• Genomics & Informatics
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• 제11권1호
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• pp.24-33
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• 2013

We had analyzed 10 exome sequencing data and single nucleotide polymorphism chips for blood cancer provided by the PGM21 (The National Project for Personalized Genomic Medicine) Award program. We had removed sample G06 because the pair is not correct and G10 because of possible contamination. In-house software somatic copy-number and heterozygosity alteration estimation (SCHALE) was used to detect one loss of heterozygosity region in G05. We had discovered 27 functionally important mutations. Network and pathway analyses gave us clues that NPM1, GATA2, and CEBPA were major driver genes. By comparing with previous somatic mutation profiles, we had concluded that the provided data originated from acute myeloid leukemia. Protein structure modeling showed that somatic mutations in IDH2, RASGEF1B, and MSH4 can affect protein structures.

• 한국문헌정보학회지
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• 제41권4호
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• pp.5-28
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• 2007

이 연구는 도서관 경영패러다임 및 기법 변화의 후속연구이다. 1980년대부터 주요 선진국은 사회변동에 따른 경영 및 행정패러다임의 변화에 주목하여 신공공경영이론을 행정개혁과 경영혁신의 사상적 원천 및 전략적 수법으로 채택하였는데. 그 이유는 무엇이며 구체적인 실천수단이 도서관의 경영개혁과 관리운영에 어떻게 적용되어 경영형태를 변용시키는 지에 대하여 분석하였다. 특히 공공도서관을 중심으로 아웃소싱, 위탁경영 및 지정관리자제도, 민간자금 활용사업을 집중적으로 논급하고 제언하였다.

• 전자공학회논문지B
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• 제31B권12호
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• pp.108-115
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• 1994

Most pattern classifiers have been designed based on the ML (Maximum Likelihood) training algorithm which is simple and relatively powerful. The ML training is an efficient algorithm to individually estimate the model parameters of each class under the assumption that all class models in a classifier are statistically independent. That assumption, however, is not valid in many real situations, which degrades the performance of the classifier. In this paper, we propose a minimum-error-rate training algorithm based on the MAP (Maximum a Posteriori) approach. The algorithm regards the normalized outputs of the classifier as estimates of the a posteriori probability, and tries to maximize those estimates. According to Bayes decision theory, the proposed algorithm satisfies the condition of minimum-error-rate classificatin. We apply this algorithm to NPM (Neural Prediction Model) for speech recognition, and derive new disrminative training algorithms. Experimental results on ten Korean digits recognition have shown the reduction of 37.5% of the number of recognition errors.

• BMB Reports
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• 제41권12호
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• pp.840-845
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• 2008

Nucleophosmin/B23, a major nucleolar phosphoprotein, is overexpressed in actively proliferating cells. In this study, we demonstrate that B23 exclusively localizes in the nucleolus, whereas ATP depletion results in the redistribution of B23 throughout the whole nucleus and destabilizes B23 via caspase-3 mediated cleavage. Interestingly, ATP binding precedes PI(3,4,5)P3 binding at lysine 263 and ATP binding mutants fail to restore the anti-apoptotic functions of B23 in PC12 cells. Thus, the ATP-B23 interaction is required for the stability of the B23 protein and regulates cell survival, confining B23 within the nucleolus in PC12 cells.

• BMB Reports
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• 제43권2호
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• pp.127-132
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• 2010

Phosphatidylinositol (3,4,5)-triphosphate ($PIP_3$) is a lipid second messenger that employs a wide range of downstream effector proteins for the regulation of cellular processes, including cell survival, polarization and proliferation. One of the most well characterized cytoplasmic targets of $PIP_3$, serine/threonine protein kinase B (PKB)/Akt, promotes cell survival by directly interacting with nucleophosmin (NPM)/B23, the nuclear target of $PIP_3$. Here, we report that nuclear $PIP_3$ competes with Akt to preferentially bind B23 in the nucleoplasm. Mutation of Arg23 and Arg25 in the PH domain of Akt prevents binding to $PIP_3$, but does not disrupt the Akt/B23 interaction. However, treatment with phosphatases PTEN or SHIP abrogates the association between Akt and B23, indicating that nuclear $PIP_3$ regulates the Akt/B23 interaction by controlling the concentration and subcellular dynamics of these two proteins.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5341-5344
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• 2013

Objectives: To explore the relationships between age, cytogenetic subgroups, molecular markers, and cells with leukemic aberrant immunophenotype in patients with acute myeloid leukemia (AML). Methods: In this study, we evaluated the correlations between age, cytogenetic subgroups (normal, balanced and unbalance karyotype), molecular mutations (NPM1, FLT3-ITD, and CEBPA mutations) and marrow leukemia cells (LC) identified by flow cytometry in 256 patients with de novo AML. Results: From age group 10-19 years to age group ${\geq}60$ years, the percentage of LC decreased from $67.0{\pm}18.4%$ to $49.0{\pm}25.1%$ (F=2.353, P=0.041). LC percentage was higher in patients with balanced karyotypes ($65.7{\pm}22.4%$), than those with unbalanced karyotypes ($46.0{\pm}26.6%$) (u=3.444, P=0.001) or a normal karyotype ($49.9{\pm}22.1%$) (u=5.093, P<0.001). Patients with FLT3-ITD ($64.3{\pm}19.5%$) had higher LC percentages compared with those without ($54.2{\pm}24.3%$) (u=2.794, P=0.007). Conclusions: Associations between age, cytogenetics, molecular markers, and marrow leukemia cells may offer beneficial information to understand the biology and pathogenesis of AML.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 추계학술대회
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• pp.748-750
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• 2017

사물인터넷이 고도의 지능화가 됨에 따라 다양한 분야로 적용되고 있다. 그중에 센서-서버-DB를 결합해 하나의 플랫폼을 만들어서 다양한 분야에 접목하면 데이터를 쉽게 관리 할 수 있는 사물인터넷 기반의 시스템이 구현 가능하다. 이에 따라, 본 논문에서는 사물인터넷 기반 NodeJS와 MongoDB를 활용하여 스마트폰 기울기에 따른 서보모터 동작 제어 시스템 구현을 위해 Rasberry Pi, 서보모터, 스마트폰으로 시스템을 구성하고, NodeJS, MongoDB, npm모듈, HTML을 활용한 서보모터 센서 값이 발생하면 NodeJS로 전송하여 데이터를 저장 관리 할 수 있도록 하였다.

• The Journal of Asian Finance, Economics and Business
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• 제8권3호
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• pp.441-449
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• 2021

Bankruptcy is indicated by the inability of the company to meet its maturity obligations. The Covid-19 pandemic has had a terrible impact on the economy and businesses. The aim of this study to determine the effect of the ratios of activity, growth, leverage, and profitability in predicting bankruptcy projected by earnings per share (EPS). The sample of this research was non-banking financial sector companies listed on the Indonesia Stock Exchange in 2015-2019 and the purposive sampling technique was used. The data analysis method used was the logistic regression method to test the hypotheses. Company growth shows the company's ability to manage sales and generate high company profits, as such, the probability of the company experiencing bankruptcy will be lower. The results of this study showed that the debt to assets ratio (DAR), debt to equity ratio (DER), and return on assets (ROA) can predict bankruptcy. Meanwhile, this research found that the total assets turnover (TATO) ratio, sales growth, and net profit margin (NPM) cannot be used to predict bankruptcy.

• The Journal of Asian Finance, Economics and Business
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• 제8권3호
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• pp.885-894
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• 2021

This study aims to analyze the effect of the ratio of profitability and solvability (leverage) on the variable stock price, which is mediated (intervening) by the variable dividend policy. Using the financial reports of manufacturing companies in the consumer goods sector, we take profitability data (ROA, ROE, GPM, and NPM), solvability data (DAR, LTDER, and DER), dividend policy (DPR), and stock price (closing price) from 24 companies, which were selected as samples, from 2011 to 2018. Data was analyzed using the Structural Equation Modeling (SEM) method. The results show that profitability, solvability, and dividend policy affect changes in stock prices, respectively. On the other hand, profitability and solvability do not affect dividend policy. The indirect relationship (intervening) is assessed using a single test, resulting in a dividend policy that can intervene in the relationship between profitability and stock prices but cannot mediate the relationship between solvability and stock prices. The implication of this research is to provide knowledge to investors about the importance of knowing the company's financial performance. Companies with good financial performance will easily develop because there are sufficient funds for company operations. By analyzing financial ratios, investors can get signals to decide whether to invest in the company they want.

• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4499-4513
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• 2022

Spent fuel behavior of dry storage was simulated in a continuous state from steady-state operation by modifying FRAPCON-4.0 to incorporate spent fuel-specific fuel behavior models. Spent fuel behavior of a typical PWR was compared with that of NuScale Power Module (NPM^TM). Current PWR discharge burnup (60 MWd/kgU) gives a sufficient margin to the hoop stress limit of 90 MPa. Most hydrogen precipitation occurs in the first 50 years of dry storage, thereby no extra phenomenological safety factor is identified for extended dry storage up to 100 years. Regulation for spent fuel management can be significantly alleviated for LWR-based SMRs. Hydride embrittlement safety criterion is irrelevant to NuScale spent fuels; they have sufficiently lower plenum pressure and hydrogen contents compared to those of PWRs. Cladding creep out during dry storage reduces the subchannel area with burnup. The most deformed cladding outer diameter after 100 years of dry storage is found to be 9.64 mm for discharge burnup of 70 MWd/kgU. It may deteriorate heat transfer of dry storage by increasing flow resistance and decreasing the view factor of radiative heat transfer. Self-regulated by decreasing rod internal pressure with opening gap, cladding creep out closely reaches the saturated point after ~50 years of dry storage.