• 농촌계획
• /
• 제20권4호
• /
• pp.1-12
• /
• 2014

This study has analyzed overseas projects of building rural communities using vacant houses. It is aimed at identifying the roles of NPO in the community-building projects and providing implications applicable to Korea. In recent years, there has been a spike in the number of vacant houses in rural areas. It is due to rapid urbanization and uneven distribution of the population across the country. Those are the reasons that prompted community-building projects. To solve the vacant house issue, there has been rising interest in building communities through vacant houses as rural resources and effectively integrating them as useful resources. However, the roles of key entity that pursues community-building projects using vacant houses have not been discussed sufficiently. Thus, this study deals with the 'Vacant House Recreation Project of NPO Corporation in Onomichi' in Hiroshima, Japan. Through the case study, the following are introduced as NPO's roles in community-building projects using vacant houses. First, pursuing promotion and attracting attention by making the utilization of vacant houses sensational; system improvement; offering information. Second, enhancing the perception of local residents by offering local services using vacant houses; offering community-building items. Third, forming a place of public discussion to solve conflicts during community-building projects using vacant houses; offering alternatives to building communities. Above all, such roles have led to the key status of NPO during its community-building projects using vacant houses. It offers the following implication for Korea: Future vacant house-related policies for rural revitalization should be done from community-building standpoint and include establishing the roles of NPO.

• 한국콘텐츠학회논문지
• /
• 제21권5호
• /
• pp.716-726
• /
• 2021

본 연구는 높은 기부금 수입을 통해 지속가능한 운영을 유지하고 있는 10개의 복지 NPO의 특성을 사례분석을 통해 탐색하였다. 다음으로 선행연구 검토를 통해 평가 기준을 도출하여 해당 NPO 기관을 평가하였다. 마지막으로 이러한 논의를 토대로 국내 복지 NPO의 지속가능한 성장과 발전을 위한 발전 방향을 제시하였다. 평가결과 기부금 수입이 높은 국내 복지 관련 NPO들은 모두 투명성이 높고, 재무안전성이 높았다. 또한 효율성 부분에서도 3점 후반대 이상으로 비교적 높은 효율성을 보였다. 또한 기부자들과 소통하기 위해 다양한 SNS를 사용하고 있음을 확인하였다. 이는 NPO들이 기부자들의 중요성을 인지하고 기부금 활성화에 최선을 다하고 있음을 보여주는 결과이다. 이러한 분석결과를 통해 NPO가 독립적인 활동을 할 수 있도록 학술적·정책적 함의를 제시하고자 한다.

• 대한방사선기술학회지:방사선기술과학
• /
• 제21권1호
• /
• pp.69-78
• /
• 1998

15Gy 선량의 방사선을 흰쥐의 위에 단일 조사하여 방사선 치료전 수반되는 금식이 비금식군과 금식군 간의 위 조직에 미치는 영향을 형태학적으로 관찰하여 다음과 같은 결론을 얻었다. 방사선 조사 후 1일 금식군에서 울혈현상과 상피 탈락현상이 관찰되었다. 방사선 조사 후 28일 금식군과 비금식군 모두 섬유화가 관찰되었으나, 금식군이 비금식군에 비해 더 많은 영역에서 섬유화가 관찰되었다. PAS 반응 양상에 있어서 방사선 조사후 7 및 14일군에서는 PAS 반응은 거의 없거나 매우 약했지만 28일군에서 비금식군은 정상군과 같은 반응 양상을 보였다. 본 실험에서 나타난 결과로 볼 때 금식군은 비금식군에 비해 고선량의 방사선에 대해 손상정도가 더 큰 것으로 나타났다.

• 한국환경성돌연변이발암원학회지
• /
• 제17권2호
• /
• pp.97-108
• /
• 1997

The drugs or xenobiotics introduced to the body, are detoxified through the process of biotransformation in the body. In this process, most of the insoluble compounds become more polar, soluble and easily excretable. But, parts of introduced materials are metabolized to highly reactive electrophilic carcinogens through activation pathways. These metabolites are toxic and can react with DNA, RNA and proteins which are nucleophilic compounds. The objective of this study is to illustrate the aleactivation pathways of two highly reactive epoxide compounds, vinyl carbamate epoxide (VCO) and 2'-(4-nitrophenoxy)oxirane (NPO). They are the ultimate electrophilic carcinogens of ethyl carbamate(urethane) and 4-nitrophenyl vinyl ether, respectively. In this research, we studied the inhibition of the mutagenic activities of VCO or NPO by nuchieophiles [glutahione(GSH) and N-acetylcysteine(NAC)], detoxifying enzymes[epoxide hydrolase and glutathione-S-transferase(GST)] and intracellular organelles (microsomes and cytosol). In addition we also tested the suppression of DNA adducts formation by GSH and NAC. The results are summerized as follow. 1. The microsomes and cytosol which contain epoxide hydrolase and GST, respectively, decreased the mutagenicity of VCO (74% and 95%, respecfivel), and NPO (35% and 93%, respectively). The nucleophilic GSH and NAC decreased the mutagenicity by 86% (VCO) and 80% (NPO), 76% (VCO) and 40% (NPO), respectively. 2. The purified epoxide hydrolase decreased the mutagenicity of two epoxides in a dose-dependent manner, and GSH also decreased the mutagenicity in the presence of GST. 3. Formation of two DNA adducts, 7-(2'-oxoethyi)guanine (OEG) and N2,3-ethenoguanine(EG), were compared in the presence of calf thymus DNA and epoxide (VCO or NPO) in vitro system. The amounts of DNA adducts were decreased in the presence of GSH (25% and 29% in VCO, 32% and 29% in NPO), and NAC (14% and 16% in VCO, 21% and 11% in NPO), respectively. From these results, it is concluded that the ultimate carcinogenic metabolites, VCO and NPO, can be made in the body, but much of them may be inactivated and detoxified by the nucleophilic GSH, NAC and detoxifying enzymes (epoxide hydrolase and GST). Therefore, by these mechanism, the formation of DNA adducts and mutagenic activities of these two epoxides may be lowered in vivo.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
• /
• pp.182-183
• /
• 2008

본 연구에서는 유전 손실이 낮고, 고분자(LCP)의 유전율을 높이기 위하여 (100-x)LCP(polymer)-xNPO(ceramic) 복합체 (x= 0, 10, 20, 30, 40, 50)의 유전 특성 및 미세구조를 연구하였다. LCP와 ceramic filler(NPO)는 Brabender Mixer를 사용하여 $300^{\circ}C$에서 혼합한 후, Hot press 사용하여 $300^{\circ}C$, 7ton 성형 압력으로 pellet 형태 $(2.5cm\times2.5cm\times0.1cm)$로 제조 하였다. LCP-NPO 복합 소재를 SEM을 통해 미세구조를 관찰하였고, 복합체의 유전 특성을 조사하였다.

• 한국주거학회:학술대회논문집
• /
• 한국주거학회 2004년도 추계학술대회 논문집
• /
• pp.425-430
• /
• 2004

Citizens' activities in making village are to create urban future. It means that it is not civil organizations, but is cooperation in making village. Accordingly, the various arrangements for the cooperation among civil organizations, administration and enterprises which have been established and developed should be made. For these, strengthening of policies to foster the establishment of civil organizations is needed on the basis of way of thinking that ${\ulcorner}$Making village should be through citizens' cooperation${\lrcorner}$. In this case, connections among administration, private NPO center, enterprise and civil organizations are needed as shown in cases of Sendai, Japan.

