone Derivative in Rat Aortic Vascular Smooth Muscle Cells

  • Kim, T-J;Hong, J-T;Ryu, C-K;Park, Y-S;Song, Y-S;Yu, M-U;Jeon, J-S;Jin, Y-R;Yun, Y-P
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.160-160
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    • 2001

  • We recently reported that, 2-chloro-3-(4-hexylphenyI)-amino-l, 4-naphthoquinone(NQ304), a naphthoquinone derivative, had potent inhibitory effects on the platelet aggregation in vitro and thrombosis in vivo. Furthermore, we reported the antiplatelet mechanism of NQ304 by the reduction of the thromboxane A2 formation, inhibition of adenosine triphosphate release and intracellular calcium mobilization.(omitted)

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NQ304, A NOVEL ANTITHROMBOTIC AGENT, INHIBITS THE PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS

  • Kim, Jin-Ho;Kim, Tack-Joong;Ryu, Chung-Kyu;Hong, Jin-Tae;Yun, Yeo-Pyo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.119-119
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    • 2002

  • Several 1,4-naphthoquinone derivatives have been reported to possess many pharmacological effects such as anti-viral, anti-fungal, anti-cancer and anti-platelet activities. However, little has been known about functional role in vascular smooth muscle cells (VSMCs).(omitted)

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Use of mothers' home meal replacement and diet quality of their young children (유아 어머니의 유아식사에서 가정간편식 이용 빈도에 따른 유아 자녀의 식사의 질 평가)

  • Kim, Bo-Yeon;Kim, Mi-Hyun
    • Journal of Nutrition and Health
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    • v.54 no.3
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    • pp.292-304
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    • 2021

  • Purpose: This study investigated the association between the mothers' use of home meal replacement (HMR) in their children's meals and the diet quality of their young children. Methods: Three hundred and thirty-seven mothers with five-year-old kindergartners in Sejong city participated in the survey from June to July 2020. The questionnaire consisted of the status of HMR use in children's meals and questions for assessing the nutrition quotient for preschoolers (NQ-P). The subjects were classified into three groups according to the frequency of HMR use in children's meals: using HMR more than three times a week (high-frequency group; [HG], n = 65), one-two times a week (moderate-frequency group; [MG], n = 145), and less than once a week (low-frequency group; [LG], n = 130). Results: The mothers' mean age was 38.3 years. The average monthly cost of purchasing HMRs was highest at 200,000-300,000 won in HG, 50,000-100,000 won in MG, and less than 50,000 won in LG (p < 0.001). The consumption frequency of processed meats, fast foods, processed beverages, and sweet & fatty snacks was significantly higher in the HG group than the other groups. The mean NQ-P score was 60.5 in HG, 63.0 in MG, and 64.5 in LG, showing a significant difference (p < 0.01). In the sub-score according to the three areas, there were no significant differences in balance and environment among the three groups. In the moderation area, however, the score was 44.1 in HG, 51.3 in MG, and 57.5 in LG Group, showing a significant difference (p < 0.001). Conclusion: The increase in HMR use was related to the decreased diet quality in the overall and moderation areas of children's diet. These results support the importance of nutrition education for mothers, which aims to reduce their children's access and exposure to processed foods, such as HMR.

  • https://doi.org/10.4163/jnh.2021.54.3.292 인용 PDF KSCI