• 하천과문화
• /
• 제10권2호
• /
• pp.102-104
• /
• 2014

• 한국정보시스템학회지:정보시스템연구
• /
• 제26권2호
• /
• pp.85-104
• /
• 2017

Purpose The purpose of this study is to improve the efficiency of the activities of loosely connected network organization through the platform(Ba) of knowledge sharing. Loosely connected network organizations have been tried to promote new work and complement the scarce resources through collaborations. NPO(Non-Profit Organization) is essential to establish cooperation networks in order to achieve the public interest on the basis of scarce resources. This study interpreted the Ba on the 'Change-On' program and analyzed the social networks of regional organizations through the activation of the Ba. The 'Change-On' program is conducted for several years to promote the efficiency of the NPO network by Daum Generation Foundation. Design/methodology/approach This study made a design to organize the Ba concept of Nonaka & Konno and presented a case of the Ba activated based on the NPO network of regional order. According to the social network analysis of regional cooperation within the network of participating organizations was extended, it was found that the principal plays a significant role as a central hub made. Findings According to the empirical analysis, this study illustrated that various types of network were formed among NPOs based on the 'Change-On'. Furthermore, the networks surrounding NPOs are extended to the other people connected to them. This means that the network of NPOs had been diversified via the facilitation of the Ba. This study throws new highlights on the new role for the Ba as a network promoter in addition to the partner as a technology-provider in the NPO ecosystem. Moreover, the network analysis between before-and-after can be used for the evaluation of the effectiveness of the various Ba programs.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권4호
• /
• pp.2271-2275
• /
• 2016

Background: The value of 5-aminolevulinic acid (ALA) in fluorescence detection of peritoneal metastases and the underlying mechanisms were evaluated in patients with peritoneal surface malignancies. Materials and Methods: Oral 5-ALA was administered at a concentration of 20 mg/kg body weight with 50 ml of water 2 hours prior to surgery (n=115). The diagnostic value of 5-ALA based fluorescence production was evaluated following white light inspection during prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Then, peptide transporter PEPT1 (ALA influx transporter) and ATP-binding cassette transporter ABCG2 (porphyrin efflux transporter) gene expression was determined with quantitative real time (qRT)-PCR and pathological diagnoses confirmed for all tissue samples. Results: The 5-ALA based photodynamic detection rate was 17% for appendiceal mucinous neoplasms, 54% for colorectal cancers, 33% for gastric cancers, 67% for diffuse malign peritoneal mesotheliomas, and 89% for epithelial ovarian cancer of peritoneal metastases. 5-ALA was detected in all cases of peritoneal metastases originating from cholangiocarcinomas whereas it was not able to detect any in granulosa cell and gastrointestinal stromal tumor cases. Furthermore, PEPT1 was overexpressed whereas ABCG2 expression was downregulated in tumors detected with fluorescence. Conclusions: 5-ALA provided 100% specificity and high sensitivity to detect peritoneal metastases in subgroups of patients with peritoneal surface mailgnancies. ALA influx transporter PEPT1 and porphyrin efflux transporter ABCG2 genes are important in tumor specific 5-ALA induced fluorescence in vivo. Further studies should clarify diagnostic utility of 5-ALA in peritoneal surface malignancies.

• Journal of Chest Surgery
• /
• 제57권2호
• /
• pp.152-159
• /
• 2024

Background: Anastomotic leakage (AL) following esophagectomy represents a serious complication that often results in prolonged hospitalization and necessitates repeated interventions, including nothing-by-mouth (NPO) restriction, endoscopic vacuum therapy (EVT), or surgical repair. In this study, we evaluated the patterns and outcomes of AL treatment. Methods: We retrospectively reviewed the medical records of patients who underwent esophagectomy for esophageal cancer at a single center between 2003 and 2020. Of 3,096 examined cases, 181 patients (5.8%) with AL were included in the study: 114 patients (63%) with cervical anastomosis (CA) and 67 (37%) with intrathoracic anastomosis (TA). Results: The incidence of AL was 11.9% in the CA and 3.2% in the TA group (p<0.001). Among patients with CA who developed AL, 87 (76.3%) were managed with NPO, 15 (13.2%) with EVT, and 12 (10.5%) with surgical repair. Over 90% of patients with cervical AL resumed an oral diet by the time of discharge, regardless of treatment method. Among patients with TA and AL, 36 (53.7%) received NPO, 25 (37.7%) underwent EVT, and 6 (9%) required surgery. Of these, 34 patients who were managed with NPO and 19 with EVT could resume an oral diet. However, only 2 patients who underwent surgery resumed an oral diet, and 2 patients required additional EVT. Conclusion: Although patients with CA displayed a higher incidence of AL, their rate of successful oral intake exceeded that of those with TA, regardless of treatment method. Among patients exhibiting AL with TA, EVT was more commonly employed than in CA cases, and it appears effective